A variant form of receptor activator of nuclear factor-κB functions as an osteoprotegerin mimic in bone and cardiac development by Riko Kitazawa, Ryuma Haraguchi, Sohei Kitazawa

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Osteoclastic activity was associated with the development of steroid-induced osteonecrosis of femoral head by Min-Cong He, Jin Zhang, Xiao-Jun Chen, Ying-Shan Shen, Bin Fang, Yi-Xian Qin, Wei He, Qiu-Shi Wei

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Protective effects of liraglutide on hypercholesterolemia-associated atherosclerosis involve attenuation of endothelial-monocyte adhesion through down-regulating the LOX-1/NF-κB si... by Aiping Wu, Ying Wu, Meiyan Song, Wen Chen, Kaizu Xu, Meifang Wu, Liming Lin

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Stellate ganglion irradiation alleviates airway inflammation in asthmatic mice via activating SIRT1 signaling pathway by Kaixuan Zhao, Haoyue Zhang, Yanbo Liu, Ying Zhou, Juan Zhi, Qianyu Wang, Dong Yang

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The Mechanism of Calcium Handling Proteins and NF-κB in Calcium Dyshomeostasis of Cardiomyocytes Caused by Acute MDMA Exposure by WANG Rong-shuai, HUANG Si-zhe, WANG Yun-yun, DENG Yan-fei, DING Zi-jiao, ZHANG Jie, LIU Yong, REN Liang, LIU Liang

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Immunological mechanism and research progress of peri-implant bone resorption by HE Yehong, FAN Zhen

“…Osteoclasts are currently the only known cells in the human body that can cause bone resorption, so their generation has been used as a clue to sort out several key pathways and factors that regulate this process, such as macrophage polarization, receptor activator of nuclear factor-κB ligand (RANKL) / receptor activator of nuclear factor-κB (RANK) / osteoprotegerin (OPG) pathway and nuclear factor-κB (NF-κB) pathway. …”
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Research progress on the regulation of signal pathways related to lung injury in sepsis by the active components of traditional Chinese medicine by RONG Jilintai*，SU He，ZHANG Ruifen，ZHANG Hairong，JIA Tingting，GUO Sihan，ZHAO Jian，LI Xiao，ZHONG Xin

“…Recent studies have shown that active components of traditional Chinese medicine（TCM）can exert anti⁃inflammatory，anti⁃oxidative stress，anti⁃pyroptosis，and anti⁃ferroptosis effects by regulating signaling pathways such as Toll⁃like receptor 4（TLR4）/nuclear factor κB（NF⁃κB），mitogen⁃activated protein kinase（MAPK），NOD⁃like receptor family pyrin domain containing 3（NLRP3）/caspase⁃1，phosphatidylinositol 3⁃kinase/protein kinase B，and nuclear factor E2⁃related factor 2/heme oxygenase⁃1，thereby alleviating sepsis⁃induced lung injury. …”
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Experimental study of the effect of Zfp260 on the differentiation of osteoclasts in periodontitis by GONG Ruonan, WANG Zuolin

“…The transfected cells were induced into osteoclasts by receptor activator of nuclear factor κB ligand (RANKL） for 7 days. Differentiated cells were harvested for tartrate resistant acid phosphatase (TRAP) staining. …”
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Novel mitophagy inducer TJ0113 alleviates pulmonary inflammation during acute lung injury by Zhengyuan Liu, Danruo Fang, Kaijun Chen, Lingling Dong, Huaqiong Huang, Zhihua Chen

“…Finally, we found that TJ0113 inhibited LPS-induced inflammation by inducing mitophagy and inhibiting nuclear factor κB (NF-κB) and inflammasome activation.ConclusionTJ0113 alleviates LPS-induced inflammation by inducing mitophagy and inhibiting NF-κB and inflammasome activation. …”
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Regulation mechanism of curcumin mediated inflammatory pathway and its clinical application: a review by Meihua Liu, Jingyi Wang, Zhen Song, Yong Pei

“…By searching the databases of Web of Science, PubMed, Google Scholar and CNKI, and integrating the latest research progress, it was found that curcumin exerted its core anti-inflammatory effects mainly by inhibiting the activation of nuclear factor-κB (NF-κB) signaling pathway, regulating the mitogen-activated protein kinase extracellular signal-regulated kinase (ERK) phosphorylation cascade, and regulating the Janus kinase/signal transducer and activator of transcription (JAK/STAT) pathway. …”
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Critical signaling pathways in osteoclast differentiation and bone resorption: mechanisms and therapeutic implications for periprosthetic osteolysis by Liangzi Yin, Liangzi Yin, Chenglin Sun, Junjie Zhang, Yan Li, Yansheng Wang, Yansheng Wang, Lunhao Bai, Zeming Lei, Zeming Lei

“…Emerging evidence highlights the pivotal roles of the RANKL/RANK/OPG axis, nuclear factor-κB (NF-κB) signaling, and mitogen-activated protein kinase/extracellular signal-regulated kinase (MAPK/ERK) cascades in osteoclast differentiation and pathological bone resorption. …”
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The effect of 4-octyl itaconate on lipopolysaccharide-induced murine calvarial osteolysis by WEN Congpeng, TONG Wuyou, CHEN Xuzhuo, LAI Linfeng

