Venom of the Endoparasitoid Wasp Pteromalus puparum: An Overview by Jia-Ying Zhu, Gong-Yin Ye, Cui Hu

“…Even great achievements have been made, further research is required to uncover the sophisticated bioactivity of the venom and isolate more novel toxic peptides/proteins.…”
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The Role of Immune Defects and Colonization of Staphylococcus aureus in the Pathogenesis of Atopic Dermatitis by Danuta Nowicka, Ewelina Grywalska

“…A deficiency in the endogenous antimicrobial peptides may be partly responsible for the susceptibility to colonization by and skin infection with S. aureus in patients with AD. …”
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The Role of Intracellular Organisms in the Pathogenesis of Inflammatory Arthritis by Animesh Singh, Sarah Karrar

“…., anticitrullinated peptides in rheumatoid arthritis), but the absence of these, in the seronegative arthritides, for example, raises question as to the underlying pathogenesis. …”
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Seaweed nutraceuticals and their therapeutic role in disease prevention by Abirami R. Ganesan, Uma Tiwari, Gaurav Rajauria

“…Seaweed bioactives including polysaccharides, pigments, fatty acids, polyphenols and peptides have been proven to possess various beneficial biological properties that could potentially contribute to functional food and nutraceutical development. …”
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An updated overview on the bacterial PhoP/PhoQ two-component signal transduction system by Meiqin Mao, Li He, Qingpi Yan

“…It regulates the expression of bacterial environmental tolerance genes, virulence factors, adhesion, and invasion-related genes by sensing various environmental signals in the host, including Mg2+, low pH, antimicrobial peptides, and osmotic pressure. In this review, we describe the PhoP/PhoQ system-induced signal composition and its feedback mechanism, and the abundance of PhoP phosphorylation in the activated state directly or indirectly controls the transcription and expression of related genes, regulating bacterial stability. …”
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Learning predictive signatures of HLA type from T-cell repertoires. by María Ruiz Ortega, Mikhail V Pogorelyy, Anastasia A Minervina, Paul G Thomas, Thierry Mora, Aleksandra M Walczak

“…T cells recognize a wide range of pathogens using surface receptors that interact directly with peptides presented on major histocompatibility complexes (MHC) encoded by the HLA loci in humans. …”
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Illuminating understudied kinases: a generalizable biosensor development method applied to protein kinase N by Julius Bogomolovas, Ju Chen

“…Our method identified a new PKN substrate peptide that we optimized for use in a fluorescent biosensor design. …”
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Interferon-α promotes HLA-B-restricted presentation of conventional and alternative antigens in human pancreatic β-cells by Alexia Carré, Fatoumata Samassa, Zhicheng Zhou, Javier Perez-Hernandez, Christiana Lekka, Anthony Manganaro, Masaya Oshima, Hanqing Liao, Robert Parker, Annalisa Nicastri, Barbara Brandao, Maikel L. Colli, Decio L. Eizirik, Jahnavi Aluri, Deep Patel, Marcus Göransson, Orlando Burgos Morales, Amanda Anderson, Laurie Landry, Farah Kobaisi, Raphael Scharfmann, Lorella Marselli, Piero Marchetti, Sylvaine You, Maki Nakayama, Sine R. Hadrup, Sally C. Kent, Sarah J. Richardson, Nicola Ternette, Roberto Mallone

“…While the resting β-cell immunopeptidome is dominated by HLA-A-restricted peptides, IFN-α largely favors HLA-B and only marginally upregulates HLA-A, translating into increased HLA-B-restricted peptide presentation and activation of HLA-B-restricted CD8+ T cells. …”
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Targeting Drug Delivery to the Lungs by Inhalation by C. O'Callaghan

“…This route of administration may be particularly attractive if it avoids the metabolic destruction encountered when some drugs are administered by alternative routes (for instance, peptides and proteins are rapidly destroyed by peptidases when Oven by the oral route). …”
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Angiotensin-(1-7)-Mediated Signaling in Cardiomyocytes by Enéas R. M. Gomes, Robson A. S. Santos, Silvia Guatimosim

