Public and patient involvement (PPI) in the design, execution and dissemination of a trial: the BISTRO trial by David Coyle, Paula Ormandy, Nancy Fernandes da Silva, Simon Davies

“…The trial was successfully completed and gave a clear answer despite interruption by the COVID pandemic. Adherence to urine collections was excellent, despite prior concerns this would prove problematic, and dropout was acceptable. …”
Get full text

Prioritizing breast cancer surgeries: insights from the KRONOS SCORE by Lucía Navarro, Lucía Navarro, Lucía Navarro, Luis Perez-Bartivas, Luis Perez-Bartivas, Luis Perez-Bartivas, David Ponferrada, David Ponferrada, David Ponferrada, Javier Cejas, Javier Cejas, Javier Cejas, Juan Adrián Camús, Juan Adrián Camús, Juan Adrián Camús, Natalia Rangel, Natalia Rangel, Natalia Rangel, Maria Porras, Cristina Morales Estevez, Cristina Morales Estevez, Cristina Morales Estevez, Amalia Palacios Eito, Amalia Palacios Eito, Amalia Palacios Eito, Pilar Rioja, Pilar Rioja, Pilar Rioja, Marina Alvarez, Marina Alvarez, Marina Alvarez, Enrique Aranda, Enrique Aranda, Enrique Aranda, Juan De La Haba-Rodríguez, Juan De La Haba-Rodríguez, Juan De La Haba-Rodríguez

“…Although guidelines suggest that a waiting period of up to four weeks is acceptable, this is often exceeded, potentially impacting treatment outcomes. The COVID-19 pandemic highlighted the need to reassess surgical urgency. …”
Get full text

Health systems analysis and evaluation of the barriers to availability, utilisation and readiness of sexual and reproductive health services in COVID-19-affected areas: a WHO mixed... by José Guilherme Cecatti, Kun Tang, Igor Toskin, Moazzam Ali, Caron Kim, Stefano Uccella, Simone Garzon, Ge Yang, Vanessa Brizuela, Pisake Lumbiganon, Seni Kouanda, Alexandra Sawyer, Nigel Sherriff, Alessia Savoldi, Anna Thorson, Marleen Temmerman, Jörg Huber, Soe Soe Thwin, Maddalena Cordioli, Massimo Mirandola, Jaime Vera, Armando Seuc, Laila Ladak, Debbie Williams, Luis Bahamondes, Deda Ogum Alangea, Abdu Mohiddin, Eunice Nahyuha Chomi, Sothornwit Jen, Modey Emefa, Hamsadvani Kuganantham, Armando Humberto Seuc, Eunice Chomi, Hanxiyue Zhang, Yifan Zhu, Yueping Guo, Chunxiao Peng, Kwasi Tropsey, Emefa Judith Modey, Rozina Karmaliani, Jen Sothornwit, Ferdinand Okwaro, Ranieri Poli, Joy Jerop Chebet, Hugo Gamerro Abrego

“…This study aims to assess the availability of contraception, comprehensive abortion care, sexually transmitted infection prevention and treatment and sexual and gender-based violence care and support services in local health facilities during COVID-19 pandemic. This is a standardised generic protocol designed for use across different global settings.Methods and analysis This study adopts both quantitative and qualitative methods to assess health facilities’ SRH service availability and readiness, and clients’ and providers’ perceptions of the availability and readiness of these services in COVID-19-affected areas. …”
Get full text

Olanzapine for young PEople with aNorexia nervosa (OPEN): results of a feasibility study by Olena Said, Dominic Stringer, Ece Sengun Filiz, Hiba Mutwalli, Sevgi Bektas, Melahat Nur Akkese, Vanessa Kellermann, Katie Ireland, Elizabeth Tyrrell-Bunge, Demelza Beishon-Murley, Joel W. T. Khor, Lee Allman, Joanna Barker, Nicus Kotze, Ben Carter, Mima Simic, Dilveer Singh Sually, Jessica Bentley, Allan H. Young, Sloane Madden, Sarah Byford, Sabine Landau, Vanessa Lawrence, Janet Treasure, Ulrike Schmidt, Dasha Nicholls, Hubertus Himmerich

“…Conclusions Possible reasons for the recruitment difficulties and low adherence rate include the high clinical workload of ED services during the COVID-19 pandemic and the reluctance of patients to agree to take olanzapine under the relatively restricted conditions of a clinical study. …”
Get full text

