Treatments for partial remission of major depressive disorder: a systematic review and meta-analysis by Marlies E Brouwer, Gert J Geurtsen, Damiaan A J P Denys, Joost Gülpen, Eva A M van Dis, Claudi L Bockting

“…There were not enough RCTs to examine effects of pharmacotherapy. Psychotherapy was associated with lower depressive symptom severity at post-treatment (Hedges’ g=0.50; 95% CI 0.23 to 0.76), but not at follow-up up to 1 year (Hedges’ g=0.36; 95% CI −0.30 to 1.02) or longer (Hedges’ g=0.02; 95% CI −0.09 to 0.12). …”
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Cross-sectional study exploring barriers to adverse drug reactions reporting in community pharmacy settings in Dhaka, Bangladesh by Tahir Mehmood Khan, Mohammad Nurul Amin, Syed Masudur Rahman Dewan, Mohammad Safiqul Islam, Mizanur Rahman Moghal, Long Chiau Ming

“…Moreover, a lack of knowledge about pharmacotherapy and the detection of ADRs was another major factor hindering their reporting (RII=0.731).Conclusions The Directorate of Drug Administration in Bangladesh needs to consider the results of this study to help it improve and simplify ADR reporting in Bangladeshi community pharmacy settings.…”
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Surgical Treatment Options for the Young and Active Middle-Aged Patient with Glenohumeral Arthritis by Sanjeev Bhatia, Andrew Hsu, Emery C. Lin, Peter Chalmers, Michael Ellman, Brian J. Cole, Nikhil N. Verma

“…Patients with lower functional demands may experience success with nonoperative measures such as injection or anti-inflammatory pharmacotherapy. When conservative management fails, surgical options are broadly classified into palliative, reparative, restorative, and reconstructive techniques. …”
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State of the Art Compendium: Canadian Thoracic Society Recommendations for Management of Chronic Obstructive Pulmonary Disease by Denis E O’Donnell, Shawn Aaron, Jean Bourbeau, Paul Hernandez, Darcy Marciniuk, Meyer Balter, Gordon Ford, Andre Gervais, Roger Goldstein, Rick Hodder, Francois Maltais, Jeremy Road

“…Management strategies, consisting of combined modern pharmacotherapy and nonpharmacotherapeutic interventions (eg, pulmonary rehabilitation and exercise training) can effectively improve symptoms, activity levels and quality of life, even in patients with severe COPD.…”
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Non-alcoholic fatty liver disease: comparative assessment of diagnostic and treatment approaches in the Russian Federation and People’s Republic of China by M. Ch. Semenistaya, Fan Jian-Gao, O. B. Velichenko, Ye. A. Kuznetsova, Ch. S. Pavlov

“…Treatment of NAFLD should integrate the range of measures including correction of patients dietic habits and physical activity up to pharmacological treatment. Pharmacotherapy is recommended in the case of nonalcoholic steatohepatitis (NASH) progression (bridging fibrosis ³ F2 and cirrhosis), as well as the earlier stages of NASH with two and more fibrosis progression risk factors (age over 50 years, diabetes mellitus, metabolic syndrome, alanine transaminase elevation). …”
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Multiple Comorbidities, Psychiatric Disorders, Healthcare Resource Utilization and Costs Among Adults with Essential Tremor: A Retrospective Observational Study in a Large US Comme... by Dingwei Dai, Ali Samiian, Joaquim Fernandes, Henriette Coetzer

“…In the 12 months following the index date, 26.0% of patients had no insurance claims for ET-related pharmacotherapy or invasive therapies. Patients with ET had a higher number of comorbidities than non-ET patients (5.3 \[3.2\] vs 4.0 \[3.3\]); a higher prevalence of psychiatric disorders (depression: 25.6% vs 15.3%; adjusted odds ratio (AOR) \[95% CI\], 1.56 \[1.41-1.73\]; anxiety: 27.7% vs 15.5%, AOR: 1.78 \[1.61-1.96\]); and higher total healthcare costs: $17 560 \[$39&#8239;972\] vs $13&#8239;237 \[$27&#8239;098\], adjusted cost ratio \[95% CI\]: 1.11 \[1.06-1.16\]; all _P_<.0001. …”
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Impact of vancomycin area under the curve in early or later phase on efficacy and nephrotoxicity in patients with enterococcal bloodstream infections: a multicenter study by Piyawadee Tangvichitrerk, Dhitiwat Changpradub, Jatapat Hemapanpairoa, Piraporn Juntanawiwat, Wichai Santimaleeworagun

