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4901
Exploring novel and potent glycogen synthase kinase-3β inhibitors through systematic drug designing approach
Published 2025-02-01“…GSK-3β modulates diverse protein targets through phosphorylation, and its aberrant activity leads to neurological complications as well as tumour onset. Therefore, inhibiting GSK-3β activity through active-site fitting molecules may offer a favourable strategy for intercepting these disorders. …”
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4902
Advances in Deep Brain Imaging with Quantum Dots: Structural, Functional, and Disease-Specific Roles
Published 2024-12-01“…This review highlights the impact of QDs on MPM, their effectiveness in overcoming light attenuation in deep tissue, and their expanding role in diagnosing and treating neurological disorders, positioning them as transformative agents for both brain imaging and intervention.…”
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4903
Congenital malformations in children of epileptic pregnant women in the Cienfuegos province (2008-2018)
Published 2022-12-01“…<p><strong>Background</strong>: in pregnant women, epilepsy is one of the most frequent neurological disorders, considered high risk due to the complications it produces. …”
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4904
Pyloric Balloon Dilatation for Delayed Gastric Emptying in Children
Published 2001-01-01“…Excluded were children with chromosomal abnormalities, neurological disorders and erosive esophagitis. Through-the-scope balloons of diameter 15 or 18 mm were positioned in the pyloric channel and inflated with air to 2334 or 1815 mmHg respectively, for 2 min. …”
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4905
Patterns of multimorbidity in primary care electronic health records: A systematic review
Published 2024-01-01“…Mental health and cardiovascular patterns were identified in all studies, often in combination with diseases of other organ systems (e.g. neurological, endocrine). Discussion These findings emphasise the frequent coexistence of physical and mental health conditions in primary care, and provide useful information for the development of targeted preventive and management strategies. …”
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4906
Harmful impacts of microplastic pollution on poultry and biodegradation techniques using microorganisms for consumer health protection: A review
Published 2025-01-01“…In humans, exposure to microplastics can lead to inflammation, immune responses, metabolic disturbances, DNA damage, neurological damage, and even cancer upon contact with mucosal membranes or absorption into the body. …”
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4907
Clinical Phenotype of Fucosidosis in Cuba
Published 2024-07-01“…<br /><strong>Results:</strong> hurleroid facies, neurological and physical development impairment, joint contractures and skeletal deformities were the most frequent clinical manifestations in the 19 diagnosed cases. 84.2 % of patients presented angiokeratoma, and in 52.7 % there was delay in psychomotor development that began in infancy and rapid neurodegeneration, with loss of motor and language skills before the age of five. 42.1 % of patients died between 10 and 20 years of age. …”
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4908
Gene Expression Profiling of the Sciatic Nerve in Streptozotocin-Induced Diabetic Rats with Peripheral Neuropathy
Published 2020-01-01“…Diabetes in Sprague-Dawley rats was induced with streptozotocin (STZ) treatment, followed with neurological tests and histological examinations to assess the neuropathic symptoms of DPN. …”
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4909
Constipations in elderly: diagnostics and treatment approach
Published 2011-03-01“…At investigation of the patient it is especially important to estimate history of drug intake, to pay the special attention to signs of obscure depression and anxiety, systemic and neurologic diseases and so- called «red flags». Constipation with delayed transit and megarectum are associated to the risk of fecal impaction, compression of urinary tract and stercoral colitis development, with intestinal perforation, blee- ding and suppuration.At treatment prescription it is necessary to take into account nature of constipation, features of clini- cal pattern, intestinal transit, incidental or persistent course. …”
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4910
Diabetic Ephrin-B2-Stimulated Peripheral Blood Mononuclear Cells Enhance Poststroke Recovery in Mice