First Detection of <i>Alphacoronavirus</i> in Bats from the World’s Largest Wetland, the Pantanal, Brazil by Tayane B. S. Magalhães, Amanda de O. Viana, Thiago B. F. Semedo, Juliane S. Saldanha, Nicole A. dos Reis, Nathalia de A. Pereira, Rachel V. P. de Barros, Hannah R. Miranda, Gabriella C. Almeida, Desyrée Y. S. R. Ozaki, Giovana S. Caleiro, Gustavo O. Fenner, Fernanda P. Vizu, Theo Kraiser, Thais P. Carvalho, Luciano M. Thomazelli, Erick G. Dorlass, Clarice W. Arns, Helena L. Ferreira, Erika Hingst-Zaher, Rogério Vieira Rossi, Guilherme S. T. Garbino, Edison L. Durigon, Jansen de Araujo, Daniel M. de Aguiar

“…Given the recent SARS-CoV-2 pandemic, we investigated the presence of CoV in bats captured in the Brazilian Pantanal. …”
Get full text

Targeting eEF1A reprograms translation and uncovers broad-spectrum antivirals against cap or m6A protein synthesis routes by Elisa Molina Molina, Joan Josep Bech-Serra, Eloi Franco-Trepat, Ignasi Jarne, Daniel Perez-Zsolt, Roger Badia, Eva Riveira-Muñoz, Edurne Garcia-Vidal, Lluís Revilla, Sandra Franco, Ferran Tarrés-Freixas, Núria Roca, Gerardo Ceada, Karl Kochanowski, Dàlia Raïch-Regué, Itziar Erkizia, Rytis Boreika, Antoni E. Bordoy, Laia Soler, Sonia Guil, Jorge Carrillo, Julià Blanco, Miguel Ángel Martínez, Roger Paredes, Alejandro Losada, Pablo Aviles, Carmen Cuevas, Júlia Vergara-Alert, Joaquim Segalés, Bonaventura Clotet, Ester Ballana, Carolina de la Torre, Nuria Izquierdo-Useros

“…By deciphering the molecular fingerprint of cells treated with therapies targeting translation we identify a rational approach to select broad-spectrum antivirals with potential to counteract future pandemic viruses.…”
Get full text

Neutralizing antibody immune correlates in COVAIL trial recipients of an mRNA second COVID-19 vaccine boost by Bo Zhang, Youyi Fong, Lauren Dang, Jonathan Fintzi, Shiyu Chen, Jing Wang, Nadine G. Rouphael, Angela R. Branche, David J. Diemert, Ann R. Falsey, Daniel S. Graciaa, Lindsey R. Baden, Sharon E. Frey, Jennifer A. Whitaker, Susan J. Little, Satoshi Kamidani, Emmanuel B. Walter, Richard M. Novak, Richard Rupp, Lisa A. Jackson, Chenchen Yu, Craig A. Magaret, Cindy Molitor, Bhavesh Borate, Sydney Busch, David Benkeser, Antonia Netzl, Derek J. Smith, Tara M. Babu, Angelica C. Kottkamp, Anne F. Luetkemeyer, Lilly C. Immergluck, Rachel M. Presti, Martín Bäcker, Patricia L. Winokur, Siham M. Mahgoub, Paul A. Goepfert, Dahlene N. Fusco, Robert L. Atmar, Christine M. Posavad, Jinjian Mu, Mat Makowski, Mamodikoe K. Makhene, Seema U. Nayak, Paul C. Roberts, Peter B. Gilbert, Dean Follmann, Coronavirus Variant Immunologic Landscape Trial (COVAIL) Study Team

“…Abstract Neutralizing antibody titer has been a surrogate endpoint for guiding COVID-19 vaccine approval and use, although the pandemic’s evolution and the introduction of variant-adapted vaccine boosters raise questions as to this surrogate’s contemporary performance. …”
Get full text

60-month follow-up of Long Limb vs. Standard Limb Roux-en-Y gastric bypass for type 2 diabetes and obesity: the LONG LIMB RCT by Saleem Ansari, Anna Kamocka, Tina Mazaheri, Ibiyemi Ilesanmi, Lara Jimenez-Pacheco, Kleopatra Alexiadou, Joanna Tan, Harvinder Chahal, Krishna Moorthy, Sanjay Purkayastha, Anne Margot Umpleby, Stephen Robert Bloom, Francesco Rubino, Alexander Dimitri Miras, Ahmed Rashid Ahmed, Tricia Tan

