Correlations among PPAR𝜸, DNMT1, and DNMT3B Expression Levels and Pancreatic Cancer by Valerio Pazienza, Francesca Tavano, Giorgia Benegiamo, Manlio Vinciguerra, Francesca Paola Burbaci, Massimiliano Copetti, Fabio Francesco di Mola, Angelo Andriulli, Pierluigi di Sebastiano

“…In this study we aimed to evaluate the expression of PPARγ, DNMT1, and DNMT3B and their correlation with clinical-pathological features in patients with pancreatic cancer (PC), and to define the effect of PPARγ activation on DNMTs expression in PC cell lines. qRT-PCR analysis showed that DNMT3B expression was downregulated in tumors compared to normal tissues (𝑃=0.03), whereas PPARγ and DNMT1 levels did not show significant alterations in PC patients. …”
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Chat GPT 4o vs residents: French language evaluation in ophthalmology by Leah Attal, Elad Shvartz, Nakhoul Nakhoul, Daniel Bahir

“…ChatGPT 4o demonstrated consistent accuracy over time, with particular strength in the fundamentals of ophthalmology, ocular pathologies, and refractive surgery. Its performance in image processing was significantly improved compared to other chatbots, though still inferior to text-based processing. …”
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Lupeol Attenuates Palmitate-Induced Hypertrophy in 3T3-L1 Adipocytes by Vaithinathan Selvaraju, Shivani R. Babu, Robert L. Judd, Thangiah Geetha

“…These adiposity-associated pathologies can be influenced by dietary components and their potential health benefits. …”
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An Intelligent Medical Imaging Approach for Various Blood Structure Classifications by Madallah Alruwaili

“…Blood is a vital body fluid and can be instrumental in identifying various pathological conditions. Nowadays, a lot of people are suffering from COVID-19 and every country has its own limited testing capacity. …”
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Remote Inflammatory Preconditioning Alleviates Lipopolysaccharide-Induced Acute Lung Injury via Inhibition of Intrinsic Apoptosis in Rats by Yong Liu, Jiahang Xu, Liang Zhao, Jing Cheng, Baojun Chen

“…As inflammation and oxidative stress are the common pathological basis of endotoxin-induced inflammatory injury and ischemic reperfusion injury (IRI), we speculate that remote ischemic preconditioning (RIPC) can be protective for ALI when used as remote inflammatory preconditioning (RInPC). …”
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25-Gauge Vitrectomy in Open Eye Injury with Retained Foreign Body by G. Sborgia, N. Recchimurzo, A. Niro, L. Sborgia, A. Sborgia, G. Alessio

“…In the last year small gauge vitrectomy has become safer and more efficient, extending the range of pathologies successfully treated. Aims. To evaluate the safety and outcomes in patients with open eye injury with retained foreign body that underwent early 25-gauge vitrectomy. …”
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Effects of Polystyrene Microplastic Exposure on Liver Cell Damage, Oxidative Stress, and Gene Expression in Juvenile Crucian Carp (<i>Carassius auratus</i>) by Xiangtong Li, Yuequn Huang, Wenrong Li, Chaoyang Deng, Weiyuan Cao, Yi Yao

“…The results demonstrated that: (1) Different concentrations of PS-MPs cause varying degrees of pathological and oxidative damage to liver tissue cells of crucian carp. …”
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Exosomes derived from liver failure patients’ plasma stimulated mesenchymal stem cells alleviate acute liver failure by Zhuoran Wang, Jun Ling, Shaoli You, Bing Zhu

“…Compared to NC-Exos, LF-Exos induced AKT phosphorylation in hepatocytes and liver tissues, inhibited D-GalN/LPS-induced apoptosis in hepatocytes, and reduced pathological liver injury in the mouse model of ALF. …”
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Cognition Deficits in Parkinson’s Disease: Mechanisms and Treatment by Congcong Fang, Longqin Lv, Shanping Mao, Huimin Dong, Baohui Liu

