SPERMATOGENESIS INDICES IN INBRED STRAINS DD/HE AND BALB/CLAC AND THEIR F1 RECIPROCAL CROSSES by M. A. Kleshchev, L. V. Osadchuk, A. V. Osadchuk

“…It is known that Y chromosome genes are important for spermatogenesis. Thus, Y chromosome mutations may be responsible for interstrain differences in spermatogenic parameters. …”
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Machine learning models for water safety enhancement by Fatemeh Ranjbar, Hossein Sadeghi, Reza Pourimani, Soraya Khanmohammadi

“…These radionuclides can infiltrate the human body through various pathways, potentially leading to cancer and genetic mutations. A study was conducted using random sampling to assess the concentrations of radioactive isotopes and heavy metals in mineral water from Iran, consumable at Arak City. …”
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MsDpo4—a DinB Homolog from Mycobacterium smegmatis—Is an Error-Prone DNA Polymerase That Can Promote G:T and T:G Mismatches by Amit Sharma, Deepak T. Nair

“…Overall, our data show that MsDpo4 has the capacity to facilitate transition mutations and can potentially impart plasticity to the genome.…”
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ATM in immunobiology: From lymphocyte development to cancer immunotherapy by Ji-Hoon Lee

“…Ataxia Telangiectasia Mutated (ATM) is a protein kinase traditionally known for its role in DNA damage response and cell cycle regulation. …”
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Facioscapulohumeral muscular dystrophy: a review of pathogenesis, clinical symptoms, and treatment by T. Mikalauskas, B. Burnytė

“…The first type is characterised by a reduction in D4Z4 repeats, while the second type is characterised by mutations in genes encoding epigenetic regulators such as SMCHD1. …”
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Therapeutic Potential of α-Synuclein Evolvability for Autosomal Recessive Parkinson’s Disease by Jianshe Wei, Gilbert Ho, Yoshiki Takamatsu, Eliezer Masliah, Makoto Hashimoto

“…The remaining are familial PD associated with gene mutations of either autosomal dominant or recessive inheritances. …”
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Principal component analysis (PCA) as a genetic diversity tool to understand the variation of rice mutant culture by S. Palaniyappan1, P. Arunachalam1*, S. Banumathy1 and S. Muthuramu2

“…More precisely, the grouping revealed that the EMS mutants of Anna (R) 4 were potentially mutated not only for the grain type and also for yield related traits such as flag leaf length and breadth, panicle length, plant height. …”
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Marfan Syndrome and Autosomal Dominant Polycystic Kidney Disease: A Case of Rare Co-occurrence or Coincidence? by Arjun Sekar

“…ADPKD and MFS are caused by totally different mutations. However, the literature review showed that vascular abnormalities and connective tissue diseases may be more common with ADPKD. …”
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Hybrid Genetic Grey Wolf Algorithm for Large-Scale Global Optimization by Qinghua Gu, Xuexian Li, Song Jiang

“…Finally, the elite individuals in the population are mutated to prevent the algorithm from falling into local optimum. …”
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Statistical - Spatial Analysis of the Core of Siberian High Pressure System Period 1955-2014) by daryosh yarahmdi, asadollah khoshkish, Mustafa Karampour, Ismail Ahmadi

“…Unlike the months of October and January, in March the central pressure had few mutations but no trend was observed. However, during this month the Earth's surface temperature has increased significantly during thementioned period.…”
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Global Fluoroquinolone Resistance Epidemiology and Implictions for Clinical Use by Axel Dalhoff

“…However, 10 to 30% of these isolates harbored first-step mutations conferring low level fluoroquinolone resistance. …”
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Circulating Dynamics of SARS-CoV-2 Variants between April 2021 and February 2022 in Turkey by Murat Sayan, Ayse Arikan, Murat Isbilen

“…In the current study, spike-genome next-generation sequencing was generated from 492 SARS-CoV-2 isolates to evaluate the mutations in Turkey from April 2021 to February 2022. …”
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Into the ears, through the head, out on the lips. How listening errors can trigger new instances of palatalisation by Olivier Glain

“…L’auteur propose une hypothèse selon laquelle les grandes mutations sociales et idéologiques qui ont caractérisé le monde anglo-saxon après la Seconde Guerre Mondiale ont favorisé le développement de palato-alvéolaires à l’origine non-standard.…”
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Fingertips Ischemia, Nephroangiosclerosis, and Focal Segmental Glomerulosclerosis: Is Genetic Thrombophilia the Unique Explanation? by Lisa Giovannini, Carlo Donadio

“…Case Presentation. 53-years-old-man with essential hypertension and nonnephrotic proteinuria (1.3 gr/24 h) and with normal renal function (eGFR-MDRD 123 mL/min/1.73 m2) was admitted to nephrology department; kidney biopsy showed FSGS; two years later the patient presented with ulceration and ischemic gangrene of the IV and V right-hand fingertips; genetic analysis demonstrated polymorphism of the methylenetetrahydrofolate reductase genes C677T (heterozygote C677T/1298AC with normal value of homocysteine) and mutations of prothrombin gene G20210A and of plasminogen activator inhibitor-1 4G/5G 675 with slight increase of its value. …”
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Role of SarA in Staphylococcus aureus: A Virulence Target For Therapeutic Strategies by Yi He Kuai, Jodi Woan-Fei Law, Yong Sze Ong, Vengadesh Letchumanan, Learn-Han Lee, Loh Teng-Hern Tan

“…SarA plays a crucial role in the pathogenic mechanisms of S. aureus and the development of biofilms, while simultaneously modulating the synthesis of multiple virulence factors and influencing the expression of specific colonization determinants, and mutations in sarA partially limit the extent of S. aureus biofilms formation. …”
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Multiple small bowel GIST as GI manifestation of neurofibromatosis type I: A case report by Habtamu Tsegaye, Adamu Tigabu

“…In NF1-associated GIST, KIT and PDGFRA mutations are frequently absent and imatinib is ineffective. …”
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Linking Epigenetics to Human Disease and Rett Syndrome: The Emerging Novel and Challenging Concepts in MeCP2 Research by Robby Mathew Zachariah, Mojgan Rastegar

“…A well-known link between epigenetics and human disease is the X-linked MECP2 gene, mutations in which lead to the neurological disorder, Rett Syndrome. …”
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Sécurité aux frontières : Portée et limites de la stratégie algérienne by Abdennour Benantar

“…Despite its contribution to securing the border strip, however, this strategy is still limited for several reasons: the State-centric orientation found whenever dealing with specific issues; the inoperativeness of some cardinal principles in an evolving context characterized by the affirmation of non-state actors; the mutations of the terrorist phenomenon; a highly unstable regional context; a lack of strategic convergence in the region.…”
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Genotype-phenotype insights of pediatric dilated cardiomyopathy by Ying Dai, Yan Wang, Youfei Fan, Bo Han

“…Future research should further explore novel pathogenic genes and mutations and strengthen genotype-phenotype correlation analyses to facilitate precise diagnosis and treatment of DCM in children.…”
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Pyruvate Kinase Deficiency Causing Priapism by Vinay Hanyalu Shankar, Bharadwaj Adithya-Sateesh, Nicole Gousy, Girma Ayele, Freyr Petursson, Rediet Atalay, Miriam Michael

“…Diagnosis is usually made by demonstration of decreased PK enzymatic activity in a spectrophotometric assay and on the detection of mutations in the PK-LR gene. Management strategies vary from full splenectomies to hematopoietic stem cell transplants with gene therapies with transfusions and administration of PK-activators coming in between. …”
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