Neural Blockade in the Evaluation and Management of Chronic Pain: An Overview by Ian Gilron

“…This article provides a general overview of the physiology and pharmacology of nerve blocks and suggests how they may affect pathophysiological mechanisms of chronic pain. Following a discussion of the rationale, clinical application and potential complications of nerve blocks, existing evidence of efficacy is reviewed. …”
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Jackstone in the Kidney: An Unusual Calculus by Serozsha Goonewardena, Umesh Jayarajah, Sanka Nalinda Kuruppu, Manoj Hilary Fernando

“…This highlights the complex pathophysiological mechanisms in stone formation which needs to be further studied. …”
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Recurrent Transient Ischemic Attacks in a Patient with POEMS Syndrome by A. Akyol, B. Nazliel, H. Z. Batur Caglayan, Y. Oner, G. Turkoz Sucak

“…POEMS syndrome, of which arterial thromboses have been mentioned as a manifestation, is rarely accompanied by transient ischemic attacks. The pathophysiologic mechanism is yet unclear and needs further investigation.…”
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Putative Key Role of Inositol Messengers in Endothelial Cells in Preeclampsia by Sirilaksana Kunjara, Patricia McLean, Laurens Rademacher, Thomas W. Rademacher, Fabiana Fascilla, Stefano Bettocchi, Marco Scioscia

“…To evaluate the pathophysiological significance, we present the response of the intracellular pathways of inositol phosphoglycans involved in cellular metabolism and propose a link with the disease.…”
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In Silico Analysis of the Gene Expression Patterns between Aldosterone-Producing Adenoma and Nonfunctional Adrenocortical Adenoma by Yongfa Dai, Jing Li, Hong Wen, Jie Liu, Jianling Li

“…All the evidence suggests that phospholipid metabolism may be an important pathophysiological mechanism for APA. Our study provides a new perspective regarding the pathophysiological mechanism of APA and offers some small molecules that may possibly be effective drugs against APA.…”
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Serum Levels of IL-1β, IL-6, TGF-β, and MMP-9 in Patients Undergoing Carotid Artery Stenting and Regulation of MMP-9 in a New In Vitro Model of THP-1 Cells Activated by Stenting by Rongrong Zhang, Fan Jiang, Cindy Si Chen, Tianzhu Wang, Jinzhou Feng, Tao Tao, Xinyue Qin

“…Inflammation plays an important role in the pathophysiological process after carotid artery stenting (CAS). …”
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Hyperthermia and targeting heat shock proteins: innovative approaches for neurodegenerative disorders and Long COVID by David M. Smadja, David M. Smadja, M. Marc Abreu, M. Marc Abreu

“…Neurodegenerative diseases (NDs) and Long COVID represent critical and growing global health challenges, characterized by complex pathophysiological mechanisms including neuronal deterioration, protein misfolding, and persistent neuroinflammation. …”
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A Rare Case of Central Pontine Myelinolysis in Overcorrection of Hyponatremia with Total Parenteral Nutrition in Pregnancy by Kalyana C. Janga, Tazleem Khan, Ciril Khorolsky, Sheldon Greenberg, Priscilla Persaud

“…In conclusion we present a complicated case serum sodium changes during pregnancy and pathophysiological effects on serum sodium changes during pregnancy.…”
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European Society for Neurogastroenterology and Motility Consensus on Gastroparesis: What Issues Remain Unresolved? by A. A. Sheptulin, A. S. Trukhmanov, O. A. Storonova, D. E. Rumyantseva

“…At the same time, there is a divergence of views regarding the role of individual pathogenetic factors of gastroparesis and their relationship with clinical symptoms, as well as the effectiveness of drugs of various groups and other treatment methods.Conclusion. The pathophysiological mechanisms of gastroparesis and the effectiveness of various treatment methods need further research.…”
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Unmasking the Enigma: Influenza Vaccine and the Rare Case of Post-Vaccination Pericarditis by Ekrem Yetiskul, Alaukika Agarwal, Gaetano Di Pietro, Faris Qaqish, Salman Khan, Shahkar Khan

“…Understanding the pathophysiological mechanisms behind vaccine-induced pericarditis and recognizing the clinical presentation are essential for healthcare professionals to diagnose, manage, and educate patients appropriately.…”
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Bone Loss Triggered by the Cytokine Network in Inflammatory Autoimmune Diseases by Dulshara Sachini Amarasekara, Jiyeon Yu, Jaerang Rho