“…In our review, we focus on a description of cognitive decline in PD, expound emphatically the pathological mechanisms underlying cognition deficits in PD, then give a comprehensive overview of specific therapeutic strategies, and finally dissect what fresh insights may bring new exciting prospect for the subfield.…”
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Clinical Presentation and Course of Pulmonary Involvement in Chronic Nonbacterial Osteomyelitis by Toni Hospach, Friederike Blankenburg, Anita Heinkele, Kristina Rücklová, Peter Müller‐Abt, Frank Weller‐Heinemann, Laura Buchtala, Jan Maier, Jasmin Kümmerle‐Deschner, Christiane Reiser, Ales Janda, Andreas Urban, Reiner Berendes, Andrea Skrabl‐Baumgartner, Jürgen Brunner, Ralf Trauzeddel, Johannes Peter Haas, Annette Holl‐Wieden, Henner Morbach, Anja Schnabel, Normi Brück, Gabriele Hahn, Wolfgang Emminger, Isabella Valent, Regine Borchers, Christian Klemann, Ilias Tsiflikas, Jens Klotsche, Kirsten Minden, Christian M. Hedrich, Thekla von Kalle

“…Although prominent hilar lymph nodes were present (in 19% of patients), no pathologic enlargement (>1 cm) was seen. When available (3 of 22 patients), histology revealed granulomatous inflammation with lymphocyte infiltration. …”
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Automated skin melanoma diagnostics based on mathematical model of artificial convolutional neural network by D. A. Gavrilov, E. I. Zakirov, E. V. Gameeva, V. Yu. Semenov, O. Yu. Aleksandrova

“…Among the most promising applica ons: automated recogni on and classifi ca on of skin diseases, detec on of pathologies on X-ray, CT, MRI, ultrasound imaging. In the proposed project, we will focusour a en on on the diagnosis of human skin diseases.At the moment, melanoma is one of the most dangerous types of malignant tumors of the skin with a lot of deaths due to rapid metastasis, which is difficult to treat. …”
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Applications of MR Finger printing derived T1 and T2 values in Adult brain: A Systematic review [version 1; peer review: 2 approved] by Rajagopal Kadavigere, Obhuli Chandran M, Kaushik Nayak, Abhijith S, Saikiran Pendem, Varsha Raghu, Shailesh Nayak S, Riyan Mohamed Sajer, Tancia Pires, Priyanka -

“…With reduced acquisition times, MRF outperforms conventional MRI in detecting subtle pathologies, distinguishing properties, and providing reliable biomarkers.…”
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A rare case of double pituitary prolactinomas: the diagnostic application of intraoperative ultrasonography and DNA methylation markers by Jared C. Reese, Thomas M. Zervos, Jack Rock, Abeer Tabbarah, Houtan Noushmehr, Grayson Herrgott, Ana Valeria Castro

“…Pituitary tumor (PT) and nontumor (NT) tissues and blood were collected for pathological and molecular assessments (genome-wide methylation level profiled using the EPIC array, at surgery and follow-up). …”
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Association between Platelet to Neutrophil Ratio (PNR) and Clinical Outcomes in STEMI Patients after Successful pPCI: A Secondary Analysis Based on a Cohort Study by Hao Wang, Xiaochun Qing, Hua Wang, Yunfei Gu

“…After adjusting for age, sex, anterior wall myocardial infarction (MI), history of MI, apelin-12, apelin-12 change rate, left ventricular end-diastolic diameter, peak cardiac troponin I, pathological Q wave, Killip classification grade, fasting blood glucose, albumin, GENSINI score, and estimated glomerular filtration rate, a nonlinear relationship was found between the PNR and MACEs in the included cohort. …”
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<i>In vitro</i> assay of biological activity of a national preparation of macrophage activating factor (GcMAF-RF) by E. V. Levites, S. S. Kirikovich, E. V. Dolgova, A. S. Proskurina, G. S. Ritter, А. A. Ostanin, E. R. Chernykh, S. S. Bogachev

