Characterisation of the effects of the chemotherapeutic agent paclitaxel on neuropathic pain-related behaviour, anxiodepressive behaviour, cognition, and the endocannabinoid system... by Chiara Di Marino, Chiara Di Marino, Chiara Di Marino, Chiara Di Marino, Álvaro Llorente-Berzal, Álvaro Llorente-Berzal, Álvaro Llorente-Berzal, Alba M. Diego, Alba M. Diego, Alba M. Diego, Ariadni Bella, Ariadni Bella, Ariadni Bella, Laura Boullon, Laura Boullon, Laura Boullon, Esther Berrocoso, Esther Berrocoso, Esther Berrocoso, Michelle Roche, Michelle Roche, Michelle Roche, David P. Finn, David P. Finn, David P. Finn

“…After the induction of the model, pain-related behaviours were assessed using von Frey, Acetone Drop and Hargreaves’ tests, Novel Object Recognition and T-Maze Spontaneous Alternation tests were used for cognition-related behaviours, Elevated Plus Maze, Open Field, and Light Dark Box tests were used to assess anxiety-related behaviours, and Sucrose Preference, Sucrose Splash, and Forced Swim tests for depression-related behaviours. …”
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Bone marrow mesenchymal stem cells derived cytokines associated with AKT/IAPs signaling ameliorate Alzheimer’s disease development by Yalan Lu, Yanfeng Xu, Li Zhou, Siyuan Wang, Yunlin Han, Kewei Wang, Chuan Qin

“…The behavioral tests, including open-field test, novel object recognition test, and Morris water maze were performed, followed by β-amyloidosis plaque and neuron apoptosis analyses. …”
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Protective Mechanism of Alisol A 24-Acetate on Brain Microvascular Endothelial Cells in Mice with Cerebral Ischemia-Reperfusion Injury by TRPM2/Akt/GSK3β Pathway by LI Huihong, DENG Yunfei, WEI Wei, ZHAN Zengtu, LIN Libin, XUE Xiehua

“…Modified neurological severity score (mNSS) was used to evaluate neurological deficit; novel object recognition test (NORT) and Morris water maze (MWM) were used to evaluate the cognitive function; immunofluorescence was used to detect the expression of CD31 in cortex; Western blot was used to detect zonula occludens-1 (ZO-1), Occludin, Claudin-5, phosphorylated nuclear factor kappa-B (p-NF-κB), interleukin-1β (IL-1β) and tumor necrosis factor-α (TNF-α), transient receptor potential melastatin-2 (TRPM2), phosphorylated protein kinase B (p-Akt), phosphorylated glycogen synthetase kinase-3β (p-GSK3β) protein expression levels.Results(1) Neurological function: compared with the sham surgery group, mNSS in the model group significantly increased at the 1st, 3rd, 5th and 7th day (<italic>P</italic>&lt;0.05); compared with the model group, mNSS in the 24A group significantly decreased at the 3rd and 7th day (<italic>P</italic>&lt;0.05). (2) Cognitive function: compared with the sham surgery group, the NORT recognition index at 1st and 24th hour in the model group was significantly lower (<italic>P</italic>&lt;0.05); compared with the model group, the 1-hour and 24-hour NORT recognition index in the 24A group significantly increased (<italic>P</italic>&lt;0.05). …”
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Eye Collateral Channel Characteristic Analysis and Identification Model Construction of Mild Cognitive Impairment by WU Tiecheng, CAO Lei, YIN Lianhua, HE Youze, LIU Zhizhen, YANG Minguang, XU Ying, WU Jinsong

“…The MCI identification model constructed based on the eye collateral channel characteristics and TCM syndrome elements, combined with the support vector machine algorithm, has good feasibility and accuracy, which can provide a basis for the objective recognition of MCI.…”
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