Incidence, prevalence, and predictors of osteoporotic fracture in adult lung transplant recipients by Elisabeth Ng, Shanal Kumar, Eldho Paul, Daniel Bennett, Luisa Rosi, Louise Fuller, Lauren Chiu, Shoshana Sztal-Mazer, Steven Ivulich, Greg Snell, Leon A. Bach, Kathryn L. Hackman

“…Antiresorptive therapy was received by 47% pre- and 89% post-LT. On multivariate analysis, risk factors for osteoporotic fracture were pre-LT osteoporotic fracture (hazard ratio (HR) 2.32 (95% confidence interval (CI) 1.09-4.96)), female sex (HR 2.08 (95% CI 1.09-3.94)), glucocorticoid use pre-LT (HR 2.08 (95% CI 1.09-3.99)), and time (months) to first ZA infusion post-LT (HR 1.04 (95% CI 1.01-1.06)). …”
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Characterization of adult T-cell leukemia/lymphoma patients with specific skin lesions in a tertiary dermatological service in Brazil by Mariana Valente, José Antonio Sanches, Youko Nukui, Jade Cury-Martins, Bruno Castro Souza, Juliana Pereira, Denis Miyashiro

“…Acute and chronic unfavorable forms had worse prognoses, with median overall survival of 23.3 and 34.1 months, respectively (p = 0.0011). After multivariate analysis, Shimoyama classification (acute) and urea levels were associated with poorer prognoses.ConclusionWe described a large Brazilian cohort of ATLL with cutaneous involvement. …”
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Evaluating risk factors for Trastuzumab-Deruxtecan Pneumonitis in patients with metastatic breast cancer by Jonathan Henricks, Tyler Haddad, Omair Ahmed, Jonathan Schoenhals, Pavnesh Kumar, Ryan Wilson, Jianing Ma, Jing Gennie Wang, Michael Wert, Vincent Esguerra, Ian Bentley, Kai Johnson, Daniel Stover, Sachin R. Jhawar, Margaret Gatti-Mays, Kevin Ho

“…Multiple pre-treatment variables were not found to be associated with T-DXd pneumonitis, including chest imaging abnormalities (41.9% vs. 47.8%, p = 0.59), prior immune checkpoint inhibitor treatment (16.0% vs. 8.7%, p = 0.50) and prior chest or breast radiation (61.5% vs. 47.8%, p = 0.20). On multivariate analysis, prior treatment with abemaciclib remained significantly associated with T-DXd pneumonitis (OR 3.25 [1.07–9.11], p = 0.04), while neither pre-treatment chest imaging abnormalities nor prior chest or breast radiation were associated (OR 1.60 [0.62–4.20], p = 0.33); OR 0.51 [0.20–1.33], p = 0.17). …”
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Development of a nomogram for predicting pancreatic portal hypertension in patients with acute pancreatitis: a retrospective study by Yong Lv, Hui Luo, Yingjie Zhang, Xiangping Wang, Yanglin Pan, Yunling Li, Qiaoyu Su, Xianchen Zhan, Linhui Zhang, Xiaoyu Kang, Shuhui Liang, Gui Ren

“…Based on the results of the multivariate analysis, a nomogram was developed. The patients were randomly divided into training and validation sets at a 7:3 ratio. …”
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Absence of Standard Modifiable Risk Factors in Middle Eastern Patients with Atherosclerotic Cardiovascular Disease. The Jordan Absence of Standard Modifiable Risk Factors (SMuRF-Le... by Hammoudeh AJ, Aldalal’ah M, Smadi EA, Alrishoud D, Alomari A, Alkhawaldeh M, Rizik A, Okour MF, Araydah M

“…One year survival in the SMuRF-less patients was significantly lower than that in the SMuRFs groups (97.7% vs.98.4% vs.98.3%, respectively, p = 0.01). Multivariate analysis showed that young age, absence of heart failure and utilization of secondary preventive medications were associated with better one year outcome.Conclusion: In this cohort of ME patients with ASCVD, nearly four in 100 were SMuRF-less. …”
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Functional status, lymphocyte-to-monocyte ratio, and platelet-to-lymphocyte ratio as prognostic factors of one-year survival rate in elderly patients with advanced-stage non-small... by Ratna Nurhayati, Aulia Rizka, Cleopas Martin Rumende, Noorwati Sutandyo, Arif Hanafi, Edy Rizal Wahyudi, Hamzah Shatri, Anna Mira Lubis, Em Yunir, Muhammad Firdaus, Yuniar Harris Prayitno, Nadira Nibras Taqiyya

