Showing 341 - 360 results of 808 for search '"mutant"', query time: 0.06s Refine Results
  1. 341

    Biophysical and Structural Studies on the Capsid Protein of the Human Immunodeficiency Virus Type 1: A New Drug Target? by José L. Neira

    Published 2009-01-01
    “…In the first part of this work, I shall review the biophysical studies carried out with the dimeric wild-type CAC protein and a mutant monomeric variant. The results open new venues for the development of drugs able to interact either with the dimeric species, hampering its assembly, or with the monomeric species, obstructing its folding. …”
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  2. 342

    Two-Component Signal Transduction System SaeRS Positively Regulates Staphylococcus epidermidis Glucose Metabolism by Qiang Lou, Yijun Qi, Yuanfang Ma, Di Qu

    Published 2014-01-01
    “…In this study, we performed a proteomic analysis of differences in expression between the S. epidermidis 1457 wild-type and saeRS mutant to identify candidates regulated by saeRS using two-dimensional gel electrophoresis (2-DE) combined with matrix-assisted laser desorption/lonization mass spectrometry (MALDI-TOF-MS). …”
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  3. 343

    A Model System for Concurrent Detection of Antigen and Antibody Based on Immunological Fluorescent Method by Yuan-Cheng Cao

    Published 2015-01-01
    “…It will be helpful to screen for both antigen and antibody particularly in the situations of the multiserotype and high-frequency mutant virus infections.…”
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  4. 344

    The zinc-finger transcription factor Blimp1/Prdm1 is required for uterine remodelling and repair in the mouse by Maria-Eleni Xypolita, Mubeen Goolam, Elizabeth K. Bikoff, Elizabeth J. Robertson, Arne W. Mould

    Published 2025-01-01
    “…The present experiments demonstrate surprisingly that Blimp1 activity in the uterus is required for tissue remodelling at sites of embryonic failure. Moreover Blimp1 mutant females are refractory to RU486 induced decidual shedding. …”
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  5. 345

    GENETIC AND MOLECULAR ANALYSIS OF COMPLEMENTATION OF THE FLAMENCO AND PIWI LOCI IN DROSOPHILA MELANOGASTER by F. A. Urusov, L. N. Nefedova, A. R. Lavrenov, N. I. Romanova, A. I. Kim

    Published 2015-01-01
    “…This paper discusses the results of the complementation test, which involves crossing strains MS and SS, mutant for the flamenco locus, with the piwi strain 3, heterozygous for a mutation in the piwi gene, followed by study of the transcription level of gypsy in the ovaries and testes of hybrids derived from these crosses. …”
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  6. 346

    Pseudorabies virus infection triggers pUL46-mediated phosphorylation of connexin-43 and closure of gap junctions to promote intercellular virus spread. by Alexander Tishchenko, Nicolás Romero, Cliff Van Waesberghe, Jonas L Delva, Oliver Vickman, Gregory A Smith, Thomas C Mettenleiter, Walter Fuchs, Barbara G Klupp, Herman W Favoreel

    Published 2025-01-01
    “…Consequently, a UL46null PRV mutant is unable to phosphorylate Cx43 or inhibit GJIC and displays reduced intercellular spread, which is effectively rescued by pharmacological inhibition of GJIC. …”
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  7. 347

    sNASP Mutation Aggravates to the TLR4-Mediated Inflammation in SLE by TAK1 Pathway by Yatao Bao, Meng Lian, Yong Chen, Xiaotian Gu, Kunyu Cao, Xiaoping Du, Jiyu Ju

    Published 2023-01-01
    “…In previous studies, we found that the mutant somatic nuclear autoantigenic sperm protein (sNASP) gene in the mouse lupus susceptibility locus Sle2 can promote the development of lupus model mice, but the mechanism is still unclear. …”
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  8. 348

    Disorders in brassinosteroids signal transduction triggers the profound molecular alterations in the crown tissue of barley under drought. by Anetta Kuczyńska, Martyna Michałek, Piotr Ogrodowicz, Michał Kempa, Paweł Krajewski, Vladimiro Cardenia, Maria Teresa Rodriguez-Estrada, Marina Pérez-Llorca, Sergi Munné-Bosch, Krzysztof Mikołajczak

    Published 2025-01-01
    “…Large-scale transcriptomic and proteomic profiling confirmed the specific re-modeling of behavior of the BRs-insensitive barley uzu1.a mutant under drought. On the other hand, a set of genes expressed independently of the genotype was identified, including dehydrin encoding genes. …”
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  9. 349

    Nicotine Has a Therapeutic Window of Effectiveness in a Drosophila melanogaster Model of Parkinson’s Disease by Brady T. Mannett, Braden C. Capt, Krista Pearman, Lori M. Buhlman, John M. VandenBrooks, Gerald B. Call

    Published 2022-01-01
    “…We show that continuous early nicotine administration improves both climbing and flight deficiencies present in homozygous park25 mutant PD model Drosophila melanogaster. Using a new climbing assay, we identify several climbing deficiencies in this PD model that are improved or rescued by continuous nicotine treatment. …”
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  10. 350

