Unveiling the wonders of bacteria-derived extracellular vesicles: From fundamental functions to beneficial applications by Mariam Rima, Mariam Dakramanji, Elie El Hayek, Tia El Khoury, Ziad Fajloun, Mohamad Rima

“…These nano-sized, membrane-encapsulated entities have captured substantial interest due to their diverse roles in pathogenesis and promising therapeutic applications. …”
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Keratoconus with two consecutive re-emergences: a case report by Peicheng Zhang, Yanchao Wu, Lixiao Ma, Dong Wang

“…Conclusions Keratoconus is a complex disorder with a multifaceted etiology and pathogenesis, including genetic, environmental, biomechanical, and cellular factors. …”
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Predicting the hub interactome of COVID-19 and oral squamous cell carcinoma: uncovering ALDH-mediated Wnt/β-catenin pathway activation via salivary inflammatory proteins by Pradeep Kumar Yadalam, Deepavalli Arumuganainar, Prabhu Manickam Natarajan, Carlos M. Ardila

“…Abstract Understanding shared pathways and mechanisms involved in the pathogenesis of diseases like oral squamous cell carcinoma (OSCC) and COVID-19 could lead to the development of novel therapeutic strategies and diagnostic biomarkers. …”
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Diagnosis and treatment of the functional dyspepsia: clinical guidelines of the Russian Gastroenterological Association by V. T. Ivashkin, I. V. Mayev, A. A. Sheptulin, T. L. Lapina, A. S. Trukhmanov, I. M. Kartavenko, V. A. Kiprianis, O. Z. Okhlobystina

“…To present the modern concept on etiology and pathogenesis of functional dyspepsia (FD) to general practitioners, as well as with the accepted approach to diagnostics and treatment of this disease. …”
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Oxidative Stress and Its Association with COVID-19: A Narrative Review by Hardi Rafat Baqi, Halgord Ali M. Farag, Abdel Hamid H. El Bilbeisi, Rafee Habib Askandar, Amany M. El Afifi

“…Especially the virus’s route to cell entry via angiotensin-converting enzyme 2 (ACE2) receptor is well known that leads to pathogenesis in angiotensin II (AT II) which are critical in NADH/NADPH oxidase inducing ROS generation. …”
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Hematological study of patients with recurrent aphthous stomatitis - Case control study by Shaheen Ali Ahmed, Ali Fakhree Alzubaidee

“… Background and Objectives: Recurrent aphthous stomatitis is common oral condition, characterized by multiple, recurrent, small, round, or ovoid ulcers with circumscribed, erythematous haloes, and yellow or grey floors. Its etiology and pathogenesis is not entirely clear linked to systemic diseases and among these, anemia, iron deficiency, folic- acid, and vitamin B12 deficiencies. …”
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Prospects of Using Microbiota Correction Methods in the Treatment of Inflammatory Bowel Disease by A. I. Akinshina, D. V. Smirnova, A. V. Zagainova, V. V. Makarov, S. M. Yudin

“…In recent years, preference has been given to more accurate and faster molecular genetic methods allowing a more detailed study of the key mechanisms by which microbiota affects the intestine in Crohn’s disease (CD) and ulcerative colitis (UC), as well as of the effect of microbial metabolites on their pathogenesis. The article provides an overview of main microbiota metabolites and their role in regulating the intestinal barrier function. …”
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Metabolic and Genetic Determinants of Lipid Metabolism Disruption in Non-Alcoholic Fatty Liver Disease by O. Yu. Kytikova, T. P. Novgorodtseva, Yu. K. Denisenko, D. A. Kovalevsky

“…Further research into the NAFLD genetic mechanisms regulating the metabolism of fatty acids appears to be promising for a deeper understanding of the pathogenesis of this multifactorial disease.…”
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Innovative nanoparticle-based approaches for modulating neutrophil extracellular traps in diseases: from mechanisms to therapeutics by Haisong Li, Can Li, Cong Fu, Yizhuo Wang, Tingting Liang, Haitao Wu, Chenxi Wu, Chang Wang, Tianmeng Sun, Shuhan Liu

“…Abstract Neutrophil extracellular traps (NETs) participate in both host defense and the pathogenesis of various diseases, such as infections, thrombosis, and tumors. …”
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Influence of immune cells and inflammatory factors on Alzheimer’s disease axis: evidence from mediation Mendelian randomization study by Linzhu, Jianxin Zhang, Wenhui Fan, Chen Su, Zhi Jin

