S100A8-CAMKK2-AMPK axis confers the protective effects of mild hypothermia against cerebral ischemia-reperfusion injury in rats by Dandan Zhang, Yuting Dai, Xiaoyan Xu, Fuguo Ma, Mingshan Wang, Weiwei Qin

“…Abstract To investigate the neuroprotective mechanism of mild hypothermia (MH) in ameliorating cerebral ischemia reperfusion (IR) injury. …”
Get full text

Microalgae, a Potential Natural Functional Food Source – a Review by Villarruel-López Angélica, Ascencio Felipe, Nuño Karla

“…The importance of algal lipids is based on their polyunsaturated fatty acids, their anti-inflammatory effects, their modulation of lipid pathways, and their neuroprotective action. Microalgae peptides can bind or inhibit specific receptors in cardiovascular diseases and cancer, while carotenoids can act as potent antioxidants. …”
Get full text

Prebiotic Properties of Dates and Their Impact on Health by Ahmad Alhomsi, Mukaddes Kılıç Bayraktar

“…Beyond gut health, dates offer additional benefits, including anti-inflammatory, antioxidant, cardiovascular, neuroprotective, and blood sugar-regulating effects. This review synthesizes recent findings on the prebiotic effects and broader health impacts of dates, suggesting their potential in dietary strategies for promoting health and preventing gastrointestinal disorders.…”
Get full text

Epigenetic Modulation of Microglia Function and Phenotypes in Neurodegenerative Diseases by Li Wang, Chao-Chao Yu, Xin-Yuan Liu, Xiao-Ni Deng, Qing Tian, Yan-Jun Du

“…Accumulating evidence indicates that microglia play both neuroprotective and detrimental roles in the onset and progression of NDDs. …”
Get full text

Age-Related Macular Degeneration (AMD) Transmitochondrial Cybrids Protected from Cellular Damage and Death by Human Retinal Progenitor Cells (hRPCs) by Jeffrey J. Yu, Daniel B. Azzam, Marilyn Chwa, Kevin Schneider, Jang-Hyeon Cho, Chinhui Hsiang, Henry Klassen, M. Cristina Kenney, Jing Yang

“…Furthermore, hRPCs cocultured with AMD cybrids showed upregulation of (1) neuronal and glial markers, as well as (2) putative neuroprotective factors, responses not found when hRPCs were cocultured with age-matched normal cybrids. …”
Get full text

Exosomes Derived from CXCR4-Overexpressing BMSC Promoted Activation of Microvascular Endothelial Cells in Cerebral Ischemia/Reperfusion Injury by Xutong Li, Ye Zhang, Yong Wang, Dan Zhao, Chengcheng Sun, Shaoting Zhou, Dongsheng Xu, Jing Zhao

“…Ischemic stroke is a severe acute cerebrovascular disease which can be improved with neuroprotective therapies at an early stage. However, due to the lack of effective neuroprotective drugs, most stroke patients have varying degrees of long-term disability. …”
Get full text

Controversies in the Anesthetic Management of Intraoperative Rupture of Intracranial Aneurysm by Tumul Chowdhury, Andrea Petropolis, Marshall Wilkinson, Bernhard Schaller, Nora Sandu, Ronald B. Cappellani

“…The third controversy pertains to hemodynamic goals. The neuroprotective effects of various factors, including hypothermia, various anesthetic/pharmacologic agents, and burst suppression, remain poorly understood and have yet to be further elucidated. …”
Get full text

The Role of the Innate Immune System in Alzheimer’s Disease and Frontotemporal Lobar Degeneration: An Eye on Microglia by Elisa Ridolfi, Cinzia Barone, Elio Scarpini, Daniela Galimberti

“…While short-term microglial activity has generally a neuroprotective role, chronic activation has been implicated in the pathogenesis of neurodegenerative disorders, including AD and FTLD. …”
Get full text

Single Photon Emission Tomography Imaging in Parkinsonian Disorders: A Review by Paul D. Acton, P. David Mozley

“…Imaging is now being utilised to elucidate the genetic contribution to Parkinson’s disease, and in longitudinal studies to assess the efficacy and mode of action of neuroprotective drug and surgical treatments. This review summarises recent applications of SPECT imaging in the study of parkinsonian disorders, with particular reference to the increasing role it is playing in the understanding, diagnosis and management of these diseases.…”
Get full text

Recent advances in mesenchymal stem cell therapy for multiple sclerosis: clinical applications and challenges by Kamran Sheikhi, Salah Ghaderi, Hassan Firouzi, Sarvenaz Rahimibarghani, Ehsan Shabani, Hamed Afkhami, Hamed Afkhami, Hamed Afkhami, Aref Yarahmadi

“…Mesenchymal stem cell (MSC) therapy offers a promising alternative, leveraging its immunomodulatory, neuroprotective, and regenerative capabilities. This review provides an in-depth analysis of MSC mechanisms of action, including immune system regulation, promotion of remyelination, and neuroregeneration. …”
Get full text

Insulin Blocks Glutamate-Induced Neurotoxicity in Differentiated SH-SY5Y Neuronal Cells by Madhavan Nampoothiri, Neetinkumar D. Reddy, Jessy John, Nitesh Kumar, Gopalan Kutty Nampurath, Mallikarjuna Rao Chamallamudi

