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361
Positively charged specificity site in cyclin B1 is essential for mitotic fidelity
Published 2025-01-01“…HeLa cells expressing pocket mutant cyclin B1 are strongly delayed in anaphase onset due to multiple defects in mitotic spindle function and timely activation of the E3 ligase APC/C. …”
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362
Pediatric Case of Li–Fraumeni Syndrome in Honduras
Published 2021-01-01“…An intraventricular tumor was identified in the occipital of the left lateral ventricle, which turned out to be a TP53-mutant choroidal plexus carcinoma.…”
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363
A Conserved Di-Lysine Motif in the E2 Transactivation Domain Regulates MmuPV1 Replication and Disease Progression
Published 2025-01-01“…Furthermore, mutation of the second lysine residue, K113, to the potential acetyl-lysine mimic glutamine (Q) abrogated E2 transcription and decreased transient replication in vitro, while the acetylation defective arginine (R) mutant remained functional. Both K113 mutants were able to induce wart formation in vivo, though disease progression appeared to be delayed in the K113Q group. …”
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364
Role of Stat3 in Skin Carcinogenesis: Insights Gained from Relevant Mouse Models
Published 2013-01-01“…Further studies using a transgenic mouse model with a gain of function mutant of Stat3 (Stat3C) expressed in the basal layer of the epidermis revealed a novel role for Stat3 in skin tumor progression. …”
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365
Pathogenicity Assay of Vibrio harveyi in Tiger Shrimp Larvae Employing Rifampicin-Resistant as A Molecular Marker
Published 2007-12-01“…Two groups of shrimp post-larvae (PL5) were immersed for 30 min in 106 CFU/ml of mutants and wild type of V. harveyi, respectively; and then placed in a 2 liter shrimp rearing tank for five days. …”
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366
RNase Y mediates posttranscriptional control of the virulence-associated CncR1 small-RNA in Helicobacter pylori
Published 2025-02-01“…The observation that the RNAse Y-mutant strain showed deregulation of several members of the CncR1 regulon suggests this ribonuclease has an important role in H. pylori posttranscriptional regulation.…”
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367
Understanding Rifampicin Resistance in Tuberculosis through a Computational Approach
Published 2014-12-01“…In this study, we modeled two resistant mutants of rpoB (S450L and H445Y) using Modeller9v10 and performed a docking analysis with RIF using AutoDock4.2 and compared the docking results of these mutants with the wild-type rpoB. …”
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368
AT2 Receptor-Interacting Proteins ATIPs in the Brain
Published 2013-01-01“…We summarize here current knowledge on the ATIP family of proteins, and we present new experimental evidence showing interaction defects between ATIP1 and two mutant forms of the AT2 receptor identified in cases of mental retardation. …”
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369
Comparative Evaluation of the Adsorption Performance of Citric Acid-Treated Peels of Trapa natans and Citrullus lanatus for Cationic Dyes Degradation from Water
Published 2022-01-01“…Thermodynamic parameters such as ΔG0, ΔS0, ΔH0, and ΔE0 are determined statistically for the adsorption performance of both novel chemically mutant biosorbents, which reflect that biosorption mechanisms are exothermic as well as spontaneous.…”
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370
Genetic analysis of pathways regulated by the von Hippel-Lindau tumor suppressor in Caenorhabditis elegans.
