Single-cell atlas reveals multi-faced responses of losartan on tubular mitochondria in diabetic kidney disease by Zhen Zhu, Guangxin Luan, Song Wu, Yiyi Song, Shuang Shen, Kaiyue Wu, Shengnan Qian, Weiping Jia, Jun Yin, Tao Ren, Jianping Ye, Li Wei

“…In addition, we highlighted a specific renal tubular subpopulation with mitophagy phenotype found in single-cell data, and preliminarily validated it with co-localization and increased expression of Pink1 and Gclc in kidney specimens of DKD patients treated with losartan. Conclusions Our research suggests that scRNA-seq can reflect the multifaceted mitochondrial landscape of DKD renal tubular cells after drug treatment, and these findings may provide new targets for DKD therapy at the organelle level.…”
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Sykepleieres erfaringer med deltakelse i beslutningsprosesser under previsitt på intensivavdeling by Karin Elisabeth Olsen, Linn Veronika Breivik, Ådel Bergland, Marie Hamilton Larsen

“…ENGLISH ABSTRACT Nurses’ experience with participation in decision-making processes during pre-round meetings in the intensive care unit Background: Pre-rounds in intensive care units (ICU) serve as formal meetings involving nurses, doctors, and other professionals to discuss patients’ medical condition and make treatment decisions. …”
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FTO rs17817449 Variant Increases the Risk of Severe Obesity in a Brazilian Cohort: A Case-Control Study by Salum KCR, Assis ISS, Kopke ÚA, Palhinha L, Abreu GM, Gouvêa LW, Teixeira MR, Mattos FCC, Nogueira Neto JF, Felício RFM, Rosado EL, Zembrzuski VM, Campos Junior M, Maya-Monteiro CM, Cabello PH, Carneiro JRI, Bozza PT, Kohlrausch FB, da Fonseca ACP

“…Therefore, we analyzed the association between obesity and specific polymorphisms in leptin-melanocortin-related genes such as LEPR rs1137101, POMC rs1042571, LEP rs7799039, BDNF rs6265, FTO rs17817449, CART rs121909065, and NPY rs16147/rs5574.Patients and Methods: The study enrolled 501 participants from Rio de Janeiro, Brazil, with obesity class II or greater (BMI ≥ 35 kg/m2) and normal weight controls (18.5≤ BMI ≤ 24.9 kg/m2). …”
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Myocarditis and neutrophil-mediated vascular leakage but not cytokine storm associated with fatal murine leptospirosisResearch in context by Stylianos Papadopoulos, David Hardy, Frédérique Vernel-Pauillac, Magali Tichit, Ivo G. Boneca, Catherine Werts

“…Our findings confirm the ineffective control of infection by neutrophils and highlight their deleterious role in vascular permeability, previously only attributed to the ability of leptospires to damage and cross endothelial junctions.Finally, the identification of death due to myocarditis rather than kidney, liver or liver failure may reflect an overlooked but common symptom associated with poor prognosis in human leptospirosis.These features of neutrophilia and myocarditis are also seen in patients, making this mouse model a paradigm for better understanding human leptospirosis and designing new therapeutic strategies. …”
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The HFA‐PEFF score identifies ‘early‐HFpEF’ phenogroups associated with distinct biomarker profiles by Michiel T.H.M. Henkens, Anne‐Mar vanOmmen, Sharon Remmelzwaal, Gideon B. Valstar, Ping Wang, Job A.J. Verdonschot, Mark R. Hazebroek, Leonard Hofstra, Vanessa P.M. vanEmpel, Joline W.J. Beulens, Hester M. denRuijter, Stephane R.B. Heymans

“…Abstract Aims The HFA‐PEFF score was developed to optimize diagnosis and to aid in early recognition of heart failure (HF) with preserved ejection fraction (HFpEF) in patients who present with HF‐like symptoms. Recognizing early‐HFpEF phenogroups is essential to better understand progression towards overt HFpEF and pave the way for early intervention and treatment. …”
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Design and validation of a questionnaire on habits, health and exercise in the use of baby carriers by Yaiza Taboada-Iglesias, María del Carmen Iglesias-Pérez, Águeda Gutiérrez-Sánchez

