Direct detection and identification of viruses in saliva using a SpecID ionization modified mass spectrometer. by Pierre Alusta, Angel Paredes, Marli Azevedo, Lisa Mullis, Dan Buzatu

“…Saliva testing has slowly gained popularity in the diagnostics based on biomarkers and other constituents ranging from organic compounds (e.g., food additives), peptides, and even microorganisms. Polymerase chain reaction (PCR) remains the gold standard for sensitive detection of SARS-CoV-2 infection in biological samples. …”
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Role of Opioid Ligands in the Irritable Bowel Syndrome by Enrico Corazziari

“…Endogenous opioid peptides – enkephalins, beta-endorphin and dynorphins – are located in specific sites of the brain, the spinal cord, the autonomic ganglia and the enteric nervous system. …”
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Epitope-imprinted biomaterials with tailor-made molecular targeting for biomedical applications by Youlu Diao, Jia Gao, Yue Ma, Guoqing Pan

“…Additionally, we discuss the application of epitope-imprinted materials in the recognition and detection of peptides, proteins, and cells. Despite these advancements, challenges such as template complexity, imprinting efficiency, and scalability remain. …”
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Chronic Kidney Disease, Obesity, and Hypertension: The Role of Leptin and Adiponectin by M. Tesauro, A. Mascali, O. Franzese, S. Cipriani, C. Cardillo, N. Di Daniele

“…Remarkable improvements have been recently achieved in the study of the endocrine features of the adipose tissue and have been able to produce hormone-like peptides named adipokines or adipocytokines. Among these adipocytokines, which represent a link between obesity, hypertension, and chronic nephropathy, leptins and adiponectin appear to play an important role. …”
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Data from a multi-year targeted proteomics study of a longitudinal birth cohort of type 1 diabetes by Lisa M. Bramer, Ernesto S. Nakayasu, Javier E. Flores, Jennifer E. Van Eyk, Michael J. MacCoss, Hemang M. Parikh, Thomas O. Metz, Bobbie-Jo M. Webb-Robertson

“…The targeted mass spectrometry assay was comprised of 694 peptides mapping to 167 proteins and the panel was measured in each subject and QC sample. …”
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Neuregulin 1 improves cognitive deficits and neuropathology in an Alzheimer’s disease model by Jiqing Xu, Fred de Winter, Catherine Farrokhi, Edward Rockenstein, Michael Mante, Anthony Adame, Jonathan Cook, Xin Jin, Eliezer Masliah, Kuo-Fen Lee

“…Decreased expression of the neuronal marker MAP2 and synaptic markers PSD95 and synaptophysin in AD mice was significantly reversed. Levels of Aβ peptides and plaques were markedly reduced. Furthermore, we showed that soluble ectodomains of both type I and type III NRG1 significantly increased expression of Aβ-degrading enzyme neprilysin (NEP) in primary neuronal cultures. …”
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Impact of dietary protein hydrolysates on cognitive performance: A systematic review of randomized controlled trials involving adults by Micah S. Adams, Ronald P. Mensink, Peter J. Joris

“…In conclusion, some studies have indicated that certain protein hydrolysates may benefit cognitive performance, but further research is needed to clarify contradictory findings and to identify beneficial bioactive peptides.…”
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Stromal Expression of CD10 in Invasive Breast Carcinoma and Its Correlation with ER, PR, HER2-neu, and Ki67 by Vandana Puri, Manjula Jain, Shaji Thomas

“…CD10 is a cell surface zinc-dependent endopeptidase, which degrades many bioactive peptides. CD10 expression in tumour stroma is associated with biological aggressiveness of many epithelial malignancies. …”
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Chemo-selective modification of cysteine residue: synthesis and application in the discovery of potential drug candidates by Yanyan Liao, Xuefeng Jiang

“…Chemo-select modification of peptides, targeting a handful of the most reactive proteinogenic amino acids (AAs), is gradually utilized to address the medical needs of peptide drugs and biopharmaceuticals. …”
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The Role of Connexin-43 in the Inflammatory Process: A New Potential Therapy to Influence Keratitis by Chu-Yang Xu, Wen-Song Zhang, Hong Zhang, Yan Cao, Hong-Yan Zhou

“…We also report several Cx43 mimic peptides which can inhibit the activity of Cx43 Hc to mediate the releasing of adenosine triphosphate (ATP), which may in turn influence the inflammatory process.…”
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The Role of Serine Proteases and Antiproteases in the Cystic Fibrosis Lung by Matthew S. Twigg, Simon Brockbank, Philip Lowry, S. Peter FitzGerald, Clifford Taggart, Sinéad Weldon

