Familial Aggregation and Risk Factors for Prostate Cancer in Affected Individuals by Julio Armando Sánchez Delgado, Nailé Edita Sánchez Lara

“…Genetic studies indicate a link between certain genetic mutations, the aggressiveness of this neoplasia, the risk of developing the disease, and patient survival rates. …”
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Immunohistochemical evaluation of P53 in squamous cell carcinoma of the esophagus by Kala K, Sarumathy G, Nithya I, Prathiba A

“…Among the molecular alterations associated with ESCC, mutations and dysregulation of the p53 tumor suppressor gene have garnered significant attention. …”
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Clinico¬pathological features and phylogenetic analysis of rabies infection in local Iraqi breed cattle by M. H. Hussain, Kh. A. Mansour, S. A. A. Al-Redah, A. J. Abid

“…In conclusion, rabies in cattle is an endemic, life-threatening, transboundary disease that affects animals and public health in Iraq and needs more studies to explain the cause behind the recorded substitution mutations and the similarity of the Iraqi isolates with Nigerian isolates.…”

Familial Lymphoproliferative Malignancies and Tandem Duplication of NF1 Gene by Gustavo Fernandes, Mirela Souto, Frederico Costa, Edite Oliveira, Bernardo Garicochea

“…Neurofibromatosis type 1 is a genetic disorder caused by loss-of-function mutations in a tumor suppressor gene (NF1) which codifies the protein neurofibromin. …”
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Cost-effectiveness of Ruxolitinib vs Best Available Therapy in the Treatment of Myelofibrosis in Spain by María Teresa Gómez-Casares, Juan Carlos Hernández-Boluda, Antonio Jiménez-Velasco, Joaquin Martínez-López, María Giovanna Ferrario, Irmina Gozalbo, Joana Gostkorzewicz, Rudi Subirá

“…Identification of the Janus Kinase (JAK) gene mutations inaugurated a new era in the targeted therapy of myeloproliferative diseases. …”
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Clinical trial participation, clinical care, and patient outcomes by practice setting: a real-world database analysis of patients with Chronic Lymphocytic Leukemia or Mantle Cell L... by Debora S. Bruno, Manoj Khanal, Xiaohong Li, Maricer P. Escalon, Katherine Winfree, Lisa M. Hess

“…Academic settings were associated with higher patient volume and were more likely to treat MCL with CAR-T, enroll patients with CLL or MCL to clinical trials, and care for patients who were younger, White, and for CLL with higher rates of del(17p) mutations (all p < 0.01). Survival was significantly longer among patients treated in academic vs community settings (median OS not reached vs 80.5 months for CLL; 95.6 vs 68.7 months for MCL from start of first-line therapy).Discussion Patients who received care in academic settings differed from those treated in the community; care in academic settings was associated with significantly longer OS and higher trial participation. …”
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Blood-based biomarkers in patients with non-small cell lung cancer treated with immune checkpoint blockade by Yo-Ting Tsai, Jeffrey Schlom, Renee N. Donahue

“…Here we review studies in which multiple blood-based biomarkers encompassing circulating soluble analytes, immune cell subsets, circulating tumor DNA, blood-based tumor mutational burden, and circulating tumor cells have shown promising associations with the clinical response of NSCLC patients to ICI therapy. …”
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Investigating the reassortment potential and pathogenicity of the S segment in Akabane virus using a reverse genetics system by Eun-Jee Na, Chang-Gi Jeong, Su-Beom Chae, Jae-Ku Oem

“…In this study, changes in viral replication and pathogenicity were investigated, particularly when the S segment of AKAV-7 was mutated using a T7 RNA polymerase-based reverse genetics (RG) system. …”
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Comparative assessment of the photosynthetic pigment content among representatives of intraspecific taxa in <i>Pisum sativum</i> L. by S. V. Bobkov, K. A. Bashkirova, E. V. Semenova, M. A. Vishnyakova

“…Homologs of the STAY-GREEN gene (SGR), with mutations enabling leaves to photosynthesize longer, have been described for a number of crops, including pea. …”
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Molecular genetics of idiopathic pulmonary fibrosis by R. N. Mustafin

“…Genetic studies have shown a role of mutations and polymorphisms in mucin genes (MUC5B), in the genes responsible for the integrity of telomeres (TERC, TERC, TINF2, DKC1, RTEL1, PARN), in surfactant-related genes (SFTPC, SFTPCA, SFTPA2, ABCA3, SP-A2), immune system genes (IL1RN, TOLLIP), and haplotypes of HLA genes (DRB1*15:01, DQB1*06:02) in IPF pathogenesis. …”
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Biomarkers of Oxidative Stress in Huntington's Disease and Other Neurological Disorders: a Comparative Study by Marisol Peña Sánchez, Gabriel Andrés Peña de los Santos, Gretel Riverón Forment, Gloria Lara Fernández, Tatiana Acosta Sánchez, Alina González-Quevedo Monteagudo

