Optimal control of chikungunya disease: Larvae reduction, treatment and prevention by Djamila Moulay, M. A. Aziz-Alaoui, Hee-Dae Kwon

“…The nature of these arboviruses is complex since it conjugates human, environmental, biological and geographical factors.Recent researchs have suggested, in particular during the Réunion Island epidemic in 2006, that the transmission by Aedes albopictus (an Aedes genus specie) has been facilitated by genetic mutations of the virus and the vector capacity to adapt to non tropical regions.In this paper we formulate an optimal control problem, based on biological observations. …”
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Advances in Immunotherapy and Targeted Therapy of Malignant Melanoma by Xue Wang, Shanshan Ma, Shuting Zhu, Liucun Zhu, Wenna Guo

“…Malignant melanoma (MM) is a malignant tumor, resulting from mutations in melanocytes of the skin and mucous membranes. …”
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Identification of selective SWI/SNF dependencies in enzalutamide-resistant prostate cancer by Bengul Gokbayrak, Umut Berkay Altintas, Shreyas Lingadahalli, Tunc Morova, Chia-Chi Flora Huang, Betul Ersoy Fazlioglu, Ivan Pak Lok Yu, Batuhan M. Kalkan, Paloma Cejas, Sonia H. Y. Kung, Ladan Fazli, Akane Kawamura, Henry W. Long, Ceyda Acilan, Tamer T. Onder, Tugba Bagci-Onder, James T. Lynch, Nathan A. Lack

“…Given that many enzalutamide-resistant tumors lack specific somatic mutations, there is strong evidence that epigenetic factors can cause enzalutamide resistance. …”
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Characterization of a pleomorphic rhabdomyosarcoma cell line by Sandra Stickler, Clemens Lang, Maximilian Rieche, Marie-Therese Eggerstorfer, Martin Hohenegger, Maximilian Hochmair, Gerhard Hamilton

“…Results of the novel functional BH1522 tests corroborate published tumor sequencing data that demonstrated alterations in receptor tyrosine kinase/MAPK, PI3K/AKT and mutated p53 as suspected drivers of malignant growth.…”
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Discontiguous recurrences of IDH-wildtype glioblastoma share a common origin with the initial tumor and are frequently hypermutated by Malcolm F. McDonald, Sricharan Gopakumar, Tareq A. Juratli, Ilker Y. Eyüpoglu, Ganesh Rao, Jacob J. Mandel, Ali Jalali

“…Exome analysis revealed shared driver and passenger mutations between discontiguous recurrences and initial tumors, supporting a common origin. …”
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Successful Kidney Transplantation for End-Stage Renal Disease in Marfan's Syndrome by Makoto Ryosaka, Kazuya Omoto, Taiji Nozaki, Kazuhiko Yoshida, Yugo Sawada, Hajime Hirano, Tomokazu Shimizu, Hideki Ishida, Kazunari Tanabe

“…Marfan’s syndrome is a systemic disorder of the connective tissue caused by mutations in the extracellular matrix protein fibrillin-1, with aortic dissection and aneurysm being its most life-threatening manifestations. …”
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Quantitative evaluation of the molecular marker using droplet digital PCR by Wonseok Shin, Haneul Kim, Dong-Yep Oh, Dong Hee Kim, Kyudong Han

“…They can be a powerful species-specific marker without regression mutations by the structure variation (SV) at the time of genomic evolution. …”
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Ego-Motion Estimation for Autonomous Vehicles Based on Genetic Algorithms and CUDA Parallel Processing by Abiel Aguilar-González, Alejandro Medina Santiago

“…By generating an initial seed of random motion candidates and iteratively mutating and selecting the best-performing individuals, we minimize the cost function that measures image similarity between frames. …”
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Latent Inflammation and Insulin Resistance in Adipose Tissue by I. S. Stafeev, A. V. Vorotnikov, E. I. Ratner, M. Y. Menshikov, Ye. V. Parfyonova

“…It mostly develops as a result of dysregulated insulin signaling in insulin-sensitive cells, as compared to inactivating mutations in insulin receptor or signaling proteins that occur relatively rare. …”
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Genomic and Metabolomic Analyses of <i>Streptomyces albulus</i> with Enhanced ε-Poly-<span style="font-variant: small-caps">l</span>-lysine Production Through Adaptive Laboratory E... by Xidong Ren, Xinjie Sun, Yan Chen, Xiangheng Xi, Yunzhe Ma, Xinyue Jiang, Xian Zhang, Chenying Wang, Deqiang Zhu, Xinli Liu

“…Genomic and metabolic analyses revealed that mutations occurred in genes responsible for transcriptional regulation, transporter, cell envelope, energy metabolism, and secondary metabolite synthesis, as well as the enrichment of metabolites involved in the biosynthesis of ε-PL. …”
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Anomalous Coronary Artery Origin in a Young Patient with Marfan Syndrome by S. B. C. P. Duarte, D. O. Beraldo, L. A. M. Cesar, A. P. Mansur, J. Y. Takada

