Neurotoxic Effect of Myricitrin in Copper-Induced Oxidative Stress Is Mediated by Increased Intracellular Ca²⁺ Levels and ROS/p53/p38 Axis by Ignacija Vlašić, Antonio Krstačić-Galić, Anđela Horvat, Nada Oršolić, Anja Sadžak, Lucija Mandić, Suzana Šegota, Maja Jazvinšćak Jembrek

“…Although commonly appreciated for their anti-oxidative and neuroprotective properties, flavonoids can also exhibit pro-oxidative activity, potentially reducing cell survival, particularly in the presence of metal ions. …”
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Tripchlorolide May Improve Spatial Cognition Dysfunction and Synaptic Plasticity after Chronic Cerebral Hypoperfusion by Zhao-Hui Yao, Xiao-li Yao, Shao-feng Zhang, Ji-chang Hu, Yong Zhang

“…Tripchlorolide (TRC) is an herbal compound with potent neuroprotective effects. The potential of TRC to improve CCH-induced cognitive impairment has not yet been determined. …”
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Deferiprone ameliorates cisplatin induced peripheral neurotoxicity via ferritinophagy adjustment by Hanan Seddiek, Mira Hanna, Amany Elsayed Mohamed Hamoud, Marawan Abd Elbaset, Ahmed M. A. Akabawy, Mohamed Zakaria Kotb, Mohamed Mansour Khalifa

“…So, we aimed to use iron chelator as a new strategy based on an anti-ferroptotic mechanism and to evaluate its neuroprotective effect against polyneuropathy in Cisplatin-treated rats. …”
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Physical Activity and Quality of Life in Retinitis Pigmentosa by Joshua D. Levinson, Ethan Joseph, Laura A. Ward, Joe R. Nocera, Machelle T. Pardue, Beau B. Bruce, Jiong Yan

“…Aerobic exercise has been found to be neuroprotective in animal models of retinal degeneration. …”
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Plasma brain-related biomarkers and potential therapeutic targets in pediatric ECMO by Sue J. Hong, Bradley J. De Souza, Kristen K. Penberthy, Lisa Hwang, David E. Procaccini, John N. Kheir, Melania M. Bembea

“…Understanding these mechanisms of injury through biomarker analysis supports potential neuroprotective strategies such as individualized blood pressure targets, judicious hypercarbia and hypoxemia correction, and immunomodulation (inhaled hydrogen and N-acetylcysteine). …”
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Electroacupuncture Therapy Effectively Protects the Rat Brain after Intracerebral Hemorrhage by Li Huang, Xuehui Fan, Yao Chen, Heng Lin, Xiaoqian Jiang, Chaoxian Yang

“…The results of this study suggest that Ea may exert neuroprotective effects by suppressing brain edema, apoptosis, excitotoxicity, and neuroinflammation.…”
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Phytochemistry and pharmacological advances of Ascophyllum nodosum in the management of human diseases: A comprehensive review by Brijesh Singh Chauhan, Yash Pal Singh

“…It contains a variety of biologically active phyto-compounds that show a vast array of pharmacological properties, including anti-inflammatory, anti-cardiovascular, anti-oxidant, anti-cancer, anti-diabetic, anti-periodontal, anti-microbial, anti-goiter, neuroprotective, and immunomodulatory effect, etc. Purpose: This comprehensive review divulges the existing knowledge from research literature on Ascophyllum nodosum extract (ANE) and offers suggestions for future research on its potential against human diseases. …”
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Comprehensive Analysis of Metabolic Changes in Mice Exposed to Corilagin Based on GC-MS Analysis by Xu B, Wang C, Zhu X, Zhu L, Han G, Cui C

“…And 12 key pathways involving glucose metabolism, lipid metabolism, and amino acid metabolism were identified following Corilagin treatment.Conclusion: This research provides insight into the action mechanism of Corilagin’s anti-oxidative, anti-inflammatory, anti-atherosclerotic, hepatoprotective, anti-tumor, and neuroprotective properties. Keywords: Corilagin, gas chromatography-mass spectrometry, metabolomics, amino acids, pharmacological mechanism…”
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Ginkgetin delays the progression of osteoarthritis by inhibiting the NF-κB and MAPK signaling pathways by Liang Zhu, Yanchi Bi, Ting Liang, Po Zhang, Xiao Xiao, Tengbo Yu

“…Ginkgetin (GK), a natural non-toxic chemical, has proven anti-inflammatory, antioxidant, anti-tumor, and neuroprotective effects. Methods First, this study utilizes network pharmacology to explore the intrinsic connection between GK and OA. …”
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Stem Cell–Based Therapies via Different Administration Route for Stroke: A Meta-analysis of Comparative Studies by Gabriella Jeanne Mulia, Novelia Anna, John Chung-Che Wu, Hon-Ping Ma, Yung-Hsiao Chiang, Ju-Chi Ou, Kai-Yun Chen

“…Stem cell–based therapies, with their neuroprotective and regenerative properties, present a promising yet highly diverse alternative. …”
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Therapeutic Potential of Agmatine in Essential Tremor Through Regulation of Lingo‐1 and Inflammatory Pathways by Zeynab Pirmoradi, Zahra Esmaili, Mohsen Nakhaie, Kristi A. Kohlmeier, Mohammad Shabani, Moazamehosadat Razavinasab, Mehran Ilaghi

