Single-cell profiling transcriptomic reveals cellular heterogeneity and cellular crosstalk in breast cancer lymphatic node, bone, and brain metastases by Longyu Zhu, Miaomiao Liu, Yuguang Shang, Jingge Cheng, Hongye Zhao, Jun Zhang, Dongxing Shen

“…Abstract Breast cancer is the most common malignant tumor in the world, and its metastasis is the main cause of death in breast cancer patients. However, the differences between primary breast cancer tissue and lymphatic node, bone, and brain metastases at the single-cell level are not fully understood. …”
Get full text

A Study of Correlation of Adiponectin Levels in Metabolic Syndrome by Apurv Singhal, Vedpal Singh Punia, Akash Bharti, Shaavi Mittal, Praveen Raman Mishra, Prem Kuma

“…Materials and Methods: This observational cross-sectional hospital-based study was performed in the Department of General Medicine, School of Medical Sciences and Research, Sharda Hospital, Greater Noida, Uttar Pradesh, India, from January 2019–June 2020. Sixty patients attending the medicine out- or inpatient department, who confirmed consent, and fit into the International Diabetes Federation (IDF) inclusion criteria for MetS, were recruited for this study. …”
Get full text

Enhanced preoperative prediction of breast lesion pathology, prognostic biomarkers, and molecular subtypes using multiple models diffusion-weighted MR imaging by Litong He, Feng Li, Yanjin Qin, Yuling Li, Qilan Hu, Zhiqiang Liu, Yunfei Zhang, Tao Ai

“…We retrospectively analyzed 132 patients with pathologically verified breast lesions (41 benign and 91 malignant) who underwent a full protocol preoperative breast MRI protocol, including a diffusion-weighted imaging (DWI) sequence with nine b values (0 to 2000 s/mm2) on a 3.0T MR scanner. …”
Get full text

Development and clinical assessment of a novel probiotic candy in the prevention of respiratory infections in asthmatic children by Rana Tafrishi, Hamid Ahanchian, Seyed ali Jafari, Abolfazl Pahlevanloo, Hamidreza Kianifar, Mohammadali Kiani, Nasrin Moazzen, Tahereh sadeghi, Peter D. Sly

“…Results: The frequency of symptomatic respiratory illnesses was significantly lower in the probiotic candy group compared to placebo in the first month (0.28 ± 0.45 vs. 0.51 ± 0.50, p = 0.054), the second month (0.08 ± 0.28 vs. 0.41 ± 0.49, p = 0.001) and the total study (0.37 ± 0.54 vs. 0.90 ± 0.73, 0.001). The percent of patients with prednisolone consumption in the probiotic group was lower than the control group (2.9% vs. 14.7%) but did not show a significant difference (p = 0.081) and no difference was seen in the rate of emergency department visits and hospitalization between the 2 groups (both p = 0.254). …”
Get full text

Efficacy of Duloxetine for Postspine Surgery Pain: A Systematic Review and Meta‐Analysis by Abdulsalam Mohammed Aleid, Faisal Alshehri, Naif Alasiri, Fatimah Alhomoud, Shouq Alsaegh, Mohammed Alrasheed, Salem Aljaddua, Ali Alasiri, Asma Boukhari, Abdulmonem Ali Alhussain, Bipin Chaurasia, Saud Nayef Aldanyowi

“…The analysis did not show any statistically significant difference between duloxetine and placebo in patients experiencing nausea or vomiting (RR = 1.37, 95% CI [0.62 to 3.00] Conclusion The findings of this study suggest that duloxetine may be effective in reducing pain 24 h after spine surgery. …”
Get full text

Conditional diffusion-generated super-resolution for myocardial perfusion MRI by Changyu Sun, Changyu Sun, Neha Goyal, Yu Wang, Darla L. Tharp, Senthil Kumar, Talissa A. Altes