“…TRAP staining showed that 4-OI effectively inhibited the osteoclast differentiation induced by receptor activator of nuclear factor κB ligand (RANKL). Micro-CT and histological staining demonstrated that 4-OI effectively alleviated the inflammatory response and bone resorption around the osteolysis site. …”
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Deferoxamine Treatment Effectively Prevents Periodontitis Progression by Reducing Inflammation and Osteoclastogenesis in Experimental Periodontitis Rats by Zhu Y, Qiao S, Pang Y, Wang H, Zhou Y

“…Immunofluorescence and molecular biology methods were employed to assess osteoclast differentiation in RAW264.7 cells after nuclear factor-κB ligand (RANKL) induction. A rat model of periodontitis was es\lished using ligature wires, and alveolar bone loss was assessed via micro-computed tomography. …”
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Effect of lincRNA-EPS on osteoclastogenesis of RAW264.7 cells induced by RANKL and LPS: An experimental study by ZHANG Xu, WANG Yabing, SU Jiansheng

“…[Objective:] To study the effect of long non-coding RNA-EPS (lincRNA-EPS) on osteoclastogenesis of RAW264.7 cells induced by receptor activator for nuclear factor-κB ligand (RANKL) and lipopolysaccharide (LPS). …”
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Adipocyte-derived IL6 and triple-negative breast cancer cell-derived CXCL1 co-activate STAT3/NF-κB pathway to mediate the crosstalk between adipocytes and triple-negative breast ca... by Guo-Tian Ruan, Li-Chen Zhu, Hai-Lun Xie, He-Yang Zhang, Meng-Meng Song, Li Deng, Han-Ping Shi

“…Mature adipose tissue co-cultured with TNBC cells increased the expression and secretion of C-X-C motif chemokine ligand 1 (CXCL1) and upregulated matrix metalloproteinase 7 (MMP7) and MMP9 in TNBC cells by activating the signal transducer and activator of transcription 3 (STAT3) /nuclear factor-κB p65 (NF-κB p65) pathway. Additionally, co-culture activated the STAT3/NF-κB p65 pathway, increasing the expression and secretion of IL6 in adipocytes. …”
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Irisin: Emerging Therapeutic Targets for Cognitive Impairment-Related Diseases by Mei Ma, Guangchan Jing, Yue Tian, Ruiying Yin, Mengren Zhang

“…The signalling pathways through which irisin improves cognitive impairment are complex and highly regulated processes, involving multiple signalling pathways such as the adenosine monophosphate-activated protein kinase (AMPK) signalling pathway, mitogen-activated protein kinase (MAPK) signalling pathway, nuclear factor-κB (NF-κB) signalling pathway, ERK-STAT3 signalling pathway, cAMP/PKA/CREB signalling pathway and Nrf2/HO-1 signalling pathway. …”
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Quercetin regulates phenotypic transformation of vascular smooth muscle cells induced by angiotensin Ⅱ through Nrf2/HO-1 signaling pathway by Mamatimin ABDURESHIT, Wei ZHU

“…QR intervention significantly reduced intracellular ROS level, increased SOD activity, decreased protein expression of vascular cell adhesion molecule-1 (VCAM-1) and phosphorylated nuclear factor-κB (NF-κB), downregulated inflammatory cytokine transcription, upregulated contractile phenotype marker expression, and attenuated apoptosis and migration capacity (P＜0.05). …”
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2′-Fucosyllactose mitigates cognitive deficits in Alzheimer models: targeting amyloid pathology, oxidative stress, and synaptic plasticity by Yeasmin Akter Munni, Khoa Nguyen Tran, Seon-Min Jeon, Meeyul Hwang, Jong-Won Yoon, Young-Ha Song, Tae Woo Oh, Tae Woo Oh, Sang Il Gum, In-Jun Yang

“…In BV2 cells, it suppressed d-galactose-induced neuroinflammation by downregulating TNF-α and IL-6, and nuclear factor-κB signaling. In PHNs, 2′-FL reduced oxidative stress, restored mitochondrial function, and limited DNA damage. …”
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Novel and Highly Potent Therapeutic Agent, Trametes Robiniophila Murr (Huaier), Mitigates Pulmonary Vascular Remodeling in Rodents by Huangshu Ye, Yue Zhang, Li Hu, Yuxin Feng, Tianfan Zhu, Qi Meng, Xiaoxuan Sun, Miaojia Zhang, Zhengsheng Mao, Feng Chen, Yanfang Yu, Qiang Wang, Jie Wang

“…Mechanistically, Huaier treatment was found to significantly inhibit the Hif1α (hypoxia‐inducible factor 1‐alpha) signaling pathway, thereby reducing excessive lactate accumulation and abnormal glycolysis, and the NF‐κB (nuclear factor κB) signaling pathway, thereby diminishing inflammatory responses. …”
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Nanorough Surface of Fibronectin Grafted Bioactive Zirconia Dental Implants by Using Glow Discharge Plasma Promotes Osseointegration in a Rabbit Model by Aung LM, Renn TY, Lin JCY, Salamanca E, Wu YF, Pan YH, Teng NC, Huang HM, Sun YS, Chang WJ

“…Osteoprotegerin (OPG) expression increased at 8 weeks, while runt-related transcription factor 2 (RUNX2), collagen 1A1 (COL1), bone sialoprotein (BSP), and receptor activator of nuclear factor κ B (RANK) exhibited the highest expression at 12 weeks. …”
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