Interleukin-18 and CD30 serum levels in patients with moderate-severe depression by Rosaria Alba Merendino, Antonio Enrico Di Rosa, Giuseppe Di Pasquale, Paola Lucia Minciullo, Carmela Mangraviti, Antonella Costantino, Antonella Ruello, Sebastiano Gangemi

“…These data strengthen the hypothesis that MSD disease is associated with an inflammatory response, mainly T-cell-helper type 1, and suggest an important role for IL-18 in the pathophysiology of MSD.…”
Get full text

Fluid flow impacts endothelial-monocyte interactions in a model of vascular inflammatory fibrosis by Isabelle Linares, Kaihua Chen, Ava Saffren, Mehran Mansouri, Vinay V. Abhyankar, Benjamin L. Miller, Stefano Begolo, Hani A. Awad, James L. McGrath

“…Studying this dysregulated tendon repair response in human pathophysiology has been historically challenging due to the reliance on animal models. …”
Get full text

Vascular Inflammation and Endothelial Dysfunction in Experimental Hypertension by Carmine Savoia, Lidia Sada, Luigi Zezza, Lorenzo Pucci, Francesco Maria Lauri, Alberto Befani, Alessandro Alonzo, Massimo Volpe

“…Low-grade inflammation localized in vascular tissue is therefore recognized as an important contributor to the pathophysiology of hypertension, to the initiation and progression of atherosclerosis as well as to the development of cardiovascular diseases.…”
Get full text

A European Approach to Irritable Bowel Syndrome Management by Michel Delvaux, Jacques Frexinos

“…On the contrary, patients with constipation-prone IBS may comprise up to 80% of the IBS population referred to these centres. The pathophysiology of IBS is based on multiple factors. Most of the therapeutics proposed for the management of patients with IBS have been developed on the assumption that motility disorders of the gut are the most reliable pathological findings among these patients. …”
Get full text

Prevention of Contrast-Induced Nephropathy through a Knowledge of Its Pathogenesis and Risk Factors by Michele Andreucci, Teresa Faga, Antonio Pisani, Massimo Sabbatini, Domenico Russo, Ashour Michael

“…After the description of CIN and its epidemiology and pathophysiology, underlying the important role played by dehydration and salt depletion, precautions for prevention of CIN are listed, suggested, and discussed. …”
Get full text

Effects of forearm rotation on wrist flexor and extensor muscle activities by Kazuhiro Ikeda, Koji Kaneoka, Naoto Matsunaga, Akira Ikumi, Masashi Yamazaki, Yuichi Yoshii

“…These results provide insights into wrist biomechanics and the pathophysiology of lateral and medial epicondylitis.…”
Get full text

The Polymorphisms with Cataract Susceptibility Impair the EPHA2 Receptor Stability and Its Cytoprotective Function by Jin Yang, Dan Li, Qi Fan, Lei Cai, Xiaodi Qiu, Peng Zhou, Yi Lu

“…Despite accumulating evidence revealing susceptibility genes for age-related cataract, its pathophysiology leading to visual impairment at the cellular and molecular level remains poorly understood. …”
Get full text

Montelukast Use and Patterns of Ambulatory Care among Asian versus Non-Asian Adult Patients with Asthma and/or Allergic Rhinitis in the United States by Joseph Vasey, Shalini Bagga, Huan Huang, Tongsheng Wang, David Thompson

“…**Background:** Asthma and allergic rhinitis (AR) are inflammatory conditions that are similar in pathophysiology. Mild-to-moderate persistent asthma has been widely treated with inhaled corticosteroids, while allergic rhinitis is commonly treated with antihistamines, nasal corticosteroids, anticholinergics, and other allergy specific medications. …”
Get full text

Sex Differences in the Allele Distribution of PGLYRP2 Variant rs892145 in Parkinson’s Disease by Caroline Ran, Karin Wirdefeldt, Olof Sydow, Per Svenningsson, Rochellys Diaz Heijtz

“…The microbiota-gut-brain axis is hypothesized to play a role in the pathophysiology of PD, and peptidoglycan recognition proteins (PGLYRPs), which modulate the gut microbiota, are, therefore, relevant candidate genes for PD. …”
Get full text

Current and Novel Therapies for Cluster Headache: A Narrative Review by Bruna de Freitas Dias, Christopher L. Robinson, Maria Dolores Villar-Martinez, Sait Ashina, Peter J. Goadsby

