Chronic Stress‐Induced and Tumor Derived SP1+ Exosomes Polarizing IL‐1β+ Neutrophils to Increase Lung Metastasis of Breast Cancer by Leyi Zhang, Jun Pan, Meijun Wang, Jini Yang, Sangsang Zhu, Lili Li, Xiaoxiao Hu, Zhen Wang, Liwei Pang, Peng Li, Fang Jia, Guohong Ren, Yi Zhang, Danying Xu, Fuming Qiu, Jian Huang

“…Collectively, this study provides a novel mechanism by which neutrophils within a pre‐metastatic niche acquire their inflamed phenotype and establishes an important link among neuroendocrine changes, exosomes, immunity, and metastasis.…”
Get full text

Immunogenic dying cells elicit potent anti-tumor T cell immunity against lung metastasis and tumorigenesis by Min Hu, Xinyu Meng, Tong Wang, Yifan Wang, Xiaodong Chen, Dongliang Xu, Wei He, Hongjia Zhang, Wenzheng Guo, Bo Jing, Siwei Zhang, Jianhua Xu, Beibei Sun, Xueqian Sun, Tingting Liu, Na Ni, Tongtong Zhang, Wenwen Cui, Xiaoyu Wu, Liping Xia, Feng Yao, Fang Zhang, Jing Du, Jiong Deng

“…Conclusion Immunization with the ICD dying tumor cells evokes potent tumor-specific T cell immunity, which provides a novel approach for cancer immunotherapy.…”
Get full text

Neurological sequelae of long COVID: a comprehensive review of diagnostic imaging, underlying mechanisms, and potential therapeutics by Grant McGee Talkington, Grant McGee Talkington, Paresh Kolluru, Timothy E. Gressett, Timothy E. Gressett, Saifudeen Ismael, Umar Meenakshi, Mariana Acquarone, Rebecca J. Solch-Ottaiano, Amanda White, Blake Ouvrier, Blake Ouvrier, Kristina Paré, Nicholas Parker, Amanda Watters, Nabeela Siddeeque, Brooke Sullivan, Nilesh Ganguli, Victor Calero-Hernandez, Gregory Hall, Michele Longo, Gregory J. Bix, Gregory J. Bix, Gregory J. Bix, Gregory J. Bix

“…In this review, we explore the mechanistic hypotheses of these neurological changes, which describe CNS invasion, neuroinflammation, blood-brain barrier disruption, and gut-brain axis dysregulation, along with the novel vascular disruption hypothesis that highlights endothelial dysfunction and hypoperfusion as a core underlying mechanism. …”
Get full text

Ellagic Acid from <i>Geranium thunbergii</i> and Antimalarial Activity of Korean Medicinal Plants by Hojong Jun, Joon-Hee Han, Min Hong, Fadhila Fitriana, Jadidan Hada Syahada, Wang-Jong Lee, Ernest Mazigo, Johnsy Mary Louis, Van-Truong Nguyen, Seok Ho Cha, Wanjoo Chun, Won Sun Park, Se Jin Lee, Sunghun Na, Soo-Ung Lee, Eun-Taek Han, Tae-Hyung Kwon, Jin-Hee Han

“…These findings suggest that ellagic acid could serve as a promising lead compound for developing a novel antimalarial agent. This study highlights the importance of exploring plant-based compounds as alternative strategies against drug-resistant malaria. …”
Get full text

Mechanisms underlying the effects of cyanogenesis on development and reproduction of Tetranychus urticae: Insights from enzyme activity and gene expression aspects by Mufeng Wu, Xiao Liang, Ying Liu, Chunling Wu, Xingkui An, Zihua Zhao, Guifeng Hao, Ijiti Oluwole Gregory, Zhihong Li, Qing Chen

“…The present findings can provide insight regarding reasonable utilization of toxic chemicals in pest management and creation of novel pest-resistant germplasm.…”
Get full text

Nitidine chloride inhibits the progression of hepatocellular carcinoma by suppressing IGF2BP3 and modulates metabolic pathways in an m6A-dependent manner by Dan-dan Xiong, Zhen-dong Chen, Jian-di Li, Yu-long Deng, Rong-quan He, Zhi-guang Huang, San-qi An, Yi-wu Dang, Gang Chen

“…Such insights provide a new direction in the study of NC’s anti-HCC mechanisms and offer novel perspectives for the treatment of HCC patients, focusing on both metabolic levels and m6A modification levels.…”
Get full text

