Showing 1,221 - 1,240 results of 1,808 for search '"pathophysiology"', query time: 0.06s Refine Results
  1. 1221

    Decreased Levels of Insulin-Regulated Aminopeptidase (IRAP) in Gestational Diabetes Mellitus: A Prospective Cohort Study by Osman Köse, Koray Gök, Elif Köse, Sezen Irmak Gözükara, Abdullah Tüten, Mehmet Sühha Bostancı

    Published 2025-01-01
    “…Background: Insulin-regulated aminopeptidase (IRAP) is involved in insulin sensitivity and glucose metabolism and is important in the pathophysiology of type 2 diabetes. Serum IRAP levels are strongly associated with type 2 diabetes and insulin resistance. …”
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    Article
  2. 1222

    Narrative Review of Free Radicals and Reactive Oxygen Species in Otitis Media by Jeongmin Lee, Seok Min Hong, Yong Sung Choi, Jinseok Lee, Joon Hyung Yeo, Sung Soo Kim, Jae Min Lee, Dong Keon Yon, Seung Geun Yeo

    Published 2024-12-01
    “…These findings suggest that levels of free radicals and ROS are strongly associated with the pathophysiology of OM.…”
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    Article
  3. 1223

    Human blood cell transcriptomics unveils dynamic systemic immune modulation along colorectal cancer progression by Pedro J Romero, Mauro Delorenzi, Amaia Martínez-Usatorre, Laura Ciarloni, Noushin Hadadi, Eric Durandau, Sylvain Monnier-Benoit, Paolo Angelino, Victoria Wosika, Alessandra Jordano Conforte, Sara S Fonseca Costa, Hector Fabio Satizabal, Jérémie Despraz, Andres Perez-Uribe, Stephan Morgenthaler, Brian Hashemi, Sahar Hosseinian-Ehrensberger

    Published 2024-11-01
    “…Moreover, some biomarkers show similar dysregulation in tumors and are implicated in known pathways of CRC pathophysiology.Conclusions The strong systemic immune modulation triggered during CRC progression leads to previously unnoticed alterations detectable in PBMCs, paving the way for the development of an early CRC screening blood test, incorporating 226 validated biomarkers identified through immunotranscriptomics.…”
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  4. 1224
  5. 1225

    MRI-based analysis of the microstructure of the thalamus and hypothalamus and functional connectivity between cortical networks in episodic cluster headache by Chiara Abagnale, Antonio Di Renzo, Giada Giuliani, Gabriele Sebastianelli, Francesco Casillo, Lucia Ziccardi, Vincenzo Parisi, Cherubino Di Lorenzo, Mariano Serrao, Francesca Caramia, Vittorio Di Piero, Gianluca Coppola

    Published 2025-01-01
    “…Moreover, we found differences in the thalamic and hypothalamic microstructures that may independently contribute to the pathophysiology of CH. These differences may reflect changes in directional organization, cell size, and density.…”
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    Article
  6. 1226

    Genetic Diversity, Repeat Motifs, and Natural Selection at the C-Terminal Knob-Associated Histidine Rich Protein (KAHRP) of Plasmodium falciparum Clinical Samples from Saudi Arabia by Saad M. Bin Dajem, Md Atique Ahmed, Marie Fe F Bohol, Syeda Wasfeea Wazid, Mohammed I. Shafeai, Fuad H. Rudiny, Ali M. Motaen, Kareem Morsy, Hani Alothaid, Ahmed A. Al-Qahtani

    Published 2022-01-01
    “…Plasmodium falciparum knob-associated histidine-rich proteins (PfKAHRPs) play an important role in cerebral malaria pathophysiology as well as pathogenesis of P. falciparum infections. …”
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    Article
  7. 1227

    The Link between Type III Reg and STAT3-Associated Cytokines in Inflamed Colonic Tissues by Xin Xu, Hirokazu Fukui, Ying Ran, Xuan Wang, Yoshihito Inoue, Nobuhiko Ebisudani, Heihachiro Nishimura, Toshihiko Tomita, Tadayuki Oshima, Jiro Watari, Hiroshi Kiyama, Hiroto Miwa

    Published 2019-01-01
    “…Reg (regenerating gene) family proteins are known to be overexpressed in gastrointestinal (GI) tissues under conditions of inflammation. However, the pathophysiological significance of Reg family protein overexpression and its regulation is still unclear. …”
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    Article
  8. 1228
  9. 1229

    Comprehensive bioinformatics analysis identifies hub genes associated with immune cell infiltration in early-onset schizophrenia by Shasha Wu, Tailian Xue, Yilin Li, Weikang Chen, Yan Ren

    Published 2025-01-01
    “…These findings contribute to the understanding of EOS pathophysiology and may help identify new diagnostic and therapeutic targets.…”
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    Article
  10. 1230

    Identification and Analysis of Potential Immune-Related Biomarkers in Endometriosis by Yanan He, Jixin Li, Yanjun Qu, Liyuan Sun, Xibo Zhao, Han Wu, Guangmei Zhang

