Revealing excitation-inhibition imbalance in Alzheimer’s disease using multiscale neural model inversion of resting-state functional MRI by Guoshi Li, Li-Ming Hsu, Ye Wu, Andrea C. Bozoki, Yen-Yu Ian Shih, Pew-Thian Yap

“…Abstract Background Alzheimer’s disease (AD) is a serious neurodegenerative disorder without a clear understanding of pathophysiology. Recent experimental data have suggested neuronal excitation-inhibition (E-I) imbalance as an essential element of AD pathology, but E-I imbalance has not been systematically mapped out for either local or large-scale neuronal circuits in AD, precluding precise targeting of E-I imbalance in AD treatment. …”
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Mpox in sports: A comprehensive framework for anticipatory planning and risk mitigation in football based on lessons from COVID-19 by Karim Chamari, Helmi Ben Saad, Wissem Dhahbi, Jad Washif, Abdelfatteh El Omri, Piotr Zmijewski, Ismail Dergaa

“…Here we review mpox’s pathophysiology and possibility of transmission in sports settings and discuss tailored strategies, including risk assessments, testing protocols, hygiene measures, and return-to-play policies. …”
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Near Fatal Asthma: Clinical and Airway Biopsy Characteristics by Richard G. Barbers, Ilias C. Papanikolaou, Michael N. Koss, Ashish Patel, Elton Katagihara, Maggie Arenas, Khalid Chan, Colleen G. Azen, Om P. Sharma

“…Inflammation and remodeling are integral parts of asthma pathophysiology. We sought to describe the clinical and pathologic features of near fatal asthma exacerbation (NFE). …”
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Sociodemographic, Electrophysiological, and Biochemical Profiles in Children with Attention Deficit Hyperactivity Disorder and/or Epilepsy by Sameh A. Abd El Naby, Yahya M. Naguib

“…Serum ferritin and zinc alteration may contribute significantly in ADHD and epilepsy pathophysiology.…”
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Administration of Recombinant Heat Shock Protein 70 Delays Peripheral Muscle Denervation in the SOD1G93A Mouse Model of Amyotrophic Lateral Sclerosis by David J. Gifondorwa, Ramon Jimenz-Moreno, Crystal D. Hayes, Hesam Rouhani, Mac B. Robinson, Jane L. Strupe, James Caress, Carol Milligan

“…The exogenous rhHsp70 was localized to the muscle and not to spinal cord or brain suggesting it modulates peripheral pathophysiology. In the current study, we focused on earlier administration of Hsp70 and its effect on initial muscle denervation. …”
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Functional Near-Infrared Spectroscopy to Probe State- and Trait-Like Conditions in Chronic Tinnitus: A Proof-of-Principle Study by Martin Schecklmann, Anette Giani, Sara Tupak, Berthold Langguth, Vincent Raab, Thomas Polak, Csanád Várallyay, Wilma Harnisch, Martin J. Herrmann, Andreas J. Fallgatter

“…Moreover, our findings of trait- and state-related oxygenation changes indicate the potential of fNIRS for the investigation of tinnitus pathophysiology and treatment response.…”
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Factors associated with lingual tonsil hypertrophy in Canadian adults by Matthew S. Harris, Brian W. Rotenberg, Kathryn Roth, Leigh J. Sowerby

“…Abstract Background Hypertrophy of the lingual tonsil tissue in the adult patient is thought to contribute to the pathophysiology of obstructive sleep apnea. The underlying etiology of lingual tonsil hypertrophy (LTH) in the adult patient is unclear and likely multifactorial. …”
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Polymorphisms of Tumor Necrosis Factor Alpha in Moroccan Patients with Gastric Pathology: New Single-Nucleotide Polymorphisms in TNF-α−193 (G/A) by A. Essadik, H. Jouhadi, T. Rhouda, S. Nadifiyine, A. Kettani, F. Maachi

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Inflammation-Related Mechanisms in Chronic Kidney Disease Prediction, Progression, and Outcome by Simona Mihai, Elena Codrici, Ionela Daniela Popescu, Ana-Maria Enciu, Lucian Albulescu, Laura Georgiana Necula, Cristina Mambet, Gabriela Anton, Cristiana Tanase

“…Recent omics advances could provide novel insights in deciphering the disease pathophysiology; thus, identification of circulating biomarker panels using state-of-the-art proteomic technologies could improve CKD early diagnosis, monitoring, and prognostics. …”
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The Role of IL-17 Promotes Spinal Cord Neuroinflammation via Activation of the Transcription Factor STAT3 after Spinal Cord Injury in the Rat by Shaohui Zong, Gaofeng Zeng, Ye Fang, Jinzhen Peng, Yong Tao, Keke Li, Jingmin Zhao