“…Protein oxidation could be related to the accumulation of mutated huntingtin over time.…”
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Inhibition of BRD4 attenuated IFNγ-induced apoptosis in colorectal cancer organoids by Akimi Yonezawa, Kana Shimomura, Koji Okamoto, Haruna Takeda

“…Methods We knocked out Brd4 in tumor organoids carrying mutations in Apc and Kras to generate Brd4KO organoids, and performed RNA-seq. …”
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Activity of Various Cathepsin Proteases and Enrichment of Klotho Protein in the Urine and Urinary Extracellular Vesicles After SARS-CoV-2 Infection by Niharika Bala, Ramish H. Rafay, Sarah C. Glover, Abdel A. Alli

“…<b>Background:</b> The severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) is responsible for causing the Coronavirus disease 2019 (COVID-19) outbreak. While mutations cause the emergence of new variants, the ancestral SARS-CoV-2 strain is unique among other strains. …”
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Comparative gametogenesis and genomic signatures associated with pollen sterility in the seedless mutant of grapevine by Siddhi Chavan, Satish Phalake, Sujata Tetali, Vitthal T. Barvkar, Ravindra Patil

“…Genome sequence data was also used to identify induced mutations in the seedless mutant, which revealed three homozygous and 25 heterozygous InDels in the genes related to male gametophyte development. …”
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Phylogenetic analysis of dermatophytes isolated from small domestic animals by A. M. Smagulova, E. V. Kukhar, T. I. Glotova, A. G. Glotov

“…The comparative analysis of the genomes of the Microsporum and Trichophyton fungi and reference strains revealed a relatively low level of intraspecies polymor- phism and point mutations of the sequences. The data analysis demonstrated a high percentage of nucleotide sequence homology, and this allows using the primers for PCR tests intended for dermatophytosis diagnosis in cats and dogs.…”
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Networking Salt Inducible Kinase 1 Regulatory Perturbations on Type 2 Diabetes- Breast Cancer Co-Morbidity Associated Molecular Bridge by Durrani I.A., John P., Bhatti A.

“…To probe into its functional niche within the co-diseasome, this study constructed and subjected SIK1 associated regulome to network modelling. Gene mutations, and transcription factors (TF), hub proteins and microRNA (miRNA) associated with SIK1 and its protein-protein interactions (PPIs) were extracted from MuTarget and EnrichR, respectively. …”
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Investigating the functional and structural effect of non-synonymous single nucleotide polymorphisms in the cytotoxic T-lymphocyte antigen-4 gene: An in-silico study. by Md Mostafa Kamal, Kazi Fahmida Haque Shantanu, Shamiha Tabassum Teeya, Md Motiar Rahman, A K M Munzurul Hasan, Douglas P Chivers, Tanveer A Wani, Atekah Hazzaa Alshammari, Mahesh Rachamalla, Francisco Carlos da Silva Junior, Md Munnaf Hossen

“…ConSurf predicted conservation scores for four nsSNPs, and Project Hope suggested that all mutations could disrupt protein interactions. Furthermore, mCSM and DynaMut2 analyses indicated a decrease in ΔΔG stability for the mutants. …”
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Eklektizismus und Experiment. ›Just Intonation‹ in Ben Johnstons späten Streichquartetten by Johannes Quint

“…In the 3rd movement of String Quartet No. 9, cycles are altered through microtonal modulation. Microtonal mutations permeate the variations of the 4th movement of String Quartet No. 10 and in the 1st movement of String Quartet No. 8 the diminution of a harmonic progression acquires a new quality due to its abundance of microtonal intervals. …”
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Analysis of the VERNALIZATION-A1 exon-4 polymorphism in polyploid wheat by A. F. Muterko, E. A. Salina

“…In recent studies, an association of missense mutations within VERNALIZATION-A1 exon-4 with modulation of quantitative values of such agronomically valuable traits as frost tolerance, vernalization requirement duration and flowering time of wheat was shown. …”
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The problem of norovirus infection in animals (literature review) by V. А. Mischenko, A. V. Mischenko, T. B. Nikeshina, O. N. Petrova, Yu. V. Brovko, A. I. Kushlubaeva

“…The norovirus genome is prone to mutations, resulting in antigenic shifts and recombination, as well as the emergence and rapid spread of new epidemic and epizootic variants. …”
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