    Published 2023-01-01
    “…Endometriosis is an inflammatory gynecological disease leading to deep pelvic pain, dyspareunia, and infertility. The pathophysiology of endometriosis is complex and depends on a variety of biological processes and pathways. …”
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    Article
  11. 1231

    The serum level of sclerostin decreases in radiographic axial spondyloarthritis patients with fatty lesions by Xuegang Li, Haijian Jiang, Xu Wang, Shuping Zhong

    Published 2025-01-01
    “…Abstract Background Currently, the pathophysiology of new bone formation in radiographic axial spondyloarthritis (r-axSpA) remains unclear. …”
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  12. 1232

    A Potential Protective Effect of Alcohol Consumption in Male Genital Lichen Sclerosus: A Case-Control Study by Joey El Khoury, Jessica Andraos, Anthony Kanbar, Rami Halabi, Serge Assaf, Anthony Mina, Sabine El Breidi, Charbel Dabal, Charbel El Hachem, Rodrigue Saad, Antoine Kassis, Maher Abdessater, Raghid El Khoury

    Published 2023-01-01
    “…The etiologies and exact pathophysiology are not well-known; however, LSc can be considered a precursor to male genital squamous cell carcinoma. …”
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    Article
  13. 1233

    IgG4 as a Biomarker in Graves’ Orbitopathy by Michał Olejarz, Ewelina Szczepanek-Parulska, Daniela Dadej, Nadia Sawicka-Gutaj, Remigiusz Domin, Marek Ruchała

    Published 2021-01-01
    “…The aim of this paper is to describe the pathophysiological, histopathological, and clinical features of Graves’ Disease (GD) and Graves’ Orbitopathy (GO) with elevated IgG4 levels. …”
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    Article
  14. 1234

    Role of Astrocytic Dysfunction in the Pathogenesis of Parkinson’s Disease Animal Models from a Molecular Signaling Perspective by Lucas Udovin, Cecilia Quarracino, María I. Herrera, Francisco Capani, Matilde Otero-Losada, Santiago Perez-Lloret

    Published 2020-01-01
    “…For a long time, astrocytic proliferation was merely considered a byproduct of neuroinflammation, but by the time being, it is clear that astrocytic dysfunction plays a far more important role in PD pathophysiology. Indeed, ongoing experimental evidence suggests the importance of astrocytes and dopaminergic neurons’ cross-linking signaling pathways. …”
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  15. 1235
  16. 1236

    Urinary interleukin 13 level in steroid sensitive and resistant nephrotic syndrome: a cross-sectional single center study by Behnam Ermian, Noosha Samieefar, Aida Vahidi, Daryoush Fahimi, Niloufar Peirovi, Mohamed Husein Aldokhi, Behnaz Bazargani, Arash Abbasi, Fahimeh Askarian, Mastaneh Moghtaderi

    Published 2025-02-01
    “…There is growing evidence on the role of T cells cytokines, including interleukin-13, in pathophysiology of nephrotic syndrome and steroid response. …”
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    Article
  17. 1237

    Association between the subclinical level of problematic internet use and habenula volume: a look at mediation effect of neuroticism by Toshiya Murai, Hironobu Fujiwara, Qi Dai, Halwa Zakia, Yusuke Kyuragi, Naoya Oishi, Yuzuki Ishikawa, Lichang Yao, Morio Aki

    Published 2025-02-01
    “…In addition, personality features have been suggested to play a role in the pathophysiology of PIU.Aims This study aimed to investigate Hb volumetry in individuals with subclinical PIU and the mediating effect of personality traits on this relationship.Methods 110 healthy adults in this cross-sectional study underwent structural magnetic resonance imaging. …”
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  18. 1238

    Voxel-Wise Brain-Wide Functional Connectivity Abnormalities in Patients with Primary Blepharospasm at Rest by Pan Pan, Shubao Wei, Huabing Li, Yangpan Ou, Feng Liu, Wenyan Jiang, Wenmei Li, Yiwu Lei, Yanqing Tang, Wenbin Guo, Shuguang Luo

    Published 2021-01-01
    “…Primary blepharospasm (BSP) is one of the most common focal dystonia and its pathophysiological mechanism remains unclear. An unbiased method was used in patients with BSP at rest to observe voxel-wise brain-wide functional connectivity (FC) changes. …”
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  19. 1239
  20. 1240

    Machine learning models reveal microbial signatures in healthy human tissues, challenging the sterility of human organs by Anargyros Skoulakis, Anargyros Skoulakis, Giorgos Skoufos, Giorgos Skoufos, Armen Ovsepian, Armen Ovsepian, Artemis G. Hatzigeorgiou, Artemis G. Hatzigeorgiou

    Published 2025-01-01
    “…Exploring the microbiome of internal tissues holds promise for elucidating the pathophysiology underlying both health and a spectrum of diseases, including sepsis, inflammation, and cancer.…”
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    Article