“…In this study, we investigated the role of IL-17 via activation of STAT3 in the pathophysiology of SCI. Objective. The purpose of the experiments is to study the expression of IL-17 and related cytokines via STAT3 signaling pathways, which is caused by the acute inflammatory response following SCI in different periods via establishing an acute SCI model in rat. …”
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Expression Profiling of Long Noncoding RNA Splice Variants in Human Microvascular Endothelial Cells: Lipopolysaccharide Effects In Vitro by Imran H. Chowdhury, Hema P. Narra, Abha Sahni, Kamil Khanipov, Casey L. C. Schroeder, Jignesh Patel, Yuriy Fofanov, Sanjeev K. Sahni

“…This study illustrates the genome-wide regulation of endothelial lncRNA splice variants in response to LPS and provides a foundation for further investigations of differentially expressed lncRNA transcripts in endothelial responses to LPS and pathophysiology of sepsis/septic shock.…”
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Effects of NSAIDs on the Release of Calcitonin Gene-Related Peptide and Prostaglandin E2 from Rat Trigeminal Ganglia by Vittorio Vellani, Giorgia Moschetti, Silvia Franchi, Chiara Giacomoni, Paola Sacerdote, Giada Amodeo

“…The trigeminal ganglia and calcitonin gene-related peptide (CGRP) have been implicated in the pathophysiology of migraine. The release of CGRP and prostaglandin E2 (PGE2) from freshly isolated rat trigeminal ganglia was evaluated after oral administration of nimesulide, etoricoxib, and ketoprofen, NSAIDs with different pharmacological features. …”
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Role of Ketamine in the Treatment of Psychiatric Disorders by Sahar Derakhshanian, Maxine Zhou, Alexander Rath, Rachel Barlow, Sarah Bertrand, Caroline DeGraw, Christopher Lee, Jamal Hasoon, Alan D. Kaye

“…It covers the epidemiology, risk factors, pathophysiology, and current treatment modalities regarding Major Depressive Disorder (MDD) and TRD. …”
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The Levels of Tumor Necrosis Factor-Alpha and Interleukin-6 in Patients with Isolated Coronary Artery Ectasia by Mustafa Aydin, Ishak Ozel Tekin, Sait Mesut Dogan, Nesligul Yildirim, Mehmet Arasli, Muhammet Rasit Sayin, Ziyaettin Aktop

“…This study provides evidence for alterations in the proinflamatory cytokines which suggest the involvement of the immune system in the pathophysiology of CAE. Further placebo-controlled studies are needed to evaluate the clinical significance of this increase in TNF-𝛼 and IL-6 levels.…”
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Brain Oxygenation During Exercise in Different Types of Chronic Lung Disease: A Narrative Review by Stella Kritikou, Andreas Zafeiridis, Georgia Pitsiou, Ioannis Gkalgkouranas, Leonidas Kastritseas, Afroditi Boutou, Konstantina Dipla

“…These differences depend on the specific pathophysiology of the lung disease and the presence of comorbidities. …”
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Galectin-1 as an Emerging Mediator of Cardiovascular Inflammation: Mechanisms and Therapeutic Opportunities by Ignacio M. Seropian, Germán E. González, Sebastián M. Maller, Daniel H. Berrocal, Antonio Abbate, Gabriel A. Rabinovich

“…Since a coordinated network of immunomodulatory and proangiogenic mediators controls cardiac homeostasis, this lectin has been proposed to play a key hierarchical role in cardiac pathophysiology via glycan-dependent regulation of inflammatory responses. …”
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Gut microbiota-derived short-chain fatty acids and depression: deep insight into biological mechanisms and potential applications by Yan Zhang, Jin Liu, Junzhe Cheng, Hongkun Hu, Yumeng Ju, Mi Wang, Bangshan Liu

“…In the present review, the roles of major SCFAs (acetate, propionate and butyrate) in the pathophysiology of depression are summarised with respect to chronic cerebral hypoperfusion, neuroinflammation, host epigenome and neuroendocrine alterations. …”
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Elevated Plasma Levels of sIL-2R in Complex Regional Pain Syndrome: A Pathogenic Role for T-Lymphocytes? by Krishna D. Bharwani, Maaike Dirckx, Dirk L. Stronks, Willem A. Dik, Marco W. J. Schreurs, Frank J. P. M. Huygen

“…The immune system has long been thought to be involved in the pathophysiology of complex regional pain syndrome (CRPS). …”
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Relation of Vitamin D levels with positive and negative symptoms of schizophrenia – A hospital based cross-sectional comparative study by Soumitra Ghosh, Bikashita Deka

“…Furthermore, it is seen that mean Vitamin D status is similar in both the groups of positive and negative schizophrenia negating the possibility of alteration of Vitamin D levels depending on the differences in symptomatology or in pathophysiology of the two groups.…”
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Acute Myopericarditis after COVID-19 Vaccine in Teenagers by Shashikanth Ambati, Michael Colon, Maya Mihic, Javier Sanchez, Adnan Bakar

“…There have been an increasing number of reports of myocarditis and pericarditis in adolescents and young adults after coronavirus disease 19 vaccinations. The pathophysiology of myocarditis after this vaccination is indeterminate currently. …”
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