Cyclin-Dependent Kinase-Like 5 (CDKL5): Possible Cellular Signalling Targets and Involvement in CDKL5 Deficiency Disorder by Syouichi Katayama, Noriyuki Sueyoshi, Tetsuya Inazu, Isamu Kameshita

“…We also discuss the relationship between changes in the phosphorylation signalling pathways and the Cdkl5 knockout mouse phenotype and consider future prospects for the treatment of mental and neurological disease associated with CDKL5 mutations.…”
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Proton Pump Inhibitors and Dementia: Physiopathological Mechanisms and Clinical Consequences by Gloria Ortiz-Guerrero, Diana Amador-Muñoz, Carlos Alberto Calderón-Ospina, Daniel López-Fuentes, Mauricio Orlando Nava Mesa

“…PPIs are a widely indicated class of drugs for gastric acid-related disorders, although most older adult users are not treated for the correct indication. Although neurological side effects secondary to PPIs are rare, several preclinical reports indicate that PPIs might increase Aβ levels, interact with tau protein, and affect the neuronal microenvironment through several mechanisms. …”
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Examining the epigenetic transmission of risk for chronic pain associated with paternal post-traumatic stress disorder: a focus on veteran populations by James Freeman, Sabrina Salberg, Melanie Noel, Richelle Mychasiuk

“…Numerous overlapping neurological pathways are implicated in both PTSD and chronic pain; many of which are susceptible to epigenetic modification, such as DNA methylation, histone modifications, and RNA regulation. …”
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Possible involvement of vitamin K insufficiency in the progression of cervical ossification of the posterior longitudinal ligament by Atsushi Kimura, Naoya Taki, Yukinori Hayashi, Yasuyuki Shiraishi, Tsukasa Ohmori, Katsushi Takeshita

“…Abstract Ossification of the posterior longitudinal ligament of the vertebral column (OPLL) is a disease characterised by ectopic bone formation in the spinal ligament that causes progressive neurological impairment. However, there are no suitable treatments for OPLL. …”
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pitolisant, a novel histamine-3 receptor competitive antagonist, and inverse agonist, in the treatment of excessive daytime sleepiness in adult patients with narcolepsy by Noeen Sarfraz, David Okuampa, Hannah Hansen, Mark Alvarez, Elyse M. Cornett, Juyeon Kakazu, Adam M. Kaye, Alan D. Kaye

“…It is also associated with many other disorders, including psychiatric disorders, neurologic illnesses, and medication side effects. Common causes of delayed and incorrect diagnoses of these conditions include lack of physician familiarity with narcolepsy symptoms and comorbidities which mask narcolepsy signs and symptoms. …”
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35 m Vertical Free Fall: How Impact Surface Influences Survival by C. Ehrnthaller, F. Gebhard

“…Following extubation on day 8 after trauma the patient did not show any peripheral neurological deficits but cerebral affection with a general slowdown. …”
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A Child as a Donor for Hematopoietic Stem Cell Transplantation: Bioethical Justification—A Case Study on Sickle Cell Disease by Andrea Z. Pereira, Ricardo Hellman, Nelson Hamerschlak, Andrea Kondo, Polianna Mara Rodrigues de Souza, Wilson Leite Pedreira, Luiz Fernando Alves Lima Mantovani, Eduardo Juan Troster, Henrique Grunspun, Marco Aurélio Scarpinella Bueno

“…The boy met all eligibility criteria to undergo HSCT, and he was suffering from cognitive and neurologic impairment due to ischemic events. A Bioethical Committee jointly discussed the ethical issues on this case after a pediatric evaluation released the very young sister for donation. …”
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Modified ‘Xingnao Kaiqiao’ acupuncture technique shortens the recovery time of comatose patients by Dan Meng, Liangfeng Wang, Shengqiang Cheng, Pan Cai

“…Background This study was conducted to analyse the therapeutic effect of the modified ‘Xingnao Kaiqiao’ acupuncture technique in the recovery of comatose patients, as well as the clinical factors that may influence recovery from coma.Methods Diagnostic and therapeutic data from 166 patients in a coma due to neurological diseases were retrospectively collected. …”
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Transcranial Alternating Current and Random Noise Stimulation: Possible Mechanisms by Andrea Antal, Christoph S. Herrmann

“…In future, the methods may be applicable in therapy of neurological and psychiatric disorders that are due to malfunctioning brain oscillations.…”
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Caudate Nucleus Volume Mediates the Link between Cardiorespiratory Fitness and Cognitive Flexibility in Older Adults by Timothy D. Verstynen, Brighid Lynch, Destiny L. Miller, Michelle W. Voss, Ruchika Shaurya Prakash, Laura Chaddock, Chandramallika Basak, Amanda Szabo, Erin A. Olson, Thomas R. Wojcicki, Jason Fanning, Neha P. Gothe, Edward McAuley, Arthur F. Kramer, Kirk I. Erickson