“…The preparation will be in demand in the field of cancer treatment, and, in addition, it can be used in the treatment of a number of neurodegenerative pathologies.…”
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Diagnosis and Treatment of Gastroesophageal Reflux Disease (Clinical Guidelines of the Russian Gastroenterological Association, Russian Scientific Medical Society of Internal Medic... by V. T. Ivashkin, A. S. Trukhmanov, I. V. Maev, O. M. Drapkina, M. A. Livzan, A. I. Martynov, T. L. Lapina, A. V. Paraskevova, D. N. Andreev, O. P. Alexeeva, S. A. Alekseenko, A. Yu. Baranovsky, O. V. Zayratyants, O. Yu. Zolnikova, O. B. Dronova, I. L. Kliaritskaia, N. V. Korochanskaya, Yu. A. Kucheryavyy, S. N. Mammaev, M. F. Osipenko, S. S. Pirogov, E. A. Poluektova, D. E. Rumyantseva, R. G. Sayfutdinov, O. A. Storonova, Yu. P. Uspenskiy, I. B. Khlynov, V. V. Tsukanov, A. A. Sheptulin

“…The diagnosis of GERD is established on the basis of anamnestic data, instrumental examination (detection of reflux esophagitis during upper gastrointestinal endoscopy, detection of pathological gastroesophageal reflux with 24-hour pH-metry or/and 24-hour pH-impedance monitoring). …”
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Fenofibrate Protects Cardiomyocytes from Hypoxia/Reperfusion- and High Glucose-Induced Detrimental Effects by Fabiola Cortes-Lopez, Alicia Sanchez-Mendoza, David Centurion, Luz G. Cervantes-Perez, Vicente Castrejon-Tellez, Leonardo del Valle-Mondragon, Elizabeth Soria-Castro, Victoria Ramirez, Araceli Sanchez-Lopez, Gustavo Pastelin-Hernandez, Wylly Ramses Garcia-Niño, Maria Sanchez-Aguilar, Luz Ibarra-Lara

“…The expression of nuclear factor erythroid 2-related factor 2 (Nrf2) increased significantly in treated cells, while pathologies increased the expression of its inhibitor Keap1. …”
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Implications of the Intestinal Microbiota in Diagnosing the Progression of Diabetes and the Presence of Cardiovascular Complications by Alina Mihaela Leustean, Manuela Ciocoiu, Anca Sava, Claudia Florida Costea, Mariana Floria, Claudia Cristina Tarniceriu, Daniela Maria Tanase

“…Microbes can be considered a complex endocrine system capable of ensuring the proper functioning of the body but are also responsible for the development of numerous pathologies (diabetes, coronary syndromes, peripheral arterial disease, neoplasia, Alzheimer’s disease, and hepatic steatosis). …”
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Gastroenteropancreatic Neuroendocrine Neoplasia Characterization in Portugal: Results from the NETs Study Group of the Portuguese Society of Endocrinology, Diabetes and Metabolism by A. P. Santos, J. Vinagre, P. Soares, I. Claro, A. C. Sanches, L. Gomes, I. Fernandes, A. L. Catarino, J. Preto, B. D. Pereira, A. P. Marques, F. Rodrigues, C. Amaral, G. Rocha, J. C. Mellidez, H. Simões, J. M. Lopes, M. J. Bugalho, On behalf of the NETs Study Group of the Portuguese Society of Endocrinology, Diabetes and Metabolism

“…We conducted a cross-sectional, multicentric study in main Portuguese centers to evaluate the clinical, pathological, and therapeutic profile of GEP-NENs. Methods. …”
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FLOT Neoadjuvant Chemotherapy Followed by Laparoscopic D2 Gastrectomy in the Treatment of Locally Resectable Advanced Gastric Cancer by Shun Zhang, Dongyi Yan, Qi Sun, Tao Du, Dongliang Cao, Yao Yang, Biao Yuan, Haiqiang Li, Xiaohua Jiang, Chun Song

“…Only one patient exhibited grade III postoperative complications. The pathologic complete remission was 13%. The common grade 3/4 adverse events from chemotherapy were leucopenia (17.4%), neutropenia (30.4%), anemia (13%), anorexia (13%), and nausea (17.4%). …”
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