Correlation analysis of the impact of Clonorchis sinensis juvenile on gut microbiota and transcriptome in mice by Xueling Deng, Shitao Li, Yuhong Wu, Jiali Yao, Wei Hou, Jiangyao Zheng, Boying Liang, Xiaole Liang, Qiping Hu, Zhanshuai Wu, Zeli Tang

“…This study aimed to investigate their relationship and potential pathogenic mechanisms. The BALB/c mouse model of early infection with C. sinensis juvenile was constructed. …”
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uN2CpolyG-mediated p65 nuclear sequestration suppresses the NF-κB-NLRP3 pathway in neuronal intranuclear inclusion disease by Yu Shen, Kaiyan Jiang, Dandan Tan, Min Zhu, Yusen Qiu, Pencheng Huang, Wenquan Zou, Jianwen Deng, Zhaoxia Wang, Ying Xiong, Daojun Hong

“…Abstract Background Neuronal intranuclear inclusion disease (NIID) is genetically linked to CGG repeat expansion in the 5’-untranslated region of the NOTCH2NLC gene, with nascent polyglycine-containing protein (uN2CpolyG) identified as a primary pathogenic factor. Emerging clinical evidence suggests that inflammation contributes to NIID pathogenesis, yet the underlying molecular mechanisms remain elusive. …”
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Virulence of Five Root-Knot Nematodes (<i>Meloidogyne</i> spp.) on Nine Industrial Hemp (<i>Cannabis sativa</i> L.) Varieties and Nematicidal Potential of Hemp Seed Extracts Agains... by Dionysios Ntinokas, Ioannis Roussis, Antonios Mavroeidis, Panteleimon Stavropoulos, Antigolena Folina, Ioanna Kakabouki, Emmanuel A. Tzortzakakis, Dimitrios Bilalis, Ioannis O. Giannakou

“…The results revealed that the five evaluated <i>Meloidogyne</i> species were pathogenic to hemp plants. The lowest shoot weights were recorded in plants that were inoculated with <i>M. javanica</i> and <i>M. luci</i> (4.65 and 4.53 g, respectively). …”
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Dual role of ramR mutation in enhancing immune activation and elevating eravacycline resistance in Klebsiella pneumoniae by Wei Yu, Peiyao Jia, Xiaobing Chu, Shengjie Li, Xinmiao Jia, Ying Zhu, Xiaoyu Liu, Yingchun Xu, Qiwen Yang

“…The ramR‐ramA regulatory system critically influences drug resistance by regulating the AcrAB‐TolC efflux pump, which also plays a crucial role in the pathogenicity of K. pneumoniae. However, the mechanism of the ramR‐ramA system on bacteria‐host interaction remains unclear. …”
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CpG-ODN Induces a Dose-Dependent Enrichment of Immunological Niches in the Spleen and Lungs of Neonatal Chicks That Correlates with the Protective Immunity against Escherichia coli by Thushari Gunawardana, Khawaja Ashfaque Ahmed, Kalhari Goonewardene, Shelly Popowich, Shanika Kurukulasuriya, Ruwani Karunarathana, Lisanework E. Ayalew, Ashish Gupta, Betty Lockerbie, Marianna Foldvari, Suresh K. Tikoo, Philip Willson, Susantha Gomis

“…Immunoprotective function of oligodeoxynucleotides containing CpG motifs (CpG-ODN) has been demonstrated in neonatal chickens against common bacterial pathogens such as E.coli and Salmonella sp. Our recent study reported that CpG-ODN administration enriches immune compartments in neonatal chicks. …”
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Risks of parasitic helminth disease outbreaks and influence of physico-chemical factors in flood prone areas of Yaoundé, Cameroon by Noura Efietngab Atembeh, Jean Patrick Molu, Jeanne Valerie Emvoutou Maboulou, Boris Fominyam, Rodrigue Nanfack Dongmo, Gabriel Bertrand Zambo, Emilie Tchinda Tiecheu, Jeannette Tombi, Lucia Nkengazong, Serge Hubert Zebaze Togouet, Jean Louis Essame Oyono

