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Alpha-defensins increase NTHi binding but not engulfment by the macrophages enhancing airway inflammation in Alpha-1 antitrypsin deficiency
Published 2025-02-01“…Despite the antimicrobial activities of α-defensins by direct bacterial killing and by modulation of immune responses, AATD individuals are paradoxically burdened by recurrent exacerbation triggered by bacterial infections, frequently with nontypeable Haemophilus influenzae (NTHi). …”
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62
TAB2 deficiency induces dilated cardiomyopathy by promoting mitochondrial calcium overload in human iPSC-derived cardiomyocytes
Published 2025-02-01“…TAB2-deficient hiPSC-CMs were found to develop phenotypic features of DCM, such as distorted sarcomeric ultrastructure, decreased contractility and energy production, and mitochondrial damage at day 30 post differentiation. Paradoxically, TAB2 knockout cell lines showed abnormal calcium handling after 40 days, later than reduced contractility, suggesting that the main cause of impaired contractility was abnormal energy production due to mitochondrial damage. …”
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63
Intracranial pressure monitoring in patients with spontaneous onset of orthostatic headache
Published 2025-02-01“…Moreover, a significant minority of patients with orthostatic headache may paradoxically have a high CSF pressure state, which can be detected using ICP monitoring. …”
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64
The sport and Lithuanian national identity
Published 2006-06-01“…One of the most vivid stereotypes that embody Lithuanian sport specifics is the affirmation that basketball is the Lithuanian national religion. Paradoxically, Lithuanians fancy themselves due to basketball victories, but perhaps they are better known for football defeats. …”
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