Inherited Paediatric Motor Neuron Disorders: Beyond Spinal Muscular Atrophy by Hooi Ling Teoh, Kate Carey, Hugo Sampaio, David Mowat, Tony Roscioli, Michelle Farrar

“…Paediatric motor neuron diseases encompass a group of neurodegenerative diseases characterised by the onset of muscle weakness and atrophy before the age of 18 years, attributable to motor neuron loss across various neuronal networks in the brain and spinal cord. …”
Get full text

Effects of Microtubule Stabilization by Epothilone B Depend on the Type and Age of Neurons by Eun-Hae Jang, Aeri Sim, Sun-Kyoung Im, Eun-Mi Hur

“…Several studies have demonstrated the therapeutic potential of applying microtubule- (MT-) stabilizing agents (MSAs) that cross the blood-brain barrier to promote axon regeneration and prevent axonal dystrophy in rodent models of spinal cord injury and neurodegenerative diseases. Paradoxically, administration of MSAs, which have been widely prescribed to treat malignancies, is well known to cause debilitating peripheral neuropathy and axon degeneration. …”
Get full text

Intraspinal Transplantation of the Adipose Tissue-Derived Regenerative Cells in Amyotrophic Lateral Sclerosis in Accordance with the Current Experts’ Recommendations: Choosing Opti... by Magdalena Kuzma-Kozakiewicz, Andrzej Marchel, Anna Kaminska, Malgorzata Gawel, Jan Sznajder, Anna Figiel-Dabrowska, Arkadiusz Nowak, Edyta Maj, Natalia Ewa Krzesniak, Bartlomiej H. Noszczyk, Krystyna Domanska-Janik, Anna Sarnowska

“…Stem cells (SCs) may constitute a perspective alternative to pharmacological treatment in neurodegenerative diseases. Although the safety of SC transplantation has been widely shown, their clinical efficiency in amyotrophic lateral sclerosis (ALS) is still to be proved. …”
Get full text

Metformin: A Possible Option in Cancer Chemotherapy by Chidiebere V. Ugwueze, Odunze J. Ogamba, Ekenechukwu E. Young, Belonwu M. Onyenekwe, Basil C. Ezeokpo

“…However, the drug has been used in experimental trials in various aspects of medicine and pharmacology such as in reproductive medicine, cancer chemotherapy, metabolic diseases, and neurodegenerative diseases. It has been in use in the treatment of polycystic ovarian disease and obesity and is being considered in type 1 diabetes. …”
Get full text

Nose to brain strategy coupled to nano vesicular system for natural products delivery: Focus on synaptic plasticity in Alzheimer's disease by Nunzia Maisto, Dalila Mango

“…However, several compounds, administered parenterally and orally, are unable to reach the brain due to the presence of the blood-brain barrier (BBB) which prevents the passage of external substances, such as proteins, peptides, or phytocompounds, representing a limit to the development of treatment for neurodegenerative diseases, such as AD. The combination of nano vesicular systems, as colloidal systems, and nose to brain (NtB) delivery depicts a new nanotechnological strategy to overtake this limit and to develop new treatment approaches for brain diseases, including the use of natural molecules in combination therapy for AD. …”
Get full text

TDP-43 nuclear retention is antagonized by hypo-phosphorylation of its C-terminus in the cytoplasm by Célia Rabhi, Nicolas Babault, Céline Martin, Bénédicte Desforges, Alexandre Maucuer, Vandana Joshi, Serhii Pankivskyi, Yitian Feng, Guillaume Bollot, Revital Rattenbach, David Pastré, Ahmed Bouhss

“…We anticipate that reducing TDP-43 C-terminus self-assembly in the cytoplasm may be an interesting strategy to reverse TDP-43 nuclear depletion in neurodegenerative diseases.…”
Get full text

Epigenetic Research of Neurodegenerative Disorders Using Patient iPSC-Based Models by Rubén Fernández-Santiago, Mario Ezquerra

“…Moreover, elucidating epigenetic regulation using patient-specific iPSC-derived neural models is expected to have a great impact to unravel the pathophysiology of neurodegenerative diseases and to hopefully expand future therapeutic possibilities. …”
Get full text

α-Synuclein fibrils enhance HIV-1 infection of human T cells, macrophages and microglia by Lia-Raluca Olari, Sichen Liu, Franziska Arnold, Julia Kühlwein, Marta Gil Miró, Ajeet Rijal Updahaya, Christina Stürzel, Dietmar Rudolf Thal, Paul Walther, Konstantin M. J. Sparrer, Karin M. Danzer, Jan Münch, Frank Kirchhoff

“…Our results suggest a detrimental interplay between HIV-1 and brain amyloids that may contribute to the development of neurodegenerative diseases.…”
Get full text

Ignoring Gender-Based Immunometabolic Reprograming, a Risky Business in Immune-Based Precision Medicine by Vijay Kumar

“…Furthermore, evidence is growing for the immune involvement in aging, metabolic and neurodegenerative diseases, and different cancers. However, further research has indicated sex/gender-based immune differences, which further increase higher incidences of various autoimmune diseases (AIDs), such as systemic lupus erythematosus (SLE), myasthenia gravis, and rheumatoid arthritis (RA) in females. …”
Get full text

