A European Approach to Irritable Bowel Syndrome Management by Michel Delvaux, Jacques Frexinos

“…Most of the therapeutics proposed for the management of patients with IBS have been developed on the assumption that motility disorders of the gut are the most reliable pathological findings among these patients. Consequently, antispasmodics and motility regulatory agents have been widely used, alone or in association with intestinal adsorbents (clay-derived preparations), and laxatives or antidiarrhetic agents. …”
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Cortico-Muscular Phase Connectivity During an Isometric Knee Extension Task in People With Early Parkinson’s Disease by Nina Omejc, Tomislav Stankovski, Manca Peskar, Milos Kalc, Paolo Manganotti, Klaus Gramann, Saso Dzeroski, Uros Marusic

“…Notably, CM phase coherence exhibited distinct scalp topography and spectra characteristics compared to the EEG power spectrum, suggesting different mechanisms underlying Parkinsonian pathological beta power increase and CM phase connectivity. …”
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Role of sirtuins in epigenetic regulation and aging control by E. M. Samoilova, S. E. Romanov, D.  A. Chudakova, P. P. Laktionov

“…Studies on the functional connection between SIRT and longevity, as well as its effect on pathological processes associated with aging, such as chronic inflammation, fibrosis, and neuroinflammation, have been critically analyzed.…”
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Hydroxyurea mitigates diabetic kidney disease through mTOR-S6K signaling pathway in STZ-induced diabetic mice by Wanying Cheng, Cenzhu Wang, Meican Ma, Yu Zhou

“…Histology was used to evaluate pathological changes. Indicators of inflammation and apoptosis were detected. …”
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Multiple Adenomatous Duodenal Polyposis by Zdena Zádorová, Jan Hajer, Václav Mandys

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Impact of HER2 Expression on the Prognosis of Muscle-Invasive Bladder Cancer Patients Treated with Bladder-Preservation Comprehensive Therapy by Yatong Chen, Fei Luo, Tingji Zhang, Jian Li

“…HER2 positivity was significantly associated with tumor size, multifocality, pathological grade, tumor stage, and pelvic lymph node metastasis (P < 0.05). …”
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The role of VNTR aggrecan gene polymorphism in the development of osteoarthritis in women by D. A. Shapovalova, A. V. Tyurin, S. S. Litvinov, E. K. Khusnutdinova, R. I. Khusainova

“…We searched for associations between the VNTR locus and OA in general and with an account of the localization of the pathological process, as well as with the presence of uCTD signs. …”
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Multiproxy analysis exploring patterns of diet and disease in dental calculus and skeletal remains from a 19th century Dutch population by Bartholdy, Bjørn Peare, Hasselstrøm, Jørgen B., Sørensen, Lambert K., Casna, Maia, Hoogland, Menno, Historisch Genootschap Beemster, Henry, Amanda G.

“…Skeletal and dental analysis was performed to explore potential relationships between pathological lesions and presence of alkaloids. Dental calculus was analysed using ultra-high-performance liquid chromatography-tandem  mass spectrometry (UHPLC-ESI-MS/MS). …”
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Exploiting gasdermin-mediated pyroptosis for enhanced antimicrobial activity of phage endolysin against Pseudomonas aeruginosa by Dorota Kuc-Ciepluch, Karol Ciepluch, Daria Augustyniak, Grzegorz Guła, Barbara Maciejewska, Artur Kowalik, Ewelina Jop, Zuzanna Drulis-Kawa, Michał Arabski

“…ABSTRACT Pyroptosis is an inflammatory immune response of eukaryotic cells to bacterial lipopolysaccharide (LPS) and other pathological stimuli, leading to the activation of the gasdermin D (GSDMD) and secretion of pore-forming domain GSDMDNterm, facilitating the release of cytokines. …”
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Pneumothorax, Pneumomediastinum, and Cervical and Facial Massive Emphysema Secondary to Colonoscopy: A Rare Complication of Colonoscopy by Ruben Daniel Perez Lopez, Julian Vargas Flores, Lenin de Jesus Orbe Garibay, Hugo Fernando Narvaez Gonzalez

“…Colonoscopy is a resource used for the diagnosis, treatment, and monitoring of benign and malignant colorectal pathologies. The incidence of perforation is 0.03%–0.65% in diagnostic colonoscopy; however, the incidence can be up to 10 times higher in therapeutic interventions, such as polypectomies, increasing the risk of complications up to 0.07–2.1%. …”
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The Accuracy of the Clinical Carpal Tunnel Syndrome Diagnosis before the Nerve Conduction Studies by A. Atkočiūnas, A. Šimkutė, Rasa Mameniškienė

