Population genomics of a natural Cannabis sativa L. collection from Iran identifies novel genetic loci for flowering time, morphology, sex and chemotyping by Mahboubeh Mostafaei Dehnavi, Annabelle Damerum, Sadegh Taheri, Ali Ebadi, Shadab Panahi, George Hodgin, Brian Brandley, Seyed Alireza Salami, Gail Taylor

“…The data obtained enabled an association analysis, linking genotypes with key phenotypes such as inflorescence characteristics, flowering time, plant morphology, tetrahydrocannabinol (THC) and cannabidiol (CBD) content, and sex. …”
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Whole-genome association studies of distribution of developmental abnormalities and other breeding-valuable qualitative traits in offspring of the Russian large-white boars by A. A. Traspov, O. V. Kostyunina, A. A. Belous, T. V. Karpushkina, N. A. Svejenceva, N. A. Zinovieva

“…Such studies are directly related to the improvement of the economic efficiency, as they allow identification and exclusion of defect animals, who may carry target genes not appearing phenotypically, from the breeding process. In the current work, we have searched for these kind of target genes and genome regions with conducting the genome-wide association studies using PorcineSNP60K BeadChips (Illumina, San Diego, USA). …”
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Gut microbiota and quantitative traits divergence at different altitude of long-tailed dwarf hamsters, Cricetulus longicaudatus by Yue Ren, Mengfan Tao, Xiaoliang Wang, Xinsheng Pu, Guangtong Guo, Kuiyou Chen, Bingyu Zhao, Yu Hou, Xin'gen Yang, Yumei Xu

“…This study shows that altitude has a big effect on the gut microbiota and phenotypic traits of long-tailed hamsters. It also shows how well this species can adapt to changes in altitude.…”
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Dynamic changes in the skin transcriptome for the melanin pigmentation in embryonic chickens by Dong Leng, Maosen Yang, Xiaomeng Miao, Zhiying Huang, Mengmeng Li, Jia Liu, Tao Wang, Diyan Li, Chungang Feng

“…ABSTRACT: Dermal hyperpigmentation stands out among the various skin pigmentation phenotypes in chickens, where most other pigmentation variants affect feather color and patterning predominantly. …”
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Rapid diagnostic testing combined with an immediate infectious disease consultation increases the rate of septic intensive care unit patients on targeted antibiotic therapy by Evelyn Kramme, Nadja Käding, Nadja Käding, Tobias Graf, Karolin Schmoll, Heidi Linnen, Katharina Nagel, Esther Grote-Levi, Susanne Hauswaldt, Dennis Nurjadi, Dennis Nurjadi, Jan Rupp, Jan Rupp, Jan Rupp

“…Regarding antimicrobial susceptibility testing (AST), genotypic testing (ePlex®) was successful for Gram-positive cocci, but inadequate for Gram-negative rods. Phenotypic resistance testing with the Accelerate PhenoTest® took too long to be successfully integrated into the intervention. …”
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Platelet–Monocyte Aggregate Instigates Inflammation and Vasculopathy in Kawasaki Disease by Yuan Zhang, Cuiping Jia, Manli Guo, Qian Chen, Ying Wen, Ting Wang, Yinyin Xie, Xuejiao Fan, Jingwen Gao, Timur O. Yarovinsky, Renjing Liu, Zhiyong Jiang, Mengmeng Wang, Jin Zhou, Di Che, Lanyan Fu, Richard Edelson, Xiaoqiong Gu, John Hwa, Wai Ho Tang

“…Monocyte‐activated platelets initiate transforming growth factor (TGF)β1 release, which results in nuclear localization of nuclear factor kappaB in monocytes, therefore, driving the phenotypic conversion of classical monocytes (CD14+CD16−) into proinflammatory monocytes (CD14+CD16+). …”
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Predictors of irritability in pediatric autistic populations: a scoping review by Sara Alatrash, Sara Alatrash, Tithi Paul, Julia Carbone, Melanie Penner, Melanie Penner, Atena Roshan Fekr, Atena Roshan Fekr, Azadeh Kushki, Azadeh Kushki

