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14161
Multi-omics analysis reveals the interplay between intratumoral bacteria and glioma
Published 2025-01-01“…These findings offer valuable insights into the intricate interplay between intratumoral bacteria and glioma, offering novel inspiration to the realm of glioma biology.…”
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14162
EUFOREA meeting on defining disease states in allergic rhinitis: towards a unified language in AR
Published 2025-02-01“…The European Forum for Research and Education in Allergy and Airway Diseases (EUFOREA) convened a meeting of experts and patient representatives to deliberate the optimal methodology for measuring AR treatment responses and establishing novel treatment goals. This paper presents a consensus on revised AR definitions, including control, severe allergic rhinoconjunctivitis (SARC), refractory severe allergic rhinoconjunctivitis (R-SARC), remission, resolution, improvement, exacerbation, treatable traits (TTs), treat to target, relapse, progression, disease modification, and prevention.…”
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14163
The Eczema Bathing Study: Weekly versus daily bathing for people with eczema? Protocol of an online, randomised controlled trial [version 2; peer review: 1 approved, 2 approved wit...
Published 2025-01-01“…The Rapid Eczema Trials project is a novel programme of research that aims to deliver multiple online RCTs, using a citizen science approach. …”
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14164
Adherence to a digital therapeutic mediates the relationship between momentary self-regulation and health risk behaviors
Published 2025-02-01“…However, the role of momentary self-regulation in achieving behavior change has been infrequently examined. Using a novel momentary self-regulation scale, this study examined how targeting self-regulation through a digital therapeutic impacts adherence to the therapeutic and two different health risk behavioral outcomes.MethodsThis prospective interventional study included momentary data for 28 days from 50 participants with obesity and binge eating disorder and 50 participants who smoked regularly. …”
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14165
Genetic Mutations of Tim-3 Ligand and Exhausted Tim-3+ CD8+ T Cells and Survival in Diffuse Large B Cell Lymphoma
Published 2020-01-01“…Furthermore, we defined a novel subtype of exhausted T cells, named as exhausted Tim-3+ CD8+ T cells, and found that patients with exhausted Tim-3+ CD8+ T cells (median survival, 62.8 months, 95% CI: 50.0–75.6) exhibited shorter survival than those with nonexhausted Tim-3- CD8+ T cells (median survival, 82.5 months, 95% CI: 72.0–92.9; p=0.034). …”
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14166
N6-methyladenosine RNA modification regulates the transcription of SLC7A11 through KDM6B and GATA3 to modulate ferroptosis
Published 2025-01-01“…This study provides a novel potential strategy and experimental support for the future treatment of cancer.…”
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14167
Editorial
Published 2019-07-01“…Drawing on social network and political participation theory and novel survey data from Belgium, Paulis explores what network patterns contribute to young people’s enrolment in a political party. …”
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14168
Quantifying the spatial patterns of retinal ganglion cell loss and progression in optic neuropathy by applying a deep learning variational autoencoder approach to optical coherence...