“…The most common diagnosis after consultation was carpal tunnel syndrome (42.6%), followed by pathologies of nerve roots or plexuses (14.5%). Out of 91 patients referred to electroneurography due to suspicion of CTS, 67 (73.6%) were confirmed cases, whereas, for 12 (13.2%) patients, no abnormalities were detected during NCS.Conclusion: Our analysis supports the theory that the electrodiagnostic examination is essential to specify and confirm the diagnosis of CTS, thus avoiding hyperdiagnosis and preventing patients from excessive surgical treatment. …”
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Coexistence of Asymptomatic Allergic Bronchopulmonary Aspergillosis and Active Pulmonary Tuberculosis: Case Report by Jia Q, Wang L, Tong X, Sun J, Fan H

“…Active tuberculosis was initially confirmed using specialized detection methods, including metagenomic next-generation sequencing and Xpert MTB/RIF analysis of bronchoalveolar lavage fluid. Subsequent pathological biopsy and Aspergillus-specific antibody tests further confirmed the diagnosis of allergic bronchopulmonary aspergillosis combined with active tuberculosis. …”
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Evaluating Functional Performance Tests in those with Non-arthritic Intra-articular Hip Pain: An International Consensus Statement by RobRoy L Martin, Amir Takla, Ashley Disantis, David Kohlrieser, Keelan Enseki, Liran Lifshitz, Louise Grant, Mario Bizzini, Mike Voight, Mark Ryan, Ryan McGovern, Timothy Tyler, Yael Steinfeld-Mass, Ashley Campbell, Yongni Zhang

“…# Background Non-arthritic intra-articular hip pain, caused by various pathologies, leads to impairments in range of motion, strength, balance, and neuromuscular control. …”
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Decreased Breg/Th17 Ratio Improved the Prognosis of Patients with Ulcerative Colitis by Xue Bing, Liang Linlang, Chen Keyan

“…Hematoxylin-eosin staining was used to observe the pathological changes of colonic mucosa. Flow cytometry was utilized to analyze the percentages of Breg cells and Th17 cells. …”
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Association of autistic personality traits with the EEG scores in non-clinical subjects during the facial video viewing by A. N. Savostyanov, D. A. Kuleshov, D. I. Klemeshova, M. S. Vlasov, A. E. Saprygin

“…The software module we are developing can be integrated with modules that allow identifying molecular genetic markers of personality traits, including traits that determine the predisposition to mental pathologies.…”
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Artificial intelligence performance in ultrasound-based lymph node diagnosis: a systematic review and meta-analysis by Xinyang Han, Jingguo Qu, Man-Lik Chui, Simon Takadiyi Gunda, Ziman Chen, Jing Qin, Ann Dorothy King, Winnie Chiu-Wing Chu, Jing Cai, Michael Tin-Cheung Ying

“…Abstract Background and objectives Accurate classification of lymphadenopathy is essential for determining the pathological nature of lymph nodes (LNs), which plays a crucial role in treatment selection. …”
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miR-7-5p Promotes Hepatic Stellate Cell Activation by Targeting Fibroblast Growth Factor Receptor 4 by Shuxia Tian, Min Chen, Bing Wang, Yonglong Han, Haonan Shang, Junming Chen

“…TargetScan was employed to predict microRNAs that targeted FGFR4 on the 3′-untranslated region (3′-UTR). miR-7-5p and FGFR4 expression in pathological liver tissues and LX-2 cells was determined using qRT-PCR and an immunoblotting assay. …”
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Examining Specific Theory-of-Mind Aspects in Amnestic and Non-Amnestic Mild Cognitive Impairment: Their Relationships with Sleep Duration and Cognitive Planning by Areti Batzikosta, Despina Moraitou, Paschalis Steiropoulos, Georgia Papantoniou, Georgios A. Kougioumtzis, Ioanna-Giannoula Katsouri, Maria Sofologi, Magda Tsolaki

“…Hence, besides the effects of MCI pathologies and especially of naMCI, sleep duration seems also to be associated with ToM performance in aging via specific executive functioning decrements. …”
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Autotransplantation of a Third Molar to Replace Compromised Molar With the Individual Three-Dimensional Printed Ultrasonic Osteotome: A Case Report by Cheng Bi, Wen Zhang, Bin Peng

“…After 24 months of follow-up, the transplanted tooth met success criteria, with no signs of pathological radiolucency, root resorption, or pain in the donor tooth. …”
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Polycaprolactone for Hard Tissue Regeneration: Scaffold Design and In Vivo Implications by Fernanda Ramírez-Ruiz, Israel Núñez-Tapia, María Cristina Piña-Barba, Marco Antonio Alvarez-Pérez, Vincenzo Guarino, Janeth Serrano-Bello

“…In the last thirty years, tissue engineering (TI) has emerged as an alternative method to regenerate tissues and organs and restore their function by implanting specific lineage cells, growth factors, or biomolecules functionalizing a matrix scaffold. Recently, several pathologies have led to bone loss or damage, such as malformations, bone resorption associated with benign or malignant tumors, periodontal disease, traumas, and others in which a discontinuity in tissue integrity is observed. …”
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