“…Statistical analyses were performed using SPSS 20.0, employing the log-rank method for bivariate analysis and Cox regression for multivariate analysis. Results: In a cohort of 108 patients, the majority were aged 60–69 years (74.1 %), male (66.7 %), diagnosed at stage IV (80.5 %), and with adenocarcinoma subtype (75.0 %). …”
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Real-world outcomes of maintenance therapy post-autologous stem cell transplantation in newly diagnosed multiple myeloma by Ka-Won Kang, Dae Sik Kim, Se Ryeon Lee, Mi Hwa Heo, Hyeon-Seok Eom, Jongheon Jung, Ji Hyun Lee, Sung-Hyun Kim, Youngil Koh, Chang-Ki Min, Seung Shin Lee, Sung-Nam Lim, Ho-Young Yhim, Myung-won Lee, Je-Jung Lee, Sung-Hoon Jung, Soo-Mee Bang, Kihyun Kim, the Korean Multiple Myeloma Working party [KMMWP]

“…The median progression-free survival (PFS) from the time of ASCT was 26.4 and 44.1 months in the no-maintenance and maintenance groups, respectively. In the multivariate analysis, the use of maintenance therapy was significantly associated with better PFS. …”
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Carcinoembryonic antigen trajectory predicts pathological complete response in advanced gastric cancer after neoadjuvant chemotherapy by Yonghe Chen, Yonghe Chen, Yonghe Chen, Dan Liu, Kaikai Wei, Yi Lin, Yi Lin, Yi Lin, Zhong Wang, Qian Sun, Huashe Wang, Huashe Wang, Huashe Wang, Junsheng Peng, Junsheng Peng, Junsheng Peng, Lei Lian, Lei Lian, Lei Lian

“…Lymph node remission also correlated with CEA trajectories, with Type I having the highest proportion of ypN0 (79.2%). Multivariate analysis identified CEA trajectory subtypes and tumor differentiation as independent predictors of pCR. …”
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Mechanical chest compression increases intrathoracic hemorrhage complications in patients receiving extracorporeal cardiopulmonary resuscitation by Yoshihisa Matsushima, Tatsuhiro Shibata, Kodai Shibao, Rei Yamakawa, Miyu Hayashida, Toshiyuki Yanai, Takashi Ishimatsu, Takehiro Homma, Shoichiro Nohara, Maki Otsuka, Yoshihiro Fukumoto

“…Intrathoracic hemorrhage requiring TAE occurred more frequently in the mechanical CPR group (18.8% vs. 2.3%, p = 0.030). On multivariate analysis, mechanical CPR was independently associated with this outcome (adjusted odds ratio 6.29; 95% confidence interval 1.20–65.10). …”
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Endothelial Activation and Stress Index (EASIX) to predict mortality after allogeneic stem cell transplantation: a prospective study by Axel Benner, Peter Dreger, Grzegorz W Basak, Christian Koenecke, Olaf Penack, Christophe Peczynski, Lucia López Corral, Ivan Moiseev, Hélène Schoemans, Zinaida Peric, Thomas Luft, Simona Sica, Mutlu Arat, Maija Itäla-Remes, Nicolaas P M Schaap, Michal Karas, Ludek Raida, Thomas Schroeder, Elisabetta Metafuni, Tulay Ozcelik, Brenda M Sandmaier, Lambros Kordelas

“…We were able to validate the cut-off and found that EASIX ≥3 was associated with more than twofold increased risk for NRM in multivariate analysis (HR=2.18, 95% CI 1.2 to 3.94; p=0.01). …”
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Risk factors associated with degenerative glenohumeral osteoarthritis by Ravi Prakash, Nitin B Jain, Ziyi Chen, Folefac D Atem, Michael S Khazzam, Rashmi Pathak, Daniel Tai, Ursa BezanPetric, Estefanie Garduno Rapp