Published 2025-02-01“…Disease classification yielded AUCs of 0.95 for glaucoma, 0.84 for ON, and 0.93 for NAION, with bLVs further increasing the AUCs to 0.96 for glaucoma, 0.93 for ON, and 0.99 for NAION.ConclusionThis study presents a novel approach to visualizing and quantifying GCL thinning patterns in optic neuropathies using the bVAE model. …”
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14169
Blood biomarker dynamics in people with relapsing multiple sclerosis treated with cladribine tablets: results of the 2-year MAGNIFY-MS study
Published 2025-02-01“…The safety profile was consistent with previous reports.DiscussionDeep longitudinal immunophenotyping, analysis of transcriptional changes, reduction in cells expressing pro-inflammatory cytokines, along with the marker of neuroaxonal damage provide novel and innovative evidence of CladT rebalancing the immune system towards a more homeostatic and less pathogenic state.Clinical Trial Registrationhttps://clinicaltrials.gov/study/, identifier NCT03364036.…”
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14170
Studying the Oncolytic Activity of <i>Streptococcus pyogenes</i> Strains Against Hepatoma, Glioma, and Pancreatic Cancer <i>In Vitro</i> and <i>In Vivo</i>
Published 2025-01-01“…Conventional treatment modalities, including radiation and chemotherapy, often fall short of achieving complete remission, highlighting the critical need for novel therapeutic strategies. One promising approach involves the oncolytic potential of Group A <i>Streptococcus</i> (GAS) strains for tumor treatment. …”
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14171
Cell-Free Strategies for Repair and Regeneration of Meniscus Injuries through the Recruitment of Endogenous Stem/Progenitor Cells
Published 2018-01-01“…The use of tissue engineering and regenerative medicine techniques may offer novel and effective approaches to repairing meniscal injuries. …”
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14172
Methicillin-Resistant <i>Staphylococcus aureus</i>: The Shifting Landscape in the United Arab Emirates
Published 2025-01-01“…The PVL-negative CC772-MRSA-V/VT was identified, representing its first report in the UAE. A novel variant, CC361-MRSA-IV (<i>tst1</i>+/PVL+), was identified. …”
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14173
LGR4 is essential for maintaining β-cell homeostasis through suppression of RANK
Published 2025-02-01“…Conclusions: These data demonstrate a novel role for LGR4 as a positive regulator of β-cell health under basal and stress-induced conditions, through suppressing the negative effects of RANK.…”
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14174
Genome-wide linkage mapping of Fusarium crown rot in common wheat (Triticum aestivum L.)
Published 2024-11-01“…Notably, QFCR.caas-5BL and QFCR.caas-6BS had been previously detected, whereas QFCR.caas-3AL, QFCR.caas-3DL, and QFCR.caas-7DS are novel loci. The favorable alleles of QFCR.caas-3DL and QFCR.caas-5BL were contributed by Zhoumai 16, while the favorable alleles for QFCR.caas-3AL, QFCR.caas-6BS, and QFCR.caas-7DS originated from Gaocheng 8901. …”
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14175
Voice EHR: introducing multimodal audio data for health
Published 2025-01-01“…Existing technologies depend on limited datasets collected with expensive recording equipment in high-income countries, which challenges deployment in resource-constrained, high-volume settings where audio data may have a profound impact on health equity.MethodsThis report introduces a novel protocol for audio data collection and a corresponding application that captures health information through guided questions.ResultsTo demonstrate the potential of Voice EHR as a biomarker of health, initial experiments on data quality and multiple case studies are presented in this report. …”
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14176
Mitral Valve Repair
Published 2025-03-01“…The primary outcomes were long-term survival, freedom from reoperation, and freedom from recurrent mitral regurgitation (moderate-severe). A novel meta-analytic volume-outcome approach using reconstructed Kaplan-Meier-derived individual patient data from the original studies was used. …”
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14177
Investigating and Completing Khanlari’s Theory on Metrical Units
Published 2024-12-01“…This study demonstrates that by completing and refining Khanlari’s approach, it is capable of describing Persian poetic meter, providing a novel understanding of the nature of metrical patterns, and can aid in simplifying the teaching of prosody while deepening its comprehension. …”
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14178
Single-Photon Detectors for Quantum Integrated Photonics
Published 2024-12-01“…This review explores the state of the art of single-photon detector research and examines the potential breakthroughs offered by novel low-dimensional materials in this field.…”
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14179
Triglyceride-glucose-body mass index and the incidence of cardiovascular diseases: a meta-analysis of cohort studies
Published 2025-01-01“…This study aims to summarize the correlation between the triglyceride-glucose-body mass index (TyG-BMI index), a novel surrogate indicator of insulin resistance, and the incidence of CVD in patients without CVD at baseline through meta-analysis. …”
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14180
WALLABY Pilot Survey: Star Formation Enhancement and Suppression in Gas-rich Galaxy Pairs
Published 2025-01-01“…We obtain individual masses of atomic hydrogen (H i ) for these paired galaxies using a novel deblending algorithm for H i data cubes. Quantifying the interaction stages and strengths with parameters motivated by first-principles analysis, we find that, at fixed stellar and H i mass, the alteration in the SFR of galaxy pairs starts when their dark matter halos are encountered. …”
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