Primary biliary cirrhosis: clinical and laboratory criteria of diagnostics and up-to-date treatment by L. Yu. Il’chenko, V. I. Reshetn’yak

“…Combined treatment of UDCA and budesonide is proposed.Conclusion. UDCA is pathogenicly proved treatment of PBC.…”
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Maturation and detoxification of synphilin-1 inclusion bodies regulated by sphingolipids by Xiuling Cao, Xiang Wu, Lei Zhao, Ju Zheng, Xuejiao Jin, Xinxin Hao, Joris Winderickx, Shenkui Liu, Lihua Chen, Beidong Liu

“…Our findings identify a conserved cellular component essential for IB maturation and suggest a mechanism by which cells may detoxify the pathogenic protein aggregates through forming mitochondrion-associated IBs.…”
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A multiplex method for rapidly identifying viral protease inhibitors by Seo Jung Hong, Samuel J Resnick, Sho Iketani, Ji Won Cha, Benjamin Alexander Albert, Christopher T Fazekas, Ching-Wen Chang, Hengrui Liu, Shlomi Dagan, Michael R Abagyan, Pavla Fajtová, Bruce Culbertson, Brooklyn Brace, Eswar R Reddem, Farhad Forouhar, J Fraser Glickman, James M Balkovec, Brent R Stockwell, Lawrence Shapiro, Anthony J O’Donoghue, Yosef Sabo, Joel S Freundlich, David D Ho, Alejandro Chavez

“…Abstract With current treatments addressing only a fraction of pathogens and new viral threats constantly evolving, there is a critical need to expand our existing therapeutic arsenal. …”
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Innovative nanoparticle-based approaches for modulating neutrophil extracellular traps in diseases: from mechanisms to therapeutics by Haisong Li, Can Li, Cong Fu, Yizhuo Wang, Tingting Liang, Haitao Wu, Chenxi Wu, Chang Wang, Tianmeng Sun, Shuhan Liu

“…While they help capture and eliminate pathogens, NETs’ excessive or dysregulated formation can lead to tissue damage and disease progression. …”
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Probiotics fermentation enhanced the bioactive properties of Gnaphalium affine water extract and improved regulation ability of gut microbiota by Qin Zhang, Shiying Yan, YuanYuan Luo, Zixin Meng, Zhihao Yu, Jian Zhao, Xiaojuan Wu, Yiming Tian, Guzhen Cui, Zhenghong Chen, Daoyan Wu

“…Additionally, the G. affine fermented beverages promoted the growth of intestinal probiotics such as Lactobacillus, Bifidobacterium, while inhibiting pathogens like Clostridium, Shigella. Moreover, the G. affine fermented beverages exhibited beneficial effects, including antibacterial, antioxidant, anti-inflammatory activities. …”
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Role of mitochondrial and lysosomal dysfunction in acute pancreatitis pathogenesis by Yuliya V Yevsyutina, V. T. Ivashkin, E. Z. Abgadzhava

“…Mitochondrial and lysosomal dysfunction acts as pathogenic basis for AP, leading to energy deprivation of pancreatic cells. …”
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Infiltration of the liver by cells of innate and adaptive immunity and their destruction in development of experimental immune concanavalin-A-induced hepatitis by S. I. Pavlovich, T. M. Bryzgina, N. V. Makogon, L. I. Aleksyuk, T. V. Martynova, R. I. Yanchy, I. N. Alekseyeva

“…Obtained data assume, that infiltration of the liver by leukocytes, in particular neutrophiles, in combination to ascending necrotic destruction of peripheral cells of innate and adaptive immunity can be the essential pathogenic mechanism at inflammatory liver diseases of T-cell origin.…”
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The large-scale whole-genome sequencing era expedited medical discovery and clinical translation by Qingxin Yang, Shuhan Duan, Yuguo Huang, Chao Liu, Mengge Wang, Guanglin He

“…This imbalance has hampered health equity and precision medicine, resulting in limited transferability of polygenic risk scores to underrepresented populations and misinterpretations of the pathogenicity of genomic variants. Recent advancements in sequencing technology have enabled the implementation of large-scale, high-quality, diverse, multi-omics, and engineered genomic projects, including the All of Us Research Program and the Trans-Omics for Precision Medicine Program. …”
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Field Diagnosis and Management of Phytophthora Diseases by Stephen H. Futch, James H. Graham

“… Phytophthora species are important soil-borne fungal pathogens worldwide that attack the root systems, trunks, and fruit of citrus trees at any age. …”
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Exploring the Ancient Persian/Unani Theory of Connection between Gastrointestinal and Respiratory Tracts: Current Evidence and Future Directions by Shahin Saeidinejat, Syed Mohd Abbas Zaidi, Alireza Ranjbar, Alireza Derakhshan