“…The 24- to 60-month extension study coincided with two waves of the COVID-19 pandemic. There was no difference between the Standard Limb and Long Limb groups for postprandial active glucagon-like peptide-1 secretion (70 ± 32 pmol/L vs. 70 ± 19 pmol/L, respectively; p = 0.43), hepatic insulin sensitivity (3.4 ± 0.9 µmol/kg/min vs. 3.4 ± 1.4 µmol/kg/min, respectively; p = 0.94) and peripheral insulin sensitivity (29.0 ± 9.1 µmol/kg/min vs. 29.2 ± 9.9 µmol/kg/min, respectively; p = 0.98) at 2 weeks post intervention. …”
Get full text

The TB27 Transcriptomic Model for Predicting Mycobacterium tuberculosis Culture Conversion by Maja Reimann, Korkut Avsar, Andrew DiNardo, Torsten Goldmann, Gunar Günther, Michael Hoelscher, Elmira Ibraim, Barbara Kalsdorf, Stefan Kaufmann, Niklas Köhler, Anna Mandalakas, Florian Maurer, Marius Müller, Dörte Nitschkowski, Ioana Olaru, Cristina Popa, Andrea Rachow, Thierry Rolling, Helmut Salzer, Patricia Sanchez-Carballo, Maren Schuhmann, Dagmar Schaub, Victor Spinu, Elena Terhalle, Markus Unnewehr, Nika Zielinski, Jan Heyckendorf, Christoph Lange

Get full text

I-SPY COVID adaptive platform trial for COVID-19 acute respiratory failure: rationale, design and operations by Carolyn S Calfee, Michael A Matthay, Paul Henderson, Martin Eklund, Laura J Esserman, Chirag Patel, Angela Haczku, Michelle Jung, Tony Oliver, Alessio Crippa, Andrea Discacciati, Kathleen D Liu, Ellen L Burnham, Nuala J Meyer, Fady A Youssef, Derek W Russell, Julie Lang, Kevin W Gibbs, Daniel C Files, Sheetal Gandotra, Purnema Madahar, Nathan K Cobb, Timothy E Albertson, Rajiv Sonti, John P Reilly, Alejandra Jauregui, Iván García, Luis E Huerta, Daniel Clark Files, Neil R Aggarwal, Adam L Asare, Jeremy R Beitler, Paul A Berger, George Cimino, Melissa H Coleman, Paul T Henderson, Caroline A G Ittner, Kashif T Khan, Jonathan L Koff, Mary LaRose, Joe Levitt, Ruixiao Lu, Jeffrey D McKeehan, Karl W Thomas, Aaron M Mittel, Albert F Yen, Alexis E Suarez, Alexis L Serra, Alpesh N Amin, Amanda Rosen, Amy L Dzierba, Anna D Barker, Ariel R Weisman, Brian M Daniel, Brian M Morrissey, Caroline AG Ittner, Chayse Jones, Christina Creel-Bulos, Christina M Angelucci, Diana Ng, Fredy Chaparro-Rojas, Gavin H Harris, Harsh V Barot, Heny Su, Jacqueline B Sutter, Jamal Dodin, Jerry S Lee, John Kazianis, Joshua F Detelich, Julie E Lang, Justin Muir, Katarzyna Gosek, Katherine L Nugent, Kimberly Yee, Laura G Rodrigues, Laura R Macias, Lindsey A Orr, Lindsie L Boerger, Lissette Rosario-Remigio, Lucia Kufa, Maged Tanios, Maria B Reyes, Max W Adelman, Maya M Juarez, Michelle Meyers, Mitchell P Sternlieb, Neil Aggarwal, Nilam S Mangalmurti, Patrice Jones, Paul L Saban, Peter S Marshall, Philiip A Robinson, Philip Yang, Rahul Nair, Richard Anthony Lee, Richard G Wunderink, Romina Wahab, Roxana A Lupu, Santhi I Kumar, Sara C Auld, Scott Fields, Se Fum Wong, Skyler J Pearson, Spencer Whealon, Timothy F Obermiller, Anita Darmanian, John Schicchi, Esmeralda Martinez, Farjad Sarafian, Julie Nguyen, Bethany Weiler-Lisowski, Jaime Wyatt, Daniel Blevins, Marylee Melendrez, Brenda Lopez, Hiwet Tzehaie, Omowunmi Amosu, Austin Simonson, Erin Hardy, Brett Lindgren, Gregory Peterfreund, Leigha Landreth, Lisa Parks

“…Introduction The COVID-19 pandemic brought an urgent need to discover novel effective therapeutics for patients hospitalised with severe COVID-19. …”
Get full text

