The Role of Cardiac Resynchronization Therapy in Heart Failure: A Narrative Review by Olivier Uwishema, Ece Karabulut, Dalal Sheikhah, Burhan Kantawala, Misgana Gallo, Fatima Soufan, Magda Wojtara

“…ABSTRACT Introduction Structural and functional cardiac defects leading to inadequate tissue oxygenation is known as Heart failure (HF) which is characterized by extensive morbidity and mortality. Pathophysiology of HF involves systolic and diastolic dysfunction, neurohormonal dysregulation, and imbalance in inflammatory mediators which complicates treatment further. …”
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Targeted nanoliposomes for precision rheumatoid arthritis therapy: a review on mechanisms and in vivo potential by Rushikesh Girase, Nayan A. Gujarathi, Amey Sukhia, Sri Sai Nikitha Kota, Tulshidas S. Patil, Abhijeet A. Aher, Yogeeta O. Agrawal, Shreesh Ojha, Charu Sharma, Sameer N. Goyal

“…It highlights the pathophysiology of RA, explores selective targeting sites, and elucidates diverse mechanisms of novel liposomal types and their applications. …”
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Comparison of Corneal Epitheliotrophic Factors of Undiluted Autologous Platelet-Rich Plasma and Autologous Serum Eye Drops for Dry Eye Disease by Passara Jongkhajornpong, Kaevalin Lekhanont, Sasivimol Rattanasiri, Prapaporn Pisitkun, Ammarin Thakkinstian

“…This could allow ophthalmologists to tailor treatments to individual patients by targeting growth factor supply based on their underlying pathophysiology. Trial registration ClinicalTrials.gov identifier, NCT04683796.…”
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A Prospective Observational Study to Establish a Correlation Between Tinnitus and Hearing Loss by Anshu Chopra, Madhurima Bannerjee, Sanjoy Ghosh

“…If a relation between tinnitus and hearing can be identified, it helps to identify the pathophysiology, which will further be helpful to plan the line of management. …”
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Fecal Microbiota Transplantation: A New Therapeutic Attempt from the Gut to the Brain by Hao-Ming Xu, Hong-Li Huang, You-Lian Zhou, Hai-Lan Zhao, Jing Xu, Di-Wen Shou, Yan-Di Liu, Yong-Jian Zhou, Yu-Qiang Nie

“…Studies show that the gut microbiota plays an important role in the pathophysiology of neurological and psychiatric disorders through the microbiota-gut-brain axis. …”
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Spatial metabolomics in mental disorders and traditional Chinese medicine: a review by Chaofang Lei, Jiaxu Chen, Zhigang Chen, Chongyang Ma, Xudong Chen, Xiongxing Sun, Xukun Tang, Jun Deng, Shiliang Wang, Junlin Jiang, Dahua Wu, Le Xie

“…These capabilities suggest that spatial metabolomics can offer significant technical support for studying the complex pathophysiology of mental disorders. Although the mechanisms underlying mental disorders have been reviewed multiple times, this paper provides a comprehensive comparison between traditional metabolomics and spatial metabolomics. …”
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Association of dopamine receptor D2 -141C insertion/deletion and dopamine beta-hydroxylase 19 bp insertion/deletion polymorphisms with schizophrenia: A case-control study in the ea... by Boukhenaf Yasmina, Sariyah Ayachi Ouarda, Achou Rayene, Iness Bernou Amina, Zohra Madoui Fatima, Sifi Karima, Larbi Rezgoun Mohamed

“…Numerous studies emphasize genetic contributions to schizophrenia, particularly focusing on genes coding for proteins in the dopaminergic pathway, which are extensively studied for their involvement in the disorder’s pathophysiology. This investigation aimed to examine the potential association between the dopamine receptor D2 (DRD2) -141C insertion/ deletion (rs1799732) and the dopamine beta-hydroxylase (DBH) 19 bp insertion/deletion (rs72393728) polymorphisms with schizophrenia in an eastern Algerian population. …”
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Glucometabolic-Related Genes as Diagnostic Biomarkers and Therapeutic Targets for Alzheimer’s Disease and Type 2 Diabetes Mellitus: A Bioinformatics Analysis by Shuo Liu, He Chen, Xiao-Dong He, Xiao-Ou Yang

“…These insights are set to enhance our understanding of the complex pathophysiology underlying these widespread chronic diseases.…”
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Ketogenic diet in psychiatry: application in treating depression among athletes by Paulina Kumięga, Zuzanna Kudas, Nikola Perchel, Aleksandra Litwin, Karolina Krzywicka, Paweł Nowocin, Piotr Wasiński, Natalia Dąbrowska, Martyna Koszyk, Dawid Kulczyński

“…KD induces ketosis, a metabolic state that enhances brain energy metabolism, reduces neuroinflammation, and stabilizes neurotransmitter function, all of which are implicated in the pathophysiology of depression. This review synthesizes findings from recent clinical trials, meta-analyses, and case studies focusing on KD's neurological and psychological effects. …”
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Clinical characteristics and associated factors of pediatric acute necrotizing encephalopathy: a retrospective study by Huiling Zhang, Yilong Wang, Qianyun Ding, Xuekun Li, Sheng Ye

