Detection of OmpA and blaPER-1 Genes and Biofilm Formation in Acinetobacter baumannii Clinical Isolates by Ban Abdulsattar, Rasha Jabbar, Susan Ibrahim

“…The automated VITEK®2 system was used to identify A. baumannii isolates phenotypically. The blaOXA51 gene confirmed A. baumannii isolates genotypically. …”
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N6-Methyladenosine in RNA and DNA: An Epitranscriptomic and Epigenetic Player Implicated in Determination of Stem Cell Fate by Pengfei Ji, Xia Wang, Nina Xie, Yujing Li

“…The mRNA m6A modification has been characterized biochemically, molecularly, and phenotypically, including elucidation of its methyltransferase complexes (m6A writer), demethylases (m6A eraser), and direct interaction proteins (readers), while limited information on the DNA m6dA is available. …”
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SARS-CoV-2 S-protein expression drives syncytia formation in endothelial cells by Katie V. Tieu, Madaline Espey, Aarthi Narayanan, Rebecca L. Heise, Farhang Alem, Daniel E. Conway

“…Because SARS-CoV-2 infections also frequently present with cardiovascular phenotypes, we sought to understand if S-protein expression would also result in syncytia formation in endothelial cells. …”
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Siglec-E augments adipose tissue inflammation by modulating TRAF3 signaling and monocytic myeloid-derived suppressor cells during obesity by Ahmed Rakib, Mousumi Mandal, Md Abdullah Al Mamun, Sonia Kiran, Nelufar Yasmen, Lexiao Li, Daniel M. Collier, Jianxiong Jiang, Frank Park, Udai P. Singh

“…We analyzed the changes in immune phenotypes, inflammatory response, adipogenesis, and levels of cytokines and chemokines after HFD and ND feeding.ResultsHFD consumption significantly increased the body weight and blood glucose levels in siglec-E KO mice relative to those of WT mice. …”
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Deep learning classification of MGMT status of glioblastomas using multiparametric MRI with a novel domain knowledge augmented mask fusion approach by İlker Özgür Koska, Çağan Koska

“…The preoperative non-invasive predictive ability and the explanation tools of the developed model may help clinicians to better understand imaging phenotypes of MGMT methylation status of glial tumors.…”
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Antimicrobial Susceptibility Profiles of Commensal <i>Staphylococcus</i> spp. Isolates from Chickens in Hungarian Poultry Farms Between 2022 and 2023 by Ábel Szabó, Ákos Jerzsele, László Kovács, Ádám Kerek

“…To uncover the underlying causes of multidrug resistance, next-generation sequencing can be employed to elucidate the genetic basis of phenotypic resistance.…”
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The use of maize haploidy inducers as a tool in agricultural plant biotechnology by A. V. Ulyanov, A. V. Karlov, E. B. Khatefov

“…Depending on their quantity, the phenotypic manifestation of the gene in the seed varies. …”
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Noncanonical IFN Signaling, Steroids, and STATs: A Probable Role of V-ATPase by Howard M. Johnson, Ezra Noon-Song, Chulbul M. Ahmed

“…Signaling of nuclear receptors such as those of estrogen and dihydrotestosterone provides templates for making sense of the specificity of gene activation by closely related cytokines, which has implications for lymphocyte phenotypes.…”
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Identification and Functional Analysis of EPOR+ Tumor-Associated Macrophages in Human Osteosarcoma Lung Metastasis by Yanxing Li, Ming Li, Rong Wei, Junlong Wu

“…Importantly, the percentage of CD163+EPOR+ TAMs had a positive linear association with malignant phenotypes as well as poor disease-free survival and overall survival time. …”
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Variability and Performance Evaluation of Released Linseed Varieties for Yield and Related Traits in South Gondar Zone, Ethiopia by Kassahun Amare, Getaneh Abebe

“…Higher genotypic coefficient of variation (GCV) and phenotypic coefficients of variation (PCV) (>20%) coupled with high heritability estimated values (>80%) were observed for seed yield per hectare, the number of capsules per plant, and tiller number. …”
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Predictors of Response to Oral Medications and Low-Histamine Diet in Patients with Chronic Urticaria by Hui-Ling Chiang, Chen-Hung Chen, Malcolm Koo, Tzung-Yi Tsai, Cheng-Han Wu

“…Chronic urticaria (CU) is comprised of diverse phenotypes, and thus, a shift towards a precision medical approach is warranted in its management. …”
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Electrophysiological properties of vestibular hair cells isolated from human crista by Nesrien Mohamed, Mohammad Al-Amin, Frances L. Meredith, Olivia Kalmanson, Anna Dondzillo, Stephen Cass, Samuel Gubbels, Katherine J. Rennie

“…A slow hyperpolarization-activated current (Ih) was observed in some hair cells in response to membrane hyperpolarization below -100 mV.DiscussionIn summary, whole cell recordings from isolated human hair cells revealed ionic currents that strongly resemble mature current phenotypes previously described in hair cells from rodent vestibular epithelia. …”
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Dissecting the genetic basis of fruiting efficiency for genetic enhancement of harvest index, grain number, and yield in wheat by Dipendra Shahi, Jia Guo, Md Ali Babar, Sumit Pradhan, Muhsin AVCI, Jordan McBreen, Zhao Liu, Guihua Bai, Paul St. Amand, Amy Bernardo, Matthew Reynolds, Gemma Molero, Sivakumar Sukumaran, John Foulkes, Jahangir Khan