Published 2018-01-01“…We investigated the therapeutic potential of peripheral blood-derived mononuclear cells (PB-MNC) harvested from diabetic patients and stimulated by ephrin-B2 (PB-MNC+) (500,000 cells), injected intravenously 18–24 hours after induced cerebral ischemia in mice. Infarct volume, neurological deficit, neurogenesis, angiogenesis, and inflammation were investigated as were the potential mechanisms of PB-MNC+ cells in poststroke neurorepair. …”
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4911
Phytocanabinoids and synthetic cannabinoids: from recreational consumption to potential therapeutic use – a review
Published 2025-01-01“…On the other hand, recent investigations have proposed a promising therapeutic potential of cannabinoid-based drugs for a wide range of medical situations, including neurological and psychiatric disorders, among other indications. …”
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4912
Machine learning-assisted cancer diagnosis in patients with paraneoplastic autoantibodies
Published 2025-01-01“…Abstract Purpose Paraneoplastic syndromes (PNS) are a group of rare disorders triggered by an immune response to malignancy, characterized by diverse neurological, muscular, and systemic symptoms. This study aims to leverage machine learning to develop a predictive model for cancer diagnosis in patients with paraneoplastic autoantibodies. …”
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4913
Increased DNA Copy Number Variation Mosaicism in Elderly Human Brain
Published 2018-01-01“…CNVs represent a significant source of genetic variation in the human genome and have been implicated in several disorders and complex traits, representing a potential mechanism that contributes to neuronal diversity and the etiology of several neurological diseases and provides new insights into the normal, complex functions of the brain. …”
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4914
Botox (OnabotulinumtoxinA) for Treatment of Migraine Symptoms: A Systematic Review
Published 2022-01-01“…Migraine is one of the most common types of headache, and it is the second most common cause of neurological disorders, with an annual prevalence of about 15% of the population. …”
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4915
A scoping review of conventional and laser acupuncture as a modality of treatment for migraine
Published 2020-03-01“…Introduction: Migraine is a common neurological disorders that typically manifests with repeated episodes of unilateral frequent throbbing headaches. …”
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4916
The Japanese encephalitis virus NS1' protein facilitates virus infection in mosquitoes.
Published 2025-01-01“…<h4>Background</h4>The Japanese encephalitis virus (JEV), a mosquito-borne flavivirus, is known for its capacity to cause severe neurological disease in Asia. Neurotropic flaviviruses within the Japanese encephalitis (JE) serogroup possess the distinctive feature of expressing a unique nonstructural protein, NS1'. …”
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4917
Brain state forecasting for precise brain stimulation: Current approaches and future perspectives
Published 2025-02-01“…Transcranial magnetic stimulation (TMS) has the potential to yield insights into cortical functions and improve the treatment of neurological and psychiatric conditions. However, its reliability is hindered by a low reproducibility of results. …”
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4918
Semiautomatic volumetry of the temporal lobes of the brain and correlation with electroencephalography results in dogs with assumed idiopathic epilepsy
Published 2025-01-01“…The MRI and EEG examination results of dogs referred for neurological diagnosis data between 2016 and 2021 were retrospectively analyzed. …”
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4919
Pengaruh Pelatihan Berprilaku Caring Terhadap Kemampuan Caring Mahasiswa Praktek Profesi Fakultas Keperawatan Unand di RSUP Dr.M.Djamil Padang
Published 2013-10-01“…Students study subjects practice the profession in Dr M Djamil Padang Hospital numbered 22 peoples and spread across nine rooms are neurologi , pulmonary , male internal , female internal , high care unit, female surgical , male surgical , trauma centere and recovery room . …”
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4920
Investigation of the physicochemical properties and pharmacokinetics of the active compounds in Quercus infectoria gall extract
Published 2024-12-01“…Assessing the ability of compounds to penetrate the blood-brain barrier is crucial for neurological treatments. Friedelin, a pentacyclic triterpene with antimicrobial and anticancer properties, can penetrate cell membranes due to its hydrophobic nature, but absorption may be limited by its molecular weight. …”
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