Unusual Presentation of Type 1 Idiopathic Macular Telangiectasia by Zaïnab Bentaleb Machkour, Philippe Denis, Laurent Kodjikian

“…The description of more cases of bilateral type 1 IMT should be helpful to more precisely define the pathophysiologic mechanism that could be different from a localized Coats’ disease of the macula area.…”
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Correlations of the Circadian Rhythmicity of Blood Pressure With Erectile Dysfunction by Ajar Koçak, Cem Şenol, Onur Yıldırım, Bilgesu Arıkan Ergün

“…ABSTRACT Erectile dysfunction (ED) and cardiovascular diseases (CVD) share common pathophysiological mechanisms. This study aimed to assess the relationship between ED and its severity with the risk of developing CVD by analyzing changes in the circadian blood pressure (BP) rhythm. …”
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Antioxidant Potential of Adiponectin and Full PPAR-γ Agonist in Correcting Streptozotocin-Induced Vascular Abnormality in Spontaneously Hypertensive Rats by Sheryar Afzal, Munavvar Abdul Sattar, Edward James Johns, Olorunfemi A. Eseyin, Ali Attiq

“…We investigated pharmacodynamically the pathophysiological role and potential implication of exogenously administered adiponectin with full and partial peroxisome proliferator-activated receptor-gamma (PPAR-γ) agonists on modulation of oxidative stress, metabolic dysregulation, and antioxidant potential in streptozotocin-induced spontaneously hypertensive rats (SHR). …”
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Aberrant Resting-State Functional Connectivity of the Dorsal Attention Network in Tinnitus by Haimeng Hu, Yining Lyu, Shihong Li, Zheng Yuan, Chuntao Ye, Zhao Han, Guangwu Lin

“…Previous functional magnetic resonance imaging (fMRI) analyses have shown that the dorsal attention network (DAN) is involved in the pathophysiological changes of tinnitus, but few relevant studies have been conducted, and the conclusions to date are not uniform. …”
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On the pursuit of reproducibility: the importance of large sample sizes in psychoimmunology by Manivel Rengasamy, Daniel Moriarity, Rebecca Price

“…., number/choice of covariates) will maximize reproducibility of psychoimmunology studies related to depression to enhance development of treatments for depression or to help understand pathophysiological mechanisms of depression.…”
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Naringin prevents heart mitochondria dysfunction during diabetic cardiomyopathy in rats by Ilya Zavodnik, Tatsiana A. Kavalenia, Siarhei N. Kirko, Elena B. Belonovskaya, Irina A. Kuzmitskaya, Yulia V. Eroshenko, Elena A. Lapshina, Vyacheslav U. Buko

“… Background and purpose: Cardiac mitochondria dysfunction plays a central pathophysiological role in the abnormal glucose metabolism in the heart and in diabetic cardiomyopathy. …”
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Altered resting-state cerebral blood flow and its relationship with molecular architecture in tremor dominant Parkinson’s disease by Shangpei Wang, Yajie Cai, Yibin Zhao, Yongqiang Yu, Xianwen Chen, Longsheng Wang

“…Perfusion alterations of the TD subtype were related to dopamine, serotonin, other excitatory neurotransmitters such as glutamate and opioid, which may provide novel insights into pathophysiological processes and guide new therapeutic targets.…”
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A Novel Metabolic Connectome Method to Predict Progression to Mild Cognitive Impairment by Min Wang, Zhuangzhi Yan, Shu-yun Xiao, Chuantao Zuo, Jiehui Jiang

“…However, existing discriminant methods are unsubtle to reveal pathophysiological changes. Therefore, we present a novel metabolic connectome-based predictive modeling to predict progression from MCI to AD accurately. …”
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Edaravone dexborneol alleviates pericyte-mediated fibrosis depositing extracellular matrix through TGF-β1/IL-11 in cerebral small vessel disease by Qingrui Duan, Zhiyang Liu, Yuxuan Xing, Haifeng Huang, Lin Zhu, Jiaxuan Liu, Peikun He, Guixian Ma, Yuhu Zhang, Kun Nie, Yuyuan Gao, Lijuan Wang

“…Abstract Background Chronic cerebral hypoperfusion (CCH) is a critical pathophysiological mechanism underlying cerebral small vessel disease (CSVD). …”
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The Effects of Neuroinflammation Induced by Typhoid Vaccine on Resting and Task‐Based Electroencephalography by Julia R Plank, Joseph CC Chen, Frederick Sundram, Nicholas Hoeh, Suresh Muthukumaraswamy, Joanne C Lin

“…ABSTRACT Introduction Considerable evidence suggests a pathophysiological role of neuroinflammation in psychiatric disorders. …”
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Clinical profile of stress hyperglycemia in medical intensive care units by Geethanjali Ganesan, Sudha Vidyasagar, Nandakrishna Bolanthakodi, Cynthia Amrutha Sukumar

