High Frequency of AIFM1 Variants and Phenotype Progression of Auditory Neuropathy in a Chinese Population by Hongyang Wang, Dan Bing, Jin Li, Linyi Xie, Fen Xiong, Lan Lan, Dayong Wang, Jing Guan, Qiuju Wang

“…To decipher the genotype-phenotype correlation of auditory neuropathy (AN) caused by AIFM1 variations, as well as the phenotype progression of these patients, exploring the potential molecular pathogenic mechanism of AN. A total of 36 families of individuals with AN (50 cases) with AIFM1 variations were recruited and identified by Sanger sequencing or next-generation sequencing; the participants included 30 patients from 16 reported families and 20 new cases. …”
Get full text

Catheter‐Related Bloodstream Infections Among Hemodialysis Patients in Northern Tanzania: Insights From a Single‐Centre Retrospective Study by Andrea R. Costantine, Sarah J. Urasa, Abid M. Sadiq, Elichilia R. Shao, Furaha S. Lyamuya, Elieishiupendo M. Niccodem, Eugénie M. Kamabu, Venance P. Maro, Elifuraha W. Mkwizu, Nyasatu G. Chamba, Francis F. Furia, Tumaini E. Mirai, Eliada B. Nziku, Doreen T. Eliah, Ibrahim Ali Ibrahim Muhina, Faryal M. Raza, Modesta P. Mitao, Kajiru G. Kilonzo

“…This study aimed to evaluate the determinants of hemodialysis CRBSI and the appropriate antibiogram for the isolated bacterial pathogens among patients attending the KCMC hemodialysis unit. …”
Get full text

Use of approved cefazolin based intramammary dry goat treatment and its effects on the milk microbiota by Delower Hossain, Filippo Biscarini, Valentina Monistero, Paola Cremonesi, Bianca Castiglioni, Anoar Jamai Masroure, Alessandro Marinoni, Sara Fusar Poli, Matteo Mezzetti, Maria Filippa Addis, Valerio Bronzo, Erminio Trevisi, Paolo Moroni

“…Differential abundance analyses identified non-pathogenic genera, such as Acinetobacter, Bacteroides, and Paracoccus, that varied between groups at different timepoints. …”
Get full text

LDHA-mediated glycolysis in stria vascularis endothelial cells regulates macrophages function through CX3CL1-CX3CR1 pathway in noise-induced oxidative stress by Ying Yi, Min-Yu Wu, Kai-Tian Chen, An-Hai Chen, Lin-Qiu Li, Qin Xiong, Xian-Ren Wang, Wen-Bin Lei, Guan-Xia Xiong, Shu-Bin Fang

“…Oxidative stress-mediated damage to the stria vascularis (SV) is one of the pathogenic mechanisms of NIHL. Recent studies indicate that glycolysis plays a critical role in endothelial cells (ECs)-related diseases. …”
Get full text

Taxonomic composition and biodiversity of the gut microbiome from patients with irritable bowel syndrome, ulcerative colitis, and asthma by A. Y. Tikunov, A. N. Shvalov, V. V. Morozov, I. V. Babkin, G. V. Seledtsova, I. O. Voloshina, I. P. Ivanova, A. V. Bardasheva, V. V. Morozova, V. V. Vlasov, N. V. Tikunova

“…The third most common in all samples were sequences of the Proteobacteria type, which contains pathogenic and opportunistic bacteria. Sequences of the Actinobacteria type were, on average, the fourth most common. …”
Get full text

Genomic and resistome analysis of Salmonella enterica isolates from retail markets in Yichun city, China by Xiaowu Jiang, Abubakar Siddique, Li Chen, Lexin Zhu, Haiyang Zhou, Li Na, Chenghao Jia, Yan Li, Min Yue

“…Moreover, key virulence genes such as cdtB, lpf and sef were also detected, in addition to Salmonella pathogenicity islands SPI-1 and SPI-2. This study reveals the prevalence of multidrug-resistant and virulent strains of Salmonella serovars in the markets of Yichuan city, posing a risk of human infections. …”
Get full text

