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Decreased Levels of Insulin-Regulated Aminopeptidase (IRAP) in Gestational Diabetes Mellitus: A Prospective Cohort Study
Published 2025-01-01“…Background: Insulin-regulated aminopeptidase (IRAP) is involved in insulin sensitivity and glucose metabolism and is important in the pathophysiology of type 2 diabetes. Serum IRAP levels are strongly associated with type 2 diabetes and insulin resistance. …”
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1222
Narrative Review of Free Radicals and Reactive Oxygen Species in Otitis Media
Published 2024-12-01“…These findings suggest that levels of free radicals and ROS are strongly associated with the pathophysiology of OM.…”
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1223
Human blood cell transcriptomics unveils dynamic systemic immune modulation along colorectal cancer progression
Published 2024-11-01“…Moreover, some biomarkers show similar dysregulation in tumors and are implicated in known pathways of CRC pathophysiology.Conclusions The strong systemic immune modulation triggered during CRC progression leads to previously unnoticed alterations detectable in PBMCs, paving the way for the development of an early CRC screening blood test, incorporating 226 validated biomarkers identified through immunotranscriptomics.…”
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1224
Paraoxonase and Arylesterase Activities, Lipid Profile, and Oxidative Damage in Experimental Ischemic Colitis Model
Published 2012-01-01“…PON1 and arylesterase play an important role in the pathophysiology of ischemic colitis.…”
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1225
MRI-based analysis of the microstructure of the thalamus and hypothalamus and functional connectivity between cortical networks in episodic cluster headache
Published 2025-01-01“…Moreover, we found differences in the thalamic and hypothalamic microstructures that may independently contribute to the pathophysiology of CH. These differences may reflect changes in directional organization, cell size, and density.…”
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1226
Genetic Diversity, Repeat Motifs, and Natural Selection at the C-Terminal Knob-Associated Histidine Rich Protein (KAHRP) of Plasmodium falciparum Clinical Samples from Saudi Arabia
Published 2022-01-01“…Plasmodium falciparum knob-associated histidine-rich proteins (PfKAHRPs) play an important role in cerebral malaria pathophysiology as well as pathogenesis of P. falciparum infections. …”
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1227
The Link between Type III Reg and STAT3-Associated Cytokines in Inflamed Colonic Tissues
Published 2019-01-01“…Reg (regenerating gene) family proteins are known to be overexpressed in gastrointestinal (GI) tissues under conditions of inflammation. However, the pathophysiological significance of Reg family protein overexpression and its regulation is still unclear. …”
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Comprehensive bioinformatics analysis identifies hub genes associated with immune cell infiltration in early-onset schizophrenia
Published 2025-01-01“…These findings contribute to the understanding of EOS pathophysiology and may help identify new diagnostic and therapeutic targets.…”
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1230
Identification and Analysis of Potential Immune-Related Biomarkers in Endometriosis
Published 2023-01-01“…Endometriosis is an inflammatory gynecological disease leading to deep pelvic pain, dyspareunia, and infertility. The pathophysiology of endometriosis is complex and depends on a variety of biological processes and pathways. …”
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1231
The serum level of sclerostin decreases in radiographic axial spondyloarthritis patients with fatty lesions
Published 2025-01-01“…Abstract Background Currently, the pathophysiology of new bone formation in radiographic axial spondyloarthritis (r-axSpA) remains unclear. …”
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1232
A Potential Protective Effect of Alcohol Consumption in Male Genital Lichen Sclerosus: A Case-Control Study
Published 2023-01-01“…The etiologies and exact pathophysiology are not well-known; however, LSc can be considered a precursor to male genital squamous cell carcinoma. …”
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1233
IgG4 as a Biomarker in Graves’ Orbitopathy
Published 2021-01-01“…The aim of this paper is to describe the pathophysiological, histopathological, and clinical features of Graves’ Disease (GD) and Graves’ Orbitopathy (GO) with elevated IgG4 levels. …”
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1234
Role of Astrocytic Dysfunction in the Pathogenesis of Parkinson’s Disease Animal Models from a Molecular Signaling Perspective
Published 2020-01-01“…For a long time, astrocytic proliferation was merely considered a byproduct of neuroinflammation, but by the time being, it is clear that astrocytic dysfunction plays a far more important role in PD pathophysiology. Indeed, ongoing experimental evidence suggests the importance of astrocytes and dopaminergic neurons’ cross-linking signaling pathways. …”
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1235
Preserved Expression of Skin Neurotrophic Factors in Advanced Diabetic Neuropathy Does Not Lead to Neural Regeneration despite Pancreas and Kidney Transplantation
Published 2018-01-01“…These findings may be important for better understanding the pathophysiology of nerve regeneration and for the development of intervention strategies.…”
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1236
Urinary interleukin 13 level in steroid sensitive and resistant nephrotic syndrome: a cross-sectional single center study
Published 2025-02-01“…There is growing evidence on the role of T cells cytokines, including interleukin-13, in pathophysiology of nephrotic syndrome and steroid response. …”
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1237
Association between the subclinical level of problematic internet use and habenula volume: a look at mediation effect of neuroticism
Published 2025-02-01“…In addition, personality features have been suggested to play a role in the pathophysiology of PIU.Aims This study aimed to investigate Hb volumetry in individuals with subclinical PIU and the mediating effect of personality traits on this relationship.Methods 110 healthy adults in this cross-sectional study underwent structural magnetic resonance imaging. …”
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1238
Voxel-Wise Brain-Wide Functional Connectivity Abnormalities in Patients with Primary Blepharospasm at Rest
Published 2021-01-01“…Primary blepharospasm (BSP) is one of the most common focal dystonia and its pathophysiological mechanism remains unclear. An unbiased method was used in patients with BSP at rest to observe voxel-wise brain-wide functional connectivity (FC) changes. …”
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1239
Incomplete remyelination via therapeutically enhanced oligodendrogenesis is sufficient to recover visual cortical function
Published 2025-01-01“…Abstract Myelin loss induces neural dysfunction and contributes to the pathophysiology of neurodegenerative diseases, injury conditions, and aging. …”
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1240
Machine learning models reveal microbial signatures in healthy human tissues, challenging the sterility of human organs
Published 2025-01-01“…Exploring the microbiome of internal tissues holds promise for elucidating the pathophysiology underlying both health and a spectrum of diseases, including sepsis, inflammation, and cancer.…”
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