“…In univariate analysis, significant associations with GH OA were found for increasing age (>40 to ≤50: OR 3.29, 95% CI 2.44 to 4.45; >50 to ≤60: OR 5.90, 95% CI 4.49 to 7.77; >60 to ≤70: OR 12.18, 95% CI 9.22 to 16.08 and >70: OR 16.54, 95% CI 12.47 to 21.94), higher BMI (≤19: OR 1.44, 95% CI 1.01 to 2.04; >25 to ≤30: OR 1.57, 95% CI 1.32 to 1.86; >30 to ≤35: OR 1.85, 95% CI 1.54 to 2.22 and >35: OR 1.77, 95% CI 1.28 to 2.45), prior shoulder injury (OR 1.30; 95% CI 1.12 to 1.50), shoulder surgery history (OR 0.71; 95% CI 0.57 to 0.87), shoulder pain at night (OR 1.35; 95% CI 1.07 to 1.70) and hypertension (OR 0.70; 95% CI 0.60 to 0.81). In multivariate analysis, significant associations remained for age (>40 to ≤50: OR 2.99, 95% CI 2.21 to 4.06; >50 to ≤60: OR 5.48, 95% CI 4.14 to 7.23; >60 to ≤70: OR 11.22, 95% CI 8.44 to 14.88 and >70: OR 16.65, 95% CI 12.45 to 22.17), BMI (≤19: OR 1.49, 95% CI 1.01 to 2.20; >25 to ≤30: OR 1.45, 95% CI 1.20 to 1.77; >30 to ≤35: OR 1.70, 95% CI 1.39 to 2.09 and >35: OR 1.78, 95% CI 1.25 to 2.55) and previous shoulder trauma (OR 0.80; 95% CI 0.68 to 0.94).Conclusion We identified increasing age and higher BMI as factors associated with GH OA. …”
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Associations between Children’s Exposure to PM2.5 and their Serum Inflammatory Responses in Taiwan by Wei-Jung Tseng, Jian-He Lu, How-Ran Chao, Ming-Hsien Tsai, Yu-Ting Chang, Liang-Jen Wang, Chih-Cheng Chen, Wan-Nurdiyana-Wan Mansor, Juliana Jalaludin, Chih-Lung Wang, Ying-I Tsai

“…Children’s serum TNF-α was significantly linked to PM2.5 exposure scenarios (p = 0.031) by the test of the multivariate analysis (adjusted R2 = 0.033, p = 0.039), but the other variables of age (p = 0.147) and gender (p = 0.291) were not statistically significant. …”
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A logistic regression model to predict long-term survival for borderline resectable pancreatic cancer patients with upfront surgery by Jin-Can Huang, Shao-Cheng Lyu, Bing Pan, Han-Xuan Wang, You-Wei Ma, Tao Jiang, Qiang He, Ren Lang

“…In the long-term group (n = 32) and short-term group (n = 72), the overall median survival time and the 1-, 2-, 3- years overall survival were 38 months, 100%, 100%, 61.3% and 10 months, 38.9%, 0%, 0%, respectively. 4 variables, including age, vascular invasion length, vascular morphological malformation, and local lymphadenopathy were confirmed as independent risk factors between the two groups following univariate and multivariate analysis. The AUC between the training set (n = 72) and the validation set (n = 32) were 0.881 and 0.875. …”
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Clinical characteristics and prognosis of amyopathic dermatomyositis patients with interstitial lung disease: insights from a retrospective cohort by Yanan Ying, Tingting Wu, Long Wang, Yun Zhang, Yiming Yu, Zaichun Deng, Qunli Ding

“…Survival was shorter among patients with ADM-OP than among control patients (p = 0.002). Cox multivariate analysis revealed that age (p = 0.002), smoking status (p = 0.011), anti-melanoma differentiation-associated gene 5 (MDA5) antibody (p = 0.017), and white blood cell count (p = 0.004) were independent predictors of shorter survival. …”
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A multicenter retrospective study of early cardiac toxicity in operable breast cancer patients receiving concurrent dual or mono anti-HER2 therapy with postoperative radiation ther... by Jing Yang, Meng-Yun Zhou, Bo Yu, Qing Lin, Yuan Yao, Hua-Ling Wu, Qi-Wei Zhu, Ming Ye, Hua-Ying Xie, Jian-Wei Wu, Gang Cai, Rong Cai, Wei-Xiang Qi, Jia-Yi Chen, Lu Cao

“…The median follow-up was 11 months. Multivariate analysis showed that left-sided breast cancer (HR 2.38; 95%CI 1.65–3.44, p < 0.001) and IMN RT (HR 1.47; 95 % CI 1.01–2.15, P-value = 0.047) are independent risk factors for ECG abnormalities. …”
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Site-specific immunoglobulin G N-glycosylation is associated with gastric cancer progression by Tingting Xu, Jianmin Huang, Jiajing Lin, Yuanyuan Liu, Yi Wang, Wenkang Shen, Jianjie He, Shuyun Chen, Xi Zhu, Yuqin Que, Mengting Hu, Yu Chen, Liming Cheng, Honghao He, Xin Liu, Si Liu

