Pregnancy-Associated Plasma Protein A Induces Inflammatory Cytokine Expression by Activating IGF-I/PI3K/Akt Pathways by Weiping Li, Hongwei Li, Li Zhou, Zijian Wang, Bing Hua

“…These findings indicate that PAPP-A may play a proinflammatory role in the pathophysiology of ACS and serve as a potential therapeutic target.…”
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Integrative bioinformatics and machine learning approach unveils potential biomarkers linking coronary atherosclerosis and fatty acid metabolism-associated gene by Hong Li, Yongyun Xu, Aiting Wang, Chuanxin Zhao, Man Zheng, Chunyan Xiang

“…Conclusions This research has successfully identified seven key FAMGs implicated in AS, offering novel insights into the pathophysiology of the disease. These findings not only contribute to our understanding of AS but also present potential biomarkers for the disease, opening avenues for more effective monitoring and progression tracking of AS.…”
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Limbal Stem Cell Deficiency: Current Treatment Options and Emerging Therapies by Michel Haagdorens, Sara Ilse Van Acker, Veerle Van Gerwen, Sorcha Ní Dhubhghaill, Carina Koppen, Marie-José Tassignon, Nadia Zakaria

“…This review focuses on limbal epithelial stem cells and the pathophysiology of LSCD. State-of-the-art therapeutic management of LSCD is described, and new and evolving techniques in ocular surface regeneration are being discussed, in particular, advantages and disadvantages of alternative cell scaffolds and cell sources for cell based ocular surface reconstruction.…”
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Liraglutide Attenuates Nonalcoholic Fatty Liver Disease through Adjusting Lipid Metabolism via SHP1/AMPK Signaling Pathway by Peng Yu, Xi Xu, Jing Zhang, Xuan Xia, Fen Xu, Jianping Weng, Xiaoyang Lai, Yunfeng Shen

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Knowledge and attitudes about human papillomavirus infection and prevention methods among medical science students in Novi Sad, Serbia: a cross-sectional study by Nikola Denda, Nemanja Maletin, Aleksandar Rašković, Dušan Prodanović, Zoran Golušin, Biljana Vučković, Marko Nemet, Milica Paut Kusturica

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Bronchoscopic lung lavage and exogenous surfactant successfully reverse respiratory failure after severe chlorine exposure: A pediatric case report by Paola Papoff, Benedetto D'Agostino, Roberto Cicchetti, Antonella Bitti, Valentina Pennetta, Elena Caresta

“…Given the underlying pathophysiology of chlorine lung injury characterized by surfactant dysfunction, the boy was treated with repeated bronchoscopic lung lavages followed by exogenous surfactant (Curosurf 30 mg/kg total), 1 h after intubation and subsequently after 6 and 12 h, when he achieved a significant and stable reduction in ventilatory requirements. …”
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Epigenetic age acceleration and methylation differences in IgG4-related cholangitis and primary sclerosing cholangitis by Alexandra Noble, Rodrigo Motta, Silvia Cabras, Belen Moron Flores, Jan Nowak, Aleksandra Glapa-Nowak, Alessandra Geremia, Jack Satsangi, Emma Culver

“…Abstract Background IgG4-related cholangitis (IgG4-SC) and primary sclerosing cholangitis (PSC) are chronic fibro-inflammatory hepatobiliary conditions, with genetic, environmental, and immunologic risk factors, in which epigenetic alterations may provide insights into pathophysiology and novel biomarkers. This study is the first to assess methylation signatures in IgG4-SC. …”
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Paradigms of intraoperative neuromonitoring in paediatric thyroid surgery by Yuchuan Li, Chunhai Zhang, Yi Zhang, Gianlorenzo Dionigi, Gianlorenzo Dionigi, Yishen Zhao, Hui Sun, Hui Sun, Yingying Wang

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Metabolic and Hepatic Effects of Energy-Reduced Anti-Inflammatory Diet in Younger Adults with Obesity by Gordana Kenđel Jovanović, Ines Mrakovcic-Sutic, Sandra Pavičić Žeželj, Indira Benjak Horvat, Lucia Šuša, Dario Rahelić, Sanja Klobučar Majanović

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Predictive Ability of Visit-to-Visit Variability of HbA1c Measurements for the Development of Diabetic Kidney Disease: A Retrospective Longitudinal Observational Study by Yunyi Yan, Nozomi Kondo, Kentaro Oniki, Hiroshi Watanabe, Tadashi Imafuku, Yuki Sakamoto, Takuro Shigaki, Akari Maruyama, Hitomi Nakazawa, Tetsuya Kaneko, Ayami Morita, Akira Yoshida, Hitoshi Maeda, Toru Maruyama, Hideaki Jinnouchi, Junji Saruwatari

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Mixture of MMP-2, MLC, and NOS Inhibitors Affects NO Metabolism and Protects Heart from Cardiac I/R Injury by Anna Krzywonos-Zawadzka, Aleksandra Franczak, Grzegorz Sawicki, Iwona Bil-Lula