“…Here, we review and discuss the involvement of the inflammatory cytokine network in the pathophysiological aspects and the therapeutic advances in inflammatory autoimmune diseases.…”
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Takotsubo Cardiomyopathy as an Early Complication of Drug-Induced Suicide Attempt by Massimo Romanò, Federica Zorzoli, Roberta Bertona, Rosvaldo Villani

“…Here, however, we document the case of a young male patient with borderline personality disorder and a clinical and angiographic presentation compatible with Takotsubo cardiomyopathy arising following a suicide attempt by voluntary drug intoxication (risperidone, barbiturates, and benzodiazepine). The potential pathophysiological mechanisms behind this unusual clinical picture are discussed.…”
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Anesthetic Management of a Surgical Patient with Chronic Renal Tubular Acidosis Complicated by Subclinical Hypothyroidism by Hiroe Yoshioka, Haruyuki Yamazaki, Rie Yasumura, Kosuke Wada, Yoshiro Kobayashi

“…Perioperative acid-base management in such patients poses many difficulties because both pathophysiologies have the potential to complicate the interpretation of capnometry and arterial blood gas analysis data; inappropriate correction of chronic metabolic acidosis may lead to postoperative respiratory deterioration. …”
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An Easy and Quick Risk-Stratified Early Forewarning Model for Septic Shock in the Intensive Care Unit: Development, Validation, and Interpretation Study by Guanghao Liu, Shixiang Zheng, Jun He, Zi-Mei Zhang, Ruoqiong Wu, Yingying Yu, Hao Fu, Li Han, Haibo Zhu, Yichang Xu, Huaguo Shao, Haidan Yan, Ting Chen, Xiaopei Shen

“…NS_HR patients, overlooked by the Sepsis-3 definition, may provide further insights into the pathophysiological processes of SS onset and help to complement its diagnosis and precise management. …”
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Akinetopsia: a systematic review on visual motion blindness by Johanna L. Browne, Lydia Krabbendam, Jan Dirk Blom, Jan Dirk Blom, Jan Dirk Blom

“…Of the clinical cases, 12% showed hemiakinetopsia, 50% continuous or progressive symptoms, and 52% a chronic course. Pathophysiologically, in right-handed individuals, the left area V5/MT was found to be particularly susceptible to acute interference, as evidenced by the experimental studies. …”
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Chronic gastritis and functional dyspepsia: is there an exit out of the dead spot? (reflections, blown together by Rome criteria III) by A. A. Sheptulin

“…Combination of specified diagnoses is most justified, which allows to estimate severity of morphological changes of mucosa of the stomach, to establish basic pathophysiological mechanisms of development of dyspeptic complaints, to determine optimal management approach.Conclusion. …”
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Research Progress of Perioperative Anesthesia Management in Patients with Hypertrophic Cardiomyopathy by LIN Shuantong, SU Xiaojun, CAO Dequan

“…Hypertrophic cardiomyopathy, a genetic hereditary disease, is highly regarded in clinical practice due to its unique pathophysiological changes, course characteristics, and hemodynamic features. …”
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Pancreatitis with Electrocardiographic Changes Mimicking Acute Myocardial Infarction by Paul Khairy, Pierre Marsolais

“…A review of the literature and possible pathophysiological mechanisms of electrocardiographic changes in acute pancreatitis, such as metabolic abnormalities, hemodynamic instability, vasopressors, pericarditis, myocarditis, a cardiobiliary reflex, exacerbation of underlying cardiac pathology, coagulopathy and coronary vasospasm, are discussed.…”
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Postanoxic Burst Suppression Electroencephalogram in a Comatose Child Associated with Spontaneous Eyelid Opening by John R. Crawford

“…These electroencephalographic findings are important for intensive care physicians to recognize and may provide further insight into the pathophysiological mechanism of this rare phenomenon.…”
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Resistant Hypertension and Obstructive Sleep Apnea: The Sparring Partners by Costas Thomopoulos, Helena Michalopoulou, Alexandros Kasiakogias, Anna Kefala, Thomas Makris

“…Enhanced target organ damage and cardiovascular morbidity represent common issues observed in both resistant hypertension and obstructive sleep apnea. Common pathophysiological features and risk factors justify their coexistence, especially in individuals with increased upper-body adiposity. …”
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