Hypoxia-induced circPLOD2a/b promotes the aggressiveness of glioblastoma by suppressing XIRP1 through binding to HuR by Aixin Yu, Yiqi Wang, Chao Duan, Jun Qin, Miaomiao Liao, Haiyan Zhu, Junrong Lei, Jun Liu, Zehao Yang, Li Yu, Hui Gui, Jinxin Xin, Weiwei Tao, Wendai Bao, Zhiqiang Dong

“…In conclusion, hypoxia-induced circPLOD2a and b are oncogenic regulators of tumour aggressiveness through attenuating the interaction between HuR and XIRP1 in glioblastoma cells and may be potential therapeutic targets for this disease.…”
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Direct Reprogramming of Mouse Fibroblasts to Neural Stem Cells by Small Molecules by Yan-Chuang Han, Yoon Lim, Michael D. Duffieldl, Hua Li, Jia Liu, Nimshitha Pavathuparambil Abdul Manaph, Miao Yang, Damien J. Keating, Xin-Fu Zhou

“…Such chemical induction removes the risks associated with current techniques such as the use of viral vectors or the induction of oncogenic factors. This technique may, therefore, enable NSC to be utilized in various applications within clinical medicine.…”
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Comparison of differences in transcriptional and genetic profiles between intra-central nervous system and extra-central nervous system large B-cell lymphoma by Shu Wang, Hong Chen, Bo Dai, Kang Zheng, Jiajun Zheng, Yuqi Zhu, Yan Yuan, Tianling Ding, Qian Wang, Liqian Xie, Rui Feng, Fengping Zhu, Jianbin Xiang, Weiqun Ding, Hong Ding, Yuan Li, Xiaodong Gu, Kunpeng Wu, Yifan Yuan, Jianping Song, Dongxiao Zhuang, Haoshu Zhong, Hanfeng Wu, Ying Mao, Tong Chen

“…In summary, our study provides comprehensive insights into the transcriptomic and genetic characteristics of PCNS-DLBCL in contrast to ecDLBCL and will help dissect the oncogenic mechanism of this disease.…”
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Metabolic reprogramming in cancer: Mechanisms and therapeutics by Shiqi Nong, Xiaoyue Han, Yu Xiang, Yuran Qian, Yuhao Wei, Tingyue Zhang, Keyue Tian, Kai Shen, Jing Yang, Xuelei Ma

“…Metabolic reprogramming is a process mediated by various factors, including oncogenes, tumor suppressor genes, changes in growth factors, and tumor–host cell interactions, which help to meet the needs of cancer cell anabolism and promote tumor development. …”
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Role of silent mutations in KRAS-mutant tumors by Jun Lu, Chao Zhou, Feng Pan, Hongyu Liu, Haohua Jiang, Hua Zhong, Baohui Han, Xiangxiang Pan

“…Kirsten-RAS (KRAS) mutations, predominantly oncogenic, are pivotal drivers in various cancers. …”
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Molecular and Phylogenetic Analysis of Bovine Papillomavirus Type 1: First Report in Iraqi Cattle by Mohammed A. Hamad, Ahmed M. Al-Shammari, Shoni M. Odisho, Nahi Y. Yaseen

“…BPV is a widely spread oncogenic virus in Iraqi cattle and is associated with the formation of both benign and malignant lesions, resulting in notable economic losses in dairy and beef cattle. …”
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Pharmacological activity of OST-01, a natural product from baccharis coridifolia, on breast cancer cells by HyunJun Kang, Dinh Hoa Hoang, Melissa Valerio, Khyatiben Pathak, William Graff, Alexis LeVee, Jun Wu, Mark A. LaBarge, David Frankhouser, Russell C. Rockne, Patrick Pirrotte, Bin Zhang, Joanne Mortimer, Le Xuan Truong Nguyen, Guido Marcucci

“…OST-01 significantly inhibited cell proliferation and oncogenic activities of TNBC cells in vitro. OST-01 also markedly inhibited TNBC tumor growth in vivo, with > 50% reduction in tumor size compared to vehicle control treatment in different in vivo models, i.e., cell line-derived (CDX), patient-derived (PDX), and mammary fat pad xenografts. …”
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Heterogeneity in polyamine metabolism dictates prognosis and immune checkpoint blockade response in hepatocellular carcinoma by Jianyan Pan, Zhong Lin, Qinchun Pan, Tao Zhu

“…Dysregulated polyamine metabolism and its interaction with oncogenic pathways promote tumor progression. However, the heterogeneity of polyamine metabolism and its effects on the immune microenvironment and response to immunotherapy in HCC remain unclear. …”
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Rapid degradation of DHX36 revealing its transcriptional role by interacting with G‐quadruplex by Ziang Lu, Jinglei Xu, Yuqi Chen, Yuanyuan Zhou, Xiaolu Zhou, Qi Wang, Qi Wei, Shaoqing Han, Ruiqi Zhao, Xiaocheng Weng, Xiaolian Zhang, Xiang Zhou

“…In vitro assays further demonstrate DHX36's interaction with G4 sequences from three specific oncogenes. These findings underscore the potential role of DHX36 in modulating gene transcription through G4 structures.…”
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Isolation of Viral Biofilms From HTLV-1 Chronically Infected T Cells and Integrity Analysis by Coline Arone, Hélène Dutartre, Delphine Muriaux

“…The human T-lymphotropic virus type-1 (HTLV-1) is an oncogenic retrovirus that predominantly spreads through cell-to-cell contact due to the limited infectivity of cell-free viruses. …”
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Dysbiosis and extraintestinal cancers by Ruishan He, Pingqian Qi, Linzhen Shu, Yidan Ding, Peng Zeng, Guosheng Wen, Ying Xiong, Huan Deng

