A cryo-shocked M2 macrophages based treatment strategy promoting repair of spinal cord injury via immunomodulation and axonal regeneration effects by Ermei Lu, Kecheng Zhou, Jiansen Miao, Yanlin Zhu, Jiyao Tang, Siting Du, Yanzhen Feng, Linyuan Jiang, Tianyao Jiang, Ting Huang, Ping Li, Xinjun Miao, Qi Han, Jian Xiao

“…This approach combines the regenerative effects of low-dose PTX with the immunoregulatory properties of LNT M2, leading to remarkable neurological recovery in SCI rats. Moreover, the scaffold’s straightforward preparation, ease of standardization, and “ready-to-use” nature make it a promising candidate for acute SCI intervention and future clinical applications. …”
Get full text

Conformational diversity in class C GPCR positive allosteric modulation by Giuseppe Cannone, Ludovic Berto, Fanny Malhaire, Gavin Ferguson, Aurelien Fouillen, Stéphanie Balor, Joan Font-Ingles, Amadeu Llebaria, Cyril Goudet, Abhay Kotecha, Vinothkumar K.R., Guillaume Lebon

“…The mGlu receptors signal transduction can be allosterically potentiated by positive allosteric modulators (PAMs) binding to the 7TMs, which are of therapeutic interest in various neurological disorders. Here, we report the cryoEM structures of metabotropic glutamate receptor 5 (mGlu5) purified with three chemically and pharmacologically distinct PAMs. …”
Get full text

Mortality Due to Subarachnoid Hemorrhage from 1999 to 2003. by Javier García Zacarías, Eduardo Hernández Ortiz, José M. Carles Zerquera, Cecilia Zacarías Chialjub, Ángel Luis Zayas Luis

“…Two thirds of the deaths were neurological where cerebral edema with endocrania hypertension and herniation followed by bronchopneumonia were predominant. …”
Get full text

Th17 Cell Response in SOD1G93A Mice following Motor Nerve Injury by Allen Ni, Tao Yang, Nichole A. Mesnard-Hoaglin, Rafael Gutierrez, Evan B. Stubbs, Susan O. McGuire, Virginia M. Sanders, Kathryn J. Jones, Eileen M. Foecking, Junping Xin

“…In conclusion, SOD1G93A mice exhibit abnormal CD4+ T cell activation with increased levels of Th17 cells prior to the onset of neurological symptoms. Motor nerve injury exacerbates Th17 cell responses and may contribute to the development of ALS, especially in those who carry genetic susceptibility to this disease.…”
Get full text

Phenotyping the males of mouse and rat strains with genetically defined behavioral disturbances in a model of sexual activation by M. A. Tikhonova, T. G. Amstislavskaya

“…Sexual dysfunctions are caused by aging, stress, or side effects of psychotropic drugs; they are symptoms of a variety of neurological and psychiatric disorders. Therefore, the study of sexual behavior appears to be an important step in modeling various animal pathologies and the effects of psychotropic drugs. …”
Get full text

Case report: Movement-related neuroplasticity in a patient after spinal cord injury in response to task-oriented bimanual training by Di Ma, Roy Rongyue Zeng, Sofina Sy Chan, Yu Pan, Jack Jiaqi Zhang

“…BackgroundBimanual motor training is an effective neurological rehabilitation strategy. However, its use has rarely been investigated in patients with paralysis caused by spinal cord injury (SCI). …”
Get full text

Expansion of Natural Killer Cells in Peripheral Blood in a Japanese Elderly with Human T-Cell Lymphotropic Virus Type 1-Related Skin Lesions by Shinsaku Imashuku, Naoko Kudo, Kagekatsu Kubo, Kouichi Ohshima

“…Natural killer (NK) cells were proposed to play an important role in the pathogenesis of human T-cell lymphotropic virus type 1- (HTLV-1-) associated neurologic disease. Our patient was a 77-year-old Japanese man, who had been treated for infective dermatitis associated with HTLV-1 for nearly 10 years. …”
Get full text

deutetrabenazine for the treatment of chorea associated with Huntington’s disease by Harshit Gupta, Wil Perkins, Cain Stark, Sathya Kikkeri, Juyeon Kakazu, Adam D. Kaye, Alan D. Kaye

“…Chorea is a movement disorder present in multiple neurologic diseases that causes involuntary and irregular muscle movements theorized to be stemming from high dopamine levels. …”
Get full text

Bifurcation Analysis and Synchronous Patterns between Field Coupled Neurons with Time Delay by Li Zhang, Xinlei An, Jiangang Zhang, Qianqian Shi

“…Exploring the biophysical properties of coupling channels is of great significance for further understanding the rhythm transitions of neural network electrical activity patterns and preventing neurological diseases. From the perspective of biophysics, the activation of magnetic field coupling is the result of the continuous release and propagation of intracellular and extracellular ions, which is very similar to the activation of chemical synaptic coupling through the continuous release of neurotransmitters. …”
Get full text

Drug response is related to NR3C1 and FAAH polymorphism in Chinese pediatric epilepsy patients by Hongli Wang, Chu Li, Qian Li, Ning Li, Huiling Qin

“…Abstract Background Childhood epilepsy is a common neurological syndrome with complex etiology and recurrent seizures. …”
Get full text

