In situ forming gels as subcutaneous delivery systems of curcumin and piperine by Walter Pula, Alessia Pepe, Francesca Ferrara, Agnese Bondi, Paolo Mariani, Maria Grazia Ortore, Alessandra Pecorelli, John Ivarsson, Giuseppe Valacchi, Elisabetta Esposito

“…Abstract In this study an in situ forming gel for curcumin and piperine delivery is investigated as a long-lasting strategy in the local treatment of inflammatory and degenerative joint disease, such as osteoarthritis and rheumatoid arthritis. Particularly glyceryl monooleate, in association with phosphatidylcholine and ethanol, were employed. …”
Get full text

Intra- and Extra-Articular Deformity of Lower Limb: Tibial Condylar Valgus Osteotomy (TCVO) and Distal Tibial Oblique Osteotomy (DTOO) for Reconstruction of Joint Congruency by Y. Watanabe, N. Takenaka, K. Kinugasa, T. Matsushita, T. Teramoto

“…Osteotomies are the established surgical procedure for the deformity of the lower limb induced by osteoarthritis (OA) of the knee and ankle. Closed-wedge (CW) and open-wedge (OW) high tibial osteotomy (HTO) are extra-articular surgery, which aim to shift the mechanical axis from medial to slightly lateral and reduce the overload in the medial compartment of the varus deformed knee by extra-articular correction. …”
Get full text

Psychological Patient-reported Outcomes Cannot Predict a Second Anterior Cruciate Ligament Injury in Patients who Return to Sports after an Anterior Cruciate Ligament Reconstructio... by Ramana Piussi, Rebecca Simonson, Johan Högberg, Roland Thomeé, Kristian Samuelsson, Eric Hamrin Senorski

“… # Study design Diagnostic/prognostic study # Methods Demographic data, isokinetic strength test data for quadriceps, as well as results for the ACL-Return to Sport after Injury scale (ACL-RSI), Knee Injury and Osteoarthritis Outcome Score (KOOS) Quality of Life, and Function in Sport and Recreation sub-scales, and the 18-item version of the Knee Self-Efficacy Scale (K-SES~18~) were extracted from a registry. …”
Get full text

Different Chondrogenic Potential among Human Induced Pluripotent Stem Cells from Diverse Origin Primary Cells by Yeri Alice Rim, Yoojun Nam, Narae Park, Hyerin Jung, Yeonsue Jang, Jennifer Lee, Ji Hyeon Ju

“…We reprogrammed hiPSCs from four different types of primary cells such as dermal fibroblasts (DF, n=3), peripheral blood mononuclear cells (PBMC, n=3), cord blood mononuclear cells (CBMC, n=3), and osteoarthritis fibroblast-like synoviocytes (OAFLS, n=3). …”
Get full text

McKenzie’s method effectiveness in patients with cervical vertebral pain. Chambas, Ciego de Ávila, 2022-2023 by Onesio Esteban de León Gutierrez, Israel Triana Pérez, Tania Alemán Martínez, Aray Pérez Pino, Félix Jorge Jiménez Cantero, Iván Castillo Ledo

“…The most frequent etiologies were osteoarthritis and inadequate posture; and as the predominant symptom, pain radiating to the upper limbs. …”
Get full text

Lumbar Spinal Stenosis Has a Negative Impact on Quality of Life Compared with Other Comorbidities: An Epidemiological Cross-Sectional Study of 1862 Community-Dwelling Individuals by Koji Otani, Shinichi Kikuchi, Shoji Yabuki, Tamaki Igarashi, Takuya Nikaido, Kazuyuki Watanabe, Shinichi Konno

“…In addition, the presence of comorbid conditions that affect QoL, such as osteoarthritis of the knee and hip, cardiovascular disease, cerebrovascular disease, or respiratory disease, was also analyzed. …”
Get full text

Simultaneous total hip and knee arthroplasties in hemophilic arthropathy: series of 5 cases by Özgür Mert Bakan, Arman Vahabi, Elcil Kaya Biçer, Fahri Şahin, Kaan Kavaklı