“…To understand the genetic architecture of FE and TGW, we performed a genome-wide association study (GWAS) in a panel of 236 US soft facultative wheats that were phenotyped in three experiments at two locations in Florida and genotyped with 20,706 single nucleotide polymorphisms (SNPs) generated from genotyping-by-sequencing (GBS). …”
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Metabolomic and Transcriptomic Analysis of the Mechanism of the Apple Coloration Change After Uncovering Fruit Bag by Pengwei Duan, Xiaojian Ma, Haiqiang Shi, Lizhe Qin, Jizhuang Du, Sumiao Yang, Jianjun Zhang

“…In this study, the pattern of metabolite accumulation and gene expression was profiled in the striped and blushed apple peels at three ripening periods to elucidate the color formation mechanism within two weeks after removing the bag. The phenotypes presented in the peel coloring process are different between SF (stripe red) and HM (blush red), which have different accumulated levels of metabolites and gene expression during the coloring process. …”
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Properties of new polycationic bacteriochlorin photosensitizers: cytotoxicity and interaction with biofilms by Irina Tiganova, Yulia Zhizhimova, Eteri Tolordava, Elena Makarova, Natalia Shevlyagina, Alexander Barmashov, Maria Baryshnikova, Vladimir Zhukhovitsky, Yulia Romanova

“…Aim: Biofilms of pathogenic bacteria are phenotypically resistant to antibiotics and other antimicrobial agents, host immune systems, and adverse environmental conditions, and are responsible for most chronic infections. …”
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Proteomic profiling of serum in cats with naturally occurring degenerative joint disease and co-morbid conditions by B. Duncan X. Lascelles, B. Duncan X. Lascelles, B. Duncan X. Lascelles, B. Duncan X. Lascelles, Rakesh Ponnala, Steven G. Kamerling, Tracey Williams

“…A greater understanding of the systems biology of DJD, DJD-associated pain, and CKD may contribute to identifying disease specific biomarkers and relevant targets for the development of therapeutics for the control of these conditions in cats, and help inform human pain therapeutic development.MethodsUsing mass spectrometry-based proteomic profiling of the serum of 200 highly phenotyped cats with varying burdens of DJD, pain, and CKD, we identified significant individual proteins and pathways.ResultsFunctional pathway analysis, based on differentially abundant proteins across individual disease states (DJD, pain, CKD), identified pathways playing a role in DJD and DJD-associated pain including acute phase response signaling, LXR/RXR and FXR/RXR activation and the complement system. …”
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Whole-Genome Sequencing and Comparative Genome Analysis Provided Insight into the Predatory Features and Genetic Diversity of Two Bdellovibrio Species Isolated from Soil by Omotayo Opemipo Oyedara, Aldo Segura-Cabrera, Xianwu Guo, Temidayo Oluyomi Elufisan, Rafael Alejandro Cantú González, Mario A. Rodríguez Pérez

“…SKB1291214, 174 bp sequence was inserted at the host interaction (hit) locus region usually attributed to prey attachment, invasion, and development of host independent Bdellovibrio phenotypes. Also, a gene equivalent to Bd0108 in B. bacteriovorus HD100 was not conserved in Bdellovibrio sp. …”
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Population genetics of spinoсerebellar ataxias caused by polyglutamine expansions by A. N. Shuvaev, O. S. Belozor, M. V. Smolnikova, D. A. Yakovleva, Andr. N. Shuvaev, O. M. Kazantseva, E. A. Pozhilenkova, O. I. Mozhei, S. Kasparov

“…These diseases are SCA1, 2, 3, 6, 7 and 17, which phenotypically belong to one group due to similarities in clinics and genetics. …”
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Illicium verum Extract and Trans-Anethole Attenuate Ovalbumin-Induced Airway Inflammation via Enhancement of Foxp3+ Regulatory T Cells and Inhibition of Th2 Cytokines in Mice by Yoon-Young Sung, Seung-Hyung Kim, Dong-Seon Kim, Ji-eun Lee, Ho Kyoung Kim

“…We investigated the effects of treatment on airway hyperresponsiveness, IgE production, pulmonary eosinophilic infiltration, immune cell phenotypes, Th2 cytokine production in bronchoalveolar lavage, Th1/Th2 cytokine production in splenocytes, forkhead box protein 3 (Foxp3) expression, and lung histology. …”
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Identification of Potential Clusters of Signs and Symptoms to Prioritize Patients’ Eligibility for AADCd Screening by 3-OMD Testing: An Italian Delphi Consensus by Carlotta Spagnoli, Roberta Battini, Filippo Manti, Duccio Maria Cordelli, Andrea Pession, Melissa Bellini, Andrea Bordugo, Gaetano Cantalupo, Antonella Riva, Pasquale Striano, Marco Spada, Francesco Porta, Carlo Fusco

“…The following statements reached the highest priority: testing pediatric patients with hypotonia, developmental delay, movement disorders, and oculogyric crises; inclusion of 3-OMD dosing on DBS in neonatal screening programs; development of a clinical score to support patients’ selection for 3-OMD screening; among atypical phenotypes based on clinical characteristics of Italian patients: testing patients with intellectual disability and parkinsonism-dystonia. …”
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