Changes in RNA Splicing: A New Paradigm of Transcriptional Responses to Probiotic Action in the Mammalian Brain by Xiaojie Yue, Lei Zhu, Zhigang Zhang

“…Protein–protein interactions and a KEGG analysis of differentially spliced genes (DSGs) revealed consistent enrichment in the spliceosome and vesicle transport complexes, as well as in pathways related to neurodegenerative diseases, synaptic function and plasticity, and substance addiction across brain regions. …”
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CD22 modulation alleviates amyloid β-induced neuroinflammation by Yu Dong Mai, Qingqing Zhang, Cheuk Lim Fung, Shui On Leung, Chi Ho Chong

“…Yet, therapeutic targets for neurodegenerative diseases based on neuroinflammation still warrant investigation. …”
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Risk Factors for Infection Associated with Ischemic Stroke in Patients over 60 Years of Age by Alexis Suárez Quesada, Alexis Álvarez Aliaga, Andrés José Quesada Vázquez, Eduardo René Valdés Ramos, Ezequiel Ernesto López Espinosa

“…<br /><strong>Conclusions:</strong> the severity of ischemic stroke, the coexistence of neurodegenerative diseases and dysphagia constitute the main risk factors for infection associated with ischemic stroke in patients over 60 years of age.…”
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Impact of glycolysis inhibitor (2-DG) and oxidation and phosphorylation uncoupler (2,4-DNP) on brain metabolites by O. B. Shevelev, M. P. Moshkin

“…A deficiency of available energy for brain cells under neurodegenerative diseases is either developed due to age-dependent underexpression of genes that encode glycolytic enzymes or induced due to the uncoupling of oxidation and phosphorylation that could be mediated by inflammatory cytokines. …”
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Magnetic resonance imaging in primates. The example of the mouse lemur (Microcebus murinus): From detection of pathological aging to therapeutic evaluations by Nelly Joseph-Mathurin, Olene Dorieux, Audrey Kraska, Anne Bertrand, Mathieu Santin, Nadine El Tannir El Tayara, Marc Dhenain

“…It leads in many cases to neurodegenerative diseases such as Alzheimer disease (AD). Rodents and particularly transgenic mice are widely used as models for research on physiopathology of cerebral aging, neurodegenerative diseases and for the evaluation of therapies. …”
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Alginate: Current Use and Future Perspectives in Pharmaceutical and Biomedical Applications by Marta Szekalska, Agata Puciłowska, Emilia Szymańska, Patrycja Ciosek, Katarzyna Winnicka

“…The recent technological advancements with using alginates, issues related to alginates suitability as matrix for three-dimensional tissue cultures, adjuvants of antibiotics, and antiviral agents in cell transplantation in diabetes or neurodegenerative diseases treatment, and an update on the antimicrobial and antiviral therapy of the alginate based drugs are also highlighted.…”
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Parkinson's Disease: Is It a Toxic Syndrome? by Seham A. Gad ELhak, Abdel Aziz A. Ghanem, Hassan AbdelGhaffar, Sahar El Dakroury, Mohamed M. Salama

“…Parkinson's disease (PD) is one of the neurodegenerative diseases which we can by certainty identify its pathology, however, this confidence disappeares when talking about the cause. …”
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Oligodendrocyte precursor cells facilitate neuronal lysosome release by Li-Pao Fang, Ching-Hsin Lin, Yasser Medlej, Renping Zhao, Hsin-Fang Chang, Qilin Guo, Zhonghao Wu, Yixun Su, Na Zhao, Davide Gobbo, Amanda Wyatt, Vanessa Wahl, Frederic Fiore, Szu-Min Tu, Ulrich Boehm, Wenhui Huang, Shan Bian, Amit Agarwal, Marcel A. Lauterbach, Chenju Yi, Jianqin Niu, Anja Scheller, Frank Kirchhoff, Xianshu Bai

“…Our findings have implications for the prevention of age-related pathologies and the treatment of neurodegenerative diseases.…”
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Illuminating the impact of N-terminal acetylation: from protein to physiology by Nina McTiernan, Ine Kjosås, Thomas Arnesen

“…At the organismal level, N-terminal acetylation is highly influential, and its impairment was recently linked to cardiac dysfunction and neurodegenerative diseases.…”
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Levodopa Responsive Parkinsonism in Patients with Hemochromatosis: Case Presentation and Literature Review by Tarun Girotra, Abhimanyu Mahajan, Christos Sidiropoulos

“…Accumulation of iron in the brain has been postulated to be associated with several neurodegenerative diseases including Parkinson’s disease. The excess iron promotes Parkin and α-synuclein aggregation in the neurons. …”
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Programmed neurite degeneration in human central nervous system neurons driven by changes in NAD+ metabolism by Markus Brüll, Selina Multrus, Michael Schäfer, Ivana Celardo, Christiaan Karreman, Marcel Leist