“…River Tongolo was the most contaminated with pathogenic forms. Water pH, orthophosphate, organic matter and alkalinity revealed negative corelations with the occurrence of Diphyllobotrium latum (r = −0.375, −0.253, −462, −0.448 respectively) while organic matter and pH showed positive correlations with the occurrence of Strongyloides stercoralis (r = 0.378) and Trichostrongylus sp. …”
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One-step diagnosis of infection and lung cancer using metagenomic sequencing by Shaoqiang Li, Yangqing Zhan, Yan Wang, Weilong Li, Xidong Wang, Haoru Wang, Wenjun Sun, Xuefang Cao, Zhengtu Li, Feng Ye

“…Onco-mNGS has emerged as a promising solution capable of accurately identifying infectious pathogens and tumors simultaneously. However, critical evidence is still lacking regarding its diagnostic performance in distinguishing between pulmonary infections, tumors, and non-infectious, non-tumor conditions in real clinical settings. …”
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Antifungal activity and mechanism of Phoebe bournei wood essential oil against two dermatophytes by Yan Yang, Qinglin Sun, Yuting Zhang, Junhua Huang, Wenjun Ma, Qi Yang, Zaikang Tong, Junhong Zhang

“…BackgroundDermatophytes are notorious pathogenic fungi that threaten human health and reduce quality of life. …”
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Thermoresponsive Gels with Rosemary Essential Oil: A Novel Topical Carrier for Antimicrobial Therapy and Drug Delivery Applications by Ludovic Everard Bejenaru, Adina-Elena Segneanu, Cornelia Bejenaru, Ionela Amalia Bradu, Titus Vlase, Dumitru-Daniel Herea, Marius Ciprian Văruţ, Roxana Maria Bălăşoiu, Andrei Biţă, Antonia Radu, George Dan Mogoşanu, Maria Viorica Ciocîlteu

“…Antimicrobial efficacy was assessed against common pathogens associated with skin infections, including <i>Staphylococcus aureus</i>, <i>Escherichia coli</i>, and <i>Candida albicans</i>. …”
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Optimization of the Antibacterial Activity of a Three-Component Essential Oil Mixture from Moroccan <i>Thymus satureioides</i>, <i>Lavandula angustifolia</i>, and <i>Origanum major... by Amine Elbouzidi, Mohamed Taibi, Naoufal El Hachlafi, Mounir Haddou, Mohamed Jeddi, Abdellah Baraich, Saad Bougrine, Ramzi A. Mothana, Mohammed F. Hawwal, Waleed A. Alobaid, Abdeslam Asehraou, Bouchra El Guerrouj, Hanae Naceiri Mrabti, Francois Mesnard, Mohamed Addi

“…Background/Objectives: The rise of antibiotic-resistant pathogens has become a global health crisis, necessitating the development of alternative antimicrobial strategies. …”
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Isoniazid urine spectrophotometry for prediction of serum pharmacokinetics in adults with TB by P. S. Rao, K. Reed, N. Modi, D. Handler, K. Petros de Guex, S. Yu, L. Kagan, R. Reiss, N. Narayanan, C. A. Peloquin, A. Lardizabal, C. Vinnard, T. A. Thomas, Y. L. Xie, S. K. Heysell

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Clinical Significance of Negative Costimulatory Molecule PD-1/PD-L1 on Peripheral Blood Regulatory T Cell Levels among Patients with Pulmonary Tuberculosis by Chenchen Yang, Fanchao Dai, Rexiti Pulati, Yan Jiao, Qian Xu

“…Our findings provide insights into the illustration of pathogenic mechanisms and immunotherapy of active pulmonary TB.…”
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Nucleic Acid Aptamers for Human Norovirus GII.4 and GII.17 Virus-Like Particles (VLPs) Exhibit Specific Binding and Inhibit VLPs from Entering Cells by Cheng C, Sun M, Li J, Xue Y, Cai X, Liu J, Wang X, Xu S, Xie Y, Zhang J