“…Introduction: Understanding the characteristics and implications of the use of baby carriers can help health care providers understand the habits of their patients and provide guidance to improve quality of life in both children and caregivers. …”
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Efficiency of lung cancer screening in early diagnosis and treatment program among community residents in Nanshan district, Shenzhen city: a cross-sectional and 2-year follow-up su... by Yarui YANG, Xujun GUO, Yuzheng FAN, Han WANG, Shengbin LI, Juan HE, Chang MA, Junbo BAI, Shengyuan LIU

“…The effectiveness of lung cancer screening among participants was evaluated by analyzing the detection rate of participants at high risk for lung cancer, the screening rate of LDCT, the follow-up results of patients with lung nodules, and the cost-effectiveness of the program. …”
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Conflict-related and sexual trauma in treatment-seeking Arabic-speaking men: a cross-sectional studyResearch in context by Max Vöhringer, Freya Specht, Christine Knaevelsrud, Birgit Wagner, Maria Böttche, Yuriy Nesterko

“…The parallels with survivors of sexual violence occurring in other contexts emphasise the need for sensitivity of researchers and practitioners when assessing sexual violence in male patients. Clinicians should furthermore bear in mind the cognitive alterations and significant barriers to disclosure, which reflect societal taboos and stigma, when working with survivors. …”
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Polimorfisme Gen Apolipoprotein E Pada Penderita Sindrom Down Trisomi 21 by Malinda Meinapuri

“…Subsequently polimorphism of APOE gene analysis has been done by using PCR and RFLP.Result : Thirty three samples were Down Syndrom patients, consist of 18 male and 15 female. Thirty three samples are control, consist of 18 male and 15 female. …”
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Deteksi Covid-19 pada Citra Sinar-X Dada Menggunakan Deep Learning yang Efisien by Novanto Yudistira, Agus Wahyu Widodo, Bayu Rahayudi

“…Abstract Covid-19 detection is an important step in identifying early patients with suspected Covid-19 so that further steps can be taken. …”
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Frailty Assessment Tools in Chronic Kidney Disease: A Systematic Review and Meta-analysis by Alisha Puri, Anita M. Lloyd, Aminu K. Bello, Marcello Tonelli, Sandra M. Campbell, Karthik Tennankore, Sara N. Davison, Stephanie Thompson

“…The modified FFP (self-reported) showed acceptable discriminative validity and agreement with the FFP in patients with KF. In CKD and KF populations, agreement between clinicians’ subjective impression of frailty and frailty tools was low. …”
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PREVALENCE OF WORK-RELATED MUSCULOSKELETAL DISORDERS AMONG IRANIAN ORTHOTISTS AND PROSTHETISTS: A STUDY ON WORK-RELATED QUALITY OF LIFE by Sarina Azizi, Vahideh Moradi, Behnam Hajiaghaei, Taher Babaee

“… BACKGROUND: Work-related musculoskeletal injuries are prevalent globally and can impact both work efficiency and the quality of services offered to patients. OBJECTIVES: This study investigated the prevalence of work-related musculoskeletal disorders among Iranian orthotists and prosthetists and its relationship with work-related quality of life. …”
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Efficacy of 5 µg and 10 µg Dexmedetomidine as Adjuvants to 3 mL 0.5% Hyperbaric Bupivacaine in Pelvic and Lower Limb Orthopaedic Surgeries: A Randomised Clinical Study by Jigisha Bharatbhai Mehta, Shreya Jatin Patel, Nilesh Vrajmohan Shah, Dinesh K Chauhan, Sara Mary Thomas

“…Materials and Methods: This randomised clinical and single-blind study study was conducted at the Operation Theatre (OT) complex of Dheeraj Hospital, SBKS, and MIRC, Sumandeep Vidyapeeth, Vadodara, Gujarat, India in the Department of Anaesthesia over a period of 18 months, from September 2022 to March 2024 and total of 82 patients scheduled for lower limb and pelvic orthopaedic surgery who were to receive spinal anaesthesia were divided into Group D1 and D2. …”
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Effects of Jianpi therapy for cancer-related fatigue:a meta-analysis of randomized controlled trials by Jiaxing Dai, Jiaxing Dai, Huili Shui, Huili Shui, Huili Shui, Yuan Wu, Huanghui Zhang, Huanghui Zhang, Yuanyin Li, Yuanyin Li, Shaowang Zhang, Shaowang Zhang, Bing Yang, Bing Yang, Bing Yang, Dongxin Tang, Dongxin Tang, Dongxin Tang