“…Conclusion This study provides valuable insights into the immunoinflammatory pathogenesis of AD and offers partial guidance for the development of relevant interventions, thereby contributing beneficial information for the prevention and treatment of related diseases.…”
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MiR-223 within neutrophil axis promotes Th17 expansion by PI3K-AKT pathway in systemic lupus erythematosus by Chengzhong Zhang, Yan Lu

“…Results We initially identified miR-223 as a pivotal factor in the pathogenesis of SLE in both MRL/lpr mice and SLE patients. …”
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The occurrence of wheat crown rot correlates with the microbial community and function in rhizosphere soil by Yajiao Wang, Jian Feng, Jianhai Gao, Sen Han, Qiusheng Li, Lingxiao Kong, Yuxing Wu

“…These findings contribute to understanding WCR pathogenesis and offer practical resources for its management.…”
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Research Progress of ROS-Mitochondrial Pathway on Cardiovascular Protection of Tea Polyphenols by Tingting DENG, Jinchan PI, Xiaoping PENG, Yufei YAO, Yiquan LI, Wenjuan LI

“…Reactive oxygen species (ROS) imbalance and mitochondrial dysfunction played critical roles in the pathogenesis of cardiovascular diseases which are the leading cause of death worldwide. …”
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A Study of Serum Adiponectin Levels in Patients with Polycystic Ovarian Syndrome and its Correlation with Various Cardiometabolic Risk Markers by G. Surendra Prasad, Uma Kaimal Saikia, Ashok Krishna Bhuyan, Abhamoni Baro

“…Background: Polycystic ovarian syndrome (PCOS) is the most common metabolic disorder in the reproductive age group, the pathogenesis of which is constantly evolving with the discovery of novel molecules and the lookout for potential therapeutic targets. …”
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Assessment of serum survivin in women with placenta previa and accreta spectrum: a cross-sectional study by Nevin Yilmaz, Isil Turan Bakirci, Busra Sahin, Gokhan Bolluk, Esra Can, Huri Dedeakayogullari

“…These associations suggest a potential role for survivin in the pathogenesis of placental complications and warrant further investigation through longitudinal studies.…”
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METTL14 modulates the progression and ferroptosis of colitis by regulating the stability of m6A-modified GPX4 by Yuhua Chen, Weicong Fan, Ying Lyu, Jingsheng Liao, Ying Zhou

“…Nevertheless, the specific relationship between N6-methyladenosine (m6A) modification at RNA transcription levels and UC pathogenesis remains unclear. We established UC cell models and mouse models through dextran sulfate sodium (DSS) induction. …”
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Identification of the immune infiltration and biomarkers in ulcerative colitis based on liquid–liquid phase separation-related genes by Zhixing Hong, Shilin Fang, Haihang Nie, Jingkai Zhou, Yuntian Hong, Lan Liu, Qiu Zhao

“…We determined the seven high accuracy diagnostic genes of UC patients and provide a new perspective on immunoregulation in UC pathogenesis. And suggest patient stratification and candidate targets for precision treatment based on hub genes screened.…”
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The impact of gut microbiome on neuro-autoimmune demyelinating diseases by Pouria Abolfazli, Cristina Nkene Apue Nchama, Brandon Lucke-Wold

“…Similarly, NMOSD exhibits gut microbiota alterations linked to disease severity, with Streptococcus and Clostridium perfringens being significant contributors, suggesting a gut–CNS interaction in pathogenesis. Prebiotic and probiotic interventions can modify gut microbiota, reduce inflammatory markers, and improve patient outcomes, indicating the therapeutic potential of targeting gut microbiota in managing MS. …”
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Enhanced ferroptosis sensitivity promotes the formation of highly myopic cataract via the DDR2-Hippo pathway by Dongling Guo, Yu Du, Xin Liu, Dan Li, Ling Wei, Xiangjia Zhu

“…Abstract Highly myopic cataract (HMC) is a leading cause of blindness among the working-age individuals, with its pathogenesis poorly understood. This study aimed to elucidate the role of ferroptosis in HMC development as well as the underlying mechanisms. …”
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Substantiation of application and estimation of efficacy of probiotics at inflammatory bowel diseases by Ye. A. Poluektova, Yu. O. Sidorina, S. Yu. Kuchumova, A. V. Korolev, O. S. Shifrin

“…The role of microflora in pathogenesis of this group of diseases becomes more and more obvious. …”
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