Antimicrobial Resistance Surveillance of Skin and Soft Tissue Infections: Hospital-Wide Bacterial Species and Antibiograms to Inform Management at a Zonal Tertiary Hospital in Mwan... by Justine BN, Mushi MF, Silago V, Igembe Z, Muyombe J, Kishengena PP, Michael Jnr NS, Maganga MG, Massenga A, Tegete F, Massaga FA, Seni J

“…This study assessed the proportion of laboratory-confirmed SSTIs, identify bacterial species involved, analyze AMR phenotypes, and investigate the risk factors associated with multidrug-resistant (MDR) SSTIs.Patients and Methods: Analytical cross-sectional study was conducted between January and June 2023, involving 614 patients with SSTIs. …”
Get full text

Acetyl-CoA synthesis in the skin is a key determinant of systemic lipid homeostasis by Phuong T.T. Nguyen, Mia Shiue, Nina Kuprasertkul, Pedro Costa-Pinheiro, Luke T. Izzo, Laura V. Pinheiro, Hayley A. Affronti, Gabriel Gugiu, Shivani Ghaisas, Joyce Y. Liu, Jordan C. Harris, Charles W. Bradley, John T. Seykora, Xiaolu Yang, Taku Kambayashi, Clementina Mesaros, Brian C. Capell, Kathryn E. Wellen

“…Dietary fat supplementation further boosts sebum production and partially rescues both the lipoatrophy and the aberrant skin phenotypes. The data establish a critical role for cytosolic acetyl-CoA synthesis in maintaining skin barrier integrity and highlight the skin as a key organ in systemic lipid regulation.…”
Get full text

Cacao floral traits are shaped by the interaction of flower position with genotype by Seunghyun Lim, Insuck Baek, Seok Min Hong, Yoonjung Lee, Silvas Kirubakaran, Moon S. Kim, Lyndel W. Meinhardt, Sunchung Park, Ezekiel Ahn

“…These findings emphasize the phenotypic diversity of cacao flowers and demonstrate the potential of machine learning in genotype identification, offering valuable insights for breeding and cultivation strategies to enhance cacao productivity.…”
Get full text

Single cell suppression profiling of human regulatory T cells by Jonas Nørskov Søndergaard, Janyerkye Tulyeu, David Priest, Shimon Sakaguchi, James B. Wing

“…Additionally, scSPOT identifies a Treg phenotypic split previously observed in viral infection and propose modes of action by the FDA-approved drugs Ipilimumab and Tazemetostat. scSPOT is thus scalable, robust, widely applicable, and may be used to better understand Treg immunobiology and screen for therapeutic compounds.…”
Get full text

RNA helicase MOV10 suppresses fear memory and dendritic arborization and regulates microtubule dynamics in hippocampal neurons by Temirlan Shilikbay, Aatiqa Nawaz, Megan Doon, Stephanie Ceman

“…Restoration of NUMA1 expression and knockdown of HAUS rescued phenotypes of the Mov10 Deletion hippocampal neurons. …”
Get full text

A mechanism-informed deep neural network enables prioritization of regulators that drive cell state transitions by Xi Xi, Jiaqi Li, Jinmeng Jia, Qiuchen Meng, Chen Li, Xiaowo Wang, Lei Wei, Xuegong Zhang

“…Some recent neural network models can connect molecular changes to cellular phenotypes, but their design lacks modeling of regulatory mechanisms, limiting the decoding of regulations behind key cellular events, such as cell state transitions. …”
Get full text

Expanding Yarrowia lipolytica’s metabolic potential for detoxification of cyanogenic glycosides in edible plants by Fidelis Azi, Zhiyu Li, Peng Xu

“…Abstract Cyanides are highly toxic chemicals in several edible plants that threaten food safety and human health. A phenotypically distinct Yarrowia lipolytica strain that efficiently detoxifies multiple cyanogenic glycosides from edible plants was constructed using a family 1 glycosyl-hydrolase (GH1). …”
Get full text

A biallelically active embryonic enhancer dictates GNAS imprinting through allele-specific conformations by Yorihiro Iwasaki, Monica Reyes, Harald Jüppner, Murat Bastepe

“…Abnormal imprinting at the GNAS gene causes multiple phenotypes, including pseudohypoparathyroidism type-1B (PHP1B), a disorder of multihormone resistance. …”
Get full text

Early-life gut mycobiome core species modulate metabolic health in mice by Mackenzie W. Gutierrez, Erik van Tilburg Bernardes, Ellen Ren, Kristen N. Kalbfleisch, Madeline Day, Ewandson Luiz Lameu, Thaís Glatthardt, Emily M. Mercer, Sunita Sharma, Hong Zhang, Ali Al-Azawy, Faye Chleilat, Simon A. Hirota, Raylene A. Reimer, Marie-Claire Arrieta

“…Intestinal nutrient transporter expression was unaffected by the presence of fungi in jejunal enteroids, yet the immune landscape in white adipose tissue was distinctly impacted by each fungal species, suggesting that these phenotypes may be a result of fungal immune regulation. …”
Get full text

Karyotype uniformity in populations of the endemic Hemiancistrus fuliginosus (Loricariidae: Hypostomini) collected in the upper and middle Uruguai River by Jocicléia Thums Konerat, Vanessa Bueno, Ana Luiza de Brito Portela-Castro, Isabel Cristina Martins-Santos, Vladimir Pavan Margarido