“…Neurobiological and physiological correlates were less explored.ConclusionThis review revealed a significant gap in understanding sociodemographic, phenotypic, and neurobiological and physiological correlates of irritability in autism. …”
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Comparative Genomic Analysis of <i>Campylobacter</i> Plasmids Identified in Food Isolates by Yiping He, Gretchen Elizabeth Dykes, Siddhartha Kanrar, Yanhong Liu, Nereus W. Gunther, Katrina L. Counihan, Joe Lee, Joseph A. Capobianco

“…The pTet plasmids were linked to tetracycline resistance phenotypes in host strains. The mega plasmids carry multiple genes (e.g., <i>aph</i>(3’)-III, type IV and VI secretion systems, and type II toxin–antitoxin systems) important for plasmid mobilization, virulence, antibiotic resistance, and the persistence of <i>Campylobacter</i>. …”
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Association of intratumoral microbiome diversity with hepatocellular carcinoma prognosis by Fengle Jiang, Yuan Dang, Zheting Zhang, Yanan Yan, Yingchao Wang, Yi Chen, Lihong Chen, Jialiang Zhang, Jingfeng Liu, Jianmin Wang

“…ABSTRACT The evidence that intratumoral microbiomes, as a rising hallmark of cancer, have a profound impact on cancer phenotypes is increasingly compelling. However, the impact of the composition and diversity of the intratumoral microbiome on the prognosis of patients undergoing surgical resection for hepatocellular carcinoma (HCC) remains incompletely understood. …”
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Statistical analysis plan for the LAST ACT clinical trial; a Leukotriene A4 hydrolase Stratified non-inferiority Trial of Adjunctive Corticosteroids for HIV-negative adults with Tu... by Joseph Donovan, Dong Huu Khanh Trinh, Ronald B. Geskus, Marcel Wolbers, Guy E. Thwaites, Nguyen Thuy Thuong Thuong, Le Thanh Hoang Nhat

“…However, benefit from corticosteroids in TBM may depend upon host leukotriene A4 hydrolase (LTA4H) genotype and the corresponding inflammatory phenotypes. This article describes the planned analyses for the primary publication of the results of the LAST ACT clinical trial (NCT03100786): ‘Leukotriene A4 hydrolase Stratified Trial of Adjunctive Corticosteroids for HIV-negative adults with Tuberculous meningitis’. …”
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Investigating the Effect and Potential Mechanism of Rhamnetin 3-<i>O</i>-α-Rhamnoside on Acute Liver Injury In Vivo and In Vitro by Dandan Deng, Borong Zhao, Hong Yang, Songsong Wang, Ziying Geng, Jiangtao Zhou, Guane Yang, Liwen Han

“…<b>Results</b>: ARR ameliorated TAA-induced growth retardation, reduced liver injury phenotypes, and decreased oxidative stress in the zebrafish. …”
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Habitat fragmentation increases the risk of local extinction of small reptiles: A case study on Phrynocephalus przewalskii by Cui Yang, Yue Qi, Jiayuan Guo, Liangfei Peng, Neng Xiong, Wenya Zhang, Wei Zhao

“…This study examines how small reptiles adapt their life history strategies in fragmented habitats and determines whether their responses are primarily due to phenotypic plasticity or genetic adaptation. We focused on Phrynocephalus przewalskii, analyzing body size, reproductive strategies, genetic structure, and diversity across three habitats with varying degrees of fragmentation. …”
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Altered NKp30, NKp46, NKG2D, and DNAM-1 Expression on Circulating NK Cells Is Associated with Tumor Progression in Human Gastric Cancer by Bin Han, Fang-yuan Mao, Yong-liang Zhao, Yi-pin Lv, Yong-sheng Teng, Mubing Duan, Weisan Chen, Ping Cheng, Ting-ting Wang, Zhong-yuan Liang, Jin-yu Zhang, Yu-gang Liu, Gang Guo, Quan-ming Zou, Yuan Zhuang, Liu-sheng Peng