“…Preoperative and postoperative evaluations included Harris Hip Score (HHS), Knee Society Score (KSS), Knee Injury and Osteoarthritis Outcome Score (KOOS), range of motion, flexion contracture (FC), Visual Analog Scale (VAS), hip-knee angle, and leg length discrepancy. …”
Get full text

Deep learning in gonarthrosis classification: a comparative study of model architectures and single vs. multi-model methods by Sahika Betul Yayli, Kutay Kılıç, Salih Beyaz

“…PurposeThis study aims to classify Kellgren–Lawrence (KL) osteoarthritis stages using knee anteroposterior X-ray images by comparing two deep learning (DL) methodologies: a traditional single-model approach and a proposed multi-model approach. …”
Get full text

Exploring molecular disparities of H-type vasculature endothelial cells in osteonecrosis of the femoral head through single-cell analysis by Wei Shi, Dong Li, Qian Xu, Kai Zhang, Xinyu Liang, Hui Li, Zhijun Li, Huafeng Zhang

“…This study, based on single-cell RNA sequencing (scRNA-seq), aims to explore the changes in H-type vasculature endothelial cells (H_ECs) in osteonecrosis of the femoral head (ONFH) and hip osteoarthritis (HOA), focusing on the death modes such as ferroptosis, pyroptosis, and parthanatos. …”
Get full text

Do Not Hallow until You Are out of the Wood! Ultrasonographic Detection of CPP Crystal Deposits in Menisci: Facts and Pitfalls by Georgios Filippou, Antonella Adinolfi, Panagiotis Bozios, Sauro Lorenzini, Valentina Picerno, Valentina Di Sabatino, Ilaria Bertoldi, Dario Gambera, Mauro Galeazzi, Bruno Frediani

“…We enrolled all patients waiting to undergo knee replacement surgery due to osteoarthritis, for one-month period. Each patient underwent US examination of the knee, focusing on the menisci. …”
Get full text

Emerging Strategies in Cartilage Repair and Joint Preservation by Mircea Adrian Focsa, Sorin Florescu, Armand Gogulescu

“…<i>Background and Objectives:</i> Cartilage repair remains a critical challenge in orthopaedic medicine due to the tissue’s limited self-healing ability, contributing to degenerative joint conditions such as osteoarthritis (OA). In response, regenerative medicine has developed advanced therapeutic strategies, including cell-based therapies, gene editing, and bioengineered scaffolds, to promote cartilage regeneration and restore joint function. …”
Get full text

Tissue-specific roles of de novo DNA methyltransferases by Dániel Márton Tóth, Flóra Szeri, Mária Ashaber, Muhyiddeen Muazu, Lóránt Székvölgyi, Tamás Arányi

“…Additionally, somatic mutations cause common conditions such as osteoarthritis, osteoporosis, clonal hematopoiesis of indeterminate potential (CHIP), hematologic malignancies, and cancer. …”
Get full text

Quality of Life as Medicine: A Pilot Studyof Patients with Chronic Illness and Pain by Soren Ventegodt, Joav Merrick, JØrgen Anderson

“…Nineteen persons with chronic illness and pain (fibromyalgia, chronic tiredness, whiplash, mild depression, and problems involving pain in arms and legs including osteoarthritis), and unemployed for 5–7 years attended the course. …”
Get full text

Semaphorin 3A Inhibits Inflammation in Chondrocytes under Excessive Mechanical Stress by Chikako Sumi, Naoto Hirose, Makoto Yanoshita, Mami Takano, Sayuri Nishiyama, Yuki Okamoto, Yuki Asakawa, Kotaro Tanimoto

“…Excessive mechanical stress causes inflammation and destruction of cartilage and is considered one of the cause of osteoarthritis (OA). Expression of semaphorin 3A (Sema3A), which is an axon guidance molecule, has been confirmed in chondrocytes. …”
Get full text

Psychometric properties of the Arabic version of the Forgotten Joint Score usage in total hip arthroplasty by Waleed Albishi, Nasser M. AbuDujain, Orfan Arafah, Ibrahim S. Alshaygy, Abdulaziz Almaawi, Zyad A. Aldosari, Mohammed N. Alhuqbani, Omar A. Aldosari, Saad M. Alangari