Prevalence of dengue and leptospirosis coinfection and associated mortality rates: a systematic review and meta-analysis by Suraj Tiwari, Mahalaqua Nazli Khatib, Rekha MM, Mandeep Kaur, Girish Chandra Sharma, Puneet Sudan, K. Satyam Naidu, Rajesh Singh, Teena Vishwakarma, Sonam Puri, Muhammed Shabil, Anuradha Yadav, Takveer Singh, Sahil Khurana, Rachana Mehta, Prakasini Satapathy, Renu Sah, Abhay M Gaidhane, Ganesh Bushi

“…Co-infection of these pathogens places additional strain on healthcare resources in endemic areas. …”
Get full text

Detection and subtyping of Blastocystis sp. in human and animal stool samples using high-resolution melting analysis by Ghodratollah Salehi Sangani, Ahmad Hosseini-Safa, Bibi Razieh Hosseini Farash, Pooria Salehi Sangani, Mehdi Zarean, Elham Moghaddas, Saeid Zoghdar Moghadam, Lida Jarahi, Ali Gholizadeh, Fariba Berenji

“…Transmission occurs via the fecal-oral route, with prevalence rates ranging from 20% in developed countries to over 60% in developing regions. Although the pathogenicity of Blastocystis remains debated, it has been detected in both symptomatic and asymptomatic individuals. …”
Get full text

A stratified two-stage tumor molecular profiling algorithm to identify clinically actionable molecular alterations in pancreatic cancer☆ by S. Hussung, D. Akhoundova, C. Pistoni, D. Lenggenhager, A. Töpfer, C. Pauli, B. Pestalozzi, C. Britschgi, M. Zoche, M. Rechsteiner, H. Moch, A. Weber, R. Fritsch

“…Compared with algorithm testing, upfront comprehensive testing detected a higher number of pathogenic molecular alterations/patient (median: five versus three, P = 0.0005), however no additional actionable alterations. …”
Get full text

Astrocytic NLRP3 cKO mitigates depression-like behaviors induced by mild TBI in mice. by Hui-Tao Miao, Jun Wang, Jing-Jing Shao, Rong-Xin Song, Wen-Guang Li, Jian-Kai Sun, Shi-Yan Jia, Dong-Xue Zhang, Xiao-Ming Li, Jian-Yong Zhao, Li-Min Zhang

“…Results: Our findings indicated that astrocyte-specific NLRP3 KO decreased cleaved caspase-1 colocalized with astrocytes, decreased pathogenic astrocytes and increased Postsynaptic density protein 95 (PSD95) intensity, and significantly alleviated mild TBI-induced depression-like behaviors. …”
Get full text

High, but variable prevalence of Sarcocystis cruzi infections in farm-raised American bison (Bison bison) beef destined for human consumption by Larissa S. de Araujo, Aditya Gupta, Marianne Dias Papadopoulos, Doaa Naguib, Jacquin Battle, Oliver Kwok, Asis Khan, Benjamin Rosenthal, Jitender P. Dubey

“…Sarcocystis cruzi (transmitted via canids) is recognized as the most pathogenic Sarcocystis species, causing abortion, low milk yield and poor body growth. …”
Get full text

Visceral adipose tissue area and proportion provide distinct reflections of cardiometabolic outcomes in weight loss; pooled analysis of MRI-assessed CENTRAL and DIRECT PLUS dietary... by Hadar Klein, Hila Zelicha, Anat Yaskolka Meir, Ehud Rinott, Gal Tsaban, Alon Kaplan, Yoash Chassidim, Yftach Gepner, Matthias Blüher, Uta Ceglarek, Berend Isermann, Michael Stumvoll, Ilan Shelef, Lu Qi, Jun Li, Frank B. Hu, Meir J. Stampfer, Iris Shai

“…Abstract Background Visceral adipose tissue (VAT) is well established as a pathogenic fat depot, whereas superficial subcutaneous adipose tissue (SAT) is associated with either an improved or neutral cardiovascular state. …”
Get full text

Identification of Nontuberculous Mycobacteria in Patients with Pulmonary Diseases in Gyeongnam, Korea, Using Multiplex PCR and Multigene Sequence-Based Analysis by Min-Jeong Kim, Kyu-Min Kim, Jeong-Ih Shin, Jong-Hun Ha, Dong-Hae Lee, Jeong-Gyu Choi, Jin-Sik Park, Jung-Hyun Byun, Jung-Wan Yoo, Seokyong Eum, Myunghwan Jung, Seung Chul Baik, Woo Kon Lee, Hyung Lyun Kang, Min-Kyoung Shin