“…Nucleolar organizer regions (NORs) were located on the short arm in terminal position of the subtelocentric chromosome pair 25 in all population, in addition to Antas River population showed a structural polymorphism (three different phenotypes). Physical mapping of 5S rDNA showed cistrons in pericentromeric position on the short arm of the metacentric chromosome pair 12 in all the populations. …”
Get full text

Conditional similarity triplets enable covariate-informed representations of single-cell data by Chi-Jane Chen, Haidong Yi, Natalie Stanley

“…This integration of information disparate more robust predictions of clinical phenotypes and holds significant potential for enhancing diagnostic and treatment strategies.…”
Get full text

Systematic comparison of Mendelian randomisation studies and randomised controlled trials using electronic databases by Jie Zheng, George Davey Smith, Tom R Gaunt, Maria K Sobczyk

“…A manual survey of the literature highlighted the potential for triangulation across a number of exposure/outcome pairs if these challenges can be addressed.Conclusions We conclude that careful triangulation of MR with RCT evidence should involve consideration of similarity of phenotypes across study designs, intervention intensity and duration, study population demography and health status, comparator group, intervention goal and quality of evidence.…”
Get full text

RECQ4-MUS81 interaction contributes to telomere maintenance with implications to Rothmund-Thomson syndrome by Raghib Ashraf, Hana Polasek-Sedlackova, Victoria Marini, Jana Prochazkova, Zdenka Hasanova, Magdalena Zacpalova, Michala Boudova, Lumir Krejci

“…We also observe that a mutation associated with Rothmund-Thomson syndrome, which produces a truncated RECQ4 unable to interact with MUS81, recapitulates these chromosome instability phenotypes. This underscores the importance of RECQ4-MUS81 in safeguarding genome integrity and suggests potential implications for human disease. …”
Get full text

Prediction of biochemical prostate cancer recurrence from any Gleason score using robust tissue structure and clinically available information by Laura E. Marin, Daniel I. Zavaleta-Guzman, Jessyca I. Gutierrez-Garcia, Daniel Racoceanu, Fanny L. Casado

“…A U-net model was used to segment phenotypic features and trained on images from the Prostate Cancer Grade Assessment (PANDA) database to segment tumorous regions from pre-processed and scored WSI of biopsies. …”
Get full text

Hybridization potential and genetic influence of parental varieties on fruit size and set rate in Gleditsia sinensis by Qingying Zeng, Yang Zhao, Xiurong Wang, Fuhua Liu, Meixuan Xie, Xingfu Zhang

“…Therefore, G. fera can serve as an excellent male parent for interspecific hybridization with G. sinensis. The phenotypic traits of the current generation’s pods are primarily influenced by the additive effects of the maternal parent and the non-additive effects of both parents. …”
Get full text

WAND: A multi-modal dataset integrating advanced MRI, MEG, and TMS for multi-scale brain analysis by Carolyn B. McNabb, Ian D. Driver, Vanessa Hyde, Garin Hughes, Hannah L. Chandler, Hannah Thomas, Christopher Allen, Eirini Messaritaki, Carl J. Hodgetts, Craig Hedge, Maria Engel, Sophie F. Standen, Emma L. Morgan, Elena Stylianopoulou, Svetla Manolova, Lucie Reed, Matthew Ploszajski, Mark Drakesmith, Michael Germuska, Alexander D. Shaw, Lars Mueller, Holly Rossiter, Christopher W. Davies-Jenkins, Tom Lancaster, C. John Evans, David Owen, Gavin Perry, Slawomir Kusmia, Emily Lambe, Adam M. Partridge, Allison Cooper, Peter Hobden, Hanzhang Lu, Kim S. Graham, Andrew D. Lawrence, Richard G. Wise, James T. R. Walters, Petroc Sumner, Krish D. Singh, Derek K. Jones

“…Given the depth of neuroimaging phenotyping, leveraging ultra-high-gradient, high-field MRI, MEG and TMS, this dataset will facilitate multi-scale and multi-modal investigations of the healthy human brain.…”
Get full text

Antimicrobial resistance profile among bacteria isolated from patients presenting with wounds at Kabale Regional Referral Hospital, South western Uganda by Andrew, Baguma, Benson, Musinguzi, Kagirita, Atek Atwiine, Joel, Bazira

“…In this study we emphasized on phenotypic characterization of bacteria that cause wound infections at Kabale Regional Hospital (KRRH) and determining the respective antimicrobial susceptibility profiles. …”
Get full text

Cytoplasmic SALL4-A isoform expression as a diagnostic marker of less aggressive tumor behavior in gastric cancer by Saeed Rahmani, Amirhesam Babajani, Maryam Abolhasani, Roya Ghods, Elham Kalantari, Zahra Madjd

“…Conclusion Cytoplasmic SALL4-A expression in GC is associated with less aggressive tumor phenotypes and shows promise as a diagnostic marker. …”
Get full text

CAG Expansion in Androgen Receptor Gene of Infertile Men in Erbil Governorate by Dashne Abdulla Salih, Karim Jalal Karim

“…Spermatogenesis and male phenotypic development during puberty are mainly done by androgen and their function is regulated by the androgen receptor (AR) gene. …”
Get full text

The Interplay of Aging and PANoptosis in Osteoarthritis Pathogenesis: Implications for Novel Therapeutic Strategies by Liu S, Zhang G, Li N, Wang Z, Lu L

“…Age-related cellular and immune dysfunctions, including cellular senescence, senescence-associated secretory phenotypes (SASPs), and immunosenescence, significantly contribute to joint degeneration. …”
Get full text