“…The forward diffusion process introduces Gaussian noise incrementally, while the reverse process employs a U-Net architecture to progressively denoise the images, conditioned on the low-resolution input image.ResultsWe trained and validated the model on a retrospective dataset of dynamic contrast-enhanced (DCE) perfusion MRI, consisting of both stress and rest images from 47 patients with heart disease. Our results showed significant image quality improvements, with a 5.1% reduction in nRMSE, a 1.1% increase in PSNR, and a 2.2% boost in SSIM compared to GAN-based super-resolution method (P < 0.05 for all metrics using paired t-test) in retrospective study. …”
Get full text

Comparison of Effect Sevoflurane-Based Anesthesia and Propofol-Based Anesthesia on the Early Postoperative Renal Function of Living Kidney Transplant Donors: A Randomized Controlle... by Cai J, Kang F, Han M, Huang X, Yan W, Wan F, Li J

“…The impact of anaesthetics on postoperative biomarkers of renal injury in living kidney transplant donors is not well understood.Patients and Methods: 70 transplant donors who underwent kidney extraction were randomly assigned to following two groups: sevoflurane (S group) and propofol (P group). …”
Get full text

Choroidal Thickness in Eyes with Band Atrophy of the Optic Nerve from Chiasmal Compression by Luiz Guilherme Marchesi Mello, Ana Claudia F. Suzuki, Giuliana Rovito de Mello, Rony Carlos Preti, Leandro C. Zacharias, Mário L. R. Monteiro

“…Methods. 33 eyes of 26 patients with band atrophy of the optic nerve and temporal visual field defects as a result of previously treated suprasellar tumors (CCL group) and 40 eyes of 21 healthy controls underwent SS-OCT scanning. …”
Get full text

Evaluating the feasibility, sensitivity, and specificity of next-generation molecular methods for pleural infection diagnosis by Peter T. Bell, Timothy Baird, John Goddard, Olusola S. Olagoke, Andrew Burke, Shradha Subedi, Tiana R. Davey, James Anderson, Derek S. Sarovich, Erin P. Price

“…We prospectively characterized 26 consecutive clinically suspected pleural infections, and 10 consecutive patients with suspected non-infective pleural effusions, using shotgun metagenomics, bacterial metataxonomics, quantitative PCR, and conventional culture. …”
Get full text

OCT Biometry (B-OCT): A New Method for Measuring Ocular Axial Dimensions by Bartosz L. Sikorski, Pawel Suchon

“…A total of 349 eyes (214 of healthy subjects, 115 of patients with cataract, and 20 with severe macular diseases) were enrolled in the study. …”
Get full text

Analisis Sistim Manajemen Dokumentasi Keperawatan pada Poliklinik Gigi Rumah Sakit di Bukittinggi by Dewi Rosmalia, Rizanda Machmud, Haryadi Mangkuto

“…<br />Kata kunci: dokumentasi, poliklinik gigi, manajemen<br /><br />Abstract <br />Nursing documentation is written proof of service to patients by nursing staff that aims to avoid errors, and incompleteness of information overlapping in nursing so good and dynamic coordination between nursing staff and improve the efficiency, effectiveness and ensure the quality of nursing care. …”
Get full text

Beyond support: exploring the dynamic and static biomechanical changes induced by preventive ankle taping: a novel cross-sectional study by María Bravo-Aguilar, Vanesa Abuín-Porras, María Blanco-Morales, Carlos Romero Morales, Jaime Almazán-Polo, Jorge Hugo Villafañe, Lorena Canosa-Carro

“…Prophylactic taping in patients with no prior history of LAS is not recommended.…”
Get full text

Genetic profiling of multidrug-resistant Acinetobacter baumannii from a tertiary care center in Malaysia by Aisyah Syakirah Shahari, Navindra Kumari Palanisamy, Fadzilah Mohd Nor

“…A total of 128 MDR A. baumannii isolates were collected from patients admitted to various wards (intensive care unit [ICU], neonatal intensive care unit, coronary care unit, high dependency ward [HDW], and general wards). …”
Get full text

Pediatric endoscopic retrograde pancreatography expertise in chronic pancreatitis: a single-center analysis by Hongxi Guo, Juan Luo, Hu Yang, Jun Yang, Hongqiang Bian, Xufei Duan, Xin Wang