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Impact of psychotropic pro re nata prescription-monitoring programme on prescriptions for inpatients with psychiatric disorders: a retrospective observational study by Yoshitaka Saito, Kyohei Sumida, Hiroyuki Muraoka, Satoru Oishi, Ryutaro Suzuki, Taiyo Nishikawa, Shin Miyake, Yukihiro Tanno, Yuki Tobita, Katsuya Otori, Ken Inada

“…Abstract Background Pro re nata (PRN) medication is used “as needed” for symptoms such as agitation and insomnia, in addition to regular daily pharmacotherapy of mental disorders. However, there is no high-quality evidence on the effectiveness of psychotropic PRN medications and concerns have been raised about their potential to contribute to polypharmacy. …”
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Biologic Therapies for Chronic Obstructive Pulmonary Disease: A Systematic Review and Network Meta-Analysis of Randomized Controlled Trials by Tyler Pitre, Daniel Lupas, Jasmine Mah, Matthew Stanbrook, Alina Blazer, Dena Zeraatkar, Terence Ho

“…Background Despite limited breakthroughs in COPD pharmacotherapy, recent trials have shown promising results for biologics in COPD patients. …”
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The efficacy and safety of the biosimilar product (Inflectra®) compared to the reference drug (Remicade®) in rescue therapy in adult patients with ulcerative colitis by Magdalena Kaniewska, Andrzej Moniuszko, Grażyna Rydzewska

“…Results : The studied groups were similar with respect to age and sex distribution, duration of the disease, extent of the disease (left-sided type, pancolitis), additional pharmacotherapy, and smoking. Clinical response following three induction doses was noted in 81% of patients receiving Remicade® compared to 77% receiving the biosimilar product, Inflectra® (NS); while clinical remission was observed in 42% receiving Remicade® and 32% receiving Inflectra® (NS), respectively. …”
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Effects of medication procurement reforms and extended prescription duration on medication coverage for hypertension in India’s public health system: a modelling study by Kunihiro Matsushita, Andrew E Moran, Matti Marklund, Prabhdeep Kaur, Lawrence J Appel, T Joseph Mattingly, Swagata Kumar Sahoo

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Engaging Community Pharmacies in Promoting Outpatient Medication Safety &ndash; Identifying and Prioritizing Research Needs by Modified Nominal Group Technique by Mäkinen E, Taimi AK, Sandler C, Schoultz AM, Holmström AR

“…Emilia Mäkinen,1 Anna-Kaisa Taimi,1,2 Charlotta Sandler,3,4 Anna Marietta Schoultz,5 Anna-Riia Holmström1 1Clinical Pharmacy Group, Division of Pharmacology and Pharmacotherapy, Faculty of Pharmacy, University of Helsinki, Helsinki, Finland; 2Pharmacy Lielahti, Tampere, Finland; 3The Association of Finnish Pharmacies, Helsinki, Finland; 4Pharmacy Lohjanharju, Lohja, Finland; 5Pharmacy Kaari, Helsinki, FinlandCorrespondence: Emilia Mäkinen, University of Helsinki, P.O. …”
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Microbial succinate promotes the response to metformin by upregulating secretory immunoglobulin a in intestinal immunity by Ying Zhang, Aiting Wang, Wei Zhao, Jia’an Qin, Yu Zhang, Bing Liu, Chengcheng Yao, Jianglan Long, Mingxia Yuan, Dan Yan

