Mechanisms of (Fisch.) Bge. var. mongholicus (Bge.) Hsiao (huang qi) and (Oliv.) Diels (dang gui) in Ameliorating Hypoxia and Angiogenesis to Delay Pulmonary Nodule Malignant Tra... by Ying Guo PhD, Peng Yang MS, Zihong Wu PhD, Sanyin Zhang PhD, Fengming You PhD

“…However, current treatments relying on follow-up and surgical excision fail to fully address clinical needs. Pathological angiogenesis plays a pivotal role in supplying oxygen necessary for the progression of PN to LC. …”
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Analysis of macular retinal thickness in polyarteritis nodosa using spectral domain optical coherence tomography by Che-Ning Yang, Chia-Ping Chen, Yi-Ting Hsieh

“…Abstract Purpose To identify the macular retinal layer thickness changes in polyarteritis nodosa (PAN) patients without pathological findings appearing in color fundus photography (CFP), and to investigate the correlations with disease durations. …”
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Ocular Findings in Infants with Microcephaly Caused by Presumed Congenital Infection by Zika Virus in Sergipe by Marco Valadares, Anne Carolyne Lelis Oliveira Pedroso, Alessandro Santana, Angela Maria da Silva, Isabela Soares Costa, Maria Luiza Doria Almeida, Roque Pacheco de Almeida

“…Other ocular alterations were seen in 15 (24.2%) patients, including pathological strabismus in 11 (17.7%) patients, congenital cataracts in 2 (3.2%) patients, and nystagmus in 2 (3.2%) patients. …”
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Short-term survivors with brain metastases have modest benefits from focal and systemic therapies and remain frequent despite improving treatment landscape by M. Czogalla, J. Stöhr, N. Gleim, K. Papsdorf, S. Klagges, P. Hambsch, T. Kuhnt, F. Nägler, A. Barrantes-Freer, J. Wach, N.H. Nicolay, C. Seidel

“…Clinical and treatment characteristics, pathological data and causes of death were documented. …”
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Diagnostic Role of Colon Capsule Endoscopy in Patients with Optimal Colon Cleaning by Ümit Akyüz, Yusuf Yılmaz, Ali Tüzün İnce, Bülent Kaya, Cengiz Pata

“…CCE appears to be a highly sensitive diagnostic modality for detecting colonic pathologies.…”
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Macrofilaricidal Activity, Acute and Biochemical Effects of Three Lichen Species Found on Mount Cameroon by Thierry Roland Kang, Jerome Nyhalah Dinga, Ayuk Elizabeth Orock, Elvis Monya, Moses Njutain Ngemenya

“…Onchocerciasis is a parasitic infection affecting a relatively small population globally but has very devastating pathological outcomes. Ivermectin and recently moxidectin are the only drugs approved for clinical management of the disease, both of which have several limitations. …”
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Comparison of [68Ga]Ga-DOTA-FAPI-04 and [18F]FDG PET/MRI in the Preoperative Diagnosis of Gastric Cancer by Tao Du, Shun Zhang, Xi-Mao Cui, Ren-Hao Hu, Hai-Yan Wang, Jian-Juan Jiang, Jun Zhao, Lan Zhong, Xiao-Hua Jiang

“…Combined with postoperative pathological staging, there was no difference in diagnostic sensitivity and specificity of lymph node staging between the FDG and FAPI groups (P>0.05). …”
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Elevated Serum Extracellular Vesicle‐Packaged SPARC in Hypertension: A Cross‐Sectional Study in a Middle‐Aged and Elderly Population by Xueying Chen, Han Guo, Xinwei Li, Yang Liu, Xinxin Li, Zhengshuo Cui, Huijuan Ma, Jianxun He, Zhechun Zeng, Huina Zhang

“…Secreted protein acidic and rich in cysteine (SPARC) is involved in many metabolic diseases and endothelial dysfunction pathological processes. This study aimed to explore the association of serum EV‐derived SPARC with hypertension incidence. …”
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Oxytocin attenuates demand for cocaine in female rats by Amy S. Kohtz, Hannah Davies, Belle Lin, Gary Aston-Jones

“…There are substantial sex differences in substance use disorders (SUDs), and a key feature of SUD is pathologically high economic demand for drug. The hypothalamic neuropeptide oxytocin (OXT) is heavily implicated in the modern treatment of SUDs. …”
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Therapeutic potential of SOX family transcription factors in osteoarthritis by Yue Huang, Zhuo Wang

“…Scholarly investigations of the molecular mechanisms that are related to the occurrence and development of osteoarthritis have shed light on the pathological causes of this condition to a certain extent, providing a foundation for its prevention and treatment. …”
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Microbial diversity and metabolomics analysis of colon contents exposed to cadmium and polystyrene microplastics by Dechun Chen, Liyu Pan, Xuan Ran, Junyu Huang, Xiaohua Teng, Falong Yang, Haifeng Liu

“…The changes of colon histopathology were observed, and the changes of microbial diversity and metabolomics of colon contents were analyzed. Pathological sections of the colon showed abnormal mucosal hyperemia with mixed exposure compared to cadmium exposure. …”
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Sleeve gastrectomy improves cardiac function and glucose-lipid metabolism disorder in obese rats induced by a high-fat and high-sugar diet by Xiaojuan Li, Luming Qiao, Wei Wang, Ying Shi, Lei Yuan, Zhiwei Zhai