“…Thus, we examined the neuroprotective effect of insulin on glutamate-induced toxicity on differentiated SH-SY5Y neuronal cells. …”
Get full text

Neuroinflammation and Cerebrovascular Disease in Old Age: A Translational Medicine Perspective by Mario Di Napoli, Imtiaz M. Shah

“…With the increasing use of reperfusion therapies, inflammatory pathways and oxidative stress remain attractive therapeutic targets for the development of adjuvant neuroprotective agents. This paper will discuss these molecular aspects of acute stroke and senescence from a bench-to-bedside research perspective.…”
Get full text

Natural sources, refined extraction, biosynthesis, metabolism, and bioactivities of dietary polymethoxyflavones (PMFs) by Renyou Gan, Yi Liu, Hang Li, Yu Xia, Huan Guo, Fang Geng, Qiguo Zhuang, Huabin Li, Dingtao Wu

“…PMFs have received increasing attention due to their multiple bioactivities, such as antioxidant, anti-inflammatory, anti-cancer, metabolic regulatory, immunoregulatory, neuroprotective, and skin protective effects. These bioactivities of PMFs should be associated with the regulation of critical molecular targets and the interaction with gut microbiota. …”
Get full text

Effects of Various Flavonoids on the α-Synuclein Fibrillation Process by Xiaoyun Meng, Larissa A. Munishkina, Anthony L. Fink, Vladimir N. Uversky

“…Over 4,000 flavonoids have been identified from various plants and foodstuffs derived from plants and have been demonstrated as potential neuroprotective agents. In this study 48 flavonoids belonging to several classes with structures differing in the position of double bonds and ring substituents were tested for their ability to inhibit the fibrillation of α-synuclein in vitro. …”
Get full text

Gene Therapy for Parkinson's Disease by Rachel Denyer, Michael R. Douglas

“…More radically, gene therapy could be used to correct the imbalances in basal ganglia circuitry associated with the symptoms of Parkinson's disease, or to preserve or restore dopaminergic neurons lost during the disease process itself. The latter neuroprotective approach is the most exciting, as it could theoretically be disease modifying rather than simply symptom alleviating. …”
Get full text

Nonhematopoietic Variants of Erythropoietin in Ischemic Stroke: Need for Step-Wise Proof-of-Concept Studies by Dirk M. Hermann

“…Neuroprotective, but not hematopoietic, variants of erythropoietin (EPO), such as Neuro-EPO, are promising candidates for treatment in the acute and subacute stroke phase. …”
Get full text

YELLOW CAMELLIAS: A REVIEW OF CHEMICAL CONSTITUENTS AND BIOLOGICAL ACTIVITIES by Thi Diep Trinh

“…Many pharmacological studies have proved that the total extracts, fractions, and isolated substances from yellow camellia species possess antioxidant, anticancer, hypolipidemic, hypoglycemic, antiallergic, hepatoprotective, neuroprotective, anxiolytic, and antidepressant activities. …”
Get full text

Asiaticoside Attenuates Chronic Restraint Stress-Induced Hippocampal CA1 Neuronal Ferroptosis via Activating BDNF/Nrf2/GPX4 Signaling Pathway by Zhou A, Feng HY, Fan CN, Wang J, Yuan ZY, Xu GH, Li CF, Huang WF, Yi LT

“…At the molecular level, asiaticoside enhanced the expression of brain-derived neurotrophic factor (BDNF), phosphorylated tropomyosin receptor kinase B (pTrkB), phosphorylated nuclear factor erythroid 2-related factor 2 (pNrf2), glutathione peroxidase 4 (GPX4), and solute carrier family 7 member 11 (SLC7A11), indicating its neuroprotective and antioxidative effects. In addition, asiaticoside suppressed the expression of ferroptosis markers, including ferritin light chain (FLC) and transferrin receptor only in CA1 region. …”
Get full text

Early Electroacupuncture Extends the rtPA Time Window to 6 h in a Male Rat Model of Embolic Stroke via the ERK1/2-MMP9 Pathway by Xin-chang Zhang, Ya-hui Gu, Wen-tao Xu, Yang-yang Song, Ao Zhang, Zhi-hui Zhang, Si-yuan Jiang, Si-qi Chang, Guang-xia Ni

“…Electroacupuncture (EA) exerts a neuroprotective effect on cerebral ischemia; however, researchers have not clearly determined whether EA increases the safety of thrombolysis and extends the therapeutic time window of rtPA administration following ischemic stroke. …”
Get full text

Complete pathway elucidation of echinacoside in Cistanche tubulosa and de novo biosynthesis of phenylethanoid glycosides by Wenqian Huang, Yaru Yan, Weisheng Tian, Xiaoxue Cui, Yingxia Wang, Yuelin Song, Ting Mo, Xiping Xu, Saijing Zhao, Yuyu Liu, Xiaohui Wang, Juan Wang, Yong Jiang, Jun Li, She-po Shi, Xiao Liu, Pengfei Tu

“…Abstract Echinacoside (ECH), one of the most representative phenylethanoid glycosides (PhGs), has considerable neuroprotective effects and is an effective ingredient in numerous commercial drugs. …”
Get full text