Developing an effective teaching model in order to improve the educational level of schools by Mehdi Mohammadi, fardin Abdollahy, Rafigh Hasani

“…Devlin & Samarawickrema (2022) showed that effective teaching criteria have changed after the Covid-19 pandemic and are more based on interactions between the teacher and students. …”
Get full text

Development of a clinical decision support tool for Primary care Management of lower Urinary tract Symptoms in men: the PriMUS study by Adrian Edwards, Ridhi Agarwal, Janine Bates, Alison Bray, Sarah Milosevic, Emma Thomas-Jones, Michael Drinnan, Marcus Drake, Peter Michell, Bethan Pell, Haroon Ahmed, Natalie Joseph-Williams, Kerenza Hood, Yemisi Takwoingi, Chris Harding

“…There was large uncertainty around the c-index and calibration slope, likely driven by the smaller sample size of the validation cohort, less than originally targeted, owing to recruitment problems, principally due to the pandemic. Thus, further external validation and recalibration may be required before the models can be used in practice to ensure applicability of the models in settings where case-mix or prevalence could differ. …”
Get full text

Selected Abstracts of the 20th International Workshop on Neonatology and Pediatrics; Cagliari (Italy); October 23-26, 2024 by --- Various Authors

“…PERCEIVED FAMILY FUNCTION, PERCEIVED SOCIAL SUPPORT AND DEPRESSION OF NEW PARENTS UNDER COVID-19 PANDEMIC: A DYADIC ANALYSIS • T. Kokkinaki, K. Koutra, O. …”
Get full text

Quarantine and anti-epidemic measures as an element of Emergency Law in Ukraine by O. O. Levytskyi

“…Sustained changes in global threats, such as pandemics, require constant analysis, updating and improvement of the legal response mechanism. …”
Get full text

Short-term health system responses to epidemics across hard to reach areas in sub-Saharan Africa: A scoping review protocol. by Annette A Murunga, Ben Ngoye, Francis P Wafula, Gilbert O Kokwaro

“…Epidemics and Pandemics (disease outbreaks) are the occurrence of cases of disease in excess of what would be normally expected. …”
Get full text

Transverse myelitis after COVID-19 disease: a case report by I. Vienažindytė, R. Balnytė, Dž. Šleiteris, M. Ališauskienė

“… Currently, a significant number of post-COVID-19 disease neurological disorders still occur, and precise analysis of them could expand the knowledge of the neurological community for future pandemics. It is important to evaluate and recognize potential neurological manifestations and complications of COVID-19, as some of them can progress rapidly and require urgent treatment. …”
Get full text

Preventive vaccines for COVID-19. An expectant reality by Ana María Ramos Cedeño, Yeny Dueñas Pérez, Alicia del Rosario Ramírez Pérez

“…Throughout the history of humanity, the full development of vaccines for the prevention of diseases that constitute pandemics is evident. The population of this century suffers the vicissitudes of the new coronavirus, and exposes an ongoing global health emergency, caused by the severe acute respiratory syndrome coronavirus 2. …”
Get full text

The impact of vaccines and vaccinations: Challenges and opportunities for modelers by Roy Curtiss III

“…The special concerns and needs in vaccine design and development are discussed in dealing with epidemics/pandemics with special emphasis on influenza and current global problems in vaccine delivery.…”
Get full text

Development of a Recombinant Omicron BA.1 Subunit Vaccine Candidate in Pichia pastoris by Sibel Kalyoncu, Dogu Sayili, Ayca Zeybek Kuyucu, Hakan Soyturk, Seyda Gullu, Busra Ersayan, Ibrahim Oguzhan Tarman, Mehmet Ender Avci, Olcay Mert, Umut Haskok, Ege Tekin, Huseyin Akinturk, Ridvan Orkut, Aysegul Demirtas, Idil Tilmensagir, Ceren Ulker, Bilgi Gungor, Mehmet Inan

“…ABSTRACT Low‐cost and safe vaccines are needed to fill the vaccine inequity gap for future pandemics. Pichia pastoris is an ideal expression system for recombinant protein production due to its cost‐effective and easy‐to‐scale‐up process. …”
Get full text

Crisis and constitutional politics in Central Europe by Peter Smuk

“…This paper aims to examine the impact of significant crisis situations on the constitutional framework over the past decade, including financial crisis, migration, pandemics and war. The paper focuses on the Visegrad countries, especially Hungary, and analyses the constitutional amendments adopted and the relevant constitutional court decisions. …”
Get full text