Microvascular dysfunction in a murine model of Alzheimer’s disease using intravital microscopy by Danielle Sidsworth, Noah Tregobov, Noah Tregobov, Colin Jamieson, Jennifer Reutens-Hernandez, Joshua Yoon, Geoffrey W. Payne, Geoffrey W. Payne, Stephanie L. Sellers, Stephanie L. Sellers, Stephanie L. Sellers, Stephanie L. Sellers

“…Early theories of AD sought to identify a single unifying explanation underlying AD pathogenesis; however, evolving evidence suggests it is a multifactorial, systemic disease, involving multiple systems. …”
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FROM ONCOLOGIST TO SURGEON - GENETICS IN COLORECTAL METASTASIS FOR SURGEONS by Marília Polo Mingueti e SILVA, Jorge SABBAGA, Henry Luiz NAJMAN, Carlos David Carvalho NASCIMENTO, Ricardo Lemos COTTA-PEREIRA, João Eduardo Leal NICOLUZZI, Maria Ignez BRAGHIROLI

“…Sporadic disease is characterized by the absence of a family history and accounts for approximately 70% of all colorectal cancers, being more common over 50 years of age, with dietary and environmental factors implicated in its pathogenesis. Sporadic disease is characterized by the absence of a family history and accounts for approximately 70% of all colorectal cancers, being more common over 50 years of age, with dietary and environmental factors implicated in its pathogenesis. …”
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Whole Exome Sequencing Reveals Rare Variants in Genes Associated with Metabolic Disorders in Women with PCOS by Priyal Sharma, Ashutosh Halder, Manish Jain, Manish Tripathi

“…Background: Polycystic ovary syndrome (PCOS) is a complex genetic trait, the pathogenesis of which is governed by an interplay of genetic and epigenetic factors. …”
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PRKD2 as a novel target for targeting the diabetes–osteoporosis nexus by Rongjin Chen, Chenhui Yang, Hefang Xiao, Ao Yang, Changshun Chen, Fei Yang, Bo Peng, Bin Geng, Yayi Xia

“…The aim of this study was to identify and validate key genes implicated in the pathogenesis of both conditions. By employing the Mfuzz time-series gene clustering method combined with transcriptome sequencing of patient serum, we systematically delineated gene expression patterns during the transition from a healthy state through DM to DMOP. …”
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Diagnostics and treatment of biliary dyskinesia: clinical guidelines of the Russian gastroenterological Association by V. T. Ivashkin, I. V. Mayev, Yu. O. Shulpekova, Ye. K. Baranskaya, A. V. Okhlobystin, A. S. Trukhmanov, T. L. Lapina, A. A. Sheptulin

“…The gallbladder dyskinesia and sphincter of Oddi dyskinesia are defined as the diseases of functional origin caused by motility and visceral sensitivity disorders. The pathogenesis of these disorders is not completely understood. …”
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Lipedema: Clinical Features, Diagnosis, and Management by Hatan Hisham Mortada, Abdulmalek W. Alhithlool, Nouf Z. AlBattal, Rashika K. Shetty, Ghaleb A. AL-Mekhlafi, Joon Pio Hong, Feras Alshomer

“…There have been relatively few studies that have precisely defined the pathogenesis, epidemiology, and treatment approaches for lipedema. …”
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Molecular characterization of Pseudomyxoma peritonei with single-cell and bulk RNA sequencing by Ye Jin Ha, Seong-Hwan Park, Seon-Kyu Kim, Ka Hee Tak, Jeong-Hwan Kim, Chan Wook Kim, Yong Sik Yoon, Seon-Young Kim, Jong Lyul Lee

“…These datasets enhance our understanding of PMP pathogenesis and provide a valuable resource for uncovering the intricate molecular landscape of PMP, with the potential to improve clinical utility through further research.…”
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Options of dyslipidemia treatment at non-alcoholic fatty liver disease by M. V. Mayevskaya, M. A. Morozova

“…Conclusion. Now data on a pathogenesis of lipid metabolism disorders at NAFLD are accumulated. …”
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Plasma mcfDNA Sequencing May Improve Usual Care Diagnostics to Detect HHV-8 Among Outpatient People with Advanced HIV by Sarah Park, Brian Epling, Morgan Richey, Daniel Lupu, Mona Mughar, Irini Sereti