“…Structural MRI was used to determine the volume of the basal ganglia nuclei in a group of older, neurologically healthy individuals (mean age 66 years, N=179). …”
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The Central Nervous System Effects and Mimicry of Common Variable Immunodeficiency (CVID): A Case Report with Literature Review by Sohail Farshad, Fernando Figueroa Rodriguez, Alexandra Halalau, Joseph Skender, Cory Rasmussen, Martin Pevzner

“…Here, we discuss CVID-associated neurological complications, its similarities to sarcoidosis, and a literature review with treatment regimens and outcomes.…”
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Acute stimulation of PBMCs drives switch from dopamine-induced anti- to proinflammatory phenotype of monocytes only in women by Leonie Fleige, Silvia Capellino

“…Another contributing factor appears to be sex, as sex-specific differences in the dopaminergic pathway are described in the neurological context as well as in autoimmune diseases. …”
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Using Short-Term Concentration Measures and Intelligence in Rehabilitation Settings by Bruce D. Kirkcaldy

“…Intellectual and concentrative ability were assessed among a group of 85, predominantly schizophrenic, patients (mean age 32 years) from a Sheltered Workshop (GWN) and neurological-psychiatric institutionalized care units within the Neuss region of North-Rhine Westphalia, Germany. …”
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Listeria Rhombencephalitis Complicating Anti-TNF Treatment during an Acute Flare of Crohn’s Colitis by L. Stratton, G. R. Caddy

“…He demonstrated poor neurological recovery. Listeria monocytogenes is an infection commonly associated with food sources. …”
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The Role of the Gastrointestinal Microbiota in Parkinson’s Disease by Maurizio Gabrielli, Lorenzo Zileri Dal Verme, Maria Assunta Zocco, Enrico Celestino Nista, Veronica Ojetti, Antonio Gasbarrini

“…Beyond its well-known neurological features, emerging evidence underscores the pivotal role of the gut–brain axis and gastrointestinal microbiota in PD pathogenesis. …”
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The Cardio- and Neuroprotective Effects of Corvitin and 2-Oxoglutarate in Rats with Pituitrin-Isoproterenol-Induced Myocardial Damage by V. Tkachenko, Y. Kovalchuk, N. Bondarenko, О. Bondarenko, G. Ushakova, A. Shevtsova

“…The imbalance between pro- and antioxidant systems, the formation of active carbonyl compounds, and the end products of glycation in the blood and tissues are the key moments in the development of heart and neurological disorders leading to a change of behavioral responses. …”
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Updates on the development of vaccines and therapeutic options against rabies by Roshan Arjun Ananda, Hooi-Leng Ser, Vengadesh Letchumanan

“…During the initial stage of infection, affected individuals usually show weakess at the bitten extremities and the virus can ultimately travel to the brain causing neurological signs. In attenuated (inactivated) form, the currently in use vaccines have been recommended by WHO for the prevention (i.e. pre-exposure prophylaxis, PrEP) and treatment (i.e. post-exposure prophylaxis, PEP) regime against the rabies virus (RABV). …”
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Neurophysiology of Drosophila Models of Parkinson’s Disease by Ryan J. H. West, Rebecca Furmston, Charles A. C. Williams, Christopher J. H. Elliott

“…Synaptic signalling deficits are observed in motor, central, and sensory systems. Given the neurological impact of disease causing mutations within these same genes in humans the phenotypes observed in fly are of significant interest. …”
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Platelet-derived HMGB1 induces NETosis, exacerbating brain damage in the photothrombotic stroke model by Sang-A. Oh, Song-I. Seol, Dashdulam Davaanyam, Seung-Woo Kim, Ja-Kyeong Lee

“…Functional inhibition of HMGB1 by intranasal administration of an HMGB1 A box 4 h post-PTS significantly suppressed NETosis induction, reduced infarct volume, and improved neurological deficits, confirming the pivotal role of HMGB1 in NETosis induction. …”
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Esketamine at a Clinical Dose Attenuates Cerebral Ischemia/Reperfusion Injury by Inhibiting AKT Signaling Pathway to Facilitate Microglia M2 Polarization and Autophagy by Gao Y, Li L, Zhao F, Cheng Y, Jin M, Xue FS

“…The expression of biomarkers related to microglial M1 and M2 phenotypes in the ischemic brain tissues was determined by immunofluorescence staining and RT-qPCR, and the expression of proteins associated with autophagy and the AKT signaling pathway in the ischemic brain tissues was assayed by Western blotting.Results: Esketamine alone and esketamine combined with rapamycin alleviated neurological impairment, improved sensorimotor function, decreased cerebral infarct volume, and mitigated tissue injury in the MCAO rats. …”
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