“…Methods The IgG N-glycome in GC was characterized using a custom high-throughput orthogonal mass spectrometry approach. Multivariate analysis was employed to identify and assess glycomic alterations. …”
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Temporal trends in guideline-recommended medical therapy after an acute heart failure decompensation event: an observational analysis from Generator Heart Failure DataMart by Antonio Gasbarrini, Giuseppe Patti, Filippo Crea, Giovanni Scambia, Domenico D'Amario, Vincenzo Valentini, Gianluigi Savarese, Alfredo Cesario, Jacopo Lenkowicz, Stefano Patarnello, Renzo Laborante, Agni Delvinioti, Andrada Mihaela Tudor, Chiara Iacomini, Antonio Iaconelli, Donato Antonio Paglianiti, Mattia Galli, Daniele Rodolico, Attilio Restivo, Giuseppe Ciliberti, Gaetano Rizzo, Emiliano Bianchini, Matteo Busti, Luca Sensini

“…Over time, an increase in the prescription rate occurred only for SGLT2 inhibitors (3% vs 10% vs 32%, p&lt;0.001), whereas the rate of the composite of all-cause death and rehospitalisation for urgent causes at 30 days remained stable (9.9% vs 10.3% vs 8.4%; p=ns). In multivariate analysis, the use of ACEi/ARB/ARNi was associated with a lower risk of 30-day all-cause death and urgent rehospitalisation (adjusted OR 0.38; 95% CI 0.24 to 0.59; p&lt;0.01). …”
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Long-term real-world evidence of CPX-351 of high-risk patients with AML identified high rate of negative MRD and prolonged OS by Thomas Cluzeau, Fabio Guolo, Edmond Chiche, Paola Minetto, Ramy Rahme, Sarah Bertoli, Luana Fianchi, Jean-Baptiste Micol, Michele Gottardi, Pierre Peterlin, Sara Galimberti, Xavier Thomas, Giuliana Rizzuto, Olivier Legrand, Michela Rondoni, Emmanuel Raffoux, Giambattista Bertani, Alexis Caulier, Michelina D’Argenio, Caroline Bonmati, Atto Billio, Caroline Lejeune, Barbara Scappini, Arnaud Pigneux, Patrizia Zappasodi, Christan Recher, Francesco Grimaldi, Lionel Ades, Roberto M. Lemoli

“…The median OS was 20.4 months vs 12.9 months for patients with MRD below or above 10–3, respectively (P = .006). In a multivariate analysis, only MRD >10–3 was associated with a poorer OS (hazard ratio, 2.6; 95% confidence interval, 1.2-5.5; P = .013). …”
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Intravenous versus subcutaneous tocilizumab in Takayasu arteritis: multicentre retrospective study by Patrice Cacoub, Arsène Mekinian, David Saadoun, Pavel I Novikov, Savino Sciascia, Corrado Campochiaro, Olivier Fain, Ilya Smitienko, Nicolas Schleinitz, Patrick Jégo, Francesco Muratore, Carlo Salvarani, Elena Galli, Sabine Berthier, Marc Lambert, François Maurier, Isabelle Kone-Paut, Sergey Moiseev, Masataka Kuwana, Alexandre Belot, Martin Michaud, Francis Gaches, Achille Aouba, Xavier Puechal, Karim Sacre, Tiphaine Goulenok, Alessandro Tomelleri, Thomas Sené, Elena Marina Baldissera, Luigi Boiardi, Abid Awisat, Ygal Benhamou, Vahan Mukuchyan, Mathieu Vautier, Azeddine Dellal, Lucie Biard, Julie Seguier, José Hernández-Rodríguez, Olivier Espitia, Sebastien Humbert, Guillaume Denis, Nolan Hassold, Dagna Lorenzo, Helene Munoz Pons, Jean Baptiste Gaultier, Le Mouel Edwige, Antoinette Perlat, Bertrand Lioger, Jonathan Broner, Virginie Dufrost, Faten Frikha, Alexandra Audemard-Verger, Pascal Woaye-Hune, Pierre Zeminsky, Moya Alvarado, Matheus Vieira, Alberto Lo Gullo

“…The factors associated with complete response to tocilizumab at 6 months in multivariate analysis, only age &lt;30 years (OR 2.85, 95% CI 1.14 to 7.12; p=0.027) and time between TAK diagnosis and tocilizumab initiation (OR 1.18, 95% CI 1.02 to 1.36; p=0.034). …”
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Neutrophil to Lymphocyte Ratio as a Predictor of Adverse Outcome in Patients with Decompensated Liver Cirrhosis by Valeriy D. Lunkov, Marina V. Maevskaya, Ekaterina K. Tsvetaeva, Ana G. Mendez, Maria S. Zharkova, Petr E. Tkachenko, Vladimir T. Ivashkin

“…Correlation analysis, univariate and multivariable analysis were provided to find factors statistically significantly associated with lethal outcome and SIRS. …”
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