Sleep in Genetically Confirmed Pantothenate Kinase-Associated Neurodegeneration: A Video-Polysomnographic Study by Maria Livia Fantini, Giovanni Cossu, Andrea Molari, Monia Cabinio, Ozlem Uyanik, Roberto Cilia, Maurizio Melis, Angelo Antonini, Luigi Ferini-Strambi

“…In contrast with other neurodegenerative diseases, no REM sleep abnormalities, especially REM sleep behavior disorder, were observed in PKAN patients, and percentage of both REM sleep atonia and phasic EMG activity were within normal ranges. …”
Get full text

Distinct patterns of prion strain deposition and toxicity in a novel whole brain organotypic slice culture system by Hailey Pineau, Valerie L. Sim

“…Abstract Prion diseases are fatal transmissible neurodegenerative diseases that affect many mammals, including humans, caused by the templated misfolding of the prion protein. …”
Get full text

Cookware as source of toxic metals: An overview by Okunola Alabi, Amos Tomiwa Afolabi

“…Aluminum used in cookware, has raised health concerns because of its possible associations with neurodegenerative diseases. Metal leaching is influenced by various factors, including acidity, cooking duration, and temperature. …”
Get full text

A Review on the Antimutagenic and Anticancer Effects of Cysteamine by Chun-Man Lee

“…It has been safely used in humans for the treatment of several pathologies including cystinosis and neurodegenerative diseases. Cysteamine has been shown to be a potent antimutagenic, anticarcinogenic, and antimelanoma in various in vitro and in vivo studies, but a review on these aspects of cysteamine’s use in medicine is lacking in the current literature. …”
Get full text

Profile of STING agonist and inhibitor research: a bibliometric analysis by Xuemei Wang, Qian Wang, Yidan Gao, Lijuan Jiang, Lingli Tang

“…BackgroundSTING is a core signaling hub molecule in the innate immune system, involved in various diseases, including infectious diseases, autoimmune diseases, tumors, aging, organ fibrosis, and neurodegenerative diseases. Its activation has shown great potential in anti-tumor and anti-infective therapies, with STING agonists emerging as a promising approach in cancer immunotherapy in recent years. …”
Get full text

Mechanism of Inflammation in Age-Related Macular Degeneration by Francesco Parmeggiani, Mario R. Romano, Ciro Costagliola, Francesco Semeraro, Carlo Incorvaia, Sergio D’Angelo, Paolo Perri, Paolo De Palma, Katia De Nadai, Adolfo Sebastiani

“…In the aging retina, free radicals and oxidized lipoproteins are considered to be major causes of tissue stress resulting in local triggers for parainflammation, a chronic status which contributes to initiation and/or progression of many human neurodegenerative diseases such as AMD. Experimental and clinical evidences strongly indicate the pathogenetic role of immunologic processes in AMD occurrence, consisting of production of inflammatory related molecules, recruitment of macrophages, complement activation, microglial activation and accumulation within those structures that compose an essential area of the retina known as macula lutea. …”
Get full text

Widespread Striatal Delivery of GDNF from Encapsulated Cells Prevents the Anatomical and Functional Consequences of Excitotoxicity by Dwaine F. Emerich, Jeffrey H. Kordower, Yaping Chu, Chris Thanos, Briannan Bintz, Giovanna Paolone, Lars U. Wahlberg

“…Because GDNF has been effective in animal models of Parkinson’s disease, stroke, epilepsy, and Huntington’s disease, among other debilitating neurodegenerative diseases, encapsulated cell-based delivery of GDNF might represent one innovative means of slowing the neural degeneration seen in a myriad of currently untreatable neurological diseases.…”
Get full text

Insights into the Allosteric Regulation of Human Hsp90 Revealed by NMR Spectroscopy by Tjaša Goričan, Simona Golič Grdadolnik

“…Errors in the process of the chaperone cycle can lead to diseases such as cancer and neurodegenerative diseases. Therefore, the activity of Hsp90 must be carefully regulated. …”
Get full text

New Insights into Chemical Profiles and Health-Promoting Effects of Edible Mushroom <i>Dictyophora indusiate</i> (Vent ex. Pers.) Fischer: A Review by Yogesh Kumar, Baojun Xu

“…DIP shows neuroprotective effects by reducing oxidative damage, improving mitochondrial function, and regulating apoptosis, making them beneficial for neurodegenerative diseases. They also activate immune responses through TLR4 and NF-κB pathways. …”
Get full text

Impact of Time Delay in Perceptual Decision-Making: Neuronal Population Modeling Approach by Urszula Foryś, Natalia Z. Bielczyk, Katarzyna Piskała, Martyna Płomecka, Jan Poleszczuk

“…Impairments in decision-making are frequently observed in neurodegenerative diseases, but the mechanisms underlying such pathologies remain elusive. …”
Get full text

Noradrenergic Modulation of Cognition in Health and Disease by Olga Borodovitsyna, Matthew Flamini, Daniel Chandler

“…Due to its role in mediating normal cognitive function, it is reasonable to expect that noradrenergic transmission becomes dysfunctional in a number of neuropsychiatric and neurodegenerative diseases characterized by cognitive deficits. …”
Get full text