Preoperative liquid biopsy transcriptomic panel for risk assessment of lymph node metastasis in T1 gastric cancer by Ping’an Ding, Jiaxiang Wu, Haotian Wu, Wenqian Ma, Tongkun Li, Peigang Yang, Honghai Guo, Yuan Tian, Jiaxuan Yang, Limian Er, Renjun Gu, Lilong Zhang, Ning Meng, Xiaolong Li, Zhenjiang Guo, Lingjiao Meng, Qun Zhao

“…Abstract Background The increasing incidence of early-stage T1 gastric cancer (GC) underscores the need for accurate preoperative risk stratification of lymph node metastasis (LNM). Current pathological assessments often misclassify patients, leading to unnecessary radical surgeries. …”
Get full text

Changes in the hematology and blood metabolites of guinea pigs (Cavia porcellus) under intensive rearing system in humid tropical conditions by Daniel Paredes-López, Rizal Robles-Huaynate, Uriel Aldava-Pardave, Miguel Morales-Cauti

“… Guinea pigs in intensive production generates an imperative necessity of physio-pathological bases for diagnosing their state of welfare, health, and production; those which are available for this species are referred to as laboratory or companion animal. …”
Get full text

The Gut Microbiota-Related Antihyperglycemic Effect of Metformin by Izabela Szymczak-Pajor, Józef Drzewoski, Małgorzata Kozłowska, Jan Krekora, Agnieszka Śliwińska

“…Growing evidence indicates that changes in gut microbial biodiversity may be associated with the development of several pathologies, including type 2 diabetes mellitus (T2DM). …”
Get full text

APLASTIC SYNDROME IN A PREGNANT WOMAN ON THE BACKGROUND OF COVID-19: A CLINICAL CASE by Индира Венеровна Сахаутдинова, Ирина Борисовна Фаткуллина, Ирина Робинзоновна Рахматуллина, Игорь Сергеевич Засядкин, Анна Юрьевна Лазарева

“…Physiological changes are also known in other systems, for example, respiratory, digestive, urinary and cardiovascular, which suggest vulnerability to the influence of pathological agents and the formation of severe infection, which can lead to an increase in maternal morbidity and mortality. …”
Get full text

Development of therapeutic supplement using roasted-cashew-nut to protect cerebral vasoconstriction injury triggered by mixture of petroleum hydrocarbons in the hypothalamus and hi... by J.K. Akintunde, V.O. Akomolafe, R.N. Ugbaja, A.M. Olude, A.D. Folayan

“…The regimen period was 28 days. Cell pathological evaluation was done using hematoxylin and eosin staining and visualized under the microscope. …”
Get full text

Abnormality detection in nailfold capillary images using deep learning with EfficientNet and cascade transfer learning by Mona Ebadi Jalal, Omar S. Emam, Cristián Castillo-Olea, Begoña García-Zapirain, Adel Elmaghraby

“…Abstract Nailfold Capillaroscopy (NFC) is a simple, non-invasive diagnostic tool used to detect microvascular changes in nailfold. Chronic pathological changes associated with a wide range of systemic diseases, such as diabetes, cardiovascular disorders, and rheumatological conditions like systemic sclerosis, can manifest as observable microvascular changes in the terminal capillaries of nailfolds. …”
Get full text

Tumor resting-state fMRI connectivity to extralesional brain is associated with cognitive performance in glioma patients by Chuh-Hyoun Na, Hans Clusmann, Martin Wiesmann, Kerstin Jütten, Verena Mainz

“…Discussion and conclusion: Intrinsic functional coupling to the rest of the brain was associated with worse cognitive performance and might relate to pathological tumor-neuron interaction on the macroscale, reflecting the invasive nature of diffusely infiltrating glioma. …”
Get full text

Role of acute respiratory diseases in pathogenesis of distal limb infections in cattle by A. D. Alekseev, O. G. Petrova, M. I. Barashkin, I. M. Milshtein, V. D. Moskvin

“…In some cases, metabolic acidosis in cattle can develop along with respiratory infection caused by viral and bacterial agents. The main pathological processes resulting from acute respiratory diseases of cattle are bronchitises, tracheites and pneumonias. …”
Get full text

Lipidopathy disrupts peripheral and central amyloid clearance in Alzheimer's disease: Where are our knowledge by Shahram Darabi, Enam Alhagh Charkhat Gorgich, Fatemeh Moradi, Auob Rustamzadeh

“…However, an imbalance in Aβ production and clearance is the central pathological feature of Alzheimer’s disease (AD), leading to the accumulation of Aβ plaques in the brain. …”
Get full text

Surgical Results of Anteromedial Plate Osteosynthesis for Diaphyseal Humerus Fracture by Ujjawal Pradhan, S. G. Thejaswi, H. Papa Naik, Sunil Baliga, Nobin Kumar Sharma, Avik Chakravorty

“…Exclusion criteria included: pathological fracture, grade open III fractures, nonunion, intra-articular fractures, preoperative radial nerve palsy, nonconsent, and loss to follow-up. …”
Get full text

Prevalence and risk factors of teat end hyperkeratosis in cows from the Urals region of Russia by A.S. Barkova, V.V. Verkhoturov

