Changes induced in mouse lipid metabolism by simultaneous impact of antisense oligonucleotide derivatives to <i>apoB</i>, <i>PCSK9</i>, and <i>apoCIII</i> mRNAs by S. I. Oshevski, Y. I. Ragino, E. V. Kashtanova, Y. V. Polonskaya, E. M. Stakhneva, V. P. Nikolin, N. A. Popova, N. A. Kolchanov, M. I. Voevoda

“…Development of new drugs able to decrease the level of “bad” cholesterol, in particular, based on antisense oligonucleotide derivatives (ASOs), remains relevant for the patients with familial hypercholesterolemia and/or intolerant to statins. …”
Get full text

SHP2 promotes the epithelial-mesenchymal transition in triple negative breast cancer cells by regulating β-catenin by Shihan Qian, Jingjing Zhu, Qing Han, Huang Cheng, Huaibin Zhou

“…Results We found that high SHP2 expression was associated with a poor prognosis in patients with TNBC. The migratory and invasive abilities of TNBC cells in vitro, as well as the metastatic potential of TNBC in mouse xenograft models, were reduced after SHP2 depletion. …”
Get full text

PENERAPAN KONSEP PENGHAWAAN ALAMI PADA DESAIN SANATORIUM DI KABUPATEN GOWA by Suhardi M, Marwati Marwati, Nursyam Nursyam

“…The Sanatorium is a container with an implementation base of preventive action that serves as a place of isolation, maintenance, and rehabilitation of TB patients (Tuberculosis). The purpose of writing is to create a sanatorium design using an original memorizing concept in Gowa District, Pattallassang subdistrict, Timbuseng village. …”
Get full text

The Promising Effect of Tocilizumab on Chronic Antibody-Mediated Rejection (cAMR) of Kidney Transplant by Łukasz Świątek, Miłosz Miedziaszczyk, Dominik Lewandowski, Filip Robakowski, Piotr Tyburski, Marta Jakubowska, Marek Karczewski, Ilona Idasiak-Piechocka

“…<b>Results</b>: Five clinical trials with a total number of 105 patients were included in our review. The mean loss of eGFR in time was −0.141 mL/min/1.73 m² (95% CI: −0.409 to 0.126; <i>p</i> = 0.298) and was found to be statistically insignificant. …”
Get full text

Analyzing Maternal Needs for &ldquo;Internet+ Nursing Service&rdquo; After Hospital Discharge: A SERVQUAL-KANO Model Approach by Ding L, Ding Y, Wang Y, Li X, Liu Y

“…This study employs a combination of the SERVQUAL and KANO models to investigate maternal requirements for Internet+ nursing services and to establish a foundation for enhancing the quality of postnatal nursing services.Patients and Methods: A questionnaire was designed by combining SERVQUAL and KANO models, and a cross-sectional survey was conducted in the obstetrics department of a tertiary hospital in China after expert correspondence. …”
Get full text

A Study of Molecular Mimicry and Immunological Cross-reactivity between Hepatitis B Surface Antigen and Myelin Mimics by Dimitrios-Petrou Bogdanos, Heather Smith, Yun Ma, Harold Baum, Giorgina Mieli-Vergani, Diego Vergani

“…Eighty-seven sera from anti-SHBsAg antibody negative patients with various diseases were tested as pathological controls. …”
Get full text

Effects of Renal Denervation via Renal Artery Adventitial Cryoablation on Atrial Fibrillation and Cardiac Neural Remodeling by Wei Wang, Zhaolei Jiang, Rongxin Lu, Hao Liu, Nan Ma, Jie Cai, Min Tang, Ju Mei

“…It may be useful in selecting therapeutic approaches for AF patients.…”
Get full text

An assessment of burden associated with problem joints in children and adults with moderate or severe haemophilia A: analysis of the CHESS-Paediatrics and CHESS II cross-sectional... by Paul McLaughlin, Hortensia De la Corte-Rodriguez, Tom Burke, Francis Nissen, Martynas Aizenas, Katya Moreno, Jamie O’Hara

“…CHESS-Paediatrics included male paediatric patients (≤ 17 years) with congenital moderate or severe haemophilia, while CHESS II included adult males (≥ 18 years) of any severity. …”
Get full text

Risk factors and machine learning prediction models for intrahepatic cholestasis of pregnancy by Yingchun Ren, Xiaoying Shan, Gengchao Ding, Ling Ai, Weiying Zhu, Ying Ding, Fuzhou Yu, Yun Chen, Beijiao Wu

“…Methods This study included ICP patients and some healthy pregnant women from Jiaxing Maternity and Child Health Care Hospital in China between July 2020 and October 2023. …”
Get full text

Identification of Potential Type II Diabetes in a Chinese Population with a Sensitive Decision Tree Approach by Dongmei Pei, Chengpu Zhang, Yu Quan, Qiyong Guo

“…We proposed a classifier based on a decision tree which used nine features of patients which are easily obtained and noninvasive as predictor variables to identify potential incidents of diabetes. …”
Get full text