“…Furthermore, enhanced pathological changes, including inflammatory cell infiltration and loss of cytoplasm striations, enhanced oil red O staining, increased TUNEL-positive cells, upregulated Bax and cleaved-caspase-3, and downregulated Bcl-2, were observed in obese rats, which were notably alleviated by SG. …”
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Relationship between the ultrasound features of different molecular subtypes of breast cancer and positive PD-1/PD-L1 expression by Ruiqian Yan, Haixia Li, Junxi Gao

“…Methods The study included 172 invasive breast cancer patients with surgical resection and pathological confirmation at the First Affiliated Hospital of Xinjiang Medical University from June 2016 to April 2022. …”
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Development and validation of nomograms for predicting pentafecta outcomes before and after robot-assisted radical prostatectomy: a retrospective study by Tanan Bejrananda, Kiyoshi Takahara, Dutsadee Sowanthip, Tomonari Motonaga, Kota Yagi, Wataru Nakamura, Masanobu Saruta, Takuhisa Nukaya, Masashi Takenaka, Kenji Zennami, Manabu Ichino, Hitomi Sasaki, Makoto Sumitomo, Ryoichi Shiroki

“…Nomograms were developed using preoperative and postoperative variables, including age, PSA level, biopsy Gleason score, clinical stage, pathological tumor stage, tumor grade, nerve sparing, and preoperative potency. …”
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Non3 is an essential Drosophila gene required for proper nucleolus assembly by E. N. Andreyeva, A. A. Ogienko, A. A. Yushkova, J. V. Popova, G. A. Pavlova, E. N. Kozhevnikova, A. V. Ivankin, M. Gatti, A. V. Pindyurin

“…Consistent with its multiple functions, the nucleolus has been implicated in many human diseases, including cancer and degenerative pathologies of the nervous system and heart. Here, we report the characterization of the Drosophila Non3 (Novel nucleolar protein 3) gene, which encodes a protein homologous to the human Brix domain-containing Rpf2 that has been shown to control ribosomal RNA (rRNA) processing. …”
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mtSTAT3 suppresses rheumatoid arthritis by regulating Th17 and synovial fibroblast inflammatory cell death with IL-17-mediated autophagy dysfunction by Seon-Yeong Lee, Jeonghyeon Moon, A Ram Lee, Young-Mee Moon, Jeong Won Choi, Chae Rim Lee, Su Been Jeon, Hee Su Sohn, Jeehee Youn, Dongyun Shin, Sung-Hwan Park, Mi-La Cho

“…Abstract Th17 cells are activated by STAT3 factors in the nucleus, and these factors are correlated with the pathologic progression of rheumatoid arthritis (RA). …”
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Antioxidant Effect of Beer Polyphenols and Their Bioavailability in Dental-Derived Stem Cells (D-dSCs) and Human Intestinal Epithelial Lines (Caco-2) Cells by Marina Di Domenico, Antonia Feola, Pasqualina Ambrosio, Federica Pinto, Giovanni Galasso, Armando Zarrelli, Giovanni Di Fabio, Marina Porcelli, Salvatore Scacco, Francesco Inchingolo, Lucio Quagliuolo, Andrea Ballini, Mariarosaria Boccellino

“…In the presence of an intense stressing event, cells activate specific responses to counteract cell death or senescence which is known to act as a key-task in the onset of age-related pathologies and in the loss of tissue homeostasis. Many studies have shown positive effects of natural compounds as beer polyphenols on biological systems. …”
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<i>Macrostomum lignano</i> as a model to study the genetics and genomics of parasitic flatworms by K. V. Ustyantsev, V. Yu. Vavilova, A. G. Blinov, E. V. Berezikov

“…Without treatment, acute and chronical infections frequently lead to the development of severe pathologies and even death. Emerging data on a decreasing eff iciency of some important anthelmintic compounds and the emergence of resistance to them force the search for alternative drugs. …”
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15-Deoxy-γ12,14-prostaglandin J2 Reduces Liver Impairment in a Model of ConA-Induced Acute Hepatic Inflammation by Activation of PPARγ and Reduction in NF-κB Activity by Kan Chen, Jingjing Li, Junshan Wang, Yujing Xia, Weiqi Dai, Fan Wang, Miao Shen, Ping Cheng, Yan Zhang, Chengfen Wang, Jing Yang, Rong Zhu, Huawei Zhang, Yuanyuan Zheng, Jie Lu, Zhuoyi Fan, Yingqun Zhou, Chuanyong Guo

“…Pretreatment with 15d-PGJ2 reduced the pathological effects of ConA-induced autoimmune hepatitis and significantly reduced the levels of cytokines after injection. 15d-PGJ2 activated PPARγ, blocked the degradation of IκBα, and inhibited the translocation of NF-κB into the nucleus. …”
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Retrospective investigation of non-traumatic small intestine perforations: Our single center 7-year clinical experiences by Sebnem Cimen, Burak Ucaner, Ahmet Kamburoglu, Cilga Ecem Lamba

“…Non-traumatic small intestine perforations (NTSIP) constitute a rare cause of acute surgical pathologies and have a high mortality and morbidity if not treated in time. …”
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