“…The construct validity of the study was evaluated using the reduced Western Ontario and McMaster Universities Osteoarthritis Index (rWOMAC). To assess the test-retest reliability, 72 people took the Ar-FJS test twice. …”
Get full text

Medial Patellofemoral Ligament Repair with Suture Tape Augmentation Can Yield Good Midterm Clinical Outcomes Regardless of Skeletal Maturity and Joint Laxity by Shinichiro Takada, Hirotaka Nakashima, Keisuke Nakayama, Soshi Uchida

“…Patient-reported clinical outcomes (PROs) were evaluated via the International Knee Documentation Committee (IKDC) score and the knee injury osteoarthritis outcome score (KOOS). In total, 17 knees (4 males and 13 females) who underwent MPFL repair with suture tape augmentation with a mean follow-up of 54.6 ± 19.5 months were included in this study. …”
Get full text

Microfragmented Adipose Tissue Injection (MFAT) May Be a Solution to the Rationing of Total Knee Replacement: A Prospective, Gender-Bias Mitigated, Reproducible Analysis at Two Yea... by Nima Heidari, Tiffanie-Marie Borg, Stefano Olgiati, Mark Slevin, Alessandro Danovi, Brady Fish, Adrian Wilson, Ali Noorani

“…Background. Knee osteoarthritis (KOA) is a significant cause of disability in a globally ageing population. …”
Get full text

Patient-reported Outcomes and Muscle Strength after a Physiotherapy-led Exercise and Support Brace Intervention in Patients with Acute Injury of the Posterior Cruciate Ligament: A... by Randi Gram Rasmussen, Julie Sandell Jacobsen, Birgitte Blaabjerg, Torsten Grønbæk Nielsen, Lene Lindberg Miller, Martin Lind

“…Changes in patient-reported outcomes were measured with the International Knee Documentation Committee Subjective Knee Form (IKDC-SKF) and the Knee injury and Osteoarthritis Outcome Score (KOOS) from baseline (diagnosis) to two-year follow-up. …”
Get full text

Impact of diffuse idiopathic skeletal hyperostosis on quality of life and locomotive syndrome in community-dwelling older adults: the Yakumo study by Kazuma Ohshima, Hiroaki Nakashima, Naoki Segi, Sadayuki Ito, Jun Ouchida, Yasuhiko Takegami, Shinya Ishizuka, Ippei Yamauchi, Yukiharu Hasegawa, Kenta Murotani, Shiro Imagama

“…Multivariate regression analysis was performed, adjusting for sex, age, body mass index, and knee osteoarthritis. Additionally, a sex-stratified analysis was performed. …”
Get full text

Effects of competition and bundled payment on the performance of hip replacement surgery in Stockholm, Sweden: results from a quasi-experimental study by Fanny Goude, Göran Garellick, Clas Rehnberg, Mikko Peltola, Henrik Malchau, Sverre Kittelsen

“…Objective To evaluate the effects of competition and a bundled payment model on the performance of hip replacement surgery.Design A quasi-experimental study where a difference-in-differences analytical framework is applied to analyse routinely collected patient-level data from multiple registers.Setting Hospitals providing hip replacement surgery in Sweden.Participants The study included patients who underwent elective primary total hip replacement due to osteoarthritis from 2005 to 2012. The final study sample consisted of 85 275 hip replacement surgeries, where the exposure group consisted of 14 570 surgeries (n=6380 prereform and n=8190 postreform) and the control group consisted of 70 705 surgeries (n=32 799 prereform and n=37 906 postreform).Intervention A reform involving patient choice, free entry of new providers and a bundled payment model for hip replacement surgery, which came into force in 2009 in Region Stockholm, Sweden.Outcome measures Performance is measured as length of stay of the surgical admission, adverse event rate within 90 days following surgery and patient satisfaction 1 year postsurgery.Results The reform successfully improved the adverse event rate (1.6 percentage reduction, p&lt;0.05). …”
Get full text