    Polymer interaction of the genes SHY2 and MSG1, NPH4 and IAR2 in the inheritance of the Arabidopsis thaliana (L.) Heynh. root system by S. G. Hablak

    Published 2017-04-01
    “…By crossing plants of the mutant lines shy2-2×msg1-2, nph4-1×iar2-1, a segregation in F2 was observed, suggesting an interaction between the polymer SHY2 and MSG1, NPH4 and IAR2 genes. …”
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  11. 351

    Distinct roles for intra- and extracellular siderophores during Aspergillus fumigatus infection. by Markus Schrettl, Elaine Bignell, Claudia Kragl, Yasmin Sabiha, Omar Loss, Martin Eisendle, Anja Wallner, Herbert N Arst, Ken Haynes, Hubertus Haas

    Published 2007-09-01
    “…Restoration of the conidial hydroxyferricrocin content partially rescues the virulence of the apathogenic siderophore null mutant Delta sidA, demonstrating an important role for the conidial siderophore during initiation of infection. …”
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  12. 352

    Mice with Catalytically Inactive Cathepsin A Display Neurobehavioral Alterations by O. Y. Calhan, V. Seyrantepe

    Published 2017-01-01
    “…Previous in vitro studies have shown that CathA has specific activity against vasoactive peptides and neuropeptides, including endothelin-1 and oxytocin. A mutant mouse with catalytically inactive CathA enzyme (CathAS190A) shows increased levels of endothelin-1. …”
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  13. 353

    The Role of the Immune System in Huntington’s Disease by Gisa Ellrichmann, Christiane Reick, Carsten Saft, Ralf A. Linker

    Published 2013-01-01
    “…Huntington’s disease (HD) is characterized by a progressive course of disease until death 15–20 years after the first symptoms occur and is caused by a mutation with expanded CAG repeats in the huntingtin (htt) protein. Mutant htt (mhtt) in the striatum is assumed to be the main reason for neurodegeneration. …”
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  14. 354

    A Cell Model for Conditional Profiling of Androgen-Receptor-Interacting Proteins by K. A. Mooslehner, J. D. Davies, I. A. Hughes

    Published 2012-01-01
    “…These preliminary results now allow future studies to focus on replacing wild-type AR with mutant AR to uncover differences in protein interactions caused by AR mutations involved in PAIS.…”
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  15. 355

    Evolutionary Pattern of Asian HIV-1 Subtype B from 1990 to 2007: In Silico Analysis Based on Envelop Protein by Sobia Kanwal, Tariq Mahmood

    Published 2012-01-01
    “…These findings might help in understanding significant structural and functional constrains of the mutant viral strains and ultimately in vaccine development.…”
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  16. 356

    Stage-specific expression and divergent functions of two insulinase-like proteases associated with host infectivity in Cryptosporidium. by Yue Huang, Shifeng Pei, Xin Lv, Fuxian Yang, Xiaoqing Gong, Na Li, Yaqiong Guo, Yaoyu Feng, Lihua Xiao

    Published 2025-01-01
    “…Consistent with this, mice infected with the INS-20-deleted mutant had reduced intestinal damage and parasite burden.…”
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  17. 357

    Latest Approved Therapies for Metastatic Melanoma: What Comes Next? by Farid Menaa

    Published 2013-01-01
    “…The recent oncogene-directed therapeutic, vemurafenib, usually produces high level of tumor shrinkage and survival benefits in many patients with B-RA mutant melanomas, although the fast and high degrees of responses are likely short-lived. …”
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  18. 358

    S-Glutathionylation of Protein Disulfide Isomerase Regulates Estrogen Receptor α Stability and Function by Ying Xiong, Yefim Manevich, Kenneth D. Tew, Danyelle M. Townsend

    Published 2012-01-01
    “…Expression of an S-glutathionylation refractory PDI mutant diminishes the toxic effects of PABA/NO. Thus, redox regulation of PDI causes its S-glutathionylation, thereby mediating cell death through activation of the UPR and abrogation of ERα stability and signaling.…”
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  19. 359

    D-stem mutation in an essential tRNA increases translation speed at the cost of fidelity. by Madison N Schrock, Krishna Parsawar, Kelly T Hughes, Fabienne F V Chevance

    Published 2025-02-01
    “…Selection for fast translation through the slow-translated UCA-UAC pair, flanked by histidine codons, resulted in the isolation of an A25G base substitution mutant in the D-stem of an essential tRNA LeuZ, which recognizes the UUA and UUG leucine codons. …”
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  20. 360

    Nucleoside analogues in treatment of liver cirrhosis as an outcome of chronic hepatitis B by I. G. Bakulin

    Published 2009-02-01
    “…Its antiviral effect limited basically by development of drug resistance of a virus as a result of mutant strains development. Terms of lamivudine treatment for patients with liver cirrhosis should be no less than 22 months, and clearance HBV DNA is achieved in 93,9 % of patients. …”
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