Impacts of plant root traits and microbial functional attributes on soil respiration components in the desert-oasis ecotone by Jinlong Wang, Jinlong Wang, Jinlong Wang, Guanghui Lv, Guanghui Lv, Guanghui Lv, Jianjun Yang, Jianjun Yang, Jianjun Yang, Xuemin He, Xuemin He, Xuemin He, Hengfang Wang, Hengfang Wang, Hengfang Wang, Wenjing Li, Wenjing Li, Wenjing Li

“…Collectively, these findings suggest that a trait-based approach holds great promise in more effectively revealing the response mechanisms of Rs composition to environmental changes, thereby offering novel vistas for future investigations into carbon cycling in terrestrial soils.…”
Get full text

Partially Isolated Dual Work Function Gate IGZO TFT With Obviously Reduced Leakage Current for 3D DRAMs by Yunjiao Bao, Gangping Yan, Lei Cao, Chuqiao Niu, Qingkun Li, Guanqiao Sang, Lianlian Li, Yanzhao Wei, Xuexiang Zhang, Jie Luo, Yanyu Yang, Gaobo Xu, Huaxiang Yin

“…Moreover, the pronounced novel structure has mitigated parasitic capacitance, thereby leading to a notable 47.7% reduction in write latency within dynamic-random-access-memory (DRAM) circuits. …”
Get full text

Multiomics unravels the complexity of male obesity: a prospective observational study by Georgios E. Papadakis, Lucie Favre, Yassine Zouaghi, Nathalie Vionnet, Nicolas J. Niederländer, Michela Adamo, James S. Acierno, Dassine Berdous, Alexia Boizot, Jenny Meylan, Julijana Ivanisevic, Emmanuelle Paccou, Hector Gallart-Ayala, Tim Reyns, Elise Van Caeneghem, Bruno Lapauw, Jérôme Pasquier, Yasser Aleman, Styliani Mantziari, Olivier Salamin, Raul Nicoli, Tiia Kuuranne, Tom Fiers, Patric Hagmann, Federico Santoni, Andrea Messina, Nelly Pitteloud

“…Conclusions Combining clinical, biochemical, and molecular markers allows adequate stratification of metabolic risk in men with obesity and provides novel tools for personalized care.…”
Get full text

Targeting estrogen-regulated system xc − promotes ferroptosis and endocrine sensitivity of ER+ breast cancer by Jiawei Cao, Tong Zhou, Tao Wu, Rixu Lin, Ju Huang, Dejin Shi, Jiawei Yu, Yinrui Ren, Changrui Qian, Licai He, Guang Wu, Zhixiong Dong, Shaofei Yuan, Haihua Gu

“…In conclusion, our data reveal that targeting estrogen-regulated SLC7A11 and SLC3A2 enhances ferroptosis in ER+ breast cancer, offering a novel therapeutic option for patients with ER+ breast cancer, particularly those with endocrine resistance.…”
Get full text

Redefining NSP12 activity in SARS-CoV-2 and its regulation by NSP8 and NSP7 by Deepa Singh, Tushar Kushwaha, Rajkumar Kulandaisamy, Vikas Kumar, Kamal Baswal, Saras H. Tiwari, Arkadyuti Ghorai, Manoj Kumar, Saroj Kumar, Soumya De, Aparoy Polamarasetty, Deepak Sehgal, Madhumohan R. Katika, Suresh Gadde, Marceline Côté, Sarala R. Kayampeta, Mohan Babu Appaiahgari, Krishna K. Inampudi

“…These findings have implications for novel drug development, and compounds inhibiting NSP7 or NSP8 interactions with NSP12 can be lethal to coronavirus replication.…”
Get full text

Irisin regulates oxidative stress and mitochondrial dysfunction through the UCP2-AMPK pathway in prion diseases by Pei Wen, Zhixin Sun, Dongming Yang, Jie Li, Zhiping Li, Mengyang Zhao, DongDong Wang, Fengting Gou, Jingjing Wang, Yuexin Dai, Deming Zhao, Lifeng Yang

“…These results suggest that irisin represents a novel and promising therapeutic approach for treating prion diseases.…”
Get full text

IMMUnity Unveiled: A Translational NETwork for tackling PARKinson's Disease – IMMUPARKNET [version 2; peer review: 2 approved] by Tamara Saksida, Alessia di Flora, Marina Romero-Ramos, Vladimirs Pilipenko, Laura Muñoz Delgado, Franca Marino, Yasemin Gursoy Ozdemir, Neda Nikolovski, Cristoforo Comi, Dale Lawson, Inês Figueira, Mitilda Gugu, Simona Poletti, Shubhra Acharya, Dogukan Pira