“…The ability of agmatine to normalize Lingo‐1 and IL‐6 expression suggests regulation of these pathways could underlie its neuroprotective action. These results suggest promise for agmatine as a prospective therapeutic agent in ET.…”
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Stem Cell Therapy for the Treatment of Amyotrophic Lateral Sclerosis: Comparison of the Efficacy of Mesenchymal Stem Cells, Neural Stem Cells, and Induced Pluripotent Stem Cells by Lauren Frawley, Noam Tomer Taylor, Olivia Sivills, Ella McPhillamy, Timothy Duy To, Yibo Wu, Beek Yoke Chin, Chiew Yen Wong

“…Results: MSCs, derived from various tissues, show neuroprotective and regenerative qualities, with clinical trials suggesting potential benefits but limited by small sample sizes and non-randomised designs. …”
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Radix Scutellariae Ameliorates Stress-Induced Depressive-Like Behaviors via Protecting Neurons through the TGFβ3-Smad2/3-Nedd9 Signaling Pathway by Fan Zhao, Chenyiyu Zhang, Dong Xiao, Weihua Zhang, Liping Zhou, Simeng Gu, Rong Qu

“…Depressive-like behaviors were evaluated by the sucrose preference test (SPT), forced swimming test (FST), open field test (OFT), and tail suspension test (TST). The neuroprotective effect of RS was evaluated with the expression of hippocampal neuron-related markers and apoptosis-associated proteins by Nissl staining, immunohistochemistry, and western blot. …”
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Melatonin supplementation for the treatment of infantile spasms: protocol for a randomised placebo-controlled triple-blind trial by Jing Wang, Tao Xu, Miao Liu, Jian Chen, Guang Yang, Weiwei Feng, Yulin Sun, Xiuyu Shi, Liping Zou

“…Melatonin has also been found to have anticonvulsant and neuroprotective properties by adjusting the circadian rhythm. …”
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The role of CXCL12/CXCR4/CXCR7 axis in cognitive impairment associated with neurodegenerative diseases by Rojin Sarallah, Shima Jahani, Alireza Soltani Khaboushan, Amir Kian Moaveni, Maryam Amiri, Masoumeh Majidi Zolbin

“…Emerging evidence suggests that modulating this axis could provide neuroprotective effects and potentially alleviate cognitive symptoms. …”
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Cerebral Microhemorrhages in Children With Congenital Heart Disease: Prevalence, Risk Factors, and Association With Neurodevelopmental Outcomes by Kristen N. Andersen, Sicong Yao, Brian R. White, Marin Jacobwitz, Jake Breimann, Jharna Jahnavi, Alexander Schmidt, Wesley B. Baker, Tiffany S. Ko, J. William Gaynor, Arastoo Vossough, Rui Xiao, Daniel J. Licht, Evelyn K. Shih

“…However, the presence of CMH on preoperative scans indicates yet unidentified nonperioperative risk factors. Neuroprotective strategies to mitigate CMH risk may improve neurodevelopmental outcomes in this vulnerable population.…”
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Identification and Analysis of Components in Yizhi Granule and Cynomolgus Monkey Plasma after Oral Administration by UPLC/ESI-Q-TOF MS and Their Protective Effects on PC12 Cells by Erwei Hao, Jianfeng Qin, Wei Wei, Jianhua Miao, Yan Xie, Xianglong Pan, Hangxuan Wu, Jinling Xie, Xiaosu Fan, Zhengcai Du, Xiaotao Hou, Jiagang Deng

“…Next, to study the therapeutic properties of YZG, the neuroprotective effect of some of the absorbed components was evaluated using PC12 cell damage caused by the Aβ25–35 model. …”
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Polyunsaturated Fatty Acid and S-Adenosylmethionine Supplementation in Predementia Syndromes and Alzheimer's Disease: A Review by Francesco Panza, Vincenza Frisardi, Cristiano Capurso, Alessia D'Introno, Anna M. Colacicco, Alessandra Di Palo, Bruno P. Imbimbo, Gianluigi Vendemiale, Antonio Capurso, Vincenzo Solfrizzi

“…Therefore, these findings underscored the critical role of SAM in maintenance of neuronal health, suggesting a possible role of SAM as a neuroprotective dietary supplement for AD patients. In fact, very recent studies on early-stage AD patients and moderate- to late-stage AD patients were conducted with a nutriceutical supplementation that included SAM, with promising results. …”
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Repressor Element 1 Silencing Transcription Factor (REST) Governs Microglia-Like BV2 Cell Migration via Progranulin (PGRN) by Tongya Yu, Yingying Lin, Yuzhen Xu, Yunxiao Dou, Feihong Wang, Hui Quan, Yanxin Zhao, Xueyuan Liu

“…The repressor element-1 silencing transcription factor (REST), a powerful transcriptional factor, was found to play a neuroprotective role in AD. Despite its possible role in disease progression, little is known about whether REST participates in microglia migration. …”
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Recent Advances in the Mechanisms of Postoperative Neurocognitive Dysfunction: A Narrative Review by Tingting Wang, Xin Huang, Shujun Sun, Yafeng Wang, Linlin Han, Tao Zhang, Tianhao Zhang, Xiangdong Chen

“…Propofol and dexmedetomidine demonstrate neuroprotective properties by suppressing neuroinflammation and microglial activation, whereas inhalational anesthetics like sevoflurane intensify oxidative stress and inflammatory responses. …”
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