Delta Cell Hyperplasia in Adult Goto-Kakizaki (GK/MolTac) Diabetic Rats by Lukáš Alán, Tomáš Olejár, Monika Cahová, Jaroslav Zelenka, Zuzana Berková, Magdalena Smětáková, František Saudek, Radoslav Matěj, Petr Ježek

“…Altered PPY-secreting cells distribution amends another component of GK PI’s pathophysiology.…”
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Genetic Polymorphisms: A Novel Perspective on Acute Pancreatitis by Yong Chen, Chao Lian Xie, Ran Hu, Cheng Yi Shen, Mei Zeng, Chang Qiang Wu, Tian Wu Chen, Chen Chen, Meng Yue Tang, Hua Dan Xue, Zheng Yu Jin, Xiao Ming Zhang

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Positive association between proinsulin and fatty liver index in people with type 2 diabetes by Akinobu Nakamura, Aika Miya, Yuka Suzuki, Hiroshi Nomoto, Hiraku Kameda, Kyu Yong Cho, So Nagai, Tatsuya Atsumi

“…Positive associations between proinsulin and fatty liver index shown in this study would support an involvement of hepato-pancreatic crosstalk in the pathophysiology of type 2 diabetes.…”
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Enhancers of cancer stem cells and epithelial–mesenchymal transition: Lin28, MUC1, and lipocalin-2 as a new prognostic axis in classical invasive lobular carcinoma of the breast... by Mohamed Alabiad, Raja Aljafil, Amany Shalaby, Ahmed M. Yehia, Mohammed Alorini, Basma Hamed Ibrahim

“…Our research may have significant implications for understanding the pathophysiology and prognosis of ILC, which could help select treatment targets.…”
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Cerebral Blood Flow in Orthostatic Intolerance by Muhammad Shahzeb Khan, Amanda J. Miller, Arooba Ejaz, Jeroen Molinger, Parag Goyal, David B. MacLeod, Ashley Swavely, Elyse Wilson, Meghan Pergola, Harikrishna Tandri, Camille Frazier Mills, Satish R Raj, Marat Fudim

“…There is a need to measure CBF, as orthostatic hypoperfusion is the shared pathophysiology for all forms of OI. In this review, we examine the literature studying CBF dysfunction in various syndromes with OI and evaluate methods of measuring CBF including transcranial Doppler ultrasound, extracranial cerebral blood flow ultrasound, near infrared spectroscopy, and wearable devices.…”
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Modulation of Second Messenger Signaling in the Brain Through PDE4 and PDE5 Inhibition: Therapeutic Implications for Neurological Disorders by Min Kyu Park, Hyun Wook Yang, Seo Young Woo, Dong Yeon Kim, Dae-Soon Son, Bo Young Choi, Sang Won Suh

“…Phosphodiesterase (PDE) enzymes regulate intracellular signaling pathways crucial for brain development and the pathophysiology of neurological disorders. Among the 11 PDE subtypes, PDE4 and PDE5 are particularly significant due to their regulation of cyclic adenosine monophosphate (cAMP) and cyclic guanosine monophosphate (cGMP) signaling, respectively, which are vital for learning, memory, and neuroprotection. …”
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The influence of the pharmacodynamic properties of drugs on indications for their use: Sodium-glucose cotransporter 2 inhibitors (SGLT2 inhibitors) by Denda Nikola I., Maletin Nemanja Z., Atanasković Marko B., Vučković Biljana A., Rašković Aleksandar L.

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Influence of Vanadium 4+ and 5+ Ions on the Differentiation and Activation of Human Osteoclasts by Matthias A. König, Oliver P. Gautschi, Hans-Peter Simmen, Luis Filgueira, Dieter Cadosch

“…Background. In the pathophysiology of implant failure, metal ions and inflammation-driven osteoclasts (OC) play a crucial role. …”
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Shivering Management in Spinal Anesthesia: Evaluating the Role of Ketamine: A Narrative Review by Siavash Sangi, Mehrdad Mesbah Kiaei, Shahnam Sedigh Maroufi, Maryam Aligholizadeh, Parisa Moradimajd, Azam Saei

“…Based on the results obtained, 10 areas were examined: Definition of shivering, Epidemiology of postoperative shivering, Pathophysiology of shivering, Risk factors for post-spinal anesthesia shivering, Spinal anesthesia, its benefits, and its impact on shivering, Post-anesthetic shivering (PAS) complications, Risk factors for postoperative shivering, Control and management of post-anesthetic shivering (PAS) dosage, Effective timing and benefits of ketamine administration in postoperative shivering. …”
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Lipid Mediator Informatics and Proteomics in Inflammation-Resolution by Yan Lu, Song Hong, Katherine Gotlinger, Charles Serhan

