Alzheimer-mutant γ-secretase complexes stall amyloid β-peptide production by Parnian Arafi, Sujan Devkota, Emily Williams, Masato Maesako, Michael S Wolfe

“…These findings provide further evidence that FAD mutations lead to stalled and stabilized γ-secretase enzyme-substrate and/or enzyme-intermediate complexes and are consistent with the stalled process rather than the products of γ-secretase proteolysis as the pathogenic trigger.…”
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Genome Characteristic of NDM-5-Producing Klebsiella Quasipneumoniae and Klebsiella Pneumoniae in China by Chen L, Liu R, Ye H, Qian J, Lou D

“…Our findings highlight the emergence of NDM-5-producing K. quasipneumoniae of clinical origin and reinforce the need for vigilant surveillance and infection control measures to curb the proliferation of these highly resistant pathogens.Keywords: blaNDM-5, Klebsiella spp., carbapenem-resistant, whole-genome sequencing…”
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Immune-mediated mechanisms in acute osteofascial compartment syndrome: insights from multi-omics analysis by Qinzhen Lu, He Ling, Yonghui Lao, Junjie Liu, Wei Su, Zhao Huang

“…Hence, there is an urgent need for research elucidating AOCS's pathogenic mechanism and exploring novel treatments. …”
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Optimizing therapeutic outcomes: preconditioning strategies for MSC-derived extracellular vesicles by Yuqi Song, Fengrui Liang, Weikun Tian, Erin Rayhill, Liping Ye, Xinghan Tian

“…However, MSCs present risks such as immunogenic responses, malignant transformation, and the potential to transmit infectious pathogens due to their intrinsic proliferative and differentiative abilities. …”
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Comparison of ultraviolet C light and isopropyl alcohol for the disinfection of cellular phones in a paediatric intensive care unit setting by L Thomas, J John, H Lochan

“…A considerable proportion of cellular phones (cell phones) used by healthcare workers (HCWs) have been shown to be contaminated with pathogenic micro-organisms, making these devices reservoirs to infect susceptible patients. …”
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Escherichia coli in septic arthritis: prevalence and antibiotics susceptibility patterns by Masroora Ali Khan, Muhammad Kamran Taj, Zahid Khan, Imran Taj, Muhammad Naeem, Saima Azam

“…Sequence analysis using the Basic Local Alignment Search Tool found high similarity with pathogenic E. coli from Egypt and China. The identified E. coli strain showed significant resistance to common antibiotics: amoxicillin, amoxicillin-clavulanate, ceftriaxone, sulfamethoxazole/trimethoprim, gentamicin, tetracycline, and erythromycin. …”
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Pathogenetic Substantiation of the Therapeutic Impact on Microbiota in Irritable Bowel Syndrome by Yu. O. Shulpekova, G. H. Babaeva, V. Yu. Rusyaev

“…Reduced microbial diversity increases susceptibility to intestinal infections and parasitoses, including those caused by protozoa conditionally pathogenic for adults, such as Blastocystis hominis hominis, Dientamoeba fragilis, Giardia lamblia. …”
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Investigation in blood-brain barrier integrity and susceptibility to immune cell penetration in a mouse model of Dravet syndrome by Cristina Alonso, Alicia García-Culebras, Valentina Satta, Inés Hernández-Fisac, Álvaro Sierra, José A. Guimaré, Ignacio Lizasoain, Javier Fernández-Ruiz, Onintza Sagredo

“…In the present study, we have investigated whether a possible early deterioration in the blood-brain barrier (BBB) may facilitate the infiltration of immune cells to the brain parenchyma, which may contribute to these pathogenic events. In this study, conditional knock-in Scn1a-A1783V mice and their controls were used at the postnatal day (PND25): (i) to compare their levels of several immune cell populations in the bone marrow and blood; and (ii) to analyze several BBB proteins, as well as the occurrence of immune cell infiltration and endogenous immunoglobulin G (IgG) extravasation into the brain parenchyma. …”
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Amyloidogenic immunoglobulin light chains disturb contractile function and calcium transients in a human cardiac spheroid model of light chain (AL) amyloidosis by Mélanie Bézard, Jean-Sébastien Vartanian-Grimaldi, Julien Henri, Denisa Calin, Amira Zaroui, Mounira Kharoubi, Thibaud Damy, Onnik Agbulut, Ekaterini Kordeli

“…However, the response of human cardiomyocytes to this pathogenic condition is currently unknown. In this work, we have set up a human cellular disease model of AL cardiac amyloidosis (AL-CA) in the form of cardiac spheroids, to study the cytotoxic effects of amyloidogenic LCs with regard to contractile function and calcium handling. …”
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Insights into quinoa endophytes: core bacterial communities reveal high stability to water stress and genotypic variation by Isaac Maestro-Gaitán, Miguel Redondo-Nieto, Sara González-Bodí, Laura Rodríguez-Casillas, Javier Matías, Luis Bolaños, María Reguera

“…Abstract Background Plant endophytes, comprising non-pathogenic bacteria, fungi, and archaea, inhabit various plant parts, including roots, stems, leaves, and seeds. …”
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Anti-motilities and anti-biofilm effects of Ageratum conyzoides L. methanol extract by Eli Compaoré, Moussa Compaoré, Vincent Ouédraogo, Ablassé Rouamba, Alimata Bancé, Mignini R. Dofini, Martin Kiendrebeogo