“…Nontuberculous mycobacteria (NTM) are widely present in environments, such as soil and water, and have recently been recognized as important pathogenic bacteria. The incidence of NTM-related infections is steadily increasing. …”
Get full text

Reduced Expression of Antimicrobial Protein Secretory Leukoprotease Inhibitor and Clusterin in Chronic Rhinosinusitis with Nasal Polyps by Yanran Huang, Ming Wang, Yu Hong, Xiangting Bu, Ge Luan, Yang Wang, Ying Li, Hongfei Lou, Chengshuo Wang, Luo Zhang

“…Antimicrobial peptides and proteins (AMPs) constitute the first line of defense against pathogenic microorganisms in the airway. The association between AMPs and chronic rhinosinusitis with nasal polyps (CRSwNP) requires further investigations. …”
Get full text

Effects of the in ovo injection of an Escherichia coli vaccine on the hatchability and subsequent early post hatch characteristics of commercial layer chicks by K.E.C. Elliott, L.L. Lindsey, J.D. Evans, S.A. Leigh, K.J. Robinson, S.A. Fatemi, A. Mousstaaid, P.D. Gerard, J. L Purswell, E.D. Peebles

“…In the commercial table egg industry, avian pathogenic E. coli (APEC) can lead to significant economic loss and bird mortality. …”
Get full text

LRRK2 Mutations and Asian Disease-Associated Variants in the First Parkinson’s Disease Cohort from Kazakhstan by Rauan Kaiyrzhanov, Akbota Aitkulova, Chingiz Shashkin, Nazira Zharkinbekova, Mie Rizig, Elena Zholdybayeva, Zharkyn Jarmukhanov, Vadim Akhmetzhanov, Gulnaz Kaishibayeva, Talgat Khaibullin, Altynay Karimova, Serik Akshulakov, Askhat Bralov, Nurlan Kissamedenov, Zhanar Seidinova, Anjela Taskinbayeva, Aliya Muratbaikyzy, Henry Houlden

“…We showed that East Asian LRRK variants could be found in Central Asian populations but their pathogenicity remains to be elucidated in larger PD cohorts.…”
Get full text

Natural Concurrent Infections with Black Spot Disease and Multiple Bacteriosis in Farmed Nile Tilapia in Central Kenya by Daniel W. Wanja, Paul G. Mbuthia, Robert M. Waruiru, Lilly C. Bebora, Helena A. Ngowi

“…Further experimental studies should be carried out to elucidate the relationship of these pathogens.…”
Get full text

Molecular investigation reveals three hemotropic mycoplasmas in cats and three tick species in China by Hongfei Shi, Guoguang Li, Dandan Li, Hongyue Zhai, Shidong Ji, Yun Hu, Long Wang, Lunguang Yao

“…Following the morphological and molecular identification of ticks, all samples were screened for pathogens using PCR detection and sequence analysis. …”
Get full text

A Prospective, Randomized Comparison of Duodenoscope Reprocessing Surveillance Methods by Travis J. De Wolfe, Nasia Safdar, Megan Meller, John Marx, Patrick R. Pfau, Eric M. Nelsen, Mark E. Benson, Anurag Soni, Mark Reichelderfer, Megan Duster, Deepak V. Gopal

“…Duodenoscope use in healthcare facilities has been associated with transmission of multidrug resistant pathogens between patients. To assist healthcare facilities in monitoring the quality of their duodenoscope reprocessing procedures and limit patient risk of infection, the Centers for Disease Control and Prevention (CDC) deployed voluntary interim duodenoscope sampling and culturing surveillance protocols in 2015. …”
Get full text

Optimization of fermentation conditions to increase the production of antifungal metabolites from Streptomyces sp. KN37 by Xiaoyue Yang, Lijing Yuan, Muhammad Zeeshan, Chuntian Yang, Wen Gao, Guoqiang Zhang, Chunjuan Wang

“…The broth dilution of strain KN37 has a strong inhibitory effect against a variety of crop pathogenic fungi. However, in practical applications, its effective biological activity is limited by medium formulations and fermentation conditions. …”
Get full text