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Assessment of Interleukin-1β in Saliva of Smoker and Non-smoker Patients with Chronic Periodontitis. by Solav Abdul-Qadir Mustafa, Haween T. Nanakaly, Hozan Wrya Azeez

“… Background and objectives: Smoking is considered a significant risk factor in periodontitis. The pathogenesis of periodontal disease may be affected by alterations of the inflammatory response by smoke. …”
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Review of Russian Abstracts Accepted for United European Gastroenterology Week (2022) by A. A. Sheptulin

“…The abstracts were devoted to topical issues of pathogenesis, diagnosis and treatment of intestinal liver and pancreatic diseases.Conclusion. …”
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A Peculiar Tracheoesophageal Fistula Caused by a Plastic Foreign Body by Chao Chen, Dingyuan Dai, Yu Guo, Chen Sun, Qi Li

“…The report investigates the unusual trajectory of this case—examining the pathway through which the foreign body became lodged in the trachea, followed by the subsequent development of TEF—and provides valuable insights into its pathogenesis and clinical significance.…”
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Bacterial overgrowth syndrome by Yu. A. Kucheryavy, T. S. Oganesyan

“…To present the up-to-date information on pathogenesis, diagnostics and treatment of bacterial overgrowth syndrome (BOS).Original positions. …”
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Study insights in the role of PGC-1α in neurological diseases: mechanisms and therapeutic potential by Mi-bo Tang, Yi-xuan Liu, Zheng-wei Hu, Hai-yang Luo, Shuo Zhang, Chang-he Shi, Yu-ming Xu, Yu-ming Xu, Yu-ming Xu

“…There is emerging evidence indicating a protective role of PGC-1α in the pathogenesis of several neurological diseases. As such, a deeper and broader understanding of PGC-1α and its role in neurological diseases is urgently needed. …”
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Cytokines in Liver Cirrhosis (Their Importance in Assessing Activity and Decompensation) by G. K. Mirodzhov, S. D. Pulatova

“…Aim: studying the role of pro-inflammatory and anti-inflammatory cytokines in the pathogenesis of liver cirrhosis progression.Materials and methods. …”
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Modern approaches to functional dyspepsia treatment by A. A. Sheptulin

“…Investigation of FD pathogenesis should be continued that will provide more differentiated treatment approach and improve the results.…”
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Gastroesophageal reflux disease and functional dyspepsia: clinical efficacy and safety of prokinetic choice by D. I. Trukhan

“…Motility disorder of gastroesophageal zone plays a leading part in pathogenesis of these diseases that assumes application prokinetics as a baseline therapy. …”
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Non-invasive imaging with ICOS-targeting monoclonal antibody for preclinical diagnosis of rheumatoid arthritis in a humanized mouse model by Shao Duan, Chao Li, Feng Yan, Yifei Xia, Shuaiming Shao, Weiyu Chen, Zunyu Xiao, Gongping Xu

“…Abstract Background Activated T cells play a pivotal role in rheumatoid arthritis (RA) pathogenesis, and imaging of activated T cells may provide a non-invasive tool for RA detection. …”
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Decreased expression of miR-200a and miR-223-3p in endometriosis during the secretory phase of menstrual cycle: Insights from a case-control study on molecular biomarkers and disea... by Yasaman Nazari Hagh, Mohamadreza Ahmadifard, Sedigheh Esmaelzadeh, Soheila Abbaszadeh, Naser Shokrzadeh

“…Some genetic markers play a crucial role in pathogenesis and infertility. Objective: This study investigates the role of miR-200a and miR-223-3p in embryo implantation and their association with EM-related infertility. …”
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Oxidative impact on lipoprotein structure: Insights from dynamic light scattering by Nickolette Kong, Natalia Penaloza, Gustavo Agreda, Angela B. Nguyen, Joseph Gutheinz, Alison Tran, Nhi Nguyen, Tuong Vi Ho, Ana Marin, Birgit Mellis, Richa Chandra

“…The need for advanced analytical tools to better understand the pathogenesis of cardiovascular disease (CVD) is critical due to its significant impact on public health. …”
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