“…IMMUPARKNET output will facilitate the improved sharing and development of research resources, straightening the road to novel treatments and identifying where existing ones can be repurposed, all, ultimately and hopefully, finding a cure for PD.…”
Get full text

Timp2 loss-of-function mutation and TIMP2 treatment in a murine model of NSCLC: Modulation of immunosuppression and oncogenic signaling by David Peeney, Sarvesh Kumar, Tej Pratap Singh, Yueqin Liu, Sandra M. Jensen, Ananda Chowdhury, Sasha Coates-Park, Joshua Rich, Sadeechya Gurung, Yu Fan, Daoud Meerzaman, William G. Stetler-Stevenson

“…In summary, we describe how TIMP2 exerts novel, anti-tumor effects in a murine model of lung cancer and that rTIMP2 treatment supports a normalizing effect on the tumor microenvironment. …”
Get full text

Classification and diagnosis of cervical lesions based on colposcopy images using deep fully convolutional networks: A man-machine comparison cohort study by Binhua Dong, Huifeng Xue, Ye Li, Ping Li, Jiancui Chen, Tao Zhang, Lihua Chen, Diling Pan, Peizhong Liu, Pengming Sun

“…This was a man–machine comparison cohort study. It presents a novel artificial intelligence (AI) model for the diagnosis of cervical lesions through colposcopy images using a Dense-U-Net image semantic segmentation algorithm. …”
Get full text

The triglyceride-glucose index trajectories are associated with cardiovascular diseases in people living with HIV: evidence from a prospective cohort study in China, 2005–2022 by Yinsong Luo, Liqin Sun, Yun He, Fang Zhao, Duo Shan, Fan Bu, Lingyun Ge, Xiaorui Li, Yiyao Hu, Xi Xiao, Hongzhou Lu, Jiaye Liu

“…Abstract Background The triglyceride-glucose (TyG) index has been validated as a novel biomarker for cardiovascular disease (CVD) risk. …”
Get full text

Individual-network based predictions of microbial interaction signatures for response to biological therapies in IBD patients by Federico Melograna, Padhmanand Sudhakar, Behnam Yousefi, Behnam Yousefi, Clara Caenepeel, Gwen Falony, Gwen Falony, Gwen Falony, Sara Vieira-Silva, Sara Vieira-Silva, Sara Vieira-Silva, Sreenikhitha Krishnamoorthy, David Fardo, Bram Verstockt, Bram Verstockt, Jeroen Raes, Jeroen Raes, Severine Vermeire, Severine Vermeire, Kristel Van Steen

“…This study introduces a novel approach using Individual Specific Networks (ISNs) derived from faecal microbial measurements of IBD patients across multiple cohorts. …”
Get full text

Development of a sustainable, green, and solar-powered filtration system for E. coli removal and greywater treatment by R. Abdallat, A.N. Bdour, A. Abu Haifa, F.F. Al-Rawash, L. Almakhadmeh, S. Hazaimeh

“…The system also uses hot water generated by a Photovoltaic solar system to sanitize the greywater, a novel concept of approach for sanitization. This innovative system is powered entirely by solar energy and can be installed in individual homes.FINDINGS:  The results of the developed solar filtration system were very efficient in reducing turbidity, chemical oxygen demand, and Escherichia coli removal: 92, 95, and 100 percent, respectively. …”
Get full text

The origin and transmission of HIV-1 CRF80_0107 among two major first-tier cities in China by Xiaorui Wang, Bo Zhu, Hanping Li, Jingwan Han, Xiaolin Wang, Lei Jia, Bohan Zhang, Jingyun Li, Linding Wang, Yongjian Liu, Hongling Wen, Lin Li

“…This highlights the importance of continuous monitoring for the emergence and dynamic changes of novel HIV-1 recombinant viruses and the necessity of implementing effective preventive measures targeting specific populations in particular regions.…”
Get full text

CircTTC13 promotes sorafenib resistance in hepatocellular carcinoma through the inhibition of ferroptosis by targeting the miR-513a-5p/SLC7A11 axis by Ying Zhang, Ruiwei Yao, Mingyi Li, Chongkai Fang, Kunliang Feng, Xiuru Chen, Jinan Wang, Rui Luo, Hanqian Shi, Xinqiu Chen, Xilin Zhao, Hanlin Huang, Shuwei Liu, Bing Yin, Chong Zhong

“…Through circRNA sequencing, we identified a novel hsa_circ_0000195 (circTTC13) that is overexpressed in HCC tissues. …”
Get full text