“…However, data on endoscopic treatment of CP in children are still limited.MethodsDemographics, etiology, surgical indications, diagnosis, treatment details, associated complications, and follow-up information were retrospectively studied in consecutive patients (&lt;18 years old) who underwent ERP for CP between January 2020 and October 2024.ResultsA total of 17 children (7 male, 10 female) with a mean age of 10.0 ± 2.7 years were included in the study. …”
Get full text

A murine model of Trypanosoma brucei-induced myocarditis and cardiac dysfunction by Nathan P. Crilly, Marcelle Dina Zita, Alexander K. Beaver, Polina Sysa-Shah, Aashik Bhalodia, Kathy Gabrielson, Luigi Adamo, Monica R. Mugnier

“…Cardiac symptoms are commonly reported in HAT patients, and intracardiac parasites with accompanying myocarditis have been observed in both natural hosts and animal models of T. brucei infection. …”
Get full text

Deep learning-based algorithm for classifying high-resolution computed tomography features in coal workers’ pneumoconiosis by Hantian Dong, Biaokai Zhu, Xiaomei Kong, Xuesen Su, Ting Liu, Xinri Zhang

“…Methods All chest high-resolution computed tomography (HRCT) medical images presented in this work were obtained from 217 coal workers' pneumoconiosis (CWP) patients and dust-exposed workers. We segmented regions of interest according to the diagnostic results, which were evaluated by radiologists. …”
Get full text

COVID-19-related stress, anxiety and vaccine hesitancy among healthcare workers in a tertiary hospital in South-Western Nigeria by Temitope Olumuyiwa Ojo, Tajudin Adesegun Adetunji, Stanley Chinedu Eneh, Baderinwa Opeyemi Akanji, Olusola Fajobi, Olanrewaju Elugbaju, Olanrewaju Ibikunle Ibigbami, Temilola Oladunmomi Owojuyigbe, Samuel Anu Olowookere, Olusegun Temitope Afolabi, Adedeji Ayodeji Onayade

“…Given their role in educating patients and community members about vaccination against infectious diseases like COVID-19, targeted interventions are needed to address hesitancy and optimize vaccine acceptance among healthcare professionals.…”
Get full text

sB7H3 in Children with Acute Appendicitis: Its Diagnostic Value and Association with Histological Findings by Xiaochen Du, Yan Chen, Jie Zhu, Zhenjiang Bai, Jun Hua, Ying Li, Haitao Lv, Guangbo Zhang

“…Furthermore, we assigned AA patients into the nonperforated appendicitis group and the perforated appendicitis group. …”
Get full text

Baicalin Mitigates Cardiac Hypertrophy and Fibrosis by Inhibiting the p85a Subunit of PI3K by Lu He, Min Zhu, Rui Yin, Liangli Dai, Juan Chen, Jie Zhou

“…Baicalin is one of the major active ingredients of a traditional Chinese herbal medicine, Huang Qin, which is used to treat patients with chest pain or cardiac discomfort. However, the underlying mechanism(s) of the cardioprotective effect of baicalin are still not fully understood. …”
Get full text

In silico development of a multi-epitope-based vaccine against Burkholderia cepacia complex using reverse vaccinology by Donya Ghorbani, Donya Ghorbani, Masoumeh Beig, Masoumeh Beig, Narjes Noori Goodarzi, Mohammad Sholeh, Mohammad Sholeh, Behzad Shahbazi, Behzad Shahbazi, Yaser Moghaddam, Farzad Badmasti

“…BackgroundMultidrug-resistant Burkholderia cenocepacia and Burkholderia multivorans have emerged as significant pathogens, particularly in patients with cystic fibrosis (CF) and chronic granulomatous disease (CGD).ObjectiveGiven the absence of approved vaccines, this study aimed to identify potential vaccine candidates against these pathogens.MethodsThe complete genomes of B. cenocepacia and B. multivorans were retrieved from the GenBank. …”
Get full text