The Hsf1-sHsp cascade has pan-antiviral activity in mosquito cells by Jieqiong Qu, Michelle Schinkel, Lisa Chiggiato, Samara Rosendo Machado, Gijs J. Overheul, Pascal Miesen, Ronald P. van Rij

“…Blocking virus replication in mosquitoes is a promising approach to prevent arbovirus transmission, the development of which requires in-depth knowledge of virus-host interactions and mosquito immunity. By integrating multi-omics data, we find that heat shock factor 1 (Hsf1) regulates eight small heat shock protein (sHsp) genes within one topologically associated domain in the genome of the Aedes aegypti mosquito. …”
Get full text

Key Role of Human ABC Transporter ABCG2 in Photodynamic Therapy and Photodynamic Diagnosis by Toshihisa Ishikawa, Hiroshi Nakagawa, Yuichiro Hagiya, Naosuke Nonoguchi, Shin-ichi Miyatake, Toshihiko Kuroiwa

Get full text

Outcome Prediction in Infectious Disease by Khie Chen Lie, Yosia Yonggara, Adeline Pasaribu, Sharifah Shakinah, Leonard Nainggolan

“…Current research explores a range of prognostic tools, from traditional scoring systems and biomarkers to cutting-edge omics technologies and artificial intelligence. These tools can differ significantly across patient populations and clinical settings, such as the emergency department (ED) and intensive care unit (ICU). …”
Get full text

The clove (Syzygium aromaticum) genome provides insights into the eugenol biosynthesis pathway by Sonia Ouadi, Nicolas Sierro, Simon Goepfert, Lucien Bovet, Gaetan Glauser, Armelle Vallat, Manuel C. Peitsch, Felix Kessler, Nikolai V. Ivanov

“…The clove genome is a new contribution to omics resources for the Myrtaceae family and an important tool for clove research.…”
Get full text

Autoimmune Hepatitis: Progress from Global Immunosuppression to Personalised Regulatory T Cell Therapy by Nwe Ni Than, Hannah C. Jeffery, Ye H. Oo

“…Future direction of diagnosis and treatment for AIH should be guided by “omics” and the immunology profile of the individual patient and clinicians should aim to deliver personalised medicine for their patients. …”
Get full text

Unveiling the prognostic value of ARID3A in breast cancer through bioinformatic analysis by Wen-Run Cai, Xu-Gang Sun, Yue Yu, Xin Wang, Xu-Chen Cao, Xiao-Feng Liu

“…Subtype-specific expression and co-expression, particularly with REXO1, were evaluated using LinkedOmics, TIMER, and bc-GenExMiner. Functional enrichment analysis was conducted via LinkedOmics. …”
Get full text

Metabolomic and lipidomic pathways in aneurysmal subarachnoid hemorrhage by Bosco Seong Kyu Yang, Spiros L. Blackburn, Philip L. Lorenzi, Huimahn A. Choi, Aaron M. Gusdon

“…Aneurysmal subarachnoid hemorrhage (aSAH) results in a complex systemic response that is critical to the pathophysiology of late complications and has important effects on outcomes. Omics techniques have expanded our investigational scope and depth into this phenomenon. …”
Get full text

Comparative and phylogenetic analyses of the chloroplast genomes of mangrove plants by Jigui Yuan, Wei Gu, Haijie Yang, Mei Wang

Get full text

Exploration of Nitrate Reductase Metabolic Pathway in Corynebacterium pseudotuberculosis by Sintia Almeida, Cassiana Sousa, Vinícius Abreu, Carlos Diniz, Elaine M. S. Dorneles, Andrey P. Lage, Debmalya Barh, Vasco Azevedo

Get full text

A Comprehensive Methodological Review of Major Developments in Bioinformatics Pipelines for Transcriptomic Data Analysis by Awais ALi, Syed Luqman Ali, Abdelkarem Omneya

“…Our findings provide valuable guidance for using omics tools effectively and developing better analysis methods. …”
Get full text

Evaluation of the Risk of Recurrence in Patients with Local Advanced Rectal Tumours by Different Radiomic Analysis Approaches by Alaa Khadidos, Adil Khadidos, Olfat M. Mirza, Tawfiq Hasanin, Wegayehu Enbeyle, Abdulsattar Abdullah Hamad