“…Actually, it is well known that besides Ang II, the RAS has other active peptides. Of particular interest is the heptapeptide Ang-(1-7) that has been shown to exert cardioprotective effects. …”
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D-Amino Acids in the Nervous and Endocrine Systems by Yoshimitsu Kiriyama, Hiromi Nochi

“…Amino acids are important components for peptides and proteins and act as signal transmitters. …”
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The Zn- or Cu-Thionein Character of a Metallothionein Determines Its Metal Load When Synthesized in Physiological (Metal-Unsupplemented) Conditions by Mercè Capdevila, Òscar Palacios, Sílvia Atrian

“…Therefore, intrinsically different roles can be hypothesized for the constitutively-produced MT peptides in the absence of any metal overload, depending on their Zn- or Cu-thionein character.…”
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Virosome, a hybrid vehicle for efficient and safe drug delivery and its emerging application in cancer treatment by Liu Hanqing, Tu Zhigang, Feng Fan, Shi Haifeng, Chen Keping, Xu Ximing

“…Studies have shown that a virosome can carry various biologically active molecules, such as nucleic acids, peptides, proteins and small organic molecules. Targeted drug delivery using virosome-based systems can be achieved through surface modifications of virosomes. …”
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Extensive Differences in Antifungal Immune Response in Two Drosophila Species Revealed by Comparative Transcriptome Analysis by Yosuke Seto, Koichiro Tamura

“…In response to the fungal infection, a transcriptome profile of immune-related genes was considerably different between D. melanogaster and D. virilis: the genes encoding antifungal peptides, Drosomycin and Metchnikowin, were highly expressed in D. melanogaster whereas, the genes encoding Diptericin and Defensin were highly expressed in D. virilis. …”
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A Narrative Review of Biomarkers and Imaging in the Diagnosis of Acute Aortic Syndrome by Ümit Arslan, Izatullah Jalalzai

“…Because AAS can be asymptomatic or present with diverse symptoms, its diagnosis requires clinical evaluation, risk scoring, and biomarkers such as D-dimer (DD), C-reactive protein (CRP), homocysteine, natriuretic peptides (BNP), and imaging modalities like computed tomography (CT), magnetic resonance imaging (MRI), and echocardiography. …”
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Surface Modification of Biomaterials: A Quest for Blood Compatibility by Achala de Mel, Brian G. Cousins, Alexander M. Seifalian

“…Nanotechnology is recognising a great role in such surface modification of cardiovascular implants through biofunctionalisation of polymers and peptides in nanocomposites and through nanofabrication of polymers which will pave the way for finding a closer blood match through haemostasis when developing cardiovascular implants with a greater degree of patency.…”
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A Comprehensive Analysis of Fibromyalgia and the Role of the Endogenous Opioid System by Mario García-Domínguez

“…One explanation for the emergence of disrupted pain modulation in individuals with fibromyalgia is a significant reduction in opioid receptor activity or an imbalance in the levels of endogenous opioid peptides. Further research is essential to clarify the complex details of the mechanisms underlying this abnormality. …”
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Marine fungi as a goldmine for novel antibiotics: a 2024 perspective by Chengqian Pan, Syed Shams ul Hassan, Ishaq Muhammad, Huizi Jin

“…These products (polyketides, alkaloids, terpenoids, and peptides) are emphasized in terms of their structures and biological activities. …”
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Research Progress on the GIP/GLP-1 Receptor Coagonist Tirzepatide, a Rising Star in Type 2 Diabetes by Zijun Ma, Kaiqin Jin, Mengmeng Yue, Xin Chen, Jun Chen

“…In addition, the very concept of synthetic peptides opens up many unknown possibilities for tirzepatide. …”
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Influence of Physical Activity and Nutrition on Obesity-Related Immune Function by Chun-Jung Huang, Michael C. Zourdos, Edward Jo, Michael J. Ormsbee

“…These include inflammatory peptides, such as TNF-α, CRP, and IL-6. Consequently, obesity is now characterized as a state of chronic low-grade systemic inflammation, a condition considerably linked to the development of comorbidity. …”
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