“…Ageratum conyzoides is one of the antimicrobial medicinal plants that is being used to fight various multi-resistant pathogenic bacteria in Burkina Faso. Aim: The aim was to promote safe medicinal use of A. conyzoides by highlighting the anti-biofilm and anti-motility effects of its methanol extract. …”
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Can infectious omphalitis in piglets be clinically diagnosed during the first three days of life? by Sophie Amalie Blirup-Plum, Henrik Elvang Jensen, Katrine Top Hartmann, Søren Saxmose Nielsen, Karen Pankoke, Mette Sif Hansen, Ken Steen Pedersen, Inge Larsen, Jens Peter Nielsen, John Elmerdahl Olsen, Egle Kudirkiene, Thomas Hartig Braunstein, Kristiane Barington

“…Except for a group of bacteria unidentified by matrix-assisted laser desorption ionisation time-of-flight (MALDI-TOF) (p = 0.02), no apparent association was found between histopathologically diagnosed omphalitis and the prevalence of specific pathogens (p > 0.05). The frequency of histopathologically diagnosed omphalitis tended to increase with increasing age in both cases and controls. …”
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Altered O-Glycans in stimulated whole saliva from patients with primary Sjögren’s syndrome and non-pSS sicca by Sarah Kamounah, Kristina A. Thomsson, Christiane Elisabeth Sørensen, Eric Paul Bennett, Niclas G. Karlsson, Anne Marie Lynge Pedersen

“…Abstract To investigate if salivary O-linked glycans are altered in primary Sjögren’s syndrome (pSS), and thus contributing to explain symptoms of oral dryness, and an impaired oral mucosal barrier function leading to changes in microbial metabolism and colonization by both pathogenic and commensal microorganisms and increased prevalence of oral diseases. …”
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Diagnosis and treatment of thyroblastoma: a case report and review of literature by Xiting Chen, Xiting Chen, Lijuan Xiong, Lijuan Xiong, Hongling Liu, Haoqiang Wang, Donghai Cheng, Wei Wang, Wenyuan He, Bo Xie, Juan Zhou

“…Next-generation sequencing (NGS) confirmed the presence of germline DICER1 heterozygous pathogenic mutation at p.G1784* in patient, accompanied by the somatic hotspot mutation at p.E1813D of the RNase IIIb domain. …”
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Duodenal Organoids From Metabolic Dysfunction-Associated Steatohepatitis Patients Exhibit Absorptive and Barrier Alterations by Alia Hadefi, Morgane Leprovots, Gilles Dinsart, Maryam Marefati, Marjorie Vermeersch, Daniel Monteyne, David Pérez-Morga, Anne Lefort, Frédérick Libert, Laurine Verset, Claire Liefferinckx, Christophe Moreno, Jacques Devière, Eric Trépo, Marie-Isabelle Garcia

“…Though MASH is closely tied to metabolic risk factors, the underlying pathogenic mechanisms remain scarcely understood. Recent research has emphasized the importance of the gut-liver axis in its pathogenesis, an aspect less explored in human studies. …”
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Development of an innovative intravaginal model of probiotic inoculation in dairy ovine flocks: positive effects on the vaginal microbiota, vaginitis and fertility by M. Toquet, J. Gomis, E. Jiménez-Trigos, E. Bataller, M. Barba, A. Sánchez, P. González-Torres, Á. Gómez-Martín

“…(Lactobacillus (L.) crispatus, L. brevis and L. gasseri) against some ruminants’ pathogens. However, their possible beneficial effects on controlling the vaginosis caused by the use of intravaginal sponges for oestrus synchronisation have not been evaluated in in vivo models. …”
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Prognostic impact of donor mitochondrial genomic variants in myelodysplastic neoplasms after stem-cell transplantation by Jing Dong, Shahram Arsang-Jang, Tao Zhang, Zhongyuan Chen, Yung-Tsi Bolon, Stephen Spellman, Raul Urrutia, Paul Auer, Wael Saber

“…In the entire donor cohort, we identified 1,825 mtDNA variants, including 67 potential pathogenic variants. Genetic variants on MT-CYB and MT-ND5 genes were identified as independent predictors of posttransplant outcomes. …”
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Synergistic toxicity of nanoplastics and Helicobacter pylori on digestive system in mice by Xiaolin Zhang, Yunqing Wang, Xiaohan Tong, Boqing Li, Sisi Liu, Yingzi Cui, Wenke Wang, Zhiqin Li, Chunlei Ma, Ying Zhang

“…Nanoplastics, in combination with pathogenic microorganisms or toxic substances, have been shown to induce oxidative stress and disrupt energy and lipid metabolism, posing significant health risks. …”
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Non-invasive imaging with ICOS-targeting monoclonal antibody for preclinical diagnosis of rheumatoid arthritis in a humanized mouse model by Shao Duan, Chao Li, Feng Yan, Yifei Xia, Shuaiming Shao, Weiyu Chen, Zunyu Xiao, Gongping Xu

“…The 4-view NIRF imaging with Cy7-ICOS mAb could detect pathogenic ICOS+ activated T cells with high sensitivity and specificity in vivo, which indicated the great potential of this imaging probe in RA early diagnosis.…”
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Vitamin D Deficiency in Patients with Type 2 Diabetes Mellitus with and without Pulmonary Tuberculosis by Wahiduddin Wahiduddin, Agung Pranoto, Sudjarwo Sudjarwo

“…Background: Vitamin D has a role in the body's calcium balance and immunodeficiency effects, and stimulates dendric cells, monocytes, T cells, macrophages in pathogenic microbes’ elimination. The variation occurrence as polymorphism on VDR might cause problem in production, transportation, and activity of vitamin D. …”
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