“…Abstract Neurite degeneration (ND) precedes cell death in many neurodegenerative diseases. However, it remains unclear how this compartmentalized cell death process is orchestrated in the central nervous system (CNS). …”
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Preclinical use of a clinically-relevant scAAV9/SUMF1 vector for the treatment of multiple sulfatase deficiency by Maximiliano Presa, Rachel M. Bailey, Somdatta Ray, Lauren Bailey, Saurabh Tata, Tara Murphy, Pierre-Alexandre Piec, Harold Combs, Steven J. Gray, Cathleen Lutz

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Neurobiology of Vascular Dementia by Ana-Maria Enciu, Stefan N. Constantinescu, Laurenţiu M. Popescu, Dafin F. Mureşanu, Bogdan O. Popescu

“…However, in a very large majority of cases, these alterations occur in an already aged brain, characterized by a milieu of cellular and molecular events common for different neurodegenerative diseases. The cell signaling defects and molecular dyshomeostasis might lead to neuronal malfunction prior to the death of neurons and the alteration of neuronal networks. …”
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Contribution of Microglia-Mediated Neuroinflammation to Retinal Degenerative Diseases by Maria H. Madeira, Raquel Boia, Paulo F. Santos, António F. Ambrósio, Ana R. Santiago

“…One common feature of retinal degenerative diseases and brain neurodegenerative diseases is chronic neuroinflammation. There is growing evidence that retinal microglia, as in the brain, become activated in the course of retinal degenerative diseases, having a pivotal role in the initiation and propagation of the neurodegenerative process. …”
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Role of Neuroinflammation in Adult Neurogenesis and Alzheimer Disease: Therapeutic Approaches by Almudena Fuster-Matanzo, María Llorens-Martín, Félix Hernández, Jesús Avila

“…Neuroinflammation, a specialized immune response that takes place in the central nervous system, has been linked to neurodegenerative diseases, and specially, it has been considered as a hallmark of Alzheimer disease, the most common cause of dementia in the elderly nowadays. …”
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The neurotoxicity of iodoacetic acid, a byproduct of drinking water disinfection by Xu Wang, Xu Wang, Xu Wang, Chunshu Rong, Ping Niu, Wei Leng, Gaihua Wang, Ziqiao He, Xin Qi, Dexi Zhao, Dexi Zhao, Jinhua Li

“…In neurological manifestations, IAA can lead to neurotransmitter disorders, neurodevelopment dysfunction, and even neurodegenerative diseases. Taken together, our review provides insights into the mechanisms of IAA neurotoxicity that will contribute to future studies of IAA neurotoxicity and its protective strategies.…”
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Targeting Mitochondrial Dysfunction in Cerebral Ischemia: Advances in Pharmacological Interventions by Igor Belenichev, Olena Popazova, Nina Bukhtiyarova, Victor Ryzhenko, Sergii Pavlov, Elina Suprun, Valentyn Oksenych, Oleksandr Kamyshnyi

“…This article highlights the critical role of mitochondrial dysfunction in the progression of neurodegenerative diseases and discusses the need for targeted therapeutic strategies to attenuate cellular damage, restore mitochondrial function, and enhance neuroprotection.…”
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Brain Plasticity and Cell Competition: Immediate Early Genes Are the Focus by Pavel P. Tregub, Yulia K. Komleva, Maria V. Kukla, Anton S. Averchuk, Anna S. Vetchinova, Natalia A. Rozanova, Sergey N. Illarioshkin, Alla B. Salmina

“…This work might inspire new gene therapy strategies targeting IEGs to regulate synaptic plasticity, and potentially prevent or mitigate neurodegenerative diseases.…”
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Consequences of Repetitive Head-Impact Exposure in Sports - literature review by Wiktoria Gajek-Flanczewska, Sebastian Flanczewski, Małgorzata Wirkijowska, Katarzyna Wójtowicz, Jakub Wirkijowski, Agata Walczak, Paulina Woźniak, Ewa Wietrzykowska, Dominika Sobolewska, Katarzyna Michalczyk-Fraszka, Martyna Śliwińska, Anna Podraza

“… Repetitive head impacts (RHIs), common in contact sports, have raised concerns about their long-term effects on brain health, potentially leading to conditions like concussions, Chronic Traumatic Encephalopathy (CTE), and other neurodegenerative diseases. CTE, a progressive tauopathy, is associated with cognitive and psychological symptoms, including memory loss and depression. …”
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An Overview of DNA Repair in Amyotrophic Lateral Sclerosis by Fabio Coppedè

“…Moreover, biochemical and genetic data on DNA repair in ALS are discussed in light of similar findings in other neurodegenerative diseases.…”
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