“…Marfan syndrome is an autosomal dominant genetic disorder that affects connective tissue and is caused by mutations in the fibrillin 1 gene present at chromosome 15. …”
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COVID-19 Whole-Genome Resequencing with Redundant Tiling PCR and Subtract-Based Amplicon Normalization Successfully Characterized SARS-CoV-2 Variants in Clinical Specimens by Tatsuki Sugi, Mizanur Rahman, Rummana Rahim, Abu Hasan, Naoko Kawai, Kyoko Hayashida, Junya Yamagishi

“…Here, we propose an additional strategy for tiling PCR for whole-genome resequencing, which can make the pipeline robust for mutations at the primer annealing site by a redundant amplicon scheme. …”
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Insulin/IGF-I and Related Signaling Pathways Regulate Aging in Nondividing Cells: from Yeast to the Mammalian Brain by Edoardo Parrella, Valter D. Longo

“…Mutations that reduce glucose or insulin/insulin-like growth factor-I (IGF-I) signaling increase longevity in organisms ranging from yeast to mammals. …”
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The Interplay between Defensins and Microbiota in Crohn’s Disease by Lorena Coretti, Alessandro Natale, Mariella Cuomo, Ermanno Florio, Simona Keller, Francesca Lembo, Lorenzo Chiariotti, Raffaela Pero

“…In addition to an immunological basis, the disease is frequently associated with genetic alterations including mutations of NOD2 gene. Several therapeutic strategies to circumvent the dysfunction observed in CD are currently under investigation. …”
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Prion protein promotes copper toxicity in Wilson disease by Raffaella Petruzzelli, Federico Catalano, Roberta Crispino, Elena V. Polishchuk, Mariantonietta Elia, Antonio Masone, Giada Lavigna, Anna Grasso, Maria Battipaglia, Lucia Vittoria Sepe, Banu Akdogan, Quirin Reinold, Eugenio Del Prete, Diego Carrella, Annalaura Torella, Vincenzo Nigro, Enrico Caruso, Nicole Innocenti, Emiliano Biasini, Ludmila V. Puchkova, Alessia Indrieri, Ekaterina Y. Ilyechova, Pasquale Piccolo, Hans Zischka, Roberto Chiesa, Roman S. Polishchuk

“…Dysfunction in key components of this network leads to the disruption of Cu homeostasis, resulting in fatal disorders such as Wilson disease, which is caused by mutations in the hepatic Cu efflux transporter ATP7B. …”
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Virulence Factors of Clostridioides (Clostridium) difficile Linked to Recurrent Infections by Laura Tijerina-Rodríguez, Licet Villarreal-Treviño, Rayo Morfín-Otero, Adrián Camacho-Ortíz, E. Garza-González

“…Several bacterial virulence factors have been associated with RCDI, including the elevated production of toxins A and B, the presence of a binary toxin CDT, and mutations in the negative regulator of toxin expression, tcdC. …”
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Hemoglobin Sunshine Seth: A Case Report of Low-Oxygen-Affinity Hemoglobinopathy by Leah S. Heidenreich, Jennifer L. Oliveira, Peter J. Holmberg, Vilmarie Rodriguez

“…Therefore, it is important to consider alternative, albeit rare, diagnoses, including hemoglobinopathies with abnormal oxygen binding properties. Mutations in the structure of alpha- and beta-globin chains can alter the affinity of hemoglobin for oxygen, and changes in oxygen affinity may result in changes in the oxygen saturation detected by pulse oximetry. …”
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Gemcitabine combined with baicalein exerts antiviral activity against PEDV by inhibiting the entry and replication phases by Yingge Zheng, Yanfei Zhang, Fangying Xiong, Dehua Luo, Yuxiang Wang, Yijia Zhang, Dengguo Wei

“…Abstract Cocktail therapy significantly reduces the development of resistance to individual medications due to viral mutations. However, for effective inhibition of a particular virus, a customized approach to combination pharmacotherapy may be essential. …”
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Association between Cysticercosis and Neoplasia: A Study Based on Autopsy Findings by Camila Lourencini Cavellani, Aline Cristina Souza da Silva, Grace Kelly Naves de Aquino Ribeiro, Lívia Ferreira Oliveira, Mara Lúcia Fonseca Ferraz, Vicente de Paula Antunes Teixeira

“…The cells with genetic mutations proliferate in a disorganized manner, leading to the development of neoplasia. …”
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Strong concordance between RNA structural and single nucleotide variants identified via next generation sequencing techniques in primary pediatric leukemia and patient-derived xeno... by Sonali P. Barwe, Anilkumar Gopalakrisnapillai, Nitin Mahajan, Todd E. Druley, E. Anders Kolb, Erin L. Crowgey

“…The presence of gene fusions representing the major driver mutations at similar allelic frequencies in PDX samples compared to primary samples and over multiple passages confirms the utility of PDX models for preclinical drug testing. …”
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