“…The word radiomics, like all domains of type omics, assumes the existence of a large amount of data. …”
Get full text

Effectiveness and safety of metoclopramide in treatment of intractable hiccup: a protocol of systematic review and meta-analysis by Tao Chen, Long Wang, Changyan Zi, Yongxiang Gao, Die Wang, Baocheng Zhang, Baojia Wang

Get full text

A systematic scoping review reveals that geographic and taxonomic patterns influence the scientific and societal interest in urban soil microbial diversity by Simon Masson, Matteo Chialva, Davide Bongiovanni, Martino Adamo, Irene Stefanini, Luisa Lanfranco

“…By coupling bibliometrics with statistical modelling we found that soil microbial traits such as biomass and respiration and omics techniques attract the interest of the scientific community while multi-taxa and time-course studies appeal more to the general public.…”
Get full text

Directed Evolution of Microbial Communities in Fermented Foods: Strategies, Mechanisms, and Challenges by Zihan Yao, Ting Xie, Hongjie Deng, Shuzhi Xiao, Tao Yang

“…Looking ahead, the integration of advanced omics technologies and computational modeling is anticipated to significantly enhance the predictability and control of microbial community evolution in food fermentation processes. …”
Get full text

Breeding for disease resilience: opportunities to manage polymicrobial challenge and improve commercial performance in the pig industry by Xuechun Bai, Graham S. Plastow

“…The next steps for managing polymicrobial challenges faced by the pig industry will include the development of large-scale multi-omics data, new phenotyping technologies, and mathematical and statistical methods adapted to these data. …”
Get full text

The Current Applications of Metabolomics in Understanding Endometriosis: A Systematic Review by Blake Collie, Jacopo Troisi, Martina Lombardi, Steven Symes, Sean Richards

“…This emerging field of omics-based science has proved to be effective at furthering the understanding of endometriosis. …”
Get full text

Impact of Ultraviolet Radiation on Skin and Blood Melanin Traits in Xichou Black-Boned Chicken: A Transcriptomic and Metabolomic Study by Xinlu Li, Zhongxiao Tian, Haojie Li, Lei Tan, Yong Zhang, Changrong Ge, Kun Wang

“…The results showed that an exposure time of 1 h per day at 47 μW/cm² was ideal for enhancing the blackness traits of the chickens, while exposure times exceeding 3 h led to a significant increase in mortality. Omics studies revealed that the mTOR pathway and tryptophan metabolism pathway are potentially involved in the biological processes by which UVA radiation affects the blackness traits of Xichou Black-boned Chickens, with the <i>FZD3</i> gene being a candidate gene for these effects. …”
Get full text

Comprehensive Analysis of the Role of SLC2A3 on Prognosis and Immune Infiltration in Head and Neck Squamous Cell Carcinoma by Manru Chu, Ke Zheng, Xiaojie Li, Zhiqiang Luo, Xin Yang, Changbo Wei

“…Coexpression of SLC2A3 was studied using LinkedOmics and STRING, and enrichment analyses were performed with R software. …”
Get full text

A GDPR-compliant solution for analysis of large-scale genomics datasets on HPC cloud infrastructure by Silvia Gioiosa, Beatrice Chiavarini, Mattia D’Antonio, Giuseppe Trotta, Balasubramanian Chandramouli, Juan Mata Naranjo, Giuseppa Muscianisi, Mirko Cestari, Elisa Rossi

“…Abstract This paper outlines the technical and organizational measures implemented by the Italian supercomputing center, CINECA, to efficiently collect, process, and store sensitive-omics data in compliance with GDPR regulations. Indeed, the explosion of High Throughput Sequencing in medicine has raised tremendous opportunities for large-scale genomic data analysis. …”
Get full text

Groundbreaking Technologies and the Biocontrol of Fungal Vascular Plant Pathogens by Carmen Gómez-Lama Cabanás, Jesús Mercado-Blanco

“…Powerful tools such as next-generation sequencing, meta-omics, and microbiome engineering allow for the targeted manipulation of microbial communities to enhance pathogen suppression. …”
Get full text