Efficacy and Safety of Mesenchymal Stem Cells in Treatment of Complex Perianal Fistulas: A Meta-Analysis by Fang Cheng, Zhong Huang, Zhi Li

“…Subgroup analyses showed that local therapy can improve the HR in patients with perianal fistulas associated with Crohn’s disease (CD) (OR=2.05; 95% CI 1.41, 3.00; P=0.0002) and cryptoglandular origin (no-Crohn) (OR=2.98; 95% CI 0.86, 10.29; P=0.08). …”
Get full text

Elastosonographic Evaluation of Endometrium in Postmenopausal Bleeding by İsmail Burak Gültekin, Orhan Altınboğa, Serap Gültekin, Elif Akkaş Yılmaz, Gökşen İnanç İmamoğlu, Afra Alkan, Tuncay Küçüközkan

“…STUDY DESIGN: A total of 80 women in their postmenopausal period were enrolled for the study; 19 with postmenopausal bleeding and 61 normal healthy controls. All patients with a history of previous uterine surgery (including myomectomy) and/or endometrial interventions such as endometrial ablation, polyp removal, hysteroscopic interventions (except solely diagnostic procedures) and endometrial sampling within one year were excluded from the study because of the possibility of endometrial changes that may interfere with elastosonographic starin ratios. …”
Get full text

Non-pharmacological interventions for primary hypertension: a systematic review and network meta-analysis protocol by Tao Xu, Fan-rong Liang, Qifu Li, Taipin Guo, Ziwen Chen, Yun-Jie Shu, Xueli Zhou

“…Introduction Primary hypertension (PH) affects over one billion individuals globally, yet less than 30% achieve controlled blood pressure (BP) with medication. Many patients require a combination of multiple medications to reach targets, but adverse effects and financial burdens undermine adherence. …”
Get full text

Identification of CD8+ T Cell-Related Genes: Correlations with Immune Phenotypes and Outcomes of Liver Cancer by Qi Pan, Ying Cheng, Donghua Cheng

“…The biological process might provide new directions for patients who are insensitive to immune therapy.…”
Get full text

A Retrospective Study in Trans Individuals Undergoing Gender Affirming Testosterone Treatment: Can Changes in Prolactin Counteract the Negative Effects on the Lipid Profile? by Jojo Steininger, Katalin Widmann, Ulrike Kaufmann, Marlene Hager, Rodrig Marculescu, Robert Krysiak, Johannes Ott

“…Overall, participants frequently displayed unfavorable changes in their lipid profile after 10–14 months of GAHT, as well as a slight but significant increase in PRL. About 20% of patients showed mild-to-moderate hyperprolactinemia (PRL > 25 ng/mL). …”
Get full text

Biologics for eosinophilic oesophagitis: a systematic review and meta-analysis by Beibei Zeng, Doudou Jia, Shengen Li, Xuna Liu, Boxu Zhu, Yanqi Zhang, Yan Zhuang, Fei Dai

“…Double-blind randomized controlled trials comparing biologics with placebo in patients with EoE and non-EoE EGIDs were collected and further screened for inclusion and exclusion. …”
Get full text

Eligibility for faricimab in a real-world diabetic macular oedema population: a cross-sectional study by Helena Norberg, Inger Westborg, Ayat Al-Najjar

“…The SMR and treatment practice populations were older (YOSEMITE 67.5±11.6 vs 62.8±10.0 years, p&lt;0.001 and RHINE 67.5±11.6 vs 61.6±10.1 years, p&lt;0.001) than those in the phase III studies and had lower CRT (YOSEMITE 446±96 vs 486±131 µm, p&lt;0.001 and RHINE 446±96 vs 471±127 µm, p=0.001).Conclusion Approximately 30% of DMO patients in the SMR met the main trial criteria from YOSEMITE and RHINE, while around 40% met the criteria based on treatment practice. …”
Get full text

Diagnosis of lung cancer using salivary miRNAs expression and clinical characteristics by Negar Alizadeh, Hoda Zahedi, Maryam Koopaie, Mahnaz Fatahzadeh, Reza Mousavi, Sajad Kolahdooz

“…Materials Samples of saliva were obtained from 40 lung cancer patients (20 lung adenocarcinoma and 20 lung squamous cell carcinoma) and 20 healthy controls. …”
Get full text

A Novel Nomogram for Predicting the Risk of Pneumonia After Intracerebral Hemorrhage by Sun Y, Zhang L, Huang B, He Q, Hu B

“…Thirty percent of qualified patients were placed in the validation group (n=763) while seventy percent of them were randomly placed in the training group (n=1784). …”
Get full text

A qualitative study of community perceptions and practices relating to blood donation in Cameroon by Solange Dabou, Wilfred Ngwa, Ngo Valery Ngo, Constantine T Asahngwa, Ghyslaine Bruna Djeunang Dongho, Regina Sinsai, Evrard Kepgang, Odette D Kibu, Ronald Mbua Gobina, Denis Alemka Foretia

“…Introduction Blood and blood products are essential for patients in need of transfusion therapy, especially those undergoing surgical procedures, childbirth and other injuries. …”
Get full text