“…Hence, an imbalance in nitric oxide (NO) metabolism along with oxidative stress is an important factor contributing to pathophysiology of cardiovascular disorders, including myocardial infarction. …”
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Gap Junctions Are Involved in the Rescue of CFTR-Dependent Chloride Efflux by Amniotic Mesenchymal Stem Cells in Coculture with Cystic Fibrosis CFBE41o- Cells by Annalucia Carbone, Roberto Zefferino, Elisa Beccia, Valeria Casavola, Stefano Castellani, Sante Di Gioia, Valentina Giannone, Manuela Seia, Antonella Angiolillo, Carla Colombo, Maria Favia, Massimo Conese

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National clinical guidelines (summary) of Association of rheumatologists of Russia, Russian gastroenterological association, Russian Association for the study of pain «Rational tre... by Ye. L. Nasonov, V. T. Ivashkin, N. N. Yakhno, A. I. Martynov, G. P. Arutyunov, A. Ye. Karateyev, L. I. Alekseyeva, N. V. Chichasova, M. A. Evseyev, M. L. Kukushkin, A. M. Lila, A. P. Rebrov, D. S. Novikova, S. S. Kopenkin, G. R. Abuzarova, K. V. Skorobogatykh, T. L. Lapina, T. V. Popkova

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A Wavelet-Based Correlation Analysis Framework to Study Cerebromuscular Activity in Essential Tremor by Yifan Zhao, Ramon C. Laguna, Yitian Zhao, Jimmy Jiang Liu, Xiongxiong He, John Yianni, Ptolemaios G. Sarrigiannis

“…This study offers the proof of principle required to implement this methodology to uncover VIM thalamic LFP-EMG interactions for (i) better understanding of the pathophysiology of tremor; (ii) objective selection of the DBS electrode contacts with the highest strength of association with the tremorogenic EMG, a particularly useful feature for the implementation of novel multicontact directional leads in clinical practice; and (iii) future research on DBS closed-loop devices.…”
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The Role of Prolactin as a Disease Activity Indicator in Some Rheumatic Diseases by Mohamed Ismail Abdelkarem, HM Fayed, Wael Abd El-Mohsen Abady, Eman Abulhagag Mohammed Mahmoud

“…Prolactin (PRL), a hormone produced by the pituitary gland and lymphocytes, significantly affects immune regulation and is implicated in the pathophysiology of these diseases. Objectives: This study aimed to evaluate the relationship between PRL levels and disease activity in RA, SLE, and scleroderma. …”
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White cord syndrome: A rare complication of adequate spinal cord decompression. A case report and review of current literature by Daan N. de Groot, Kennedy Ogenio, F. Yaney Jiang, Niels A. van der Gaag

“…Conclusion: White cord syndrome is a rare but serious complication following spinal decompression surgery, requiring prompt diagnosis and intervention. The exact pathophysiology remains unclear. Despite its rarity, it is crucial for clinicians to be aware of this condition so that diagnosis and treatment—encompassing adequate spinal cord perfusion, dexamethasone administration, and physiotherapy—can be promptly initiated. …”
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Altered cortical network dynamics during observing and preparing action in patients with corticobasal syndrome by Marius Krösche, Christian J. Hartmann, Markus Butz, Alfons Schnitzler, Jan Hirschmann

“…However, the electrophysiological mechanisms underlying these symptoms remain poorly understood.To explore the pathophysiology of CBS, we recorded magnetoencephalographic (MEG) data from 17 CBS patients and 20 age-matched controls during an observe-to-imitate task. …”
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Molecular Mechanisms and Therapeutic Prospects of Immunotherapy and Targeted Therapy in Primary Central Nervous System Lymphoma by Lin Zhong MM, Anqing Lu MB, Xiyue Lu MM, Xiaoyin Liu MD, Lujia Cao MM, Shihong Zhu MM, SiJun Diao MM, Xu Cheng MM, Hongwei Wu MB, Jing Chen MD

“…With a deeper understanding of the pathophysiology of PCNSL, various therapies, including CD20 monoclonal antibodies, Bruton's tyrosine kinase (BTK) inhibitors, immunomodulatory drugs, immune checkpoint inhibitors, phosphoinositide 3-kinase (PI3 K)/mammalian target of rapamycin(mTOR) inhibitors, and chimeric antigen receptor (CAR) -T cells are increasingly being applied and have demonstrated considerable efficacy. …”
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Detecting early cognitive deficits in preclinical Alzheimer’s disease using a remote digital multi-day learning paradigm by Roos J. Jutten, Daniel Soberanes, Cassidy P. Molinare, Stephanie Hsieh, Michelle E. Farrell, Aaron S. Schultz, Dorene M. Rentz, Gad A. Marshall, Keith A. Johnson, Reisa A. Sperling, Rebecca E. Amariglio, Kathryn V. Papp

“…Our results suggest that diminished MDLCs track with advanced AD pathophysiology, and demonstrate how a digital multi-day learning paradigm can provide novel insights about cognitive decline during preclinical AD.…”
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Genetic diversity leads to differential inflammatory responses to cigarette smoke in mice by Md Imam Faizan, Gagandeep Kaur, Sadiya Bi Shaikh, Felix Effah, Hoshang Unwalla, Irfan Rahman

“…The findings provide valuable insight into how genetic diversity affects immune responses in response to acute CS/ETS exposure, with implications for understanding diverse human responses to environmental stressors in studying lung pathophysiology.…”
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