“…Genetic associations suggest a familial risk for developing CH, with lifestyle factors also potentially playing a role. The pathophysiology involves alterations in both central and peripheral nervous system, with the hypothalamus, trigeminocervical complex, and neuropeptides such as calcitonin gene-related peptide (CGRP) being implicated. …”
Get full text

Neutrophils: From Inflammatory Bowel Disease to Colitis-Associated Colorectal Cancer by Chen T, Liu J, Hang R, Chen Q, Wang D

“…Neutrophils affect the pathophysiology of IBD through various mechanisms, including the production of reactive oxygen species (ROS), degranulation, the release of inflammatory mediators and chemokines, and the formation of neutrophil extracellular traps (NETs). …”
Get full text

Evaluation of Inflammatory Markers in a Large Sample of Obstructive Sleep Apnea Patients without Comorbidities by Izolde Bouloukaki, Charalampos Mermigkis, Nikolaos Tzanakis, Eleftherios Kallergis, Violeta Moniaki, Eleni Mauroudi, Sophia E. Schiza

“…Systemic inflammation is important in obstructive sleep apnea (OSA) pathophysiology and its comorbidity. We aimed to assess the levels of inflammatory biomarkers in a large sample of OSA patients and to investigate any correlation between these biomarkers with clinical and polysomnographic (PSG) parameters. …”
Get full text

Posterior reversible encephalopathy syndrome related to severe hypomagnesaemia by Martín Naya Rosato, María Luisa Núñez Calvo, Lucía Barrera López

“…Discussion: PRES pathophysiology is unknown, while its incidence is probably underestimated. …”
Get full text

Ischemic Postconditioning Mitigates Retinopathy in Tree Shrews with Diabetic Cerebral Ischemia by Ling Zhao, Qiwei Liao, Yueting Zhang, Shufen Tan, Shuqing Li, Tingyu Ke

Get full text

Melasma management: Unveiling recent breakthroughs through literature analysis by Darshan Kumar R, Richa Sood, Prashant Tiwari

“…This review focuses on recent methodological advancements in elucidating the pathophysiology of melasma and the development of novel treatment strategies. …”
Get full text

Investigation of Chemokine Receptor CCR2V64Il Gene Polymorphism and Migraine without Aura in the Iranian Population by Alireza Zandifar, Maryam Taheriun, Samira Soleimani, Faraidoon Haghdoost, Mohamadhasan Tajaddini, Shaghayegh Haghjooy Javanmard

“…Inflammation plays an important part in migraine pathophysiology. C-C chemokine receptor 2 (CCR2) is an important chemokine for monocyte aggregation and transendothelial monocyte migration. …”
Get full text

Link between bilaterality and type 2 inflammation in respiratory epithelial adenomatoid hamartomas: A two-center retrospective cohort study. by Yujin Heo, Sang Duk Hong, Hyo Yeol Kim, Gwanghui Ryu, Kyung Won Kwon, Yong Gi Jung

“…These findings underscore the need for further investigation into REAH pathophysiology and emphasize the importance of bilaterality in clinical assessment.…”
Get full text

Osteopontin Bridging Innate and Adaptive Immunity in Autoimmune Diseases by Nausicaa Clemente, Davide Raineri, Giuseppe Cappellano, Elena Boggio, Francesco Favero, Maria Felicia Soluri, Chiara Dianzani, Cristoforo Comi, Umberto Dianzani, Annalisa Chiocchetti

Get full text

A pilot exploratory study for analysis of clinical features and plasma catecholamines in blepharospasm by Lixia Zhu, Hongmei Meng, Wuqiong Zhang, Lijuan Wang, Weixuan Zhao, Jiaai Li, Nilupaer Shafeng, Huaiyu Sun, Ting Jiang, Huiqing Liu, Yu Guo, Shuai Hou

“…These findings highlight the importance of abnormal DA metabolism in BSP pathophysiology and suggest that anxiety symptoms may contribute to BSP pathogenesis by affecting CAs, providing new perspectives for future diagnosis, treatment, and prognostic evaluation of BSP.…”
Get full text

Aberrant T Helper 17 Cells and Related Cytokines in Bone Marrow Microenvironment of Patients with Acute Myeloid Leukemia by Tian Tian, Shuang Yu, Min Wang, Cunzhong Yuan, Hua Zhang, Chunyan Ji, Daoxin Ma

“…In this study, we mainly investigate the role of Th17 cells, Th1 cells, and their related cytokines in the pathophysiology of AML. BM and PB were extracted from ND, CR, and relapsed-refractory AML patients and controls. …”
Get full text