“…In the setting of medical intensive care units (ICU), it significantly contributes to patient morbidity and mortality.It initates a cascade of pathophysiological responses that in turn increase blood glucose and insulin resistance. …”
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The influence of uterine leiomyomatosis on the onset of psoriasis: a nationwide population-based study of 2.5 million Korean females by Yeong Ho Kim, Hyun Jee Kim, Jee Yun Doh, Kyung Do Han, Ji Hyun Lee

“…Abstract Background Uterine leiomyomatosis and psoriasis are prevalent conditions and shared pathophysiological factors indicate a potential association. …”
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Grem1 inhibits osteogenic differentiation of MBMSCs in OVX rats through BMP/Smad1/5 signaling pathway by Shan-shan Yang, Min LinHu, Xiao-hua Hu, Si-si Jiang, Wen-yue Hu, Xiao-hong Yang

“…Objective: This study aims to explore how Grem1 regulates the differentiation and signaling activity of mandibular bone marrow mesenchymal stem cells (MBMSCs), affecting their osteogenic differentiation capacity and participating in the pathophysiological mechanism of postmenopausal mandibular osteoporosis. …”
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Wogonin Inhibits Cardiac Hypertrophy by Activating Nrf-2-Mediated Antioxidant Responses by Xiaowen Shi, Bin Zhang, Zhenliang Chu, Bingjiang Han, Xueping Zhang, Ping Huang, Jibo Han

“…Oxidative stress is an important pathophysiological mechanism of cardiac hypertrophy. Wogonin (Wog), an important flavonoid derived from the root of Scutellaria baicalensis Georgi, is known to possess antioxidant properties. …”
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Inhibition of hippocampal interleukin-6 receptor-evoked signalling normalises long-term potentiation in dystrophin-deficient mdx mice by Kimberley A. Stephenson, Aaron Barron, Mark G. Rae, Dervla O'Malley

“…The additional challenge of pathophysiological levels of IL-6 resulted in altered cellular bioenergetics, which may be key to cognitive deficits associated with the loss of dystrophin.…”
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Stress during Lactation Induces Insulin Resistance Associated with an Increase in Type 1 Cannabinoid Receptors in Liver and Adipose Tissue by Liza Fonseca, Valeska Castillo, Carolina Aguirre, Paulo Silva, Ana M. Ronco, Miguel Llanos

“…These results indicate that increased abundance of CB1R in liver and epididymal fat alters tissue functionality likely associated with development of systemic metabolic alterations such as insulin resistance in adult mice. All these pathophysiological facts are long-term consequences of nociceptive stress during lactation.…”
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Functional Disorders of the Biliary Tract and Cholelithiasis: Analysis of a Possible Relationship by Yu. O. Shulpekova, I. R. Popova, V. M. Nechaev

“…Lithogenic bile is considered as the pathophysiological basis for the development of biliary dyskinesia and cholelithiasis. …”
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Association between non-high-density lipoprotein cholesterol and type 2 diabetes: a systematic review and meta-analysis of cohort studies by Mengqi Han, Yue Shen, Xin Guo, Cheng Hong, Xincan Ji, Haoyang Guo, Yuelong Jin, Hui Yuan

“…Large prospective cohort studies are needed to validate these findings, and further studies are required in order to elucidate the underlying pathophysiologic mechanisms underlying the association between non-HDL and T2D.…”
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Palmitic Acid Induces Production of Proinflammatory Cytokines Interleukin-6, Interleukin-1β, and Tumor Necrosis Factor-α via a NF-κB-Dependent Mechanism in HaCaT Keratinocytes by Bing-rong Zhou, Jia-an Zhang, Qian Zhang, Felicia Permatasari, Yang Xu, Di Wu, Zhi-qiang Yin, Dan Luo

“…To investigate whether palmitic acid can be responsible for the induction of inflammatory processes, HaCaT keratinocytes were treated with palmitic acid at pathophysiologically relevant concentrations. Secretion levels of interleukin-6 (IL-6), tumor necrosis factor-α (TNF-α), interleukin-1β (IL-1β), NF-κB nuclear translocation, NF-κB activation, Stat3 phosphorylation, and peroxisome proliferator-activated receptor alpha (PPARα) mRNA and protein levels, as well as the cell proliferation ability were measured at the end of the treatment and after 24 hours of recovery. …”
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Effect of Genetic Predisposition on Blood Lipid Traits Using Cumulative Risk Assessment in the Korean Population by Min Jin Go, Joo-Yeon Hwang, Dong-Joon Kim, Hye-Ja Lee, Han Byul Jang, Kyung-Hee Park, Jihyun Song, Jong-Young Lee

“…Post-GWAS functional characterization of these variants is further required to elucidate their pathophysiological roles and biological mechanisms.…”
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