“…The interaction between the respiratory and gastrointestinal systems can occur through several mechanisms, including commonalities in embryonic sources, role of identical mediators and receptors, influence of common pathogens in the lungs and gut, similarity of microbiota patterns and changes, and same inflammatory and mucosal responses. …”
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Werner Syndrome Caused by Homozygous Frameshift Variant c.1578del in WRN by Jovita Patricija Druta, Gunda Petraitytė, Aušra Sasnauskienė, Eglė Preikšaitienė

“…The patient was initially diagnosed with secondary small fiber sensory polyneuropathy and myotonia, but further genetic testing revealed the homozygous pathogenic variant c.1578del in the WRN gene associated with Werner syndrome. …”
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Ischemic Changes in the Mucous Membrane of the Transverse Colon as a Complication of Acute Pancreatitis by D. A. Semenov, S. G. Shapovalyants, D. E. Seleznev, O. I. Yudin, S. V. Korolev, N. A. Gracheva, L. M. Mikhaleva, K. S. Paramonenko

“…Negative results of analysis for toxins A and B of Clostridioides difficile and pathogenic intestinal flora were obtained. By the means of intensive care, it was possible to achieve complete stabilization of the patient's condition, normalization of laboratory blood parameters and relief of ischemic processes in the colon wall.Conclusion. …”
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Ischemic heart disease and reflux-esophagitis: complexities of the differential diagnosis and treatment. by Yu. N. Belenkov, Ye. V. Privalova, A. O. Yusupova, M. V. Kozhevnikova

“…Application of prokinetics in complex treatment of RE at IHD patients is pathogenically proven. Combination of diseases requires long treatment, dictates necessity of choice of the safe agent, having no negative effect on the course of IHD.Conclusion. …”
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Treatment of irritable bowel syndrome: the past, present and future by V. T. Ivashkin, Ye. A. Poluektova, O. S. Lyashenko, D. V. Reykhart

“…Prescription of probiotics, peripheral opioid receptor agonists at IBS is pathogenicly proven and allows to increase treatment efficacy significantly.…”
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MDM2 inhibition is associated with the emergence of TP53-altered clonal hematopoiesis by Vishesh Khanna, Gohar Eslami, Rochelle Reyes, Robert Diep, Sebastian Fernandez-Pol, Henning Stehr, Carlos Jose Suarez, Harlan Pinto, James M. Ford, Tian Yi Zhang, Christopher T. Chen

“…Her pancytopenia was associated with 20 distinct pathogenic TP53 mutations in peripheral blood and bone marrow not present in drug-resistant tumor tissue. …”
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Endothelial SHANK3 regulates tight junctions in the neonatal mouse blood-brain barrier through β-Catenin signaling by Yong-Eun Kim, Minseong Kim, Sunwhi Kim, Raham Lee, Yusuke Ujihara, Esther Magdalena Marquez-Wilkins, Yong-Hui Jiang, Esther Yang, Hyun Kim, Changhoon Lee, Changwon Park, Il Hwan Kim

“…These findings highlight a pathogenic mechanism stemming from the ASD-risk Shank3, emphasizing the significance of neonatal BECs in the BBB as a potential therapeutic target for ASD.…”
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Recent advances in nanomaterials and their mechanisms for infected wounds management by Jianping Zhu, Fan Xia, Shuaifei Wang, Yan Guan, Fuqiang Hu, Fangying Yu

“…Wounds infected by bacteria pose a considerable challenge in the field of healthcare, particularly with the increasing prevalence of antibiotic-resistant pathogens. Traditional antibiotics often fail to achieve effective results due to limited penetration, resistance development, and inadequate local concentration at wound sites. …”
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Inactivation of the CMAH gene and deficiency of Neu5Gc play a role in human brain evolution by Yuxin Liu, Jinhong Li, Qicai Liu

“…The inactivation of CMAH protected our ancestors from some pathogens and reduced the level of N-glycolylneuraminic acid (Neu5Gc) in brain tissue. …”
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NALCN expression is down-regulated and associated with immune infiltration in gastric cancer by Xuewei Li, Xuewei Li, Na Wu, Chen Wang, Beibei Pei, Xiaoyan Ma, Jun Xie, Jun Xie, Wenhui Yang

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Antimicrobial Resistance Surveillance of Skin and Soft Tissue Infections: Hospital-Wide Bacterial Species and Antibiograms to Inform Management at a Zonal Tertiary Hospital in Mwan... by Justine BN, Mushi MF, Silago V, Igembe Z, Muyombe J, Kishengena PP, Michael Jnr NS, Maganga MG, Massenga A, Tegete F, Massaga FA, Seni J

“…The most frequent SSTIs types were surgical site infections (30.0%), chronic wounds (27.9%), and traumatic wounds (19.7%). The commonest pathogens were Staphylococcus aureus (17.1%), Escherichia coli (17.1%), and K. pneumoniae (16.0%). …”
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