“…To this light, we characterized the surface receptor phenotypes of peripheral blood NK cells and examined their clinical relevance to human gastric cancer (GC). …”
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Macro- and Micro-Nutrient Composition and Antioxidant Activity of Chickpea and Pea Accessions by Michela Costantini, Carmine Summo, Mariangela Centrone, Iga Rybicka, Mariagrazia D’Agostino, Paolo Annicchiarico, Francesco Caponio, Stefano Pavan, Grazia Tamma, Antonella Pasqualone

“…Despite the dataset investigated in our study included a limited number of accessions, it was possible to highlight the influence of the chemical composition on the antioxidant activity due to the high phenotypic diversity found between the accessions, emphasising the importance of selecting the antioxidant activity assay according to the matrix to be evaluated.…”
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Evaluation of Risk Factors Causing Diagnostic Delay in Non-steroidal Anti-inflammatory Drug-exacerbated Respiratory Disease by Melek Cihanbeylerden, Hazal Kayıkçı, Çise Tüccar, Ebru Damadoğlu, Gül Karakaya, Ali Fuat Kalyoncu

“…OBJECTIVE: Non-steroidal anti-inflammatory drug (NSAID)-exacerbated respiratory disease (N-ERD) can be difficult to diagnose due to the heterogeneity of phenotypes and a lack of validated in vitro tests. This study aimed to provide a better understanding of the course of N-ERD disease, analyze whether there was a delay in clinical diagnosis, and explore the factors that might cause diagnostic delay. …”
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Isolation and characterization of mercuric reductase by newly isolated halophilic bacterium, Bacillus firmus MN8 by M. Noroozi, M.A. Amoozegar, A.A. Pourbabaei, N.S. Naghavi, Z. Nourmohammadi

“…According to phylogenetic sequencing of 16S rRNA gene and phenotypic characteristics, the strain was categorized in the Bacillus genus and nearly related to Bacillus firmus. …”
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Xanthomonas citri subsp. citri requires a genus-specific outer membrane protein and TolB to coordinate cell membrane integrity and virulence by Leilei Wu, Xueyan Zhu, Hang Long, Xinyu Huang, Shuying Zhu, Qi Xue, Ziao Li, Huasong Zou

“…The deletion of tolB resulted in similar phenotypic alterations as the OMPXan mutant in salt stress tolerance, cell membrane integrity, and the expression of hrpG, hrpX, hrpD6, and hrcC for pathogenicity. …”
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Causal relationship between immune cells and risk of heart failure: evidence from a Mendelian randomization study by Wenjing Cao, Zefu Yang, Liumei Mo, Zhenhao Liu, Jiawei Wang, Zhenhong Zhang, Kui Wang, Wei Pan

“…There is a significant causal relationship between these phenotypes and heart failure. These immunophenotypes, 8 of which were in B cells, 5 in cDC, 2 in T cell maturation stage, 2 in monocytes, 3 in myeloid cells, 7 in TBNK and 13 in Treg. …”
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Exploiting somatic oncogenic driver alterations in a patient with Li-Fraumeni syndrome– paving the path towards precision medicine: a case report by Carolin Seeling, Sonja Dahlum, Ralf Marienfeld, Vera Jan, Brigitte Rack, Uwe Gerstenmaier, Ambros J. Beer, Regine Mayer-Steinacker, Wolfgang Thaiss, Thomas F. E. Barth, Thomas Seufferlein, Nadine T. Gaisa, Stephan Stilgenbauer, Wolfgang Janni, Reiner Siebert, Hartmut Döhner, Verena I. Gaidzik

“…Conclusions In the era of accessible and comprehensive genetic and phenotypic tumor profiling, this case study of a patient with Li-Fraumeni syndrome underscores the success of precision oncology in harnessing additional somatic oncogenic driver alterations. …”
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Exploring the bidirectional causality between neuroticism and frailty: a Mendelian randomization analysis by Yuhang Xing, Rui Pu, Mengdie Fu, Zhikang Wang, Zhen Wang, Xiaopeng Shang, Guoli Yang, Zhiwei Jiang

“…In this bi-directional MR study, there were positive causal relationships between neuroticism-related phenotypes and frailty, and in the reverse direction, frailty was also positively correlated with neuroticism.…”
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