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MSC-sEVs exacerbate senescence by transferring bisecting GlcNAcylated GPNMB
Published 2025-01-01“…Abstract Background The senescence of bone marrow mesenchymal stem cells (BMMSCs) is increasingly recognized as a critical factor contributing to the pathophysiology of age-related diseases. Recent studies suggest that small extracellular vesicles (sEVs) derived from the serum of elderly individuals may play a pivotal role in promoting BMMSC senescence. …”
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Single-cell atlas of human pancreatic islet and acinar endothelial cells in health and diabetes
Published 2025-02-01“…Thus, our data provide a single-cell vascular atlas of human pancreas, enabling deeper understanding of pancreatic pathophysiology in health and disease.…”
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Improved Patient Outcomes by Normalizing Sympathovagal Balance: Differentiating Syncope—Precise Subtype Differentiation Leads to Improved Outcomes
Published 2018-01-01“…Improved understanding of the underlying pathophysiology by more accurate subtyping leads to more precise therapy and improved outcomes.…”
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Recent trends in research on the role of cholesterol in leukemia: a bibliometric and visualization study
Published 2025-01-01“…BackgroundCholesterol metabolism significantly impacts leukemia pathophysiology, affecting tumor cell survival, proliferation, and treatment resistance. …”
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Volatile Organic Compounds as Biomarkers of Gastrointestinal Diseases and Nutritional Status
Published 2019-01-01“…Analytical methods are continuously developed to allow for better detection and quantification of metabolites, thus enabling the detection of a broader spectrum of pathophysiology and disease biomarkers.…”
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Canadian Thoracic Society Recommendations for Management of Chronic Obstructive Pulmonary Disease – 2007 Update
Published 2007-01-01“…Our understanding of the pathophysiology of this complex condition continues to grow and our ability to offer effective treatment to those who suffer from it has improved considerably. …”
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Age of Insomnia Onset Correlates with a Reversal of Default Mode Network and Supplementary Motor Cortex Connectivity
Published 2018-01-01“…This might lead to alterations in brain connectivity patterns as those captured by functional connectivity fMRI analysis, leading to potential insight about primary insomnia (PI) pathophysiology as well as the impact of long-term exposure to sleep deprivation. …”
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Recent Advances in the Mechanisms of Postoperative Neurocognitive Dysfunction: A Narrative Review
Published 2025-01-01“…Despite increasing research efforts, the pathophysiological mechanisms underlying PND remain inadequately characterized, underscoring the need for a more integrated framework to guide targeted interventions. …”
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Recalcitrant Female Pattern Hair Loss Like Alopecia Unveils Unexpected Rare Entity
Published 2025-01-01“…These data might offer a deeper understanding of MUHH pathophysiology ending in efficacious treatment options.Plain language summary: Marie-Unna hereditary hypotrichosis (MUHH) is a rare genetic condition that causes a distinct pattern of hair loss. …”
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Inhibition of inflammatory cell infiltration by antagonistic peptides that specifically bind to CCR5 via regulation of the NF-kB signaling pathway in rats with colitis
Published 2021-05-01“…Introduction CC chemokine receptor 5 (CCR5) and the NF-kB signaling pathway play important roles in the pathophysiology of inflammatory bowel disease (IBD). Previously, we synthesized two peptides (GH and HY peptides) that specifically bind to the first and the second extracellular loops (ECL1 and ECL2, respectively) of CCR5 and preliminarily found an inhibitory effect of these peptides on colitis. …”
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Angiotensin IV Receptors in the Rat Prefrontal Cortex: Neuronal Expression and NMDA Inhibition
Published 2024-12-01“…Background: N-methyl-D-aspartate type glutamate receptors (NMDARs) are fundamental to neuronal physiology and pathophysiology. The prefrontal cortex (PFC), a key region for cognitive function, is heavily implicated in neuropsychiatric disorders, positioning the modulation of its glutamatergic neurotransmission as a promising therapeutic target. …”
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Evaluation of the Diversities in the Inflammatory Responses in Cats With Bacterial and Viral Infections
Published 2024-11-01“…This study aimed to investigate the diversities of inflammatory responses between bacterial and viral infections in cats to figure out their role in the pathophysiology of these infections. Methods Seventy‐five owned cats were included in the study. …”
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Association of reported sleep disturbances with objectively assessed mild cognitive impairment among adults in the United States
Published 2025-02-01“…Various sleep disturbances have been associated with mild cognitive impairment, but the role of specific disturbances in mild cognitive impairment pathophysiology remains unclear. This study investigated the associations between distinct sleep disturbances and mild cognitive impairment in adults aged 50 and older using nationally representative data. …”
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Mutual mediation effects of homocysteine and PCSK9 on coronary lesion severity in patients with acute coronary syndrome: interplay with inflammatory and lipid markers
Published 2025-01-01“…These results highlight the complex interactions between lipid metabolism and inflammation in the pathophysiology of ACS, suggesting that targeting both Hcy and PCSK9 may offer novel therapeutic strategies to mitigate severe coronary lesions among high-risk patients.…”
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Acute Pain Burden and Opioid Dose Requirements after Cesarean Delivery in Parturients with Preexisting Chronic Back Pain and Migraine
Published 2021-01-01“…However, each specific chronic pain condition has unique pathophysiology, and it is possible that the effect of each condition on postoperative pain is different. …”
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Cochlear implantation and cognitive function in the older adult population: current state of the art and future perspectives
Published 2025-05-01“…Future perspectives are considered to shed light into the pathophysiology of cognitive decline due to hearing loss and how objective measures may contribute to this field. …”
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Adeno-associated virus-based gene therapy for hemophilia–addressing the gaps
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