“…In a healthy individual these proteases aid in the phagocytic process by degrading microbial peptides and are kept in homeostatic balance by cognate antiproteases. …”
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Aspects of improving metrological characteristics of a sensor based on palladium nanoparticles for methionine determination by Eduard V. Gorchakov, Darya O. Perevezentseva, Elena A. Vaitulevich, Oksana V. Dubinina

“…This amino acid serves as a precursor for the biosynthesis of proteins and peptides, as well as a donor of methyl groups, making it an essential participant in numerous biochemical processes, including cysteine synthesis. …”
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Role of PPARG in Chemosensitivity-Regulating Network for Hypopharyngeal Squamous Cell Carcinoma by Fanyong Kong, Boxuan Han, Jiaming Chen, Xixi Shen, Lizhen Hou, Jugao Fang, Meng Lian

“…PPARG gets enriched in several key functional groups that have been implicated in the regulation of chemosensitivity, including those associated with the response to nutrients, vitamins, and peptides, the cellular response to chemical stress, and the regulation of hormone secretion and growth. …”
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Fluorescein-based SynNotch adaptors for regulating gene expression responses to diverse extracellular and matrix-based cues by Jeremy C. Tran, Christopher J. Kuffner, Alexander M. Marzilli, Ryan Emily Miller, Zachary E. Silfen, Jeffrey B. McMahan, D. Christopher Sloas, Christopher S. Chen, John T. Ngo

“…We further show that fluorescein-conjugated extracellular matrix (ECM)-binding peptides can be used to regulate SynNotch activity depending on the folding state of collagen-based ECM networks. …”
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PROTEOMIC PROFILING OF BLOOD-BASED BIOMARKERS IN THE EARLY DETECTION OF ALZHEIMERS DISEASE by Syeda Uroosa Hashmi, Fahad Farooq Lasi

“…AD is linked directly to the amyloid-beta peptides. The monomeric forms of Aβ aggregate to form fibrils and a variety of oligomers which later become neurotoxic. …”
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The Expanding Family of Bone Marrow Homing Factors for Hematopoietic Stem Cells: Stromal Derived Factor 1 Is Not the Only Player in the Game by Mariusz Z. Ratajczak, ChiHwa Kim, Anna Janowska-Wieczorek, Janina Ratajczak

“…., C3 complement cascade cleavage fragments and antimicrobial cationic peptides, such as cathelicidin/LL-37 or β2-defensin) as well as prostaglandin E2 (PGE2). …”
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Beta-Defensin-2 and Beta-Defensin-3 Reduce Intestinal Damage Caused by Salmonella typhimurium Modulating the Expression of Cytokines and Enhancing the Probiotic Activity of Enteroc... by Alessandra Fusco, Vittoria Savio, Marcella Cammarota, Alberto Alfano, Chiara Schiraldi, Giovanna Donnarumma

“…To manage substantial microbial exposure, epithelial surfaces of the intestinal tract produce a diverse arsenal of antimicrobial peptides (AMPs), including, of considerable importance, the β-defensins, which directly kill or inhibit the growth of microorganisms. …”
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Constitutive Expression of Functionally Active Protease-Activated Receptors 1 and 2 in Human Conjunctival Epithelial Cells by Timothy J. Nickel, Mohammad H. Kabir, Jaya Talreja, Daniel J. Stechschulte, Kottarappat N. Dileepan

“…The results show that HCECs constitutively express PAR1 and PAR2 mRNA and proteins, and produce significant amounts of IL-6 when incubated with specific PAR-activating enzymes or agonist peptides. Thrombin- and tryptase-induced HCEC activation was blocked by PAR1 and PAR2 neutralizing antibodies, respectively, and by specific enzyme inhibitors. …”
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Engineered Bacillus subtilis WB600/ZD prevents Salmonella Infantis-induced intestinal inflammation and alters the colon microbiota in a mouse model by Wei Li, Xue Wang, Keyuan Chen, Yaohong Zhu, Guiyan Yang, Yipeng Jin, Jiufeng Wang

“…Abstract Antimicrobial peptides (AMPs) are instrumental in maintaining intestinal homeostasis and have emerged as potential therapeutic candidates for ameliorating intestinal bacterial infections. …”
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Efficient reduction of β-lactoglobulin allergenicity in milk using Clostridium tyrobutyricum Z816 by Qianru Zhao, Yuwei Wang, Zhengming Zhu, Quanyu Zhao, Liying Zhu, Ling Jiang

“…Clostridium tyrobutyricum Z816 was selected for the degradation of β-LG, which was successfully reduced by about 90 % using permeabilized bacteria under the optimized conditions. The hydrolyzed peptides were identified by liquid chromatography-tandem mass spectrometry (LC-MS/MS) and analyzed by molecular modeling, which indicated that C. tyrobutyricum Z816 could effectively degrade the antigenic epitopes of β-LG. …”
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