“…Analysis of morbidity in farms with different levels of milk productivity showed that as animal productivity increases, more teats with signs of pathological changes are registered. Simultaneously, teat lesions are also observed when using robotic milking machines, but in smaller numbers. …”
Get full text

Endoplasmic Reticulum Stress: Its Role in Disease and Novel Prospects for Therapy by Axel H. Schönthal

“…A number of physiological and pathological conditions, as well as a variety of pharmacological agents, are able to disturb proper ER function and thereby cause ER stress, which severely impairs protein folding and therefore poses the risk of proteotoxicity. …”
Get full text

Study on the Nomogram Model Based on Dual-energy Computed Tomography for Predicting Lymph Node Metastasis in Papillary Thyroid Carcinoma by Bo GAO, Jingbin ZHANG, Huizhi MI, Haiqiao SUN, Xiaohui LI, Jiaxing WU, Kexin ZHANG, Shaotong WANG, Xuan SU, Xinyue CUI

“…Each patient underwent preoperative neck dual-energy-enhanced CT, and postoperative pathological results revealed 105 lymph nodes as metastatic and 136 as non-metastatic. …”
Get full text

Pediatric pancreatic acinar cell carcinoma with a non-canonical BRAF-KMT2C fusion and a classic SND1-BRAF fusion: a case report and literature review by Yaqin Wang, Jiasi Zhang, Dimin Nie, Ai Zhang, Qun Hu, Aiguo Liu

“…Case presentation We report a case of pediatric PACC in a 7-year-old male presenting with a large, non-tender abdominal mass (11 cm x 11 cm) on the right side. Pathological and imaging evidence confirmed the diagnosis of PACC, with no lymph node infiltration or distant metastasis. …”
Get full text

Point prevalence survey of antibiotics in a pediatric tertiary hospital in the Republic of Panama by Ximena Norero, Dora Estripeaut, Elizabeth Castaño, Jacqueline Levy, Paola Lichtenberger, José Pablo Díaz-Madriz, José Luis Bustos, Robin Rojas Cortés, Gabriel Levy-Hara

“…The findings suggest it is necessary to assess the need for ampicillin, gentamicin, and piperacillin-tazobactam use in patients admitted to pediatric critical care units, with special emphasis on children with pneumonia and sepsis diagnosis, the most common pathologies for which an antimicrobial was prescribed.…”
Get full text

MYH9 promotes malignant progression of glioma cells through regulating β-catenin stability via epithelial-mesenchymal transition signaling pathway by Zigui Chen, Chao Liu, Wei Zheng, Zhilong Li, Yuanhui Tang, Jun Peng, Changfeng Miao, Dandan Zheng, Ying Xia

“…EMT is involved in multiple physiological and pathological processes in the human body. The occurrence of EMT involves many signal transduction pathways and complex molecular mechanisms related to calnexin, growth factors, transcription factors, and the microenvironment. …”
Get full text

Deep learning and radiomics for gastric cancer serosal invasion: automated segmentation and multi-machine learning from two centers by Hui Shang, Tao Feng, Dong Han, Fengying Liang, Bin Zhao, Lihang Xu, Zhendong Cao

“…Methods This study enrolled 311 patients from two centers with pathologically confirmed of GC. we employed a deep learning model, U-Mamba, to obtain fully automatic segmentation of the spleen CT images. …”
Get full text

Monascus red pigment influence on hydroxyapatite nanoparticles-mediated renal toxicity in rats by Nasser N. Alqurashy, Mokhtar I. Yousef, Ahmed A. Hussein, Maher A. Kamel, Abeer El Wakil

“…Moreover, an increase in inflammatory (TNF-α and TGF-β) and apoptotic (caspace-3) markers, an elevation in gene-based kidney injuries markers (Kim-1 and lipocalin-2), and pathological tissue changes were determined. Meanwhile, co-treatment with different doses of biopigment and HANPs have reduced oxidative stress via their potent antioxidant effect. …”
Get full text

Immunogenic characteristics of <i>Avibacterium paragallinаrum</i> (serogroup B) isolates and strains by M. S. Firsova, V. A. Yevgrafova, A. V. Potekhin, R. V. Yashin, O. V. Pruntova, V. S. Russaleyev

“…The paper presents the results of tests for immunogenic properties of antigens of 13 infectious coryza isolates recovered from the pathological material delivered to the FGBI “ARRIAH” from poultry farms of the Russian Federation and the Republic of Belarus. …”
Get full text

SHMT2 Overexpression Predicts Poor Prognosis in Intrahepatic Cholangiocarcinoma by Shanglei Ning, Siquan Ma, Abdul Qahar Saleh, Lingyu Guo, Zixiao Zhao, Yuxin Chen

“…Furthermore, SHMT2 level was closely associated with tumor T stage (P=0.017) and tumor TNM stage (P=0.041) in patients with iCCA, but not with age, gender, tumor size, tumor number, pathological grade, vascular invasion, or N stage. Moreover, Kaplan-Meier analysis suggested that patients with lower SHMT2 level have longer survival rate than those with high expression (45.8 vs 23.1%, P=0.030). …”
Get full text