“…Metformin is the first-line pharmacotherapy for type 2 diabetes mellitus; however, many patients respond poorly to this drug in clinical practice. …”
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Functional Constipation in Children: overview and new outcomes by Kamila Stępień, Maria Przygoda, Joanna Śnieżna, Gabriela Trestka, Sabina Adamczyk, Urszula Zelik, Jakub Dziewic, Wojciech Florczak, Wiktoria Domino, Jagienka Włodyka, Karol Dzwonnik

“…Management includes dietary modifications, behavioral interventions, pharmacotherapy, and, in some cases, biofeedback therapy. …”
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An online intervention relationship enhancement couple therapy program versus systematic desensitization on sexual performance anxiety in women undergoing infertility treatment wit... by Maryam Afzal Dehkordi, Tahmineh Farajkhoda, Mahdi Khanabadi, Farimah Shamsi

“…Psychological interventions are options for couples who do not tolerate psychiatric medications or like psychotherapy with pharmacotherapy. Objective: This study aimed to compare the effectiveness of relationship enhancement couple therapy program (RECT) vs. systematic desensitization (SD) on sexual anxiety. …”
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Chemoproteomic analysis of the promising candidate molecule of the indole derivative with lab code SV-1010 and other non-steroidal anti-inflammatory drugs by Pavel A. Galenko-Yaroshevsky, Ivan Yu. Torshin, Andrey N. Gromov, Ivan A. Reyer, Olga A. Gromova, Tereza R. Glechyan, Konstantin F. Suzdalev, Andrey V. Zadorozhniy, Anait V. Zelenskaya

“…Introduction: For effective and safe pharmacotherapy of pain, it is important to evaluate the mechanisms and spectrum of action of non-steroidal anti-inflammatory drugs (NSAIDs), including their effect on the proteom, central effect, as well as pain relieving and anti-inflammatory effects. …”
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Comparing standard treatment of moderate to severe obstructive sleep apnoea to add-on acetazolamide treatment: An open-label randomised controlled trial by Anurag Tripathi, Ved Prakash, Hemant Kumar, Mohammad Arif, Atul Tiwari, Sachin Kumar, Mrityunjaya Singh, Deepak Sharma, Shubhra Srivastava

“…Conclusion: The addition of acetazolamide to CPAP therapy improves efficacy in OSA treatment parameters among moderate-to-severe OSA, reduces total and NREM AHI as well as ODI without an increase in adverse effects. With added pharmacotherapy, the combination therapy represents a potential adjunctive treatment for managing OSA.…”
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The Link Between Gut Microbiota and Depression: Exploring the Correlation by Adam Juśkiewicz, Olga Grelewicz, Natalia Kucy, Elwira Servaas, Mateusz Haber, Paula Kula, Adrianna Czachor, Alicja Kotula

“…Despite advancements in pharmacotherapy and psychotherapeutic interventions, a substantial proportion of individuals with depression experience treatment resistance, recurrence of symptoms, or inadequate response to standard treatments. …”
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Pain Associated with Endometriosis. A Review of Quality of Life. Psychological Aspects, Career Development, Sexual Health, and Intimate Partner Relationships by Marlena Zubiak, Martyna Byrska, Hanna Barska-Kobylińska, Sara Langner, Ewa Katarzyna Malaka, Marta Janura, Jagoda Elias, Wiktor Biesiada, Sara Szydłowska, Krzysztof Błaszków

“…Treatment includes pharmacotherapy and surgical interventions, depending on the severity of symptoms, the location of lesions, and their extent. …”
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Comparison of scores for predictability of corticosteroid failure in patients with acute severe ulcerative colitis by Knežević Milica A., Janjić Nebojša M., Lečić Vuk B., Todorović Nemanja B., Damjanov Dimitrije D.

“…In relation to rescue therapy, the Lindgren score >8 showed a higher positive predictive value (62.5% vs 47.6%) and higher specificity (70% vs 45%) than the Oxford index, while the negative predictive value and sensitivity of both scores amounted to 100%. Conclusion: Pharmacotherapy with intravenous CS was effective in most acute severe ulcerative colitis patients, but in a certain number of patients it was necessary to include rescue therapy. …”
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