Published 2004-10-01“…However, persisting differential gene expression in hif-1 versus hif-1; vhl-1 double mutant worms clearly distinguished HIF-1-independent effects of VHL-1 inactivation. …”
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371
Design, Expression, and Inhibitory Effects of Antagonistic Single-Chain Platelet-Derived Growth Factor on Lung Cancer Cells
Published 2025-01-01“…Molecular dynamics simulations of the designed antagonistic sc-PDGF showed a noteworthy reduction in binding affinity at the mutant interface, indicating a reduced capability to effectively bind the receptor. …”
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372
Structural Predictive Model of Presenilin-2 Protein and Analysis of Structural Effects of Familial Alzheimer’s Disease Mutations
Published 2021-01-01“…These relationships allow for studying the system from a structural approach with the determination of small distance changes, potential surfaces, electrostatic maps, and angle changes, which favor the comparison between wild-type and mutant systems. With the results obtained, it is expected to complement experimental data reported in the literature from models that would allow us to understand the effects of the selected mutations.…”
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373
Pathogenesis of Myeloproliferative Neoplasms: Role and Mechanisms of Chronic Inflammation
Published 2015-01-01“…Moreover, the JAK inhibitor clinical trials showed that the reduction of symptoms linked to inflammation was beneficial to patients even in the absence of significant decrease in the JAK2-V617F mutant load. These observations suggested that part of the inflammation observed in patients with JAK2-mutated MPNs may not be the consequence of JAK2 mutation. …”
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374
CK2α-mediated phosphorylation of DUB3 promotes YAP1 stability and oncogenic functions
Published 2025-01-01“…On the contrary, the loss of Thr495 phosphorylation by the phosphorylation-defective mutant DUB3 T495A, the cancer-related mutant DUB3 D496H and CK2 inhibition failed to deubiquitinate and stabilize YAP1 effectively. …”
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375
Examination of Molecular Effects of MYLK Deletion in a Patient with Extensive Aortic, Carotid, and Abdominal Dissections That Underlie the Genetic Dysfunction
Published 2020-01-01“…We also provide the electrostatics calculations from the wild type and mutant variant. Through a combined multiomic approach of clinical, functional, and protein informatics, we arrive at a data fusion for determination of pathogenicity embedded within the genetic code for this particular genetic variant, which, as a platform, continues to broaden its scope across the field of variants of uncertain significance classification.…”
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376
Herpes Simplex Virus-2 Glycoprotein Interaction with HVEM Influences Virus-Specific Recall Cellular Responses at the Mucosa
Published 2012-01-01“…Mice were primed with attenuated HSV-2 expressing wild-type gD or mutant gD unable to engage HVEM and challenged 32 days later with virulent HSV-2 expressing wild-type gD. …”
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377
Leiomodin creates a leaky cap at the pointed end of actin-thin filaments.
Published 2020-09-01“…Data from experiments performed in cardiomyocytes provide additional support for the competition model; specifically, expression of a leiomodin mutant that is unable to interact with tropomyosin fails to displace tropomodulin at thin filament pointed ends and fails to elongate thin filaments. …”
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378
Fission yeast cells deficient in siderophore biosynthesis require Str2 for ferrichrome-dependent growth
Published 2025-02-01“…Further analysis identified that conserved amino acids Tyr539 and Tyr553 in the last predicted loop of Str2 are required for supporting Fc-dependent growth of a sib1Δ sib2Δ mutant strain. Collectively, these findings indicate that the vacuolar Str2 protein plays a role in the consumption of Fc as an iron source, while also revealing the involvement of the vacuole in iron release from exogenous Fc after its assimilation.…”
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379
A two-strain HIV-1 mathematical model to assess the effects of chemotherapy on disease parameters
Published 2005-09-01“…We explore the effects of chemotherapy on the dynamics of two viral strains and T lymphocytes with one mutant strain phenotypically resistant to drug effects. …”
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380
Congenital Oligodendroglioma: Clinicopathologic and Molecular Assessment with Review of the Literature
Published 2015-01-01“…The mass was excised and the microscopic appearance was that of a classic low grade oligodendroglioma composed of cells with uniformly round nuclei, perinuclear halos, delicate branching capillaries, and an absence of high grade features. Mutant specific (R132H) isocitrate dehydrogenase-1 (IDH1) immunohistochemistry was negative, and the tumor lacked detectable 1p or 19q deletions by fluorescent in situ hybridization (FISH). …”
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