“…By incorporating them with system biology analysis, we review here our initial steps toward elucidating relationships among a range of bimolecular classes and provide an appreciation of their roles and activities in the pathophysiology of disease. LM informatics employing liquid chromatography-ultraviolet-tandem mass spectrometry (LC-UV-MS/MS), gas chromatography-mass spectrometry (GC-MS), computer-based automated systems equipped with databases and novel searching algorithms, and enzyme-linked immunosorbent assay (ELISA) to evaluate and profile temporal and spatial production of mediators combined with proteomics at defined points during experimental inflammation and its resolution enable us to identify novel mediators in resolution. …”
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Cathepsin K Deficiency Impaired Ischemia-Induced Neovascularization in Aged Mice by Xueling Yue, Haiying Jiang, Ying Xu, Manli Xia, Xian-Wu Cheng

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Comparison between Carotid Artery Wall Thickness Measured by Multidetector Row Computed Tomography Angiography and Intimae-Media Thickness Measured by Sonography by Živorad N. Savić, Ivan I. Soldatović, Milan D. Brajović, Aleksandra M. Pavlović, Dušan R. Mladenović, Vesna D. Škodrić-Trifunović

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Lats2-Underexpressing Bone Marrow-Derived Mesenchymal Stem Cells Ameliorate LPS-Induced Acute Lung Injury in Mice by Liang Dong, Lang Li

“…The pathophysiology of the acute lung injury (ALI) is characterized by the damage of alveolar epithelial cells, which can be repaired by exogenous bone marrow-derived mesenchymal stem cells (BMSCs). …”
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Altered shear stress of blood flow causes plasma membrane damage in endothelial cells by Nikita Raj, Chang Pan, Ann Marleen Starke, Anna L. L. Matos, Oliver Soehnlein, Volker Gerke

“…Thus, shear stress alterations, which frequently occur at sites of endothelial dysfunction and before associated pathophysiology, cause membrane wounds in the endothelium, which are repaired efficiently to maintain a functional vasculature.…”
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A study on Bacterial Infections Associated with Central Nervous System in Pakistani Population by Muneeba Afzal, Hamza Altaf, Tayyaba Faiz, Samra Mannan

“… Objective: This paper reviews the evolving trends and epidemiology of CNS infections in Pakistan over four decades, exploring pathophysiology, diagnostic criteria, and treatment approaches through systematic review and meta-analysis. …”
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Copper and iron as unique trace elements linked to fibromyalgia risk by Wenxing Zeng, Minhua Hu, Luyao Ma, Feng Huang, Ziwei Jiang

“…This study provides new evidence of the roles of Cu and Fe in the pathophysiology of FM and underscores the importance of considering trace elements in the prevention and treatment strategies for FM. …”
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Molecular Signatures of Human Chronic Atrial Fibrillation in Primary Mitral Regurgitation by Günseli Çubukçuoğlu Deniz, Serkan Durdu, Yeşim Doğan, Esra Erdemli, Hilal Özdağ, Ahmet Ruchan Akar

“…We aimed to compare the gene expression profiles of patients with degenerative MR in AFib and sinus rhythm (SR) for a clearer picture of AFib pathophysiology. Methods. After transcriptomic analysis and bioinformatics (n=59), differentially expressed genes were defined using 1.5-fold change as the threshold. …”
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Association of functional variants in miRNA genes with the risk of coronary heart disease by Taqweem Ul Haq, Muhammad Riaz Khan, Sajjad Ali, Tariq Aziz, Thamer H. Albekairi, Aftab Ali Shah

“…Environmental and genetic factors contribute to the pathophysiology of CHD. In this study, we investigated the associations of miRNA genes MIR222, MIR423, MIR4274, and MIR3117 with the pathogenesis of CHD. …”
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Glycogen Synthase Kinase-3 Regulates Production of Amyloid-β Peptides and Tau Phosphorylation in Diabetic Rat Brain by Zhong-Sen Qu, Liang Li, Xiao-Jiang Sun, Yu-Wu Zhao, Jin Zhang, Zhi Geng, Jian-Liang Fu, Qing-Guo Ren

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Enhancing medical English proficiency: the current status and development potential of peer-assisted learning in medical education by Peixin Lin, Yuexin Cai, Sijia He, Xinxin Li, Yuanke Liang, Tian Huang, Juanyun Li, Baohang Lin, Gang Xin, Haoyu Lin

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