The Prevalence of Restless Legs Syndrome in Patients with Migraine: A Systematic Review and Meta-Analysis by Hooman Ghasemi, Behnam Khaledi-Paveh, Alireza Abdi, Rostam Jalali, Nader Salari, Aliakbar Vaisi-Raygani, Masoud Mohammadi

“…Migraine is a severe and debilitating neurologic disorder and is claimed to be the sixth disabling illness in the world. …”
Get full text

Neurosurgical aspects of marble bone disease: treatment modalities and outcome by Mahmoud Mohammed Gamal, Roshdy Elkhayat, Hassan Mohammed Hassan

“…Conclusion Marble bone disease or osteopetrosis is a rare hereditary disorder with multiple neurological impacts. Increased ICP and CNs compression are the most common. …”
Get full text

Structural Analysis of Inhibitor Binding to Enterovirus-D68 3C Protease by Vincent N. Azzolino, Ala M. Shaqra, Akbar Ali, Nese Kurt Yilmaz, Celia A. Schiffer

“…Enterovirus-D68 (EV68) continues to present as a global health issue causing respiratory illness and outbreaks associated with long-lasting neurological disease, with no antivirals or specific treatment options. …”
Get full text

Case Report: Targeted plasticity in spinal cord injury—the role of focal muscle vibration and neurocognitive rehabilitation in adaptative synaptic change along sensory and motor ci... by Filippo Camerota, Naomi Francesca Pocino, Federico Zangrando, Roberta Di Tommaso, Marco Paoloni, Massimiliano Mangone, Claudia Celletti

“…The gait analysis evaluation showed a reduction in stride time bilaterally, an increase in average walking speed, increased cadence, and a slight increase in step length.ConclusionThe improvements obtained have highlighted the relevance of the fMV application associated to physiotherapy in the field of neurological rehabilitation, particularly emphasizing the interest in increasing the number of sessions correlated with more durable clinical improvements over time. …”
Get full text

Pathogenic PDE12 variants impair mitochondrial RNA processing causing neonatal mitochondrial disease by Lindsey Van Haute, Petra Páleníková, Jia Xin Tang, Pavel A Nash, Mariella T Simon, Angela Pyle, Monika Oláhová, Christopher A Powell, Pedro Rebelo-Guiomar, Alexander Stover, Michael Champion, Charulata Deshpande, Emma L Baple, Karen L Stals, Sian Ellard, Olivia Anselem, Clémence Molac, Giulia Petrilli, Laurence Loeuillet, Sarah Grotto, Tania Attie-Bitach, Jose E Abdenur, Robert W Taylor, Michal Minczuk

“…Our data suggest that PDE12 regulates mitochondrial RNA processing and its loss results in neurological and muscular phenotypes.…”
Get full text

Prion Diseases and the Gastrointestinal Tract by Gwynivere A Davies, Adam R Bryant, John D Reynolds, Frank R Jirik, Keith A Sharkey

“…They are uniformly fatal neurological diseases, which are characterized by ataxia and vacuolation in the central nervous system. …”
Get full text

Altered Brain Glucose Consumption in Cogan’s Syndrome by Paolo Mora, Livia Ruffini, Caterina Ghetti, Stella Ghirardini, Maura Scarlattei, Giorgio Baldari, Carla Cidda, Pierangela Rubino, Stefano A. Gandolfi, Jelka G. Orsoni

“…This study revealed areas of significantly altered CMRglc in patients with CS (any subform) without neurologic complains and normal conventional neuroimaging. …”
Get full text

Myasthenic Crisis in an Elderly Patient with Positive Antibodies against Acetylcholine and Anti-MuSK, Successfully Treated with Noninvasive Mechanical Ventilation by José A. Fernández, Antonio Fernández-Valiñas, Daniel Hernández, Joel Orozco, Antonio Lugo

“…After 24 hours the patient showed respiratory deterioration and neurological impairment. Endotracheal intubation was rejected, so ventilatory support with noninvasive ventilation was started. …”
Get full text

Dose and strain dependent lethality of Usutu virus in an Ifnar−/− mouse model by Johanna M. Duyvestyn, Eleanor M. Marshall, Peter J. Bredenbeek, Barry Rockx, Martijn J. van Hemert, Marjolein Kikkert

“…While usually mild or asymptomatic in humans, neurological disorders are increasingly observed, which has boosted interest and the need for better understanding of the pathogenesis of various USUV lineages. …”
Get full text

Novel carbon dots with dual Modulatory effects on the bone marrow and spleen as a potential therapeutic candidate for treating spinal cord injury by Junjin Li, Hongda Wang, Yuanquan Li, Chunzhen Wang, Haiwen Feng, Yilin Pang, Jie Ren, Chuanhao Li, Erke Gao, Dejing Zhang, Dunxu Hu, Pengtian Zhao, Han Ding, Baoyou Fan, Tao Zhang, Xiaomeng Song, Zhijian Wei, Guangzhi Ning, Yong-Qiang Li, Shiqing Feng

“…Our findings demonstrate that EJCDs effectively reduce myeloid cell infiltration post-spinal cord injury and promote neurological recovery, making them promising therapeutic candidates for treating spinal cord injuries.…”
Get full text