“…Purpose The main purpose of this study is to gain a deeper understanding of the clinical characteristics and pathophysiology of ANE through a retrospective study, and to provide clinical practitioners with more effective. diagnostic and treatment strategies to improve patient survival rates and quality of life. …”
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Prevention of Cardiovascular Disease: Screening for Magnesium Deficiency by Paolo Severino, Lucrezia Netti, Marco Valerio Mariani, Annalisa Maraone, Andrea D’Amato, Rossana Scarpati, Fabio Infusino, Mariateresa Pucci, Carlo Lavalle, Viviana Maestrini, Massimo Mancone, Francesco Fedele

“…In fact, magnesium deficiency is involved in the pathophysiology of arterial hypertension, diabetes mellitus, dyslipidemia, metabolic syndrome, endothelial dysfunction, coronary artery disease, cardiac arrhythmias, and sudden cardiac death. …”
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Promoting epithelial regeneration in chemically induced acute lung injury through Sox9-positive alveolar type 2 epithelial cells by Chao Cao, Obulkasim Memete, Yu Dun, Lin Zhang, Fuli Liu, Daikun He, Jian Zhou, Yiru Shao, Jie Shen

“…Methods In this study, we generated Sox9 flox/flox ;Sftpc Cre−ERT2 mice and examined the effects of Sox9+AEC2 cells on the pathophysiology of epithelial damage during chemical-induced acute lung injury. …”
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Lipid Isolated from a Leishmania donovani Strain Reduces Escherichia coli Induced Sepsis in Mice through Inhibition of Inflammatory Responses by Subhadip Das, Nabanita Chatterjee, Dipayan Bose, Somenath Banerjee, Prajnamoy Pal, Tarun Jha, Krishna Das Saha

“…To evaluate the in vivo effect, E. coli induced murine sepsis model was used focusing on the changes in different parameter(s) of lung injury caused by sepsis, namely, edema, vascular permeability, and pathophysiology, and the status of different cytokine-chemokine(s) and adhesion molecule(s). …”
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Exploring cardiovascular implications in systemic lupus erythematosus: A holistic analysis of complications, diagnostic criteria, and therapeutic modalities, encompassing pharmacol... by Dawi John, Affa Scarlet, Misakyan Yura, Fardeheb Sabrina, Kades Samuel, Kiriaki Anthony, Mohan Aishvaryaa Shree, Norris Brandon, Yoon Sonyeol, Venketaraman Vishwanath

“…Nearly one-third of SLE-related deaths are attributed to cardiovascular diseases, necessitating a deeper understanding of cardiac pathophysiology. The impact of SLE on the cardiovascular system manifests in various ways, including recurrent and resistant pericarditis, severe myocarditis, and pleural effusion. …”
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What is the relationship between exposure to environmental pollutants and severe mental disorders? A systematic review on shared biological pathways by Pierluigi Catapano, Mario Luciano, Salvatore Cipolla, Daniela D'Amico, Alessandra Cirino, Maria Chiara Della Corte, Gaia Sampogna, Andrea Fiorillo

“…A better understanding of those pathways is important for the progress of knowledge on the pathophysiology of severe mental disorders according to the one health model, that promotes a collaborative, multisectoral, and transdisciplinary approach across various levels to optimize health outcomes by recognizing the interconnectedness of humans, animals, plants, and their shared environment.…”
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Orally administered prednisolone decreases plasma arginine vasopressin and serum copeptin concentrations in healthy dogs by Mathieu Victor Paulin, Dorsa Mehrabanpour, Suraj Unniappan, Elisabeth C. R. Snead

“…Abstract Background The pathophysiology of polyuria and polydipsia secondary to exogenous glucocorticoid excess is incompletely understood. …”
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A Genome-Wide Analysis of Long Noncoding RNAs in Circulating Leukocytes and Their Differential Expression in Type 1 Diabetes Patients by Yihan Liu, Xiaoming Du, Jia Cui, Changlong Li, Meng Guo, Jianyi Lv, Xin Liu, Jingtao Dou, Xiaoyan Du, Hongjuan Fang, Zhenwen Chen

“…Among the 9 confirmed lncRNAs, lncRNA MSTRG.128697 and lncRNA MSTRG.128958 were novel and human-specific; however, further validation is required. lncRNA MSTRG.63013 has orthologous sequences in the mouse genome and was identified as a key node for etiology and pathophysiology in animal studies, which will help understand the epigenetic mechanisms of T1D complications.…”
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Reduced γ-Aminobutyric Acid and Glutamate+Glutamine Levels in Drug-Naïve Patients with First-Episode Schizophrenia but Not in Those at Ultrahigh Risk by Junjie Wang, Yingying Tang, Tianhong Zhang, Huiru Cui, Lihua Xu, Botao Zeng, Yu Li, Gaiying Li, Chunbo Li, Hui Liu, Zheng Lu, Jianye Zhang, Jijun Wang

“…Altered γ-aminobutyric acid (GABA), glutamate (Glu) levels, and an imbalance between GABAergic and glutamatergic neurotransmissions have been involved in the pathophysiology of schizophrenia. However, it remains unclear how these abnormalities impact the onset and course of psychosis. …”
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Impact of Prenatal Stress on Neuroendocrine Programming by Odile Viltart, Christel C. A. Vanbesien-Mailliot

“…This organizational phenomenon, encompassing prenatal environmental events, altered fetal growth, and development of long-term pathophysiology, has been named early-life programming. …”
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Systemic Immune-inflammation Index in Evaluation of Inflammation in Rheumatoid Arthritis Patients by Amela DERVISEVIC, Almir FAJKIC, Elmedina JAHIC, Lejla DERVISEVIC, Zurifa AJANOVIC, Enisa ADEMOVIC, Asija ZACIRAGIC

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