“…This research systematically evaluates the effectiveness of Jianpi therapy in reducing fatigue in cancer patients through a meta-analytic review.MethodsAn exhaustive search was performed within PubMed, Embase, Web of Science, Cochrane Library, SinoMed, Wanfang Data, China Science and Technology Journal Database, and China National Knowledge Infrastructure (CNKI) for randomized controlled trials concerning the application of Jianpi therapy to address CRF. …”
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Cancer cells avoid ferroptosis induced by immune cells via fatty acid binding proteins by Maria Angelica Freitas-Cortez, Fatemeh Masrorpour, Hong Jiang, Iqbal Mahmud, Yue Lu, Ailing Huang, Lisa K. Duong, Qi Wang, Tiffany A. Voss, Claudia S. Kettlun Leyton, Bo Wei, Wai-Kin Chan, Kevin Lin, Jie Zhang, Efrosini Tsouko, Shonik Ganjoo, Hampartsoum B. Barsoumian, Thomas S. Riad, Yun Hu, Carola Leuschner, Nahum Puebla-Osorio, Jing Wang, Jian Hu, Michael A. Davies, Vinay K. Puduvalli, Cyrielle Billon, Thomas P. Burris, Philip L. Lorenzi, Boyi Gan, James W. Welsh

“…Clinical trial data revealed that higher FABP7 expression correlates with poorer overall survival and progression-free survival in patients undergoing immunotherapy. Conclusions Our study uncovers a novel mechanism by which cancer cells evade immune-mediated ferroptosis through Fabp7 upregulation. …”
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Application of Shenling lotion in nursing of perineal injury after vaginal delivery (参苓洗液在经阴道分娩产妇产后会阴损伤护理中的应用效果研究) by TANG Yang (唐杨), PENG Hong (彭鸿), WU Qiuxiang (吴秋香), WANG Yan (王燕), WANG Mingyang (王明洋), CHEN Lingfang (陈陵芳)

“…The incidence of vaginal dysbacteriosis, condition of wound healing, pain, perineal edema, comfort of puerperal women, compliance and satisfaction with nursing interventions were compared between two groups. Results All patients recovered with a grade a level of wound healing, and no case of vaginal dysbacteriosis was reported. …”
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Disrupting EDEM3‐induced M2‐like macrophage trafficking by glucose restriction overcomes resistance to PD‐1/PD‐L1 blockade by Shaoyong Peng, Minshan Wu, Qian Yan, Gaopo Xu, Yumo Xie, Guannan Tang, Jinxin Lin, Zixu Yuan, Xiaoxia Liang, Ze Yuan, Jingrong Weng, Liangliang Bai, Xiaolin Wang, Huichuan Yu, Meijin Huang, Yanxin Luo, Xiaoxia Liu

“…Abstract Background Immunotherapy is beneficial for some colorectal cancer (CRC) patients, but immunosuppressive networks limit its effectiveness. …”
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Surgeons are apprehensive to use DCD lungs despite similar post-transplant outcomes: A 20-year UNOS retrospective analysis by J. Sam Meyer, MSc, Oliver K. Jawitz, MD, MHS, Yury Peysakhovich, MD, Dan Aravot, MD, Matthew G. Hartwig, MD, MHS, Yaron D. Barac, MD, PhD

“…DCD, and 2.43 [95% 1.83, 3.22, p < 0.001] times higher than patients >50 in DBD vs DCD donors. In addition, for each era, the odds for procuring DCD vs. …”
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Perbedaan Rerata Kadar Soluble Fms-Like Tyrosine Kinase-1 (Sflt-1) Serum pada Penderita Early Onset, Late Onset Preeklampsia Berat / Eklampsia dan Kehamilan Normal by Laila Rahmi, Rahmatina B. Herman, Yusrawati .

“…The objective of this study was to determine the differences between the mean serum levels of sFlt-1 in patients with early onset, late onset severe preeclampsia/eclampsia and normal pregnancy.…”
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Urban monitoring, evaluation and application of COVID-19 listed vaccine effectiveness: a health code blockchain study by Tao Wang, Hongyan Li, Chaoqun Li, Zheheng Li

“…Simulation finds that the higher the proportion of unobserved completed vaccination patients who are not infected, the lower the estimate of observed effectiveness; and the lower the true effectiveness, the larger the gap between observed effectiveness and true effectiveness. …”
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