“…AP4-2 and AP17-4 were able to differentiate HuNoV from other diarrhea-causing pathogens or unrelated proteins (P < 0.0001). VLP/porcine gastric mucin (PGM) binding blockade assays revealed that AP4-2 and AP17-4 blocked the binding of HuNoV VLPs to PGM. …”
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Apolipoprotein A-V Is a Novel Diagnostic and Prognostic Predictor in Pediatric Patients with Sepsis: A Prospective Pilot Study in PICU by Chunxia Wang, Yun Cui, Huijie Miao, Xi Xiong, Jiaying Dou, Lujing Shao, Xiaomeng Tang, Yucai Zhang

“…In subgroup analysis, serum levels of ApoA5 were significantly correlated with sepsis-associated multiple organ dysfunction syndrome (MODS) (P<0.001), shock (P=0.002), acute kidney injury (AKI) (P<0.001), acute liver injury (ALI) (P=0.002), and gastrointestinal (GI) dysfunction (P=0.012), but not respiratory failure, brain injury, and pathogenic species (all P>0.05). Correlation analyses revealed significant correlations of serum ApoA5 with Ca2+ concentration. …”
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Comprehensive analysis of full genome sequence and Bd-milRNA/target mRNAs to discover the mechanism of hypovirulence in Botryosphaeria dothidea strains on pear infection with BdCV1... by Wangcheng Hu, Hui Luo, Yuekun Yang, Qiong Wang, Ni Hong, Guoping Wang, Aiming Wang, Liping Wang

“…Therefore, it is vital to explore interactions between B. dothidea and mycovirus to clarify the pathogenic mechanisms of B. dothidea and hypovirulence of B. dothidea in pear. …”
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Biological Characteristics and Whole-Genome Analysis of a Porcine <i>E. coli</i> Phage by Shenghui Wan, Nana Li, Sajid Habib, Pei Zheng, Yanfang Li, Yan Liang, Yonggang Qu

“…(1) Background: In recent years, the increasing emergence of multidrug-resistant pathogens in pig farms has begun to pose a severe threat to animal welfare and, by extension, public health. …”
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The use of Curcuma longa extract to control Edwardsiella tarda infection on Clarias sp. by Dinamella Wahjuningrum, Muharram Nur Ikhsan, , Sukenda, Yan Evan

“…ABSTRACT    Target production of catfish in aquaculture can be reached by suppressing the pathogenic bacterial infection. Previous works had shown that turmeric Curcuma longa has antibacterial activity. …”
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The gene Sr38 for bread wheat breeding in Western Siberia by E. S. Skolotneva, V. N. Kelbin, V. P. Shamanin, N. I. Boyko, V. A. Aparina, E. A. Salina

“…It contains the Lr37, Yr17, and Sr38 genes, which support seedling resistance to the pathogens Puccinia triticina Eriks., P. striiformis West. f. sp. tritici, and P. graminis Pers. f. sp. tritici Eriks. …”
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Aspergillus fumigatus Influences Gasdermin-D-Dependent Pyroptosis of the Lung via Regulating Toll-Like Receptor 2-Mediated Regulatory T Cell Differentiation by Wei Yan, Yi-si Zhao, Ke Xie, Yu Xing, Fang Xu

“…The immune escape of pathogens may be through suppressing the inflammatory response mediated by regulatory T cells (Tregs). …”
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Extracellular vesicles from fifth-stage larval Angiostrongylus cantonensis upregulate cholesterol biosynthesis and suppress NLRP2-associated inflammatory responses in mouse astrocy... by Chien-Ju Cheng, Lian-Chen Wang, Lichieh Julie Chu, Kuang-Yao Chen, Ching-Yun Huang, Kuo-Lun Lan, Kuo-Yang Huang

“…The highly abundant proteins in L5 EVs that have immunomodulatory or pathogenic potential in the host deserve further investigation. …”
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