“…The dissemination of pathogens through the circulation may contribute to the establishment of an immune-suppressive environment that promotes carcinogenesis in extraintestinal organs either directly or indirectly. The oncogenic cascade always engages in the disruption of hormonal regulation and inflammatory responses, the induction of genomic instability and mutations, and the dysregulation of adult stem cell proliferation. …”
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Metastatic Urothelial Carcinoma from Transplanted Kidney with Complete Response to an Immune Checkpoint Inhibitor by Ryan S. Chiang, Ashton A. Connor, Brant A. Inman, Wen-Chi Foo, David N. Howell, John F. Madden, Matthew J. Ellis, Aparna S. Rege, Michael R. Harrison

“…In this report, we also discuss the oncogenic potential of BK virus, the use of checkpoint inhibitors in urothelial carcinoma, and the feasibility of retransplant for this patient population.…”
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The crosstalk between SND1 and PDCD4 is associated with chemoresistance of non-small cell lung carcinoma cells by Yun Zhao, Shanel Dhani, Vladimir Gogvadze, Boris Zhivotovsky

“…Previously, we demonstrated the oncogenic role of Tudor Staphylococcal nuclease (TSN, also known as Staphylococcal nuclease domain-containing protein 1, SND1), in regulating chemoresistance in NSCLC cells. …”
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FBXW7 Reduces the Cancer Stem Cell-Like Properties of Hepatocellular Carcinoma by Regulating the Ubiquitination and Degradation of ACTL6A by Xing Wang, Ying Li, Yongning Li, Peng Liu, Songbai Liu, Yaozhen Pan

“…The in vivo ubiquitination assay showed that FBXW7 repressed HCC malignancy by regulating the oncogenic activity of ACTL6A in a ubiquitin-dependent manner. …”
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miR-370-3p as a Novel Biomarker Promotes Breast Cancer Progression by Targeting FBLN5 by Jiahui Mao, Lingxia Wang, Junying Wu, Yichun Wang, Huiyan Wen, Xueming Zhu, Bo Wang, Huan Yang

“…In cancer, miRNAs can be divided into oncogenes or tumor suppressors on the basis of their functions in the carcinogenic process. …”
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Transcriptome Concordance Between Borderline Tumors and Endometrioid Carcinoma: An Integrative Genomic Analysis by Mio Takahashi, Kohei Nakamura, Tatsuyuki Chiyoda, Chihiro Okada, Sachio Nohara, Reika Takamatsu, Shintaro Yanazume, Hiroaki Kobayashi, Hiroshi Nishihara, Wataru Yamagami

“…Furthermore, the transcriptomic data highlighted a novel and substantial similarity between BOTs and EC, suggesting deeper biological linkages, including potentially shared oncogenic pathways or tumor microenvironmental factors. …”
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Myogenesis gone awry: the role of developmental pathways in rhabdomyosarcoma by Annika L. Gustafson, Annika L. Gustafson, Annika L. Gustafson, Adam D. Durbin, Kristin B. Artinger, Heide L. Ford, Heide L. Ford, Heide L. Ford

“…In FP-RMS, the PAX3/7-FOXO1 chromosomal translocation results in restructured chromatin, altering the binding of many MRFs and driving an oncogenic state. In FN-RMS, re-expression of MRFs, as well as other myogenic TFs, blocks terminal differentiation and holds cells in a proliferative, stem-cell-like state. …”
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New Insights in the Pathogenesis of HPV Infection and the Associated Carcinogenic Processes: The Role of Chronic Inflammation and Oxidative Stress by Simona Roxana Georgescu, Cristina Iulia Mitran, Madalina Irina Mitran, Constantin Caruntu, Maria Isabela Sarbu, Clara Matei, Ilinca Nicolae, Sandra Milena Tocut, Mircea Ioan Popa, Mircea Tampa

“…Reactive oxygen species exert a harmful effect on proteins, lipids, and nucleic acids. Viral oncogenes E5, E6, and E7 are involved in the development of chronic inflammation through various mechanisms. …”
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Pancreatic cancer cells infiltrate nerves through TGFbeta1-driven perineural epithelial-to-mesenchymal-like transdifferentiation by Theresa Krauss, Ibrahim Halil Gürcinar, Ulrike Bourquain, Maren Hieber, Evelyn N. Krohmer, Nan Wu, Sergey Tokalov, Rüdiger Goess, Carmen Mota Reyes, Dieter Saur, Helmut Friess, Güralp O. Ceyhan, Ihsan Ekin Demir, Okan Safak

“…In an autochthonous mouse model with elevated endogenous TGFbeta1 levels in addition to oncogenic Kras activation (Ptf1aCre/+, LSL-KrasG12D/+, LSL-R26Tgfβ/+), decreased perineural integrity could be reproduced in vivo.Collectively, these findings underscore the role played by TGFbeta1-overexpressing pancreatic cancer cells in the dismantling of perineural barriers during neural invasion.…”
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Pre-therapeutic efficacy of the CDK inhibitor dinaciclib in medulloblastoma cells by Marta Buzzetti, Sonia Morlando, Dimitrios Solomos, Ammara Mehmood, Alexander W. I. Cox, Mattia Chiesa, Yuri D’Alessandra, Michela Garofalo, Caroline H. Topham, Gianpiero Di Leva

“…We found that dinaciclib-triggered apoptosis is triggered by CDK9 inhibition and the resultant reduction in RNA pol II phosphorylation, which leads to the downregulation of